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Items: 1 to 50 of 55

1.

A 3.3 Å-Resolution Structure of Hyperthermophilic Respiratory Complex III Reveals the Mechanism of its Thermal Stability.

Zhu G, Zeng H, Zhang S, Juli J, Pang X, Hoffmann J, Zhang Y, Morgner N, Zhu Y, Peng G, Michel H, Sun F.

Angew Chem Int Ed Engl. 2019 Nov 28. doi: 10.1002/anie.201911554. [Epub ahead of print] Review.

PMID:
31778296
2.

Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain.

Viet KK, Wagner A, Schwickert K, Hellwig N, Brennich M, Bader N, Schirmeister T, Morgner N, Schindelin H, Hellmich UA.

Structure. 2019 Aug 6;27(8):1246-1257.e5. doi: 10.1016/j.str.2019.04.016. Epub 2019 Jun 6.

PMID:
31178222
3.

LanI-Mediated Lantibiotic Immunity in Bacillus subtilis: Functional Analysis.

Geiger C, Korn SM, Häsler M, Peetz O, Martin J, Kötter P, Morgner N, Entian KD.

Appl Environ Microbiol. 2019 May 16;85(11). pii: e00534-19. doi: 10.1128/AEM.00534-19. Print 2019 Jun 1.

4.

An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments.

Grammbitter GLC, Schmalhofer M, Karimi K, Shi YM, Schöner TA, Tobias NJ, Morgner N, Groll M, Bode HB.

J Am Chem Soc. 2019 Oct 23;141(42):16615-16623. doi: 10.1021/jacs.8b10776. Epub 2019 Apr 3.

PMID:
30908039
5.

Purification of a Crenarchaeal ATP Synthase in the Light of the Unique Bioenergetics of Ignicoccus Species.

Kreuter LJ, Weinfurtner A, Ziegler A, Weigl J, Hoffmann J, Morgner N, Müller V, Huber H.

J Bacteriol. 2019 Mar 13;201(7). pii: e00510-18. doi: 10.1128/JB.00510-18. Print 2019 Apr 1.

6.

Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs.

Hellwig N, Peetz O, Ahdash Z, Tascón I, Booth PJ, Mikusevic V, Diskowski M, Politis A, Hellmich Y, Hänelt I, Reading E, Morgner N.

Chem Commun (Camb). 2018 Dec 4;54(97):13702-13705. doi: 10.1039/c8cc06284f.

7.

Lipid Conversion by Cell-Free Synthesized Phospholipid Methyltransferase Opi3 in Defined Nanodisc Membranes Supports an in Trans Mechanism.

Henrich E, Löhr F, Pawlik G, Peetz O, Dötsch V, Morgner N, de Kroon AI, Bernhard F.

Biochemistry. 2018 Oct 9;57(40):5780-5784. doi: 10.1021/acs.biochem.8b00807. Epub 2018 Sep 24.

PMID:
30226041
8.

LILBID and nESI: Different Native Mass Spectrometry Techniques as Tools in Structural Biology.

Peetz O, Hellwig N, Henrich E, Mezhyrova J, Dötsch V, Bernhard F, Morgner N.

J Am Soc Mass Spectrom. 2019 Jan;30(1):181-191. doi: 10.1007/s13361-018-2061-4. Epub 2018 Sep 17. Erratum in: J Am Soc Mass Spectrom. 2019 Feb 11;:.

9.

Insights into Cotranslational Membrane Protein Insertion by Combined LILBID-Mass Spectrometry and NMR Spectroscopy.

Peetz O, Henrich E, Laguerre A, Löhr F, Hein C, Dötsch V, Bernhard F, Morgner N.

Anal Chem. 2017 Nov 21;89(22):12314-12318. doi: 10.1021/acs.analchem.7b03309. Epub 2017 Oct 30.

PMID:
29039652
10.

Peptidomimetics That Inhibit and Partially Reverse the Aggregation of Aβ1-42.

Stark T, Lieblein T, Pohland M, Kalden E, Freund P, Zangl R, Grewal R, Heilemann M, Eckert GP, Morgner N, Göbel MW.

Biochemistry. 2017 Sep 12;56(36):4840-4849. doi: 10.1021/acs.biochem.7b00223. Epub 2017 Aug 25.

PMID:
28841311
11.

Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence.

Lannes L, Young P, Richter C, Morgner N, Schwalbe H.

Chembiochem. 2017 Oct 18;18(20):2033-2044. doi: 10.1002/cbic.201700390. Epub 2017 Sep 8.

PMID:
28805284
12.

A Janus-Faced IM30 Ring Involved in Thylakoid Membrane Fusion Is Assembled from IM30 Tetramers.

Saur M, Hennig R, Young P, Rusitzka K, Hellmann N, Heidrich J, Morgner N, Markl J, Schneider D.

Structure. 2017 Sep 5;25(9):1380-1390.e5. doi: 10.1016/j.str.2017.07.001. Epub 2017 Aug 10.

13.

Acyl modification and binding of mitochondrial ACP to multiprotein complexes.

Angerer H, Schönborn S, Gorka J, Bahr U, Karas M, Wittig I, Heidler J, Hoffmann J, Morgner N, Zickermann V.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1913-1920. doi: 10.1016/j.bbamcr.2017.08.006. Epub 2017 Aug 9.

14.

Helical jackknives control the gates of the double-pore K+ uptake system KtrAB.

Diskowski M, Mehdipour AR, Wunnicke D, Mills DJ, Mikusevic V, Bärland N, Hoffmann J, Morgner N, Steinhoff HJ, Hummer G, Vonck J, Hänelt I.

Elife. 2017 May 16;6. pii: e24303. doi: 10.7554/eLife.24303.

15.

From Gene to Function: Cell-Free Electrophysiological and Optical Analysis of Ion Pumps in Nanodiscs.

Henrich E, Sörmann J, Eberhardt P, Peetz O, Mezhyrova J, Morgner N, Fendler K, Dötsch V, Wachtveitl J, Bernhard F, Bamann C.

Biophys J. 2017 Sep 19;113(6):1331-1341. doi: 10.1016/j.bpj.2017.03.026. Epub 2017 Apr 24.

16.

Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology.

Henrich E, Peetz O, Hein C, Laguerre A, Hoffmann B, Hoffmann J, Dötsch V, Bernhard F, Morgner N.

Elife. 2017 Jan 9;6. pii: e20954. doi: 10.7554/eLife.20954.

17.

The synaptic vesicle protein SV31 assembles into a dimer and transports Zn2.

Waberer L, Henrich E, Peetz O, Morgner N, Dötsch V, Bernhard F, Volknandt W.

J Neurochem. 2017 Jan;140(2):280-293. doi: 10.1111/jnc.13886. Epub 2016 Dec 5.

18.

Mapping light-driven conformational changes within the photosensory module of plant phytochrome B.

von Horsten S, Straß S, Hellwig N, Gruth V, Klasen R, Mielcarek A, Linne U, Morgner N, Essen LO.

Sci Rep. 2016 Oct 3;6:34366. doi: 10.1038/srep34366.

19.

The interchange of immunophilins leads to parallel pathways and different intermediates in the assembly of Hsp90 glucocorticoid receptor complexes.

Ebong IO, Beilsten-Edmands V, Patel NA, Morgner N, Robinson CV.

Cell Discov. 2016 Apr 5;2:16002. doi: 10.1038/celldisc.2016.2. eCollection 2016.

20.

Studies on the X-Ray and Solution Structure of FeoB from Escherichia coli BL21.

Hagelueken G, Hoffmann J, Schubert E, Duthie FG, Florin N, Konrad L, Imhof D, Behrmann E, Morgner N, Schiemann O.

Biophys J. 2016 Jun 21;110(12):2642-2650. doi: 10.1016/j.bpj.2016.05.018.

21.

Stoichiometry and deletion analyses of subunits in the heterotrimeric F-ATP synthase c ring from the acetogenic bacterium Acetobacterium woodii.

Brandt K, Müller DB, Hoffmann J, Langer JD, Brutschy B, Morgner N, Müller V.

FEBS J. 2016 Feb;283(3):510-20. doi: 10.1111/febs.13606. Epub 2015 Dec 24.

22.

Visualizing Specific Cross-Protomer Interactions in the Homo-Oligomeric Membrane Protein Proteorhodopsin by Dynamic-Nuclear-Polarization-Enhanced Solid-State NMR.

Maciejko J, Mehler M, Kaur J, Lieblein T, Morgner N, Ouari O, Tordo P, Becker-Baldus J, Glaubitz C.

J Am Chem Soc. 2015 Jul 22;137(28):9032-43. doi: 10.1021/jacs.5b03606. Epub 2015 Jul 13.

PMID:
26102160
23.

Hsp70 forms antiparallel dimers stabilized by post-translational modifications to position clients for transfer to Hsp90.

Morgner N, Schmidt C, Beilsten-Edmands V, Ebong IO, Patel NA, Clerico EM, Kirschke E, Daturpalli S, Jackson SE, Agard D, Robinson CV.

Cell Rep. 2015 May 5;11(5):759-69. doi: 10.1016/j.celrep.2015.03.063. Epub 2015 Apr 23.

24.

A subset of annular lipids is linked to the flippase activity of an ABC transporter.

Bechara C, Nöll A, Morgner N, Degiacomi MT, Tampé R, Robinson CV.

Nat Chem. 2015 Mar;7(3):255-62. doi: 10.1038/nchem.2172. Epub 2015 Feb 2.

PMID:
25698336
25.

Flexible stoichiometry and asymmetry of the PIDDosome core complex by heteronuclear NMR spectroscopy and mass spectrometry.

Nematollahi LA, Garza-Garcia A, Bechara C, Esposito D, Morgner N, Robinson CV, Driscoll PC.

J Mol Biol. 2015 Feb 27;427(4):737-752. doi: 10.1016/j.jmb.2014.11.021. Epub 2014 Dec 18.

26.

Comparative cross-linking and mass spectrometry of an intact F-type ATPase suggest a role for phosphorylation.

Schmidt C, Zhou M, Marriott H, Morgner N, Politis A, Robinson CV.

Nat Commun. 2013;4:1985. doi: 10.1038/ncomms2985.

27.

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump.

Marcoux J, Wang SC, Politis A, Reading E, Ma J, Biggin PC, Zhou M, Tao H, Zhang Q, Chang G, Morgner N, Robinson CV.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9704-9. doi: 10.1073/pnas.1303888110. Epub 2013 May 20.

28.

Mass spectrometry--from peripheral proteins to membrane motors.

Morgner N, Montenegro F, Barrera NP, Robinson CV.

J Mol Biol. 2012 Oct 12;423(1):1-13. doi: 10.1016/j.jmb.2012.06.033. Epub 2012 Jun 28. Review.

29.

Massign: an assignment strategy for maximizing information from the mass spectra of heterogeneous protein assemblies.

Morgner N, Robinson CV.

Anal Chem. 2012 Mar 20;84(6):2939-48. doi: 10.1021/ac300056a. Epub 2012 Mar 7.

PMID:
22409725
30.

Linking structural change with functional regulation-insights from mass spectrometry.

Morgner N, Robinson CV.

Curr Opin Struct Biol. 2012 Feb;22(1):44-51. doi: 10.1016/j.sbi.2011.12.003. Epub 2012 Jan 31. Review.

PMID:
22300497
31.

Mass spectrometry of intact V-type ATPases reveals bound lipids and the effects of nucleotide binding.

Zhou M, Morgner N, Barrera NP, Politis A, Isaacson SC, Matak-Vinković D, Murata T, Bernal RA, Stock D, Robinson CV.

Science. 2011 Oct 21;334(6054):380-385. doi: 10.1126/science.1210148.

32.

Heterogeneity and dynamics in the assembly of the heat shock protein 90 chaperone complexes.

Ebong IO, Morgner N, Zhou M, Saraiva MA, Daturpalli S, Jackson SE, Robinson CV.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17939-44. doi: 10.1073/pnas.1106261108. Epub 2011 Oct 19.

33.

X-ray structure of the dimeric cytochrome bc(1) complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution.

Kleinschroth T, Castellani M, Trinh CH, Morgner N, Brutschy B, Ludwig B, Hunte C.

Biochim Biophys Acta. 2011 Dec;1807(12):1606-15. doi: 10.1016/j.bbabio.2011.09.017. Epub 2011 Oct 3.

34.

Functional dissection of the proton pumping modules of mitochondrial complex I.

Dröse S, Krack S, Sokolova L, Zwicker K, Barth HD, Morgner N, Heide H, Steger M, Nübel E, Zickermann V, Kerscher S, Brutschy B, Radermacher M, Brandt U.

PLoS Biol. 2011 Aug;9(8):e1001128. doi: 10.1371/journal.pbio.1001128. Epub 2011 Aug 23.

35.

Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer.

Natan E, Baloglu C, Pagel K, Freund SM, Morgner N, Robinson CV, Fersht AR, Joerger AC.

J Mol Biol. 2011 Jun 10;409(3):358-68. doi: 10.1016/j.jmb.2011.03.047. Epub 2011 Mar 30.

36.

Structures of SAS-6 suggest its organization in centrioles.

van Breugel M, Hirono M, Andreeva A, Yanagisawa HA, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M, Ebong IO, Robinson CV, Johnson CM, Veprintsev D, Zuber B.

Science. 2011 Mar 4;331(6021):1196-9. doi: 10.1126/science.1199325. Epub 2011 Jan 27.

37.

Mass spectrometry reveals stable modules in holo and apo RNA polymerases I and III.

Lane LA, Fernández-Tornero C, Zhou M, Morgner N, Ptchelkine D, Steuerwald U, Politis A, Lindner D, Gvozdenovic J, Gavin AC, Müller CW, Robinson CV.

Structure. 2011 Jan 12;19(1):90-100. doi: 10.1016/j.str.2010.11.009.

38.

Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus.

Esposito D, Sankar A, Morgner N, Robinson CV, Rittinger K, Driscoll PC.

Structure. 2010 Oct 13;18(10):1378-90. doi: 10.1016/j.str.2010.08.006.

39.

Polypyrimidine tract-binding protein stimulates the poliovirus IRES by modulating eIF4G binding.

Kafasla P, Morgner N, Robinson CV, Jackson RJ.

EMBO J. 2010 Nov 3;29(21):3710-22. doi: 10.1038/emboj.2010.231. Epub 2010 Sep 21.

40.

ATP synthases: cellular nanomotors characterized by LILBID mass spectrometry.

Hoffmann J, Sokolova L, Preiss L, Hicks DB, Krulwich TA, Morgner N, Wittig I, Schägger H, Meier T, Brutschy B.

Phys Chem Chem Phys. 2010 Nov 7;12(41):13375-82. doi: 10.1039/c0cp00733a. Epub 2010 Aug 27.

41.

Separating and visualising protein assemblies by means of preparative mass spectrometry and microscopy.

Benesch JL, Ruotolo BT, Simmons DA, Barrera NP, Morgner N, Wang L, Saibil HR, Robinson CV.

J Struct Biol. 2010 Nov;172(2):161-8. doi: 10.1016/j.jsb.2010.03.004. Epub 2010 Mar 15.

PMID:
20227505
42.

Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP.

Hernández H, Makarova OV, Makarov EM, Morgner N, Muto Y, Krummel DP, Robinson CV.

PLoS One. 2009 Sep 28;4(9):e7202. doi: 10.1371/journal.pone.0007202.

43.

Ultraslow oligomerization equilibria of p53 and its implications.

Natan E, Hirschberg D, Morgner N, Robinson CV, Fersht AR.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14327-32. doi: 10.1073/pnas.0907840106. Epub 2009 Aug 10.

44.

Polypyrimidine tract binding protein stabilizes the encephalomyocarditis virus IRES structure via binding multiple sites in a unique orientation.

Kafasla P, Morgner N, Pöyry TA, Curry S, Robinson CV, Jackson RJ.

Mol Cell. 2009 Jun 12;34(5):556-68. doi: 10.1016/j.molcel.2009.04.015.

45.

Three-dimensional structure of A1A0 ATP synthase from the hyperthermophilic archaeon Pyrococcus furiosus by electron microscopy.

Vonck J, Pisa KY, Morgner N, Brutschy B, Müller V.

J Biol Chem. 2009 Apr 10;284(15):10110-9. doi: 10.1074/jbc.M808498200. Epub 2009 Feb 8.

46.

Subunit mass fingerprinting of mitochondrial complex I.

Morgner N, Zickermann V, Kerscher S, Wittig I, Abdrakhmanova A, Barth HD, Brutschy B, Brandt U.

Biochim Biophys Acta. 2008 Oct;1777(10):1384-91. doi: 10.1016/j.bbabio.2008.08.001. Epub 2008 Aug 15.

47.

Binding sites of the viral RNA element TAR and of TAR mutants for various peptide ligands, probed with LILBID: a new laser mass spectrometry.

Morgner N, Barth HD, Brutschy B, Scheffer U, Breitung S, Göbel M.

J Am Soc Mass Spectrom. 2008 Nov;19(11):1600-11. doi: 10.1016/j.jasms.2008.07.001. Epub 2008 Jul 3.

48.

The influence of densely organized maltose shells on the biological properties of poly(propylene imine) dendrimers: new effects dependent on hydrogen bonding.

Klajnert B, Appelhans D, Komber H, Morgner N, Schwarz S, Richter S, Brutschy B, Ionov M, Tonkikh AK, Bryszewska M, Voit B.

Chemistry. 2008;14(23):7030-41. doi: 10.1002/chem.200800342.

PMID:
18576443
49.

An intermediate step in the evolution of ATPases: a hybrid F(0)-V(0) rotor in a bacterial Na(+) F(1)F(0) ATP synthase.

Fritz M, Klyszejko AL, Morgner N, Vonck J, Brutschy B, Muller DJ, Meier T, Müller V.

FEBS J. 2008 May;275(9):1999-2007. doi: 10.1111/j.1742-4658.2008.06354.x. Epub 2008 Mar 19.

50.

A tridecameric c ring of the adenosine triphosphate (ATP) synthase from the thermoalkaliphilic Bacillus sp. strain TA2.A1 facilitates ATP synthesis at low electrochemical proton potential.

Meier T, Morgner N, Matthies D, Pogoryelov D, Keis S, Cook GM, Dimroth P, Brutschy B.

Mol Microbiol. 2007 Sep;65(5):1181-92. Epub 2007 Jul 21.

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