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Items: 1 to 50 of 62

1.

Parsing and Quantification of Raw Orbitrap Mass Spectrometer Data Using RawQuant.

Kovalchik KA, Moggridge S, Chen DDY, Morin GB, Hughes CS.

J Proteome Res. 2018 Jun 1;17(6):2237-2247. doi: 10.1021/acs.jproteome.8b00072. Epub 2018 Apr 26.

PMID:
29682972
2.

Extending the Compatibility of the SP3 Paramagnetic Bead Processing Approach for Proteomics.

Moggridge S, Sorensen PH, Morin GB, Hughes CS.

J Proteome Res. 2018 Apr 6;17(4):1730-1740. doi: 10.1021/acs.jproteome.7b00913. Epub 2018 Mar 27.

PMID:
29565595
3.

Molecular characterization of ERBB2-amplified colorectal cancer identifies potential mechanisms of resistance to targeted therapies: a report of two instructive cases.

Owen DR, Wong HL, Bonakdar M, Jones M, Hughes CS, Morin GB, Jones SJM, Renouf DJ, Lim H, Laskin J, Marra M, Yip S, Schaeffer DF.

Cold Spring Harb Mol Case Stud. 2018 Apr 2;4(2). pii: a002535. doi: 10.1101/mcs.a002535. Print 2018 Apr.

4.

PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia.

Lai D, Chen M, Su J, Liu X, Rothe K, Hu K, Forrest DL, Eaves CJ, Morin GB, Jiang X.

Sci Transl Med. 2018 Feb 7;10(427). pii: eaan8735. doi: 10.1126/scitranslmed.aan8735.

PMID:
29437150
5.

Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress.

Mathew V, Tam AS, Milbury KL, Hofmann AK, Hughes CS, Morin GB, Loewen CJR, Stirling PC.

J Cell Biol. 2017 Dec 4;216(12):4027-4040. doi: 10.1083/jcb.201612018. Epub 2017 Oct 4.

6.

Using Public Data for Comparative Proteome Analysis in Precision Medicine Programs.

Hughes CS, Morin GB.

Proteomics Clin Appl. 2018 Mar;12(2). doi: 10.1002/prca.201600179. Epub 2017 Oct 23.

PMID:
28887829
7.

Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy.

Choutka C, DeVorkin L, Go NE, Hou YC, Moradian A, Morin GB, Gorski SM.

Autophagy. 2017 Sep 2;13(9):1573-1589. doi: 10.1080/15548627.2017.1339004. Epub 2017 Aug 14.

8.

The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type.

Wang Y, Chen SY, Karnezis AN, Colborne S, Santos ND, Lang JD, Hendricks WP, Orlando KA, Yap D, Kommoss F, Bally MB, Morin GB, Trent JM, Weissman BE, Huntsman DG.

J Pathol. 2017 Jul;242(3):371-383. doi: 10.1002/path.4912. Epub 2017 Jun 2.

PMID:
28444909
9.

Investigating Acquisition Performance on the Orbitrap Fusion When Using Tandem MS/MS/MS Scanning with Isobaric Tags.

Hughes CS, Spicer V, Krokhin OV, Morin GB.

J Proteome Res. 2017 May 5;16(5):1839-1846. doi: 10.1021/acs.jproteome.7b00091. Epub 2017 Apr 20.

PMID:
28418257
10.

Evaluating the Characteristics of Reporter Ion Signal Acquired in the Orbitrap Analyzer for Isobaric Mass Tag Proteome Quantification Experiments.

Hughes CS, Zhu C, Spicer V, Krokhin OV, Morin GB.

J Proteome Res. 2017 May 5;16(5):1831-1838. doi: 10.1021/acs.jproteome.7b00092. Epub 2017 Apr 20.

PMID:
28418254
11.

CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.

Tien JF, Mazloomian A, Cheng SG, Hughes CS, Chow CCT, Canapi LT, Oloumi A, Trigo-Gonzalez G, Bashashati A, Xu J, Chang VC, Shah SP, Aparicio S, Morin GB.

Nucleic Acids Res. 2017 Jun 20;45(11):6698-6716. doi: 10.1093/nar/gkx187.

12.

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

Funnell T, Tasaki S, Oloumi A, Araki S, Kong E, Yap D, Nakayama Y, Hughes CS, Cheng SG, Tozaki H, Iwatani M, Sasaki S, Ohashi T, Miyazaki T, Morishita N, Morishita D, Ogasawara-Shimizu M, Ohori M, Nakao S, Karashima M, Sano M, Murai A, Nomura T, Uchiyama N, Kawamoto T, Hara R, Nakanishi O, Shumansky K, Rosner J, Wan A, McKinney S, Morin GB, Nakanishi A, Shah S, Toyoshiba H, Aparicio S.

Nat Commun. 2017 Feb 23;8(1):7. doi: 10.1038/s41467-016-0008-7.

13.

Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research.

Hughes CS, McConechy MK, Cochrane DR, Nazeran T, Karnezis AN, Huntsman DG, Morin GB.

Sci Rep. 2016 Oct 7;6:34949. doi: 10.1038/srep34949.

14.

Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia.

Barakauskas VE, Moradian A, Barr AM, Beasley CL, Rosoklija G, Mann JJ, Ilievski B, Stankov A, Dwork AJ, Falkai P, Morin GB, Honer WG.

Schizophr Res. 2016 Nov;177(1-3):44-51. doi: 10.1016/j.schres.2016.03.002. Epub 2016 Mar 9.

15.

Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.

Dixon-Clarke SE, Elkins JM, Cheng SW, Morin GB, Bullock AN.

Sci Rep. 2015 Nov 24;5:17122. doi: 10.1038/srep17122.

16.

The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors.

Wang Y, Chen J, Yang W, Mo F, Senz J, Yap D, Anglesio MS, Gilks B, Morin GB, Huntsman DG.

Neoplasia. 2015 Aug;17(8):650-60. doi: 10.1016/j.neo.2015.08.003.

17.

MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation.

Pon JR, Wong J, Saberi S, Alder O, Moksa M, Grace Cheng SW, Morin GB, Hoodless PA, Hirst M, Marra MA.

Nat Commun. 2015 Aug 6;6:7953. doi: 10.1038/ncomms8953.

18.

Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis.

Chen J, Wang Y, McMonechy MK, Anglesio MS, Yang W, Senz J, Maines-Bandiera S, Rosner J, Trigo-Gonzalez G, Grace Cheng SW, Kim J, Matzuk MM, Morin GB, Huntsman DG.

J Pathol. 2015 Oct;237(2):215-25. doi: 10.1002/path.4569. Epub 2015 Jul 6.

PMID:
26033159
19.

The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy.

Chittaranjan S, Xu J, Kuzyk M, Dullat HK, Wilton J, DeVorkin L, Lebovitz C, Morin GB, Marra MA, Gorski SM.

Biol Open. 2015 Apr 2;4(5):672-84. doi: 10.1242/bio.20148417.

20.

Activation of an endogenous retrovirus-associated long non-coding RNA in human adenocarcinoma.

Gibb EA, Warren RL, Wilson GW, Brown SD, Robertson GA, Morin GB, Holt RA.

Genome Med. 2015 Mar 5;7(1):22. doi: 10.1186/s13073-015-0142-6. eCollection 2015.

21.

Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity.

Chittaranjan S, Chan S, Yang C, Yang KC, Chen V, Moradian A, Firme M, Song J, Go NE, Blough MD, Chan JA, Cairncross JG, Gorski SM, Morin GB, Yip S, Marra MA.

Oncotarget. 2014 Sep 15;5(17):7960-79.

22.

The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB.

DeVorkin L, Go NE, Hou YC, Moradian A, Morin GB, Gorski SM.

J Cell Biol. 2014 May 26;205(4):477-92. doi: 10.1083/jcb.201303144.

23.

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.

Berg T, Thoene S, Yap D, Wee T, Schoeler N, Rosten P, Lim E, Bilenky M, Mungall AJ, Oellerich T, Lee S, Lai CK, Umlandt P, Salmi A, Chang H, Yue L, Lai D, Cheng SW, Morin RD, Hirst M, Serve H, Marra MA, Morin GB, Gascoyne RD, Aparicio SA, Humphries RK.

Blood. 2014 Jun 19;123(25):3914-24. doi: 10.1182/blood-2012-12-473439. Epub 2014 May 6.

24.

The 3' overhangs at Tetrahymena thermophila telomeres are packaged by four proteins, Pot1a, Tpt1, Pat1, and Pat2.

Premkumar VL, Cranert S, Linger BR, Morin GB, Minium S, Price C.

Eukaryot Cell. 2014 Feb;13(2):240-5. doi: 10.1128/EC.00275-13. Epub 2013 Dec 2.

25.

The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.

van Wietmarschen N, Moradian A, Morin GB, Lansdorp PM, Uringa EJ.

J Biol Chem. 2012 Dec 21;287(52):43351-8. doi: 10.1074/jbc.M112.431270. Epub 2012 Nov 13.

26.

Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage.

Anglesio MS, Wang Y, Yang W, Senz J, Wan A, Heravi-Moussavi A, Salamanca C, Maines-Bandiera S, Huntsman DG, Morin GB.

J Pathol. 2013 Feb;229(3):400-9. doi: 10.1002/path.4135.

PMID:
23132766
27.

Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.

Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett SE, Griffith M, Marra MA, Morin GB.

Mol Cell Biol. 2012 Nov;32(22):4691-704. doi: 10.1128/MCB.06267-11. Epub 2012 Sep 17.

28.

Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors.

Liu X, Chen M, Lobo P, An J, Grace Cheng SW, Moradian A, Morin GB, Van Petegem F, Jiang X.

Proteomics. 2012 Jul;12(13):2094-106. doi: 10.1002/pmic.201100553.

PMID:
22623184
29.

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan SK, Griffith M, Moradian A, Cheng SW, Morin GB, Watson P, Gelmon K, Chia S, Chin SF, Curtis C, Rueda OM, Pharoah PD, Damaraju S, Mackey J, Hoon K, Harkins T, Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello JF, Meyer IM, Eaves CJ, Wasserman WW, Jones S, Huntsman D, Hirst M, Caldas C, Marra MA, Aparicio S.

Nature. 2012 Apr 4;486(7403):395-9. doi: 10.1038/nature10933.

30.

Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer.

Griffith M, Mwenifumbo JC, Cheung PY, Paul JE, Pugh TJ, Tang MJ, Chittaranjan S, Morin RD, Asano JK, Ally AA, Miao L, Lee A, Chan SY, Taylor G, Severson T, Hou YC, Griffith OL, Cheng GS, Novik K, Moore R, Luk M, Owen D, Brown CJ, Morin GB, Gill S, Tai IT, Marra MA.

Pharmacogenomics J. 2013 Apr;13(2):148-58. doi: 10.1038/tpj.2011.65. Epub 2012 Jan 17.

PMID:
22249354
31.

Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.

Heravi-Moussavi A, Anglesio MS, Cheng SW, Senz J, Yang W, Prentice L, Fejes AP, Chow C, Tone A, Kalloger SE, Hamel N, Roth A, Ha G, Wan AN, Maines-Bandiera S, Salamanca C, Pasini B, Clarke BA, Lee AF, Lee CH, Zhao C, Young RH, Aparicio SA, Sorensen PH, Woo MM, Boyd N, Jones SJ, Hirst M, Marra MA, Gilks B, Shah SP, Foulkes WD, Morin GB, Huntsman DG.

N Engl J Med. 2012 Jan 19;366(3):234-42. doi: 10.1056/NEJMoa1102903. Epub 2011 Dec 21.

32.

Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers.

Yip S, Butterfield YS, Morozova O, Chittaranjan S, Blough MD, An J, Birol I, Chesnelong C, Chiu R, Chuah E, Corbett R, Docking R, Firme M, Hirst M, Jackman S, Karsan A, Li H, Louis DN, Maslova A, Moore R, Moradian A, Mungall KL, Perizzolo M, Qian J, Roldan G, Smith EE, Tamura-Wells J, Thiessen N, Varhol R, Weiss S, Wu W, Young S, Zhao Y, Mungall AJ, Jones SJ, Morin GB, Chan JA, Cairncross JG, Marra MA.

J Pathol. 2012 Jan;226(1):7-16. doi: 10.1002/path.2995. Epub 2011 Nov 10.

33.

The Pot1a-associated proteins Tpt1 and Pat1 coordinate telomere protection and length regulation in Tetrahymena.

Linger BR, Morin GB, Price CM.

Mol Biol Cell. 2011 Nov;22(21):4161-70. doi: 10.1091/mbc.E11-06-0551. Epub 2011 Sep 7.

34.

A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation.

Tognon CE, Martin MJ, Moradian A, Trigo G, Rotblat B, Cheng SW, Pollard M, Uy E, Chow C, Carboni JM, Gottardis MM, Pollak M, Morin GB, Sorensen PH.

Oncogene. 2012 Mar 8;31(10):1334-40. doi: 10.1038/onc.2011.323. Epub 2011 Aug 1.

PMID:
21804605
35.

Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas.

McConechy MK, Anglesio MS, Kalloger SE, Yang W, Senz J, Chow C, Heravi-Moussavi A, Morin GB, Mes-Masson AM; Australian Ovarian Cancer Study Group, Carey MS, McAlpine JN, Kwon JS, Prentice LM, Boyd N, Shah SP, Gilks CB, Huntsman DG.

J Pathol. 2011 Apr;223(5):567-73. doi: 10.1002/path.2848. Epub 2011 Mar 7.

PMID:
21381030
36.

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, Morin GB, Aparicio SA.

Blood. 2011 Feb 24;117(8):2451-9. doi: 10.1182/blood-2010-11-321208. Epub 2010 Dec 29.

37.

ARID1A mutations in endometriosis-associated ovarian carcinomas.

Wiegand KC, Shah SP, Al-Agha OM, Zhao Y, Tse K, Zeng T, Senz J, McConechy MK, Anglesio MS, Kalloger SE, Yang W, Heravi-Moussavi A, Giuliany R, Chow C, Fee J, Zayed A, Prentice L, Melnyk N, Turashvili G, Delaney AD, Madore J, Yip S, McPherson AW, Ha G, Bell L, Fereday S, Tam A, Galletta L, Tonin PN, Provencher D, Miller D, Jones SJ, Moore RA, Morin GB, Oloumi A, Boyd N, Aparicio SA, Shih IeM, Mes-Masson AM, Bowtell DD, Hirst M, Gilks B, Marra MA, Huntsman DG.

N Engl J Med. 2010 Oct 14;363(16):1532-43. doi: 10.1056/NEJMoa1008433. Epub 2010 Sep 8.

38.

Alternative expression analysis by RNA sequencing.

Griffith M, Griffith OL, Mwenifumbo J, Goya R, Morrissy AS, Morin RD, Corbett R, Tang MJ, Hou YC, Pugh TJ, Robertson G, Chittaranjan S, Ally A, Asano JK, Chan SY, Li HI, McDonald H, Teague K, Zhao Y, Zeng T, Delaney A, Hirst M, Morin GB, Jones SJ, Tai IT, Marra MA.

Nat Methods. 2010 Oct;7(10):843-7. doi: 10.1038/nmeth.1503. Epub 2010 Sep 12.

PMID:
20835245
39.

Cytosolic protein interactions of the schizophrenia susceptibility gene dysbindin.

Mead CL, Kuzyk MA, Moradian A, Wilson GM, Holt RA, Morin GB.

J Neurochem. 2010 Jun;113(6):1491-503. doi: 10.1111/j.1471-4159.2010.06690.x. Epub 2010 Mar 14.

40.

ALEXA: a microarray design platform for alternative expression analysis.

Griffith M, Tang MJ, Griffith OL, Morin RD, Chan SY, Asano JK, Zeng T, Flibotte S, Ally A, Baross A, Hirst M, Jones SJ, Morin GB, Tai IT, Marra MA.

Nat Methods. 2008 Feb;5(2):118. doi: 10.1038/nmeth0208-118. No abstract available.

PMID:
18235430
41.

Large-scale mapping of human protein-protein interactions by mass spectrometry.

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D.

Mol Syst Biol. 2007;3:89. Epub 2007 Mar 13.

42.

Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites.

Colwill K, Wells CD, Elder K, Goudreault M, Hersi K, Kulkarni S, Hardy WR, Pawson T, Morin GB.

BMC Biotechnol. 2006 Mar 6;6:13.

43.

Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells.

Allsopp RC, Morin GB, Horner JW, DePinho R, Harley CB, Weissman IL.

Nat Med. 2003 Apr;9(4):369-71. No abstract available.

PMID:
12669037
44.

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation.

Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL.

Blood. 2003 Jul 15;102(2):517-20. Epub 2003 Mar 27.

45.

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.

Kaminker PG, Kim SH, Taylor RD, Zebarjadian Y, Funk WD, Morin GB, Yaswen P, Campisi J.

J Biol Chem. 2001 Sep 21;276(38):35891-9. Epub 2001 Jul 13.

46.

Functional requirement of p23 and Hsp90 in telomerase complexes.

Holt SE, Aisner DL, Baur J, Tesmer VM, Dy M, Ouellette M, Trager JB, Morin GB, Toft DO, Shay JW, Wright WE, White MA.

Genes Dev. 1999 Apr 1;13(7):817-26.

47.

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.

Greenberg RA, O'Hagan RC, Deng H, Xiao Q, Hann SR, Adams RR, Lichtsteiner S, Chin L, Morin GB, DePinho RA.

Oncogene. 1999 Feb 4;18(5):1219-26.

48.

Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation.

Greenberg RA, Allsopp RC, Chin L, Morin GB, DePinho RA.

Oncogene. 1998 Apr 2;16(13):1723-30.

49.

Extension of life-span by introduction of telomerase into normal human cells.

Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE.

Science. 1998 Jan 16;279(5349):349-52.

50.

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT.

Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB, Morin GB.

Nat Genet. 1997 Dec;17(4):498-502.

PMID:
9398860

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