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Items: 1 to 50 of 187

1.

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M.

Diabetes Care. 2019 Nov 21. pii: dc190880. doi: 10.2337/dc19-0880. [Epub ahead of print]

PMID:
31753960
2.

In situ analysis reveals that CFTR is expressed in only a small minority of β-cells in normal adult human pancreas.

White MG, Maheshwari RR, Anderson SJ, Berlinguer-Palmini R, Jones C, Richardson SJ, Rotti PG, Armour SL, Ding Y, Krasnogor N, Engelhardt JF, Gray MA, Morgan NG, Shaw JAM.

J Clin Endocrinol Metab. 2019 Nov 21. pii: dgz209. doi: 10.1210/clinem/dgz209. [Epub ahead of print]

PMID:
31748811
3.

Evidence that a STAT3 Mutation Causing Hyper IgE Syndrome Leads to Repression of Transcriptional Activity.

Bahal S, Houssen ME, Manson A, Lorenzo L, Russell MA, Morgan NG, Tahami F, Grigoriadou S.

Case Reports Immunol. 2019 Oct 13;2019:1869524. doi: 10.1155/2019/1869524. eCollection 2019.

4.

Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells.

Dhayal S, Zummo FP, Anderson MW, Thomas P, Welters HJ, Arden C, Morgan NG.

J Mol Endocrinol. 2019 Nov;63(4):285-296. doi: 10.1530/JME-19-0096.

PMID:
31614336
5.

How, When, and Where Do Human β-Cells Regenerate?

Basile G, Kulkarni RN, Morgan NG.

Curr Diab Rep. 2019 Jun 27;19(8):48. doi: 10.1007/s11892-019-1176-8. Review.

PMID:
31250214
6.

Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns.

Jeffery N, Richardson S, Chambers D, Morgan NG, Harries LW.

Hum Mol Genet. 2019 Aug 15;28(16):2763-2774. doi: 10.1093/hmg/ddz094.

7.

Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter].

Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Lloyd RE, Morgan NG, Pugliese A.

Diabetologia. 2019 Jun;62(6):1100-1103. doi: 10.1007/s00125-019-4873-6. Epub 2019 Apr 23. No abstract available.

PMID:
31016358
8.

Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass.

King R, Hill JL, Saha B, Tong Y, Strutt BJ, Russell MA, Morgan NG, Richardson SJ, Hill DJ.

Nutrients. 2019 Mar 12;11(3). pii: E605. doi: 10.3390/nu11030605.

9.

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes.

Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, Babon JAB, Haliyur R, Powers AC, Yang C, Kent SC, Derr AG, Kucukural A, Garber MG, Morgan NG, Harlan DM.

Diabetes. 2019 May;68(5):988-1001. doi: 10.2337/db18-0686. Epub 2019 Mar 4.

10.

Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.

Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Insel RA, Lernmark Å, Lloyd RE, Morgan NG, Pugliese A.

Diabetologia. 2019 May;62(5):744-753. doi: 10.1007/s00125-019-4811-7. Epub 2019 Jan 23.

11.

The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes.

Leslie KA, Russell MA, Taniguchi K, Richardson SJ, Morgan NG.

Diabetologia. 2019 Jan;62(1):87-98. doi: 10.1007/s00125-018-4750-8. Epub 2018 Oct 18.

12.

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.

Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM, Op de Beeck A, Castela A, Marselli L, Krogvold L, Dahl-Jorgensen K, Marchetti P, Morgan NG, Richardson SJ, Eizirik DL.

EBioMedicine. 2018 Oct;36:367-375. doi: 10.1016/j.ebiom.2018.09.040. Epub 2018 Sep 27.

13.

Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made.

Morgan NG, Richardson SJ.

Diabetologia. 2018 Dec;61(12):2499-2506. doi: 10.1007/s00125-018-4731-y. Epub 2018 Sep 25. Review.

14.

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes.

Vecchio F, Lo Buono N, Stabilini A, Nigi L, Dufort MJ, Geyer S, Rancoita PM, Cugnata F, Mandelli A, Valle A, Leete P, Mancarella F, Linsley PS, Krogvold L, Herold KC, Elding Larsson H, Richardson SJ, Morgan NG, Dahl-Jørgensen K, Sebastiani G, Dotta F, Bosi E; DRI_Biorepository Group; Type 1 Diabetes TrialNet Study Group, Battaglia M.

JCI Insight. 2018 Sep 20;3(18). pii: 122146. doi: 10.1172/jci.insight.122146. eCollection 2018 Sep 20.

15.

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells.

Ifie E, Russell MA, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik DL, Morgan NG, Richardson SJ.

Diabetologia. 2018 Nov;61(11):2344-2355. doi: 10.1007/s00125-018-4704-1. Epub 2018 Aug 3.

16.

Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention.

Richardson SJ, Morgan NG.

Curr Opin Pharmacol. 2018 Dec;43:11-19. doi: 10.1016/j.coph.2018.07.006. Epub 2018 Jul 29. Review.

17.

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.

Shields BM, McDonald TJ, Oram R, Hill A, Hudson M, Leete P, Pearson ER, Richardson SJ, Morgan NG, Hattersley AT; TIGI Consortium.

Diabetes Care. 2018 Jul;41(7):1486-1492. doi: 10.2337/dc18-0465. Epub 2018 Jun 7.

18.

Abnormal islet sphingolipid metabolism in type 1 diabetes.

Holm LJ, Krogvold L, Hasselby JP, Kaur S, Claessens LA, Russell MA, Mathews CE, Hanssen KF, Morgan NG, Koeleman BPC, Roep BO, Gerling IC, Pociot F, Dahl-Jørgensen K, Buschard K.

Diabetologia. 2018 Jul;61(7):1650-1661. doi: 10.1007/s00125-018-4614-2. Epub 2018 Apr 18.

19.

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes.

Kronenberg-Versteeg D, Eichmann M, Russell MA, de Ru A, Hehn B, Yusuf N, van Veelen PA, Richardson SJ, Morgan NG, Lemberg MK, Peakman M.

Diabetes. 2018 Apr;67(4):687-696. doi: 10.2337/db17-0021. Epub 2018 Jan 17.

20.

A novel de novo activating mutation in STAT3 identified in a patient with common variable immunodeficiency (CVID).

Russell MA, Pigors M, Houssen ME, Manson A, Kelsell D, Longhurst H, Morgan NG.

Clin Immunol. 2018 Feb;187:132-136. doi: 10.1016/j.clim.2017.11.007. Epub 2017 Nov 24.

PMID:
29180260
21.

Bringing the human pancreas into focus: new paradigms for the understanding of Type 1 diabetes.

Morgan NG.

Diabet Med. 2017 Jul;34(7):879-886. doi: 10.1111/dme.13365. Epub 2017 May 15. Review.

PMID:
28429491
22.

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.

Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, Grym H, Ustinov J, Wartiovaara K, Hawkins RD, Silvennoinen O, Varjosalo M, Morgan NG, Otonkoski T.

Cell Rep. 2017 Apr 11;19(2):281-294. doi: 10.1016/j.celrep.2017.03.055.

23.

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

Dharmadhikari G, Stolz K, Hauke M, Morgan NG, Varki A, de Koning E, Kelm S, Maedler K.

Sci Rep. 2017 Apr 5;7:45319. doi: 10.1038/srep45319.

24.

Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes.

Willcox A, Richardson SJ, Walker LSK, Kent SC, Morgan NG, Gillespie KM.

Diabetologia. 2017 Jul;60(7):1294-1303. doi: 10.1007/s00125-017-4221-7. Epub 2017 Feb 17.

25.

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes.

Busse N, Paroni F, Richardson SJ, Laiho JE, Oikarinen M, Frisk G, Hyöty H, de Koning E, Morgan NG, Maedler K.

Oncotarget. 2017 Feb 21;8(8):12620-12636. doi: 10.18632/oncotarget.14896.

26.

Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes.

Wedgwood KC, Richardson SJ, Morgan NG, Tsaneva-Atanasova K.

Front Physiol. 2016 Dec 27;7:633. doi: 10.3389/fphys.2016.00633. eCollection 2016.

27.

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Morgan NG, Powers AC, Pugliese A, Richardson SJ, In't Veld PA.

Diabetologia. 2017 Apr;60(4):753-755. doi: 10.1007/s00125-016-4195-x. Epub 2017 Jan 9. No abstract available.

28.

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.

Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, von Herrath M, Pugliese A, Atkinson MA, Morgan NG.

Diabetologia. 2016 Nov;59(11):2448-2458. doi: 10.1007/s00125-016-4067-4. Epub 2016 Aug 9.

29.

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.

Ferru-Clément R, Spanova M, Dhayal S, Morgan NG, Hélye R, Becq F, Hirose H, Antonny B, Vamparys L, Fuchs PF, Ferreira T.

J Cell Sci. 2016 Jun 15;129(12):2368-81. doi: 10.1242/jcs.183590. Epub 2016 May 3.

30.

Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells.

Laiho JE, Oikarinen M, Richardson SJ, Frisk G, Nyalwidhe J, Burch TC, Morris MA, Oikarinen S, Pugliese A, Dotta F, Campbell-Thompson M, Nadler J, Morgan NG, Hyöty H; JDRF nPOD-Virus Group.

J Clin Virol. 2016 Apr;77:21-8. doi: 10.1016/j.jcv.2016.01.015. Epub 2016 Feb 2.

31.

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes.

Leete P, Willcox A, Krogvold L, Dahl-Jørgensen K, Foulis AK, Richardson SJ, Morgan NG.

Diabetes. 2016 May;65(5):1362-9. doi: 10.2337/db15-1615. Epub 2016 Feb 8.

32.

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.

Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, Vetere A, Richardson S, Morgan NG, Christensen DP, Gilbert TJ, Hooker JM, Leroy M, Walpita D, Mandrup-Poulsen T, Wagner BK, Holson EB.

ACS Chem Biol. 2016 Feb 19;11(2):363-74. doi: 10.1021/acschembio.5b00640. Epub 2015 Dec 7.

PMID:
26640968
33.

Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835-3845.

Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, Dunger DB, Powrie J, Willcox A, Foulis AK, Richardson SJ, de Rinaldis E, Morgan NG, Lorenc A, Peakman M.

Diabetes. 2015 Sep;64(9):3334. doi: 10.2337/db15-er09a. No abstract available.

34.

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells.

Marroqui L, Lopes M, dos Santos RS, Grieco FA, Roivainen M, Richardson SJ, Morgan NG, Op de Beeck A, Eizirik DL.

Elife. 2015 Jun 10;4:e06990. doi: 10.7554/eLife.06990.

35.

The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor.

Taniguchi K, Russell MA, Richardson SJ, Morgan NG.

Diabetologia. 2015 Sep;58(9):2056-63. doi: 10.1007/s00125-015-3645-1. Epub 2015 Jun 9.

PMID:
26055066
36.

The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120.

Bjursell M, Xu X, Admyre T, Böttcher G, Lundin S, Nilsson R, Stone VM, Morgan NG, Lam YY, Storlien LH, Lindén D, Smith DM, Bohlooly-Y M, Oscarsson J.

PLoS One. 2014 Dec 26;9(12):e114942. doi: 10.1371/journal.pone.0114942. eCollection 2014.

37.

Islet inflammation in human type 1 diabetes mellitus.

Morgan NG, Leete P, Foulis AK, Richardson SJ.

IUBMB Life. 2014 Nov;66(11):723-34. doi: 10.1002/iub.1330. Epub 2014 Dec 11. Review.

38.

Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes.

Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike MC, Richardson SJ, Leete P, Morgan NG, Oikarinen S, Oikarinen M, Laiho JE, Hyöty H, Ludvigsson J, Hanssen KF, Dahl-Jørgensen K.

Diabetes. 2015 May;64(5):1682-7. doi: 10.2337/db14-1370. Epub 2014 Nov 24.

39.

The impact of anti-inflammatory cytokines on the pancreatic β-cell.

Russell MA, Morgan NG.

Islets. 2014;6(3):e950547. doi: 10.4161/19382014.2014.950547. Review.

40.

Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

Morgan NG, Richardson SJ.

Trends Endocrinol Metab. 2014 Dec;25(12):611-9. doi: 10.1016/j.tem.2014.08.002. Epub 2014 Aug 28.

PMID:
25175301
41.

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.

Flanagan SE, Haapaniemi E, Russell MA, Caswell R, Allen HL, De Franco E, McDonald TJ, Rajala H, Ramelius A, Barton J, Heiskanen K, Heiskanen-Kosma T, Kajosaari M, Murphy NP, Milenkovic T, Seppänen M, Lernmark Å, Mustjoki S, Otonkoski T, Kere J, Morgan NG, Ellard S, Hattersley AT.

Nat Genet. 2014 Aug;46(8):812-814. doi: 10.1038/ng.3040. Epub 2014 Jul 20.

42.

Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes.

Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, Dunger DB, Powrie J, Willcox A, Foulis AK, Richardson SJ, de Rinaldis E, Morgan NG, Lorenc A, Peakman M.

Diabetes. 2014 Nov;63(11):3835-45. doi: 10.2337/db14-0365. Epub 2014 Jun 17. Erratum in: Diabetes. 2015 Sep;64(9):3334.

43.

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.

Stone VM, Dhayal S, Brocklehurst KJ, Lenaghan C, Sörhede Winzell M, Hammar M, Xu X, Smith DM, Morgan NG.

Diabetologia. 2014 Jun;57(6):1182-91. doi: 10.1007/s00125-014-3213-0. Epub 2014 Mar 25.

44.

Pancreatic pathology in type 1 diabetes mellitus.

Richardson SJ, Morgan NG, Foulis AK.

Endocr Pathol. 2014 Mar;25(1):80-92. doi: 10.1007/s12022-014-9297-8. Review.

PMID:
24522639
45.

Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter].

Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, Bone AJ, Foulis AK, Frisk G, Flodström-Tullberg M, Hober D, Hyoty H, Pugliese A, Morgan NG.

Diabetologia. 2014 Mar;57(3):647-9. doi: 10.1007/s00125-014-3167-2. Epub 2014 Jan 16. No abstract available.

PMID:
24429580
46.

Infection of human islets of Langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway.

Anagandula M, Richardson SJ, Oberste MS, Sioofy-Khojine AB, Hyöty H, Morgan NG, Korsgren O, Frisk G.

J Med Virol. 2014 Aug;86(8):1402-11. doi: 10.1002/jmv.23835. Epub 2013 Nov 19.

PMID:
24249667
47.

Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas.

Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, Bone AJ; nPOD-V Consortium, Foulis AK, Frisk G, Flodstrom-Tullberg M, Hober D, Hyoty H, Morgan NG.

Diabetologia. 2014 Feb;57(2):392-401. doi: 10.1007/s00125-013-3094-7. Epub 2013 Nov 5.

PMID:
24190581
48.

The diagnosis of insulitis in human type 1 diabetes.

Campbell-Thompson ML, Atkinson MA, Butler AE, Chapman NM, Frisk G, Gianani R, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Korsgren O, Morgan NG, Powers AC, Pugliese A, Richardson SJ, Rowe PA, Tracy S, In't Veld PA.

Diabetologia. 2013 Nov;56(11):2541-3. doi: 10.1007/s00125-013-3043-5. Epub 2013 Sep 5. No abstract available.

PMID:
24006089
49.

Induction of an antiviral state and attenuated coxsackievirus replication in type III interferon-treated primary human pancreatic islets.

Lind K, Richardson SJ, Leete P, Morgan NG, Korsgren O, Flodström-Tullberg M.

J Virol. 2013 Jul;87(13):7646-54. doi: 10.1128/JVI.03431-12. Epub 2013 May 1.

50.

Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells.

Russell MA, Cooper AC, Dhayal S, Morgan NG.

Islets. 2013 Mar-Apr;5(2):95-105. doi: 10.4161/isl.24249. Epub 2013 Mar 1.

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