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Items: 1 to 50 of 229

1.

Large-scale investigation of the reasons why potentially important genes are ignored.

Stoeger T, Gerlach M, Morimoto RI, Nunes Amaral LA.

PLoS Biol. 2018 Sep 18;16(9):e2006643. doi: 10.1371/journal.pbio.2006643. eCollection 2018 Sep.

2.

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging.

Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI.

Cell Rep. 2017 Nov 7;21(6):1481-1494. doi: 10.1016/j.celrep.2017.10.038.

3.

In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging.

Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau B, Nillegoda NB.

Aging Cell. 2017 Dec;16(6):1414-1424. doi: 10.1111/acel.12686. Epub 2017 Oct 10.

4.

Long-range correlations and fractal dynamics in C. elegans: Changes with aging and stress.

Alves LGA, Winter PB, Ferreira LN, Brielmann RM, Morimoto RI, Amaral LAN.

Phys Rev E. 2017 Aug;96(2-1):022417. doi: 10.1103/PhysRevE.96.022417. Epub 2017 Aug 29.

5.

Rethinking HSF1 in Stress, Development, and Organismal Health.

Li J, Labbadia J, Morimoto RI.

Trends Cell Biol. 2017 Dec;27(12):895-905. doi: 10.1016/j.tcb.2017.08.002. Epub 2017 Sep 7. Review.

PMID:
28890254
6.

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H.

J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10.

7.

Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.

Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5703-E5711. doi: 10.1073/pnas.1618417114. Epub 2017 Jun 26.

8.

Shaping proteostasis at the cellular, tissue, and organismal level.

Sala AJ, Bott LC, Morimoto RI.

J Cell Biol. 2017 May 1;216(5):1231-1241. doi: 10.1083/jcb.201612111. Epub 2017 Apr 11. Review.

9.

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, Tartaglia GG, Saunders DN, Wilson MR, Oliver SG, Morimoto RI, Dobson CM, Vendruscolo M, Favrin G, Yerbury JJ.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E3935-E3943. doi: 10.1073/pnas.1613854114. Epub 2017 Apr 10.

10.

Correction to "Chiral Cyclohexane 1,3-Diones as Inhibitors of Mutant SOD1-Dependent Protein Aggregation for the Treatment of ALS".

Zhang Y, Benmohamed R, Zhang W, Kim J, Edgerly CK, Zhu Y, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB.

ACS Med Chem Lett. 2017 Feb 24;8(3):377. doi: 10.1021/acsmedchemlett.7b00070. eCollection 2017 Mar 9.

11.

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.

Cell. 2017 Feb 23;168(5):944. doi: 10.1016/j.cell.2016.12.041. No abstract available.

12.

Susan Lindquist 1949-2016.

Morimoto RI.

Nat Struct Mol Biol. 2016 Dec 6;23(12):1072-1073. doi: 10.1038/nsmb.3339. No abstract available.

PMID:
27922616
13.

E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response.

Li J, Chauve L, Phelps G, Brielmann RM, Morimoto RI.

Genes Dev. 2016 Sep 15;30(18):2062-2075. Epub 2016 Sep 29.

14.

A network approach to discerning the identities of C. elegans in a free moving population.

Winter PB, Brielmann RM, Timkovich NP, Navarro HT, Teixeira-Castro A, Morimoto RI, Amaral LA.

Sci Rep. 2016 Oct 11;6:34859. doi: 10.1038/srep34859.

15.

A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation.

Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4753-8. doi: 10.1073/pnas.1516604113. Epub 2016 Apr 11.

16.

Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.

Teixeira-Castro A, Jalles A, Esteves S, Kang S, da Silva Santos L, Silva-Fernandes A, Neto MF, Brielmann RM, Bessa C, Duarte-Silva S, Miranda A, Oliveira S, Neves-Carvalho A, Bessa J, Summavielle T, Silverman RB, Oliveira P, Morimoto RI, Maciel P.

Brain. 2015 Nov;138(Pt 11):3221-37. doi: 10.1093/brain/awv262. Epub 2015 Sep 15.

17.

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.

Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B.

Nature. 2015 Aug 13;524(7564):247-51. doi: 10.1038/nature14884. Epub 2015 Aug 5.

18.

Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.

Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl FU, Nagata K, Morimoto RI.

EMBO J. 2015 Sep 14;34(18):2334-49. doi: 10.15252/embj.201591711. Epub 2015 Jul 29.

19.

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction.

Labbadia J, Morimoto RI.

Mol Cell. 2015 Aug 20;59(4):639-50. doi: 10.1016/j.molcel.2015.06.027. Epub 2015 Jul 23.

20.

Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis.

Zhang Y, Zhao KT, Fox SG, Kim J, Kirsch DR, Ferrante RJ, Morimoto RI, Silverman RB.

J Med Chem. 2015 Aug 13;58(15):5942-9. doi: 10.1021/acs.jmedchem.5b00561. Epub 2015 Jul 31.

21.

The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis.

Brandvold KR, Morimoto RI.

J Mol Biol. 2015 Sep 11;427(18):2931-47. doi: 10.1016/j.jmb.2015.05.010. Epub 2015 May 21. Review.

22.

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.

Cell. 2015 May 7;161(4):919-32. doi: 10.1016/j.cell.2015.03.032. Erratum in: Cell. 2017 Feb 23;168(5):944.

23.

The biology of proteostasis in aging and disease.

Labbadia J, Morimoto RI.

Annu Rev Biochem. 2015;84:435-64. doi: 10.1146/annurev-biochem-060614-033955. Epub 2015 Mar 12. Review.

24.

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases.

Ciryam P, Kundra R, Morimoto RI, Dobson CM, Vendruscolo M.

Trends Pharmacol Sci. 2015 Feb;36(2):72-7. doi: 10.1016/j.tips.2014.12.004. Epub 2015 Jan 27. Review.

25.

Investigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. elegans.

Nussbaum-Krammer CI, Neto MF, Brielmann RM, Pedersen JS, Morimoto RI.

J Vis Exp. 2015 Jan 8;(95):52321. doi: 10.3791/52321.

26.

Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase.

Tatum MC, Ooi FK, Chikka MR, Chauve L, Martinez-Velazquez LA, Steinbusch HWM, Morimoto RI, Prahlad V.

Curr Biol. 2015 Jan 19;25(2):163-174. doi: 10.1016/j.cub.2014.11.040. Epub 2014 Dec 31.

27.

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease.

Brehme M, Voisine C, Rolland T, Wachi S, Soper JH, Zhu Y, Orton K, Villella A, Garza D, Vidal M, Ge H, Morimoto RI.

Cell Rep. 2014 Nov 6;9(3):1135-50. doi: 10.1016/j.celrep.2014.09.042. Epub 2014 Oct 23.

28.

Geroscience: linking aging to chronic disease.

Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F.

Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039.

29.

Modulation of the maladaptive stress response to manage diseases of protein folding.

Roth DM, Hutt DM, Tong J, Bouchecareilh M, Wang N, Seeley T, Dekkers JF, Beekman JM, Garza D, Drew L, Masliah E, Morimoto RI, Balch WE.

PLoS Biol. 2014 Nov 18;12(11):e1001998. doi: 10.1371/journal.pbio.1001998. eCollection 2014 Nov.

30.

Deuteration and fluorination of 1,3-bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione to improve its pharmacokinetic properties.

Xia G, Benmohamed R, Morimoto RI, Kirsch DR, Silverman RB.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5098-101. doi: 10.1016/j.bmcl.2014.08.066. Epub 2014 Sep 15.

31.

Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling.

van Oosten-Hawle P, Morimoto RI.

Genes Dev. 2014 Jul 15;28(14):1533-43. doi: 10.1101/gad.241125.114. Review.

32.

Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis.

Trippier PC, Zhao KT, Fox SG, Schiefer IT, Benmohamed R, Moran J, Kirsch DR, Morimoto RI, Silverman RB.

ACS Chem Neurosci. 2014 Sep 17;5(9):823-9. doi: 10.1021/cn500147v. Epub 2014 Jul 18.

33.

How the nucleus copes with proteotoxic stress.

Shibata Y, Morimoto RI.

Curr Biol. 2014 May 19;24(10):R463-74. doi: 10.1016/j.cub.2014.03.033. Review.

34.

Proteostasis and the aging proteome in health and disease.

Morimoto RI, Cuervo AM.

J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S33-8. doi: 10.1093/gerona/glu049. Review.

35.

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition.

Yu A, Shibata Y, Shah B, Calamini B, Lo DC, Morimoto RI.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1481-90. doi: 10.1073/pnas.1321811111. Epub 2014 Apr 1.

36.

Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.

Ryno LM, Genereux JC, Naito T, Morimoto RI, Powers ET, Shoulders MD, Wiseman RL.

ACS Chem Biol. 2014 Jun 20;9(6):1273-83. doi: 10.1021/cb500062n. Epub 2014 Apr 16.

37.

Proteostasis and longevity: when does aging really begin?

Labbadia J, Morimoto RI.

F1000Prime Rep. 2014 Feb 3;6:7. doi: 10.12703/P6-7. eCollection 2014. Review.

38.

Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1.

Kitamura A, Inada N, Kubota H, Matsumoto G, Kinjo M, Morimoto RI, Nagata K.

Genes Cells. 2014 Mar;19(3):209-24. doi: 10.1111/gtc.12125. Epub 2014 Jan 23.

39.

Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases.

Nussbaum-Krammer CI, Morimoto RI.

Dis Model Mech. 2014 Jan;7(1):31-9. doi: 10.1242/dmm.013011. Review.

40.

Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses.

van Oosten-Hawle P, Morimoto RI.

J Exp Biol. 2014 Jan 1;217(Pt 1):129-36. doi: 10.1242/jeb.091249. Review.

41.

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.

Ciryam P, Tartaglia GG, Morimoto RI, Dobson CM, Vendruscolo M.

Cell Rep. 2013 Nov 14;5(3):781-90. doi: 10.1016/j.celrep.2013.09.043. Epub 2013 Oct 31.

42.

Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease.

Gidalevitz T, Wang N, Deravaj T, Alexander-Floyd J, Morimoto RI.

BMC Biol. 2013 Sep 30;11:100. doi: 10.1186/1741-7007-11-100.

43.

Malfolded protein structure and proteostasis in lung diseases.

Balch WE, Sznajder JI, Budinger S, Finley D, Laposky AD, Cuervo AM, Benjamin IJ, Barreiro E, Morimoto RI, Postow L, Weissman AM, Gail D, Banks-Schlegel S, Croxton T, Gan W.

Am J Respir Crit Care Med. 2014 Jan 1;189(1):96-103. doi: 10.1164/rccm.201306-1164WS.

44.

Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response.

Silva MC, Amaral MD, Morimoto RI.

PLoS Genet. 2013 Aug;9(8):e1003711. doi: 10.1371/journal.pgen.1003711. Epub 2013 Aug 29.

45.

Ribosome-associated chaperones act as proteostasis sentinels.

Kirstein-Miles J, Morimoto RI.

Cell Cycle. 2013 Aug 1;12(15):2335-6. doi: 10.4161/cc.25703. Epub 2013 Jul 15. No abstract available.

46.

Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease.

Bersuker K, Hipp MS, Calamini B, Morimoto RI, Kopito RR.

J Biol Chem. 2013 Aug 16;288(33):23633-8. doi: 10.1074/jbc.C113.481945. Epub 2013 Jul 9.

47.

ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases.

Calamini B, Silva MC, Madoux F, Hutt DM, Khanna S, Chalfant MA, Allais C, Ouizem S, Saldanha SA, Ferguson J, Mercer BA, Michael C, Tait BD, Garza D, Balch WE, Roush WR, Morimoto RI, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 17 [updated 2013 Apr 5].

48.

Huntington's disease: underlying molecular mechanisms and emerging concepts.

Labbadia J, Morimoto RI.

Trends Biochem Sci. 2013 Aug;38(8):378-85. doi: 10.1016/j.tibs.2013.05.003. Epub 2013 Jun 12. Review.

49.

Regulation of organismal proteostasis by transcellular chaperone signaling.

van Oosten-Hawle P, Porter RS, Morimoto RI.

Cell. 2013 Jun 6;153(6):1366-78. doi: 10.1016/j.cell.2013.05.015.

50.

Identification of a tissue-selective heat shock response regulatory network.

Guisbert E, Czyz DM, Richter K, McMullen PD, Morimoto RI.

PLoS Genet. 2013 Apr;9(4):e1003466. doi: 10.1371/journal.pgen.1003466. Epub 2013 Apr 18.

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