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Items: 1 to 50 of 182


Polyanions provide selective control of APC/C interactions with the activator subunit.

Mizrak A, Morgan DO.

Nat Commun. 2019 Dec 20;10(1):5807. doi: 10.1038/s41467-019-13864-1.


Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site.

Rosen LE, Klebba JE, Asfaha JB, Ghent CM, Campbell MG, Cheng Y, Morgan DO.

Nat Commun. 2019 Nov 15;10(1):5189. doi: 10.1038/s41467-019-13209-y.


The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function.

Qin L, Mizrak A, Guimarães DSPSF, Tambrin HM, Morgan DO, Hall MC.

J Biol Chem. 2019 Nov 15;294(46):17249-17261. doi: 10.1074/jbc.RA119.009468. Epub 2019 Sep 27.


Firing of Replication Origins Frees Dbf4-Cdc7 to Target Eco1 for Destruction.

Seoane AI, Morgan DO.

Curr Biol. 2017 Sep 25;27(18):2849-2855.e2. doi: 10.1016/j.cub.2017.07.070. Epub 2017 Sep 14.


Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.

Davey NE, Morgan DO.

Mol Cell. 2016 Oct 6;64(1):12-23. doi: 10.1016/j.molcel.2016.09.006. Review.


Cell division: Mitotic regulation comes into focus.

Morgan DO.

Nature. 2016 Aug 25;536(7617):407-8. Epub 2016 Aug 10. No abstract available.


Cell Size Determines the Strength of the Spindle Assembly Checkpoint during Embryonic Development.

Galli M, Morgan DO.

Dev Cell. 2016 Feb 8;36(3):344-52. doi: 10.1016/j.devcel.2016.01.003.


Quantitative framework for ordered degradation of APC/C substrates.

Lu D, Girard JR, Li W, Mizrak A, Morgan DO.

BMC Biol. 2015 Nov 16;13:96. doi: 10.1186/s12915-015-0205-6.


An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.

Girard JR, Tenthorey JL, Morgan DO.

J Biol Chem. 2015 Oct 2;290(40):24614-25. doi: 10.1074/jbc.M115.678193. Epub 2015 Aug 25.


Multiple mechanisms determine the order of APC/C substrate degradation in mitosis.

Lu D, Hsiao JY, Davey NE, Van Voorhis VA, Foster SA, Tang C, Morgan DO.

J Cell Biol. 2014 Oct 13;207(1):23-39. doi: 10.1083/jcb.201402041. Epub 2014 Oct 6.


Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis.

Eshleman HD, Morgan DO.

J Cell Sci. 2014 Nov 15;127(Pt 22):4974-83. doi: 10.1242/jcs.161273. Epub 2014 Sep 18.


Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate.

Matsusaka T, Enquist-Newman M, Morgan DO, Pines J.

Biol Open. 2014 Sep 12;3(10):904-12. doi: 10.1242/bio.20149415.


Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency.

Van Voorhis VA, Morgan DO.

Curr Biol. 2014 Jul 7;24(13):1556-62. doi: 10.1016/j.cub.2014.05.052. Epub 2014 Jun 12.


Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis.

Naylor SG, Morgan DO.

J Cell Sci. 2014 Mar 1;127(Pt 5):1128-37. doi: 10.1242/jcs.144097. Epub 2014 Jan 10.


Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology.

Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat KM.

J Am Chem Soc. 2013 Dec 4;135(48):18153-9. doi: 10.1021/ja408704u. Epub 2013 Nov 20.


The D box meets its match.

Morgan DO.

Mol Cell. 2013 Jun 6;50(5):609-10. doi: 10.1016/j.molcel.2013.05.023.


Sequential primed kinases create a damage-responsive phosphodegron on Eco1.

Lyons NA, Fonslow BR, Diedrich JK, Yates JR 3rd, Morgan DO.

Nat Struct Mol Biol. 2013 Feb;20(2):194-201. doi: 10.1038/nsmb.2478. Epub 2013 Jan 13.


The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.

Foster SA, Morgan DO.

Mol Cell. 2012 Sep 28;47(6):921-32. doi: 10.1016/j.molcel.2012.07.031. Epub 2012 Aug 30.


Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation.

Yaakov G, Thorn K, Morgan DO.

Dev Cell. 2012 Jul 17;23(1):124-36. doi: 10.1016/j.devcel.2012.06.007.


Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism.

Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP.

Curr Biol. 2011 Nov 22;21(22):1870-7. doi: 10.1016/j.cub.2011.09.051. Epub 2011 Nov 10.


Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes.

Schaefer JB, Morgan DO.

J Biol Chem. 2011 Dec 30;286(52):45186-96. doi: 10.1074/jbc.M111.310094. Epub 2011 Nov 9.


Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase.

Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ER, Rubin SM, Morgan DO, Loog M.

Nature. 2011 Oct 12;480(7375):128-31. doi: 10.1038/nature10560.


Dynamics of Cdk1 substrate specificity during the cell cycle.

Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M.

Mol Cell. 2011 Jun 10;42(5):610-23. doi: 10.1016/j.molcel.2011.05.016.


Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase.

Lyons NA, Morgan DO.

Mol Cell. 2011 May 6;42(3):378-89. doi: 10.1016/j.molcel.2011.03.023.


Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin.

Rodrigo-Brenni MC, Foster SA, Morgan DO.

Mol Cell. 2010 Aug 27;39(4):548-59. doi: 10.1016/j.molcel.2010.07.027.


The hidden rhythms of the dividing cell.

Morgan DO.

Cell. 2010 Apr 16;141(2):224-6. doi: 10.1016/j.cell.2010.03.042.


Cyclin-dependent kinases: a family portrait.

Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ.

Nat Cell Biol. 2009 Nov;11(11):1275-6. doi: 10.1038/ncb1109-1275. No abstract available.


Mechanisms of ubiquitin transfer by the anaphase-promoting complex.

Matyskiela ME, Rodrigo-Brenni MC, Morgan DO.

J Biol. 2009;8(10):92. doi: 10.1186/jbiol184. Review.


Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.

Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO.

Science. 2009 Sep 25;325(5948):1682-6. doi: 10.1126/science.1172867.


Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.

Matyskiela ME, Morgan DO.

Mol Cell. 2009 Apr 10;34(1):68-80. doi: 10.1016/j.molcel.2009.02.027.


Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis.

Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP.

Mol Cell. 2009 Mar 13;33(5):581-90. doi: 10.1016/j.molcel.2009.01.032.


The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast.

Tully GH, Nishihama R, Pringle JR, Morgan DO.

Mol Biol Cell. 2009 Feb;20(4):1201-12. doi: 10.1091/mbc.E08-08-0822. Epub 2008 Dec 24.


SnapShot: Cell-cycle regulators II.

Morgan DO.

Cell. 2008 Nov 28;135(5):974-974.e1. doi: 10.1016/j.cell.2008.10.040. No abstract available.


SnapShot: cell-cycle regulators I.

Morgan DO.

Cell. 2008 Nov 14;135(4):764-764.e1. doi: 10.1016/j.cell.2008.10.039. No abstract available.


Cyclin-specific control of ribosomal DNA segregation.

Sullivan M, Holt L, Morgan DO.

Mol Cell Biol. 2008 Sep;28(17):5328-36. doi: 10.1128/MCB.00235-08. Epub 2008 Jun 30.


Positive feedback sharpens the anaphase switch.

Holt LJ, Krutchinsky AN, Morgan DO.

Nature. 2008 Jul 17;454(7202):353-7. doi: 10.1038/nature07050. Epub 2008 Jun 15.


Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.

Enquist-Newman M, Sullivan M, Morgan DO.

Mol Cell. 2008 May 23;30(4):437-46. doi: 10.1016/j.molcel.2008.04.004.


Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.

Blethrow JD, Glavy JS, Morgan DO, Shokat KM.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1442-7. doi: 10.1073/pnas.0708966105. Epub 2008 Jan 30.


A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.

Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM.

Chem Biol. 2007 Nov;14(11):1261-72.


Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis.

Ko N, Nishihama R, Tully GH, Ostapenko D, Solomon MJ, Morgan DO, Pringle JR.

Mol Biol Cell. 2007 Dec;18(12):5139-53. Epub 2007 Oct 17.


Finishing mitosis, one step at a time.

Sullivan M, Morgan DO.

Nat Rev Mol Cell Biol. 2007 Nov;8(11):894-903. Review.


The role of self-association in Fin1 function on the mitotic spindle.

Woodbury EL, Morgan DO.

J Biol Chem. 2007 Nov 2;282(44):32138-43. Epub 2007 Sep 4.


Sequential E2s drive polyubiquitin chain assembly on APC targets.

Rodrigo-Brenni MC, Morgan DO.

Cell. 2007 Jul 13;130(1):127-39.


Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

Goga A, Yang D, Tward AD, Morgan DO, Bishop JM.

Nat Med. 2007 Jul;13(7):820-7. Epub 2007 Jun 24.


Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.

Woodbury EL, Morgan DO.

Nat Cell Biol. 2007 Jan;9(1):106-12. Epub 2006 Dec 17.


An architectural map of the anaphase-promoting complex.

Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP.

Genes Dev. 2006 Feb 15;20(4):449-60.


Enzymology of the anaphase-promoting complex.

Carroll CW, Morgan DO.

Methods Enzymol. 2005;398:219-30.


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