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Items: 10


Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.

Schmid CL, Kennedy NM, Ross NC, Lovell KM, Yue Z, Morgenweck J, Cameron MD, Bannister TD, Bohn LM.

Cell. 2017 Nov 16;171(5):1165-1175.e13. doi: 10.1016/j.cell.2017.10.035.


Novel Endomorphin Analogs Are More Potent and Longer-Lasting Analgesics in Neuropathic, Inflammatory, Postoperative, and Visceral Pain Relative to Morphine.

Feehan AK, Morgenweck J, Zhang X, Amgott-Kwan AT, Zadina JE.

J Pain. 2017 Dec;18(12):1526-1541. doi: 10.1016/j.jpain.2017.08.007. Epub 2017 Sep 20.


RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.

Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn LM, Scharager-Tapia C, Pascal B, Martinez-Acedo P, Khare K, Subramaniam S.

Sci Signal. 2016 Nov 15;9(454):ra111.


Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria.

Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aubé J, Jones SR, Martin TJ, Bohn LM.

Sci Signal. 2016 Nov 29;9(456):ra117.


Endomorphin analog analgesics with reduced abuse liability, respiratory depression, motor impairment, tolerance, and glial activation relative to morphine.

Zadina JE, Nilges MR, Morgenweck J, Zhang X, Hackler L, Fasold MB.

Neuropharmacology. 2016 Jun;105:215-227. doi: 10.1016/j.neuropharm.2015.12.024. Epub 2015 Dec 31.


Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus.

Morgenweck J, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM.

Neuropharmacology. 2015 Dec;99:600-9. doi: 10.1016/j.neuropharm.2015.08.027. Epub 2015 Aug 25.


Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms.

Griggs RB, Donahue RR, Morgenweck J, Grace PM, Sutton A, Watkins LR, Taylor BK.

Pain. 2015 Mar;156(3):469-82. doi: 10.1097/


PPARγ activation blocks development and reduces established neuropathic pain in rats.

Morgenweck J, Griggs RB, Donahue RR, Zadina JE, Taylor BK.

Neuropharmacology. 2013 Jul;70:236-46. doi: 10.1016/j.neuropharm.2013.01.020. Epub 2013 Feb 13.


Anti-inflammatory mesenchymal stem cells (MSC2) attenuate symptoms of painful diabetic peripheral neuropathy.

Waterman RS, Morgenweck J, Nossaman BD, Scandurro AE, Scandurro SA, Betancourt AM.

Stem Cells Transl Med. 2012 Jul;1(7):557-65. doi: 10.5966/sctm.2012-0025. Epub 2012 Jul 9.


Activation of peroxisome proliferator-activated receptor gamma in brain inhibits inflammatory pain, dorsal horn expression of Fos, and local edema.

Morgenweck J, Abdel-Aleem OS, McNamara KC, Donahue RR, Badr MZ, Taylor BK.

Neuropharmacology. 2010 Feb;58(2):337-45. doi: 10.1016/j.neuropharm.2009.10.008. Epub 2009 Nov 3.

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