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Optimised insert design for improved single-molecule imaging and quantification through CRISPR-Cas9 mediated knock-in.

Khan AO, White CW, Pike JA, Yule J, Slater A, Hill SJ, Poulter NS, Thomas SG, Morgan NV.

Sci Rep. 2019 Oct 2;9(1):14219. doi: 10.1038/s41598-019-50733-9.


Response to Blast-like Shear Stresses Associated with Mild Blast-Induced Brain Injury.

Ravin R, Morgan NY, Blank PS, Ravin N, Guerrero-Cazares H, Quinones-Hinojosa A, Zimmerberg J.

Biophys J. 2019 Oct 1;117(7):1167-1178. doi: 10.1016/j.bpj.2019.07.052. Epub 2019 Aug 15.


Amid fields of rubble, scars, and lost gear, signs of recovery observed on seamounts on 30- to 40-year time scales.

Baco AR, Roark EB, Morgan NB.

Sci Adv. 2019 Aug 7;5(8):eaaw4513. doi: 10.1126/sciadv.aaw4513. eCollection 2019 Aug.


Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish.

Paul CD, Bishop K, Devine A, Paine EL, Staunton JR, Thomas SM, Thomas JR, Doyle AD, Miller Jenkins LM, Morgan NY, Sood R, Tanner K.

Cell Syst. 2019 Aug 28;9(2):187-206.e16. doi: 10.1016/j.cels.2019.07.005. Epub 2019 Aug 21.


Two different Clostridium perfringens strains produce different levels of necrotic enteritis in broiler chickens.

Gharib-Naseri K, Kheravii SK, Keerqin C, Morgan N, Swick RA, Choct M, Wu SB.

Poult Sci. 2019 Aug 19. pii: pez480. doi: 10.3382/ps/pez480. [Epub ahead of print]


Multitasking Rab Proteins in Autophagy and Membrane Trafficking: A Focus on Rab33b.

Morgan NE, Cutrona MB, Simpson JC.

Int J Mol Sci. 2019 Aug 12;20(16). pii: E3916. doi: 10.3390/ijms20163916. Review.


SLFN14 gene mutations associated with bleeding.

Stapley RJ, Pisareva VP, Pisarev AV, Morgan NV.

Platelets. 2019 Aug 4:1-4. doi: 10.1080/09537104.2019.1648781. [Epub ahead of print] No abstract available.


Determination of gastrointestinal passage rate using three different markers in laying hens.

Kolakshyapati M, Bailey C, Zimazile Sibanda T, Morgan N, Ruhnke I.

J Anim Physiol Anim Nutr (Berl). 2019 Sep;103(5):1427-1436. doi: 10.1111/jpn.13145. Epub 2019 Jul 12.


Inherited Thrombocytopenia: Update on Genes and Genetic Variants Which may be Associated With Bleeding.

Almazni I, Stapley R, Morgan NV.

Front Cardiovasc Med. 2019 Jun 19;6:80. doi: 10.3389/fcvm.2019.00080. eCollection 2019. Review.


How, When, and Where Do Human β-Cells Regenerate?

Basile G, Kulkarni RN, Morgan NG.

Curr Diab Rep. 2019 Jun 27;19(8):48. doi: 10.1007/s11892-019-1176-8. Review.


High-throughput platelet spreading analysis: a tool for the diagnosis of platelet- based bleeding disorders.

Khan AO, Maclachlan A, Lowe GC, Nicolson PLR, Al Ghaithi R, Thomas SG, Watson SP, Pike JA, Morgan NV; UK GAPP Study Group.

Haematologica. 2019 Jun 20. pii: haematol.2019.225912. doi: 10.3324/haematol.2019.225912. [Epub ahead of print]


Examining the Factor Structure of the Moral Injury Events Scale in a Veteran Sample.

Richardson CB, Chesnut RP, Morgan NR, Bleser JA, Perkins DF, Vogt D, Copeland LA, Finley E.

Mil Med. 2019 Jun 11. pii: usz129. doi: 10.1093/milmed/usz129. [Epub ahead of print]


Potential genetic causes of miscarriage in euploid pregnancies: a systematic review.

Colley E, Hamilton S, Smith P, Morgan NV, Coomarasamy A, Allen S.

Hum Reprod Update. 2019 Jul 1;25(4):452-472. doi: 10.1093/humupd/dmz015.


Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns.

Jeffery N, Richardson S, Chambers D, Morgan NG, Harries LW.

Hum Mol Genet. 2019 Aug 15;28(16):2763-2774. doi: 10.1093/hmg/ddz094.


Assessing in vitro dermal absorption of dry residues of agrochemical sprays using human skin within OECD TG 428.

Aggarwal M, Fisher P, Kluxen FM, Maas W, Morgan N, Parr-Dobrzanski R, Strupp C, Wiemann C.

Regul Toxicol Pharmacol. 2019 Aug;106:55-67. doi: 10.1016/j.yrtph.2019.04.016. Epub 2019 Apr 25.


Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter].

Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Lloyd RE, Morgan NG, Pugliese A.

Diabetologia. 2019 Jun;62(6):1100-1103. doi: 10.1007/s00125-019-4873-6. Epub 2019 Apr 23. No abstract available.


Spatial control of oxygen delivery to three-dimensional cultures alters cancer cell growth and gene expression.

Wulftange WJ, Rose MA, Garmendia-Cedillos M, da Silva D, Poprawski JE, Srinivasachar D, Sullivan T, Lim L, Bliskovsky VV, Hall MD, Pohida TJ, Robey RW, Morgan NY, Gottesman MM.

J Cell Physiol. 2019 Nov;234(11):20608-20622. doi: 10.1002/jcp.28665. Epub 2019 Apr 22.


Xpert MTB/RIF Ultra for Detection of Mycobacterium tuberculosis in Cerebrospinal Fluid.

Chin JH, Musubire AK, Morgan N, Pellinen J, Grossman S, Bhatt JM, Wadda V, Ssengooba W.

J Clin Microbiol. 2019 May 24;57(6). pii: e00249-19. doi: 10.1128/JCM.00249-19. Print 2019 Jun. No abstract available.


Effect of arabinoxylo-oligosaccharides and arabinoxylans on net energy and nutrient utilization in broilers.

Morgan NK, Keerqin C, Wallace A, Wu SB, Choct M.

Anim Nutr. 2019 Mar;5(1):56-62. doi: 10.1016/j.aninu.2018.05.001. Epub 2018 May 15.


Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass.

King R, Hill JL, Saha B, Tong Y, Strutt BJ, Russell MA, Morgan NG, Richardson SJ, Hill DJ.

Nutrients. 2019 Mar 12;11(3). pii: E605. doi: 10.3390/nu11030605.


HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes.

Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, Babon JAB, Haliyur R, Powers AC, Yang C, Kent SC, Derr AG, Kucukural A, Garber MG, Morgan NG, Harlan DM.

Diabetes. 2019 May;68(5):988-1001. doi: 10.2337/db18-0686. Epub 2019 Mar 4.


African Americans and Scleroderma: Examining the Root Cause of the Association.

Morgan ND, Gelber AC.

Arthritis Care Res (Hoboken). 2019 Sep;71(9):1151-1153. doi: 10.1002/acr.23860. Epub 2019 Aug 10. No abstract available.


Pathways between urbanization and harmful substance use.

Morgan N, Mall S.

Curr Opin Psychiatry. 2019 May;32(3):218-223. doi: 10.1097/YCO.0000000000000488.


Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.

Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Insel RA, Lernmark Å, Lloyd RE, Morgan NG, Pugliese A.

Diabetologia. 2019 May;62(5):744-753. doi: 10.1007/s00125-019-4811-7. Epub 2019 Jan 23.


Longitudinal Trends in Quality of Life and Physical Function in Frail Older Dialysis Patients: A Comparison of Assisted Peritoneal Dialysis and In-Center Hemodialysis.

Iyasere O, Brown E, Gordon F, Collinson H, Fielding R, Fluck R, Johansson L, Morgan N, Stoves J, Vardhan A, Woodrow G, Davenport A.

Perit Dial Int. 2019 Mar-Apr;39(2):112-118. doi: 10.3747/pdi.2018.00086. Epub 2019 Jan 18.


Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1).

Li J, Kennedy LJ, Walker SJ, Wang H, Li JJ, Hong Z, O'Connor SP, Ye XY, Chen S, Wu S, Yoon DS, Nayeem A, Camac DM, Ramamurthy V, Morin PE, Sheriff S, Wang M, Harper TW, Golla R, Seethala R, Harrity T, Ponticiello RP, Morgan NN, Taylor JR, Zebo R, Maxwell B, Moulin F, Gordon DA, Robl JA.

ACS Med Chem Lett. 2018 Nov 13;9(12):1170-1174. doi: 10.1021/acsmedchemlett.8b00307. eCollection 2018 Dec 13.


Loss of Function in Escherichia coli Exposed to Environmentally Relevant Concentrations of Benzalkonium Chloride.

Forbes S, Morgan N, Humphreys GJ, Amézquita A, Mistry H, McBain AJ.

Appl Environ Microbiol. 2019 Feb 6;85(4). pii: e02417-18. doi: 10.1128/AEM.02417-18. Print 2019 Feb 15.


Investigation of the contribution of an underlying platelet defect in women with unexplained heavy menstrual bleeding.

Lowe GC, Fickowska R, Al Ghaithi R, Maclachlan A, Harrison P, Lester W, Watson SP, Myers B, Clark J, Morgan NV.

Platelets. 2019;30(1):56-65. doi: 10.1080/09537104.2018.1543865. Epub 2018 Dec 6.


Comparing the molecular and global rheology of a fluid under high pressures.

Dench J, di Mare L, Morgan N, Wong JSS.

Phys Chem Chem Phys. 2018 Dec 12;20(48):30267-30280. doi: 10.1039/c8cp05155k.


Dermal Absorption of Pesticide Residues.

Clarke JF, Cordery SF, Morgan NA, Knowles PK, Guy RH.

Chem Res Toxicol. 2018 Dec 17;31(12):1356-1363. doi: 10.1021/acs.chemrestox.8b00227. Epub 2018 Dec 6.


Insights into sudden cardiac death: exploring the potential relevance of non-diagnostic autopsy findings.

Raju H, Parsons S, Thompson TN, Morgan N, Zentner D, Trainer AH, James PA, Winship IM, Kalman JM, Vohra J.

Eur Heart J. 2019 Mar 7;40(10):831-838. doi: 10.1093/eurheartj/ehy654.


Evaluation of the Total Thrombus-Formation System (T-TAS): application to human and mouse blood analysis.

Al Ghaithi R, Mori J, Nagy Z, Maclachlan A, Hardy L, Philippou H, Hethershaw E, Morgan NV, Senis YA, Harrison P.

Platelets. 2019;30(7):893-900. doi: 10.1080/09537104.2018.1535704. Epub 2018 Oct 26.


A comprehensive targeted next-generation sequencing panel for genetic diagnosis of patients with suspected inherited thrombocytopenia.

Johnson B, Doak R, Allsup D, Astwood E, Evans G, Grimley C, James B, Myers B, Stokley S, Thachil J, Wilde J, Williams M, Makris M, Lowe GC, Wallis Y, Daly ME, Morgan NV; UK GAPP Study Group.

Res Pract Thromb Haemost. 2018 Oct 8;2(4):640-652. doi: 10.1002/rth2.12151. eCollection 2018 Oct.


A novel approach for evaluating programs designed to serve military veterans: Using an adapted common components analysis.

Richardson CB, Morgan NR, Bleser JA, Aronson KR, Perkins DF.

Eval Program Plann. 2019 Feb;72:145-151. doi: 10.1016/j.evalprogplan.2018.10.012. Epub 2018 Oct 5.


The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes.

Leslie KA, Russell MA, Taniguchi K, Richardson SJ, Morgan NG.

Diabetologia. 2019 Jan;62(1):87-98. doi: 10.1007/s00125-018-4750-8. Epub 2018 Oct 18.


Enzymes and/or combination of organic acid and essential oils supplementation in pasture-fed free-range laying hens increased the digestibility of nutrients and non-starch polysaccharides.

Iqbal Z, Metzger F, Singh M, Morgan N, Swick RA, Perez-Maldonado RA, M'Sadeq SA, Zentek J, Ruhnke I.

Poult Sci. 2019 Mar 1;98(3):1410-1424. doi: 10.3382/ps/pey479.


PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.

Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM, Op de Beeck A, Castela A, Marselli L, Krogvold L, Dahl-Jorgensen K, Marchetti P, Morgan NG, Richardson SJ, Eizirik DL.

EBioMedicine. 2018 Oct;36:367-375. doi: 10.1016/j.ebiom.2018.09.040. Epub 2018 Sep 27.


Factors associated with recidivism at a South African forensic psychiatric hospital.

Morgan N, Del Fabbro G.

S Afr J Psychiatr. 2018 Apr 30;24:1125. doi: 10.4102/sajpsychiatry.v24i0.1125. eCollection 2018.


Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made.

Morgan NG, Richardson SJ.

Diabetologia. 2018 Dec;61(12):2499-2506. doi: 10.1007/s00125-018-4731-y. Epub 2018 Sep 25. Review.


Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes.

Vecchio F, Lo Buono N, Stabilini A, Nigi L, Dufort MJ, Geyer S, Rancoita PM, Cugnata F, Mandelli A, Valle A, Leete P, Mancarella F, Linsley PS, Krogvold L, Herold KC, Elding Larsson H, Richardson SJ, Morgan NG, Dahl-Jørgensen K, Sebastiani G, Dotta F, Bosi E; DRI_Biorepository Group; Type 1 Diabetes TrialNet Study Group, Battaglia M.

JCI Insight. 2018 Sep 20;3(18). pii: 122146. doi: 10.1172/jci.insight.122146. eCollection 2018 Sep 20.


Phenotype description and response to thrombopoietin receptor agonist in DIAPH1-related disorder.

Westbury SK, Downes K, Burney C, Lozano ML, Obaji SG, Toh CH, Sevivas T, Morgan NV, Erber WN, Kempster C, Moore SF, Thys C, Papadia S, Ouwehand WH; NIHR BioResource–Rare Diseases, Laffan MA, Gomez K, Freson K, Rivera J, Mumford AD.

Blood Adv. 2018 Sep 25;2(18):2341-2346. doi: 10.1182/bloodadvances.2018020370. No abstract available.


Determining Physical and Mental Health Conditions Present in Older Adult Refugees: A Mini-Review.

Frost CJ, Morgan NJ, Allkhenfr H, Dearden S, Ess R, Albalawi WF, Berri A, Benson LS, Gren LH.

Gerontology. 2019;65(3):209-215. doi: 10.1159/000491695. Epub 2018 Aug 21. Review.


Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells.

Ifie E, Russell MA, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik DL, Morgan NG, Richardson SJ.

Diabetologia. 2018 Nov;61(11):2344-2355. doi: 10.1007/s00125-018-4704-1. Epub 2018 Aug 3.


Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention.

Richardson SJ, Morgan NG.

Curr Opin Pharmacol. 2018 Dec;43:11-19. doi: 10.1016/j.coph.2018.07.006. Epub 2018 Jul 29. Review.


A radial calibration window for analytical ultracentrifugation.

LeBrun T, Schuck P, Wei R, Yoon JS, Dong X, Morgan NY, Fagan J, Zhao H.

PLoS One. 2018 Jul 30;13(7):e0201529. doi: 10.1371/journal.pone.0201529. eCollection 2018.


Mutation in GNE is associated with severe congenital thrombocytopenia.

Futterer J, Dalby A, Lowe GC, Johnson B, Simpson MA, Motwani J, Williams M, Watson SP, Morgan NV; UK GAPP Study Group.

Blood. 2018 Oct 25;132(17):1855-1858. doi: 10.1182/blood-2018-04-847798. Epub 2018 Jun 25. No abstract available.


C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.

Shields BM, McDonald TJ, Oram R, Hill A, Hudson M, Leete P, Pearson ER, Richardson SJ, Morgan NG, Hattersley AT; TIGI Consortium.

Diabetes Care. 2018 Jul;41(7):1486-1492. doi: 10.2337/dc18-0465. Epub 2018 Jun 7.


Brief Report: Whole-Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans.

Gourh P, Remmers EF, Boyden SE, Alexander T, Morgan ND, Shah AA, Mayes MD, Doumatey A, Bentley AR, Shriner D, Domsic RT, Medsger TA Jr, Steen VD, Ramos PS, Silver RM, Korman B, Varga J, Schiopu E, Khanna D, Hsu V, Gordon JK, Saketkoo LA, Gladue H, Kron B, Criswell LA, Derk CT, Bridges SL Jr, Shanmugam VK, Kolstad KD, Chung L, Jan R, Bernstein EJ, Goldberg A, Trojanowski M, Kafaja S, Maksimowicz-McKinnon KM, Mullikin JC, Adeyemo A, Rotimi C, Boin F, Kastner DL, Wigley FM.

Arthritis Rheumatol. 2018 Oct;70(10):1654-1660. doi: 10.1002/art.40541. Epub 2018 Aug 29.


Role of the novel endoribonuclease SLFN14 and its disease-causing mutations in ribosomal degradation.

Fletcher SJ, Pisareva VP, Khan AO, Tcherepanov A, Morgan NV, Pisarev AV.

RNA. 2018 Jul;24(7):939-949. doi: 10.1261/rna.066415.118. Epub 2018 Apr 20.


Abnormal islet sphingolipid metabolism in type 1 diabetes.

Holm LJ, Krogvold L, Hasselby JP, Kaur S, Claessens LA, Russell MA, Mathews CE, Hanssen KF, Morgan NG, Koeleman BPC, Roep BO, Gerling IC, Pociot F, Dahl-Jørgensen K, Buschard K.

Diabetologia. 2018 Jul;61(7):1650-1661. doi: 10.1007/s00125-018-4614-2. Epub 2018 Apr 18.

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