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Items: 1 to 50 of 87


Bidirectional Optogenetically-Induced Plasticity of Evoked Responses in the Rat Medial Prefrontal Cortex Can Impair or Enhance Cognitive Set-Shifting.

Bulin SE, Hohl KM, Paredes D, Silva JD, Morilak DA.

eNeuro. 2020 Jan 6;7(1). pii: ENEURO.0363-19.2019. doi: 10.1523/ENEURO.0363-19.2019. Print 2020 Jan/Feb.


Ciliary neurotrophic factor signaling in the rat orbitofrontal cortex ameliorates stress-induced deficits in reversal learning.

Girotti M, Silva JD, George CM, Morilak DA.

Neuropharmacology. 2019 Dec 1;160:107791. doi: 10.1016/j.neuropharm.2019.107791. Epub 2019 Sep 22.


Vortioxetine reverses medial prefrontal cortex-mediated cognitive deficits in male rats induced by castration as a model of androgen deprivation therapy for prostate cancer.

Sharp AM, Lertphinyowong S, Yee SS, Paredes D, Gelfond J, Johnson-Pais TL, Leach RJ, Liss M, Risinger AL, Sullivan AC, Thompson IM, Morilak DA.

Psychopharmacology (Berl). 2019 Nov;236(11):3183-3195. doi: 10.1007/s00213-019-05274-4. Epub 2019 May 28.


A Rodent Model of Exposure Therapy: The Use of Fear Extinction as a Therapeutic Intervention for PTSD.

Paredes D, Morilak DA.

Front Behav Neurosci. 2019 Mar 11;13:46. doi: 10.3389/fnbeh.2019.00046. eCollection 2019. Review.


Shock-probe Defensive Burying Test to Measure Active versus Passive Coping Style in Response to an Aversive Stimulus in Rats.

Fucich EA, Morilak DA.

Bio Protoc. 2018 Sep 5;8(17). pii: e2998. doi: 10.21769/BioProtoc.2998.


Ketamine Corrects a Deficit in Reversal Learning Caused by Chronic Intermittent Cold Stress in Female Rats.

Paredes D, Silva JD, Morilak DA.

Int J Neuropsychopharmacol. 2018 Dec 1;21(12):1109-1113. doi: 10.1093/ijnp/pyy080.


Activity in the Ventral Medial Prefrontal Cortex Is Necessary for the Therapeutic Effects of Extinction in Rats.

Fucich EA, Paredes D, Saunders MO, Morilak DA.

J Neurosci. 2018 Feb 7;38(6):1408-1417. doi: 10.1523/JNEUROSCI.0635-17.2017. Epub 2018 Jan 15.


Prefrontal cortex executive processes affected by stress in health and disease.

Girotti M, Adler SM, Bulin SE, Fucich EA, Paredes D, Morilak DA.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:161-179. doi: 10.1016/j.pnpbp.2017.07.004. Epub 2017 Jul 6. Review.


Deficits in cognitive flexibility induced by chronic unpredictable stress are associated with impaired glutamate neurotransmission in the rat medial prefrontal cortex.

Jett JD, Bulin SE, Hatherall LC, McCartney CM, Morilak DA.

Neuroscience. 2017 Mar 27;346:284-297. doi: 10.1016/j.neuroscience.2017.01.017. Epub 2017 Jan 26.


Chronic Vortioxetine Treatment Reduces Exaggerated Expression of Conditioned Fear Memory and Restores Active Coping Behavior in Chronically Stressed Rats.

Hatherall L, Sánchez C, Morilak DA.

Int J Neuropsychopharmacol. 2017 Apr 1;20(4):316-323. doi: 10.1093/ijnp/pyw105.


Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex.

Patton MS, Lodge DJ, Morilak DA, Girotti M.

Neuropsychopharmacology. 2017 May;42(6):1220-1230. doi: 10.1038/npp.2016.236. Epub 2016 Oct 17.


Therapeutic Effects of Extinction Learning as a Model of Exposure Therapy in Rats.

Fucich EA, Paredes D, Morilak DA.

Neuropsychopharmacology. 2016 Dec;41(13):3092-3102. doi: 10.1038/npp.2016.127. Epub 2016 Jul 15.


Antidepressant-like cognitive and behavioral effects of acute ketamine administration associated with plasticity in the ventral hippocampus to medial prefrontal cortex pathway.

Jett JD, Boley AM, Girotti M, Shah A, Lodge DJ, Morilak DA.

Psychopharmacology (Berl). 2015 Sep;232(17):3123-33. doi: 10.1007/s00213-015-3957-3. Epub 2015 May 20.


Interleukin-6 attenuates serotonin 2a receptor signaling by activating the JAK-STAT pathway.

Donegan JJ, Patton MS, Chavera TS, Berg KA, Morilak DA, Girotti M.

Mol Pharmacol. 2015;87(3):492-500. doi: 10.1124/mol.114.096289. Epub 2014 Dec 30.


Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats.

Wallace A, Pehrson AL, Sánchez C, Morilak DA.

Int J Neuropsychopharmacol. 2014 Oct;17(10):1695-706. doi: 10.1017/S1461145714000571. Epub 2014 May 23.


A novel role for brain interleukin-6: facilitation of cognitive flexibility in rat orbitofrontal cortex.

Donegan JJ, Girotti M, Weinberg MS, Morilak DA.

J Neurosci. 2014 Jan 15;34(3):953-62. doi: 10.1523/JNEUROSCI.3968-13.2014.


Exogenous prenatal corticosterone exposure mimics the effects of prenatal stress on adult brain stress response systems and fear extinction behavior.

Bingham BC, Sheela Rani CS, Frazer A, Strong R, Morilak DA.

Psychoneuroendocrinology. 2013 Nov;38(11):2746-57. doi: 10.1016/j.psyneuen.2013.07.003. Epub 2013 Aug 12.


Effects of milnacipran on cognitive flexibility following chronic stress in rats.

Naegeli KJ, O'Connor JA, Banerjee P, Morilak DA.

Eur J Pharmacol. 2013 Mar 5;703(1-3):62-6. doi: 10.1016/j.ejphar.2013.02.006. Epub 2013 Feb 17.


Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress.

Girotti M, Donegan JJ, Morilak DA.

Psychoneuroendocrinology. 2013 Jul;38(7):1158-69. doi: 10.1016/j.psyneuen.2012.11.004. Epub 2012 Dec 4.


Too much of a good thing: blocking noradrenergic facilitation in medial prefrontal cortex prevents the detrimental effects of chronic stress on cognition.

Jett JD, Morilak DA.

Neuropsychopharmacology. 2013 Mar;38(4):585-95. doi: 10.1038/npp.2012.216. Epub 2012 Nov 7.


Modulating the modulators: interaction of brain norepinephrine and cannabinoids in stress.

Morilak DA.

Exp Neurol. 2012 Dec;238(2):145-8. doi: 10.1016/j.expneurol.2012.08.016. Epub 2012 Aug 19. No abstract available.


Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity.

Roth MK, Bingham B, Shah A, Joshi A, Frazer A, Strong R, Morilak DA.

Neuropharmacology. 2012 Nov;63(6):1118-26. doi: 10.1016/j.neuropharm.2012.07.034. Epub 2012 Jul 25.


5-HT2A receptors in the orbitofrontal cortex facilitate reversal learning and contribute to the beneficial cognitive effects of chronic citalopram treatment in rats.

Furr A, Lapiz-Bluhm MD, Morilak DA.

Int J Neuropsychopharmacol. 2012 Oct;15(9):1295-305. doi: 10.1017/S1461145711001441. Epub 2011 Oct 19.


Prenatal stress induces long term stress vulnerability, compromising stress response systems in the brain and impairing extinction of conditioned fear after adult stress.

Green MK, Rani CS, Joshi A, Soto-Piña AE, Martinez PA, Frazer A, Strong R, Morilak DA.

Neuroscience. 2011 Sep 29;192:438-51. doi: 10.1016/j.neuroscience.2011.06.041. Epub 2011 Jun 22.


Chronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain.

Girotti M, Donegan JJ, Morilak DA.

Psychoneuroendocrinology. 2011 Sep;36(8):1164-74. doi: 10.1016/j.psyneuen.2011.02.008. Epub 2011 Mar 15.


Beneficial effects of desipramine on cognitive function of chronically stressed rats are mediated by alpha1-adrenergic receptors in medial prefrontal cortex.

Bondi CO, Jett JD, Morilak DA.

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):913-23. doi: 10.1016/j.pnpbp.2010.04.016. Epub 2010 Apr 24.


A cognitive deficit induced in rats by chronic intermittent cold stress is reversed by chronic antidepressant treatment.

Danet M, Lapiz-Bluhm S, Morilak DA.

Int J Neuropsychopharmacol. 2010 Sep;13(8):997-1009. doi: 10.1017/S1461145710000039. Epub 2010 Feb 11.


Behavioural assays to model cognitive and affective dimensions of depression and anxiety in rats.

Lapiz-Bluhm MD, Bondi CO, Doyen J, Rodriguez GA, Bédard-Arana T, Morilak DA.

J Neuroendocrinol. 2008 Oct;20(10):1115-37. doi: 10.1111/j.1365-2826.2008.01772.x. Epub 2008 Jul 30.


Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats.

Lapiz-Bluhm MD, Soto-Piña AE, Hensler JG, Morilak DA.

Psychopharmacology (Berl). 2009 Jan;202(1-3):329-41. doi: 10.1007/s00213-008-1224-6. Epub 2008 Jun 30.


Chronic intermittent hypoxia sensitizes acute hypothalamic-pituitary-adrenal stress reactivity and Fos induction in the rat locus coeruleus in response to subsequent immobilization stress.

Ma S, Mifflin SW, Cunningham JT, Morilak DA.

Neuroscience. 2008 Jul 17;154(4):1639-47. doi: 10.1016/j.neuroscience.2008.04.068. Epub 2008 May 6.


Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.

Zhao Z, Baros AM, Zhang HT, Lapiz MD, Bondi CO, Morilak DA, O'Donnell JM.

Neuropsychopharmacology. 2008 Dec;33(13):3190-200. doi: 10.1038/npp.2008.45. Epub 2008 Apr 16.


Blockade of autoreceptor-mediated inhibition of norepinephrine release by atipamezole is maintained after chronic reuptake inhibition.

Lapiz MD, Zhao Z, Bondi CO, O'Donnell JM, Morilak DA.

Int J Neuropsychopharmacol. 2007 Dec;10(6):827-33. Epub 2007 Aug 15.


Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment.

Bondi CO, Rodriguez G, Gould GG, Frazer A, Morilak DA.

Neuropsychopharmacology. 2008 Jan;33(2):320-31. Epub 2007 Apr 4.


Noradrenergic facilitation of shock-probe defensive burying in lateral septum of rats, and modulation by chronic treatment with desipramine.

Bondi CO, Barrera G, Lapiz MD, Bedard T, Mahan A, Morilak DA.

Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):482-95. Epub 2006 Dec 26.


Chronic treatment with desipramine improves cognitive performance of rats in an attentional set-shifting test.

Lapiz MD, Bondi CO, Morilak DA.

Neuropsychopharmacology. 2007 May;32(5):1000-10. Epub 2006 Nov 1.


Galanin-mediated anxiolytic effect in rat central amygdala is not a result of corelease from noradrenergic terminals.

Barrera G, Hernandez A, Poulin JF, Laforest S, Drolet G, Morilak DA.

Synapse. 2006 Jan;59(1):27-40.


Role of brain norepinephrine in the behavioral response to stress.

Morilak DA, Barrera G, Echevarria DJ, Garcia AS, Hernandez A, Ma S, Petre CO.

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Dec;29(8):1214-24. Epub 2005 Oct 13. Review.


Administration of the galanin antagonist M40 into lateral septum attenuates shock probe defensive burying behavior in rats.

Echevarria DJ, Hernandez A, Diogenes A, Morilak DA.

Neuropeptides. 2005 Oct;39(5):445-51. Epub 2005 Aug 9.


One for all or one for one: does co-transmission unify the concept of a brain galanin "system" or clarify any consistent role in anxiety?

Barrera G, Echevarria DJ, Poulin JF, Laforest S, Drolet G, Morilak DA.

Neuropeptides. 2005 Jun;39(3):289-92. Epub 2005 Jan 28. Review.


What should animal models of depression model?

Frazer A, Morilak DA.

Neurosci Biobehav Rev. 2005;29(4-5):515-23. Review.


Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders.

Morilak DA, Frazer A.

Int J Neuropsychopharmacol. 2004 Jun;7(2):193-218. Epub 2004 Mar 5. Review.


Regulation of the norepinephrine transporter by chronic administration of antidepressants.

Benmansour S, Altamirano AV, Jones DJ, Sanchez TA, Gould GG, Pardon MC, Morilak DA, Frazer A.

Biol Psychiatry. 2004 Feb 1;55(3):313-6.


Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems.

Gould GG, Pardon MC, Morilak DA, Frazer A.

Neuropsychopharmacology. 2003 Sep;28(9):1633-41. Epub 2003 Jun 25.

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