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Items: 1 to 50 of 152

1.

Acoustic levitation as a screening method for excipient selection in the development of dry powder vaccines.

Morgan BA, Xing Z, Cranston ED, Thompson MR.

Int J Pharm. 2019 May 30;563:71-78. doi: 10.1016/j.ijpharm.2019.03.026. Epub 2019 Mar 29.

PMID:
30930189
2.

Comparative evidence for the independent evolution of hair and sweat gland traits in primates.

Kamberov YG, Guhan SM, DeMarchis A, Jiang J, Wright SS, Morgan BA, Sabeti PC, Tabin CJ, Lieberman DE.

J Hum Evol. 2018 Dec;125:99-105. doi: 10.1016/j.jhevol.2018.10.008. Epub 2018 Nov 7.

PMID:
30502901
3.

Hyperoxidation of Peroxiredoxins: Gain or Loss of Function?

Veal EA, Underwood ZE, Tomalin LE, Morgan BA, Pillay CS.

Antioxid Redox Signal. 2018 Mar 1;28(7):574-590. doi: 10.1089/ars.2017.7214. Epub 2017 Sep 8. Review.

PMID:
28762774
4.

Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation.

Day AM, Smith DA, Ikeh MA, Haider M, Herrero-de-Dios CM, Brown AJ, Morgan BA, Erwig LP, MacCallum DM, Quinn J.

PLoS Pathog. 2017 Jan 30;13(1):e1006131. doi: 10.1371/journal.ppat.1006131. eCollection 2017 Jan.

5.

Direct control of regulatory T cells by keratinocytes.

Kashiwagi M, Hosoi J, Lai JF, Brissette J, Ziegler SF, Morgan BA, Georgopoulos K.

Nat Immunol. 2017 Mar;18(3):334-343. doi: 10.1038/ni.3661. Epub 2017 Jan 16.

6.

Stabilization of β-Catenin Does Not Increase Dermal Papilla Cell Number in the Hair Follicle.

Chi W, Morgan O, Wu E, Morgan BA.

J Invest Dermatol. 2017 Jan;137(1):245-246. doi: 10.1016/j.jid.2016.08.014. Epub 2016 Sep 1. No abstract available.

7.

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.

Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI.

Autophagy. 2016 Oct 2;12(10):1917-1930. Epub 2016 Jul 8.

8.

Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library.

Deng H, Zhou J, Sundersingh FS, Summerfield J, Somers D, Messer JA, Satz AL, Ancellin N, Arico-Muendel CC, Sargent Bedard KL, Beljean A, Belyanskaya SL, Bingham R, Smith SE, Boursier E, Carter P, Centrella PA, Clark MA, Chung CW, Davie CP, Delorey JL, Ding Y, Franklin GJ, Grady LC, Herry K, Hobbs C, Kollmann CS, Morgan BA, Pothier Kaushansky LJ, Zhou Q.

ACS Med Chem Lett. 2015 Jul 21;6(8):919-24. doi: 10.1021/acsmedchemlett.5b00179. eCollection 2015 Aug 13.

9.

Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).

Ding Y, O'Keefe H, DeLorey JL, Israel DI, Messer JA, Chiu CH, Skinner SR, Matico RE, Murray-Thompson MF, Li F, Clark MA, Cuozzo JW, Arico-Muendel C, Morgan BA.

ACS Med Chem Lett. 2015 Jul 7;6(8):888-93. doi: 10.1021/acsmedchemlett.5b00138. eCollection 2015 Aug 13.

10.

A genetic basis of variation in eccrine sweat gland and hair follicle density.

Kamberov YG, Karlsson EK, Kamberova GL, Lieberman DE, Sabeti PC, Morgan BA, Tabin CJ.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9932-7. doi: 10.1073/pnas.1511680112. Epub 2015 Jul 20.

11.

Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells.

Rieder SA, Metidji A, Glass DD, Thornton AM, Ikeda T, Morgan BA, Shevach EM.

J Immunol. 2015 Jul 15;195(2):553-63. doi: 10.4049/jimmunol.1500627. Epub 2015 Jun 10.

12.

Earlier-born secondary hair follicles exhibit phenotypic plasticity.

Chi W, Wu E, Morgan BA.

Exp Dermatol. 2015 Apr;24(4):265-8. doi: 10.1111/exd.12608. Epub 2015 Jan 12.

13.

The fission yeast Schizosaccharomyces pombe as a model to understand how peroxiredoxins influence cell responses to hydrogen peroxide.

Veal EA, Tomalin LE, Morgan BA, Day AM.

Biochem Soc Trans. 2014 Aug;42(4):909-16. doi: 10.1042/BST20140059. Review.

PMID:
25109978
14.

The dermal papilla: an instructive niche for epithelial stem and progenitor cells in development and regeneration of the hair follicle.

Morgan BA.

Cold Spring Harb Perspect Med. 2014 Jul 1;4(7):a015180. doi: 10.1101/cshperspect.a015180. Review.

15.

Harmonic Scalpel versus electrocautery and surgical clips in head and neck free-flap harvesting.

Dean NR, Rosenthal EL, Morgan BA, Magnuson JS, Carroll WR.

Ear Nose Throat J. 2014 Jun;93(6):E36-9.

PMID:
24932828
16.

Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis.

Deng H, Bernier SG, Doyle E, Lorusso J, Morgan BA, Westlin WF, Evindar G.

ACS Med Chem Lett. 2013 Aug 27;4(10):942-7. doi: 10.1021/ml400194r. eCollection 2013 Oct 10.

17.

Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.

Kollmann CS, Bai X, Tsai CH, Yang H, Lind KE, Skinner SR, Zhu Z, Israel DI, Cuozzo JW, Morgan BA, Yuki K, Xie C, Springer TA, Shimaoka M, Evindar G.

Bioorg Med Chem. 2014 Apr 1;22(7):2353-65. doi: 10.1016/j.bmc.2014.01.050. Epub 2014 Feb 7.

PMID:
24593905
18.

The "skinny" on Wnt signaling in stem cells.

Morgan BA.

Cell Stem Cell. 2013 Dec 5;13(6):638-40. doi: 10.1016/j.stem.2013.11.012.

19.

A peroxiredoxin promotes H2O2 signaling and oxidative stress resistance by oxidizing a thioredoxin family protein.

Brown JD, Day AM, Taylor SR, Tomalin LE, Morgan BA, Veal EA.

Cell Rep. 2013 Dec 12;5(5):1425-35. doi: 10.1016/j.celrep.2013.10.036. Epub 2013 Nov 21.

20.

Transcriptional regulation of the Ikzf1 locus.

Yoshida T, Landhuis E, Dose M, Hazan I, Zhang J, Naito T, Jackson AF, Wu J, Perotti EA, Kaufmann C, Gounari F, Morgan BA, Georgopoulos K.

Blood. 2013 Oct 31;122(18):3149-59. doi: 10.1182/blood-2013-01-474916. Epub 2013 Sep 3.

21.

Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape.

Patterson MJ, McKenzie CG, Smith DA, da Silva Dantas A, Sherston S, Veal EA, Morgan BA, MacCallum DM, Erwig LP, Quinn J.

Antioxid Redox Signal. 2013 Dec 20;19(18):2244-60. doi: 10.1089/ars.2013.5199. Epub 2013 Jul 9.

22.

Orally active fumagillin analogues: transformations of a reactive warhead in the gastric environment.

Arico-Muendel CC, Blanchette H, Benjamin DR, Caiazzo TM, Centrella PA, DeLorey J, Doyle EG, Johnson SR, Labenski MT, Morgan BA, O'Donovan G, Sarjeant AA, Skinner S, Thompson CD, Griffin ST, Westlin W, White KF.

ACS Med Chem Lett. 2013 Feb 22;4(4):381-6. doi: 10.1021/ml3003633. eCollection 2013 Apr 11.

23.

Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline.

Chi W, Wu E, Morgan BA.

Development. 2013 Apr;140(8):1676-83. doi: 10.1242/dev.090662. Epub 2013 Mar 13.

24.

In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor.

Podolin PL, Bolognese BJ, Foley JF, Long E 3rd, Peck B, Umbrecht S, Zhang X, Zhu P, Schwartz B, Xie W, Quinn C, Qi H, Sweitzer S, Chen S, Galop M, Ding Y, Belyanskaya SL, Israel DI, Morgan BA, Behm DJ, Marino JP Jr, Kurali E, Barnette MS, Mayer RJ, Booth-Genthe CL, Callahan JF.

Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:25-31. doi: 10.1016/j.prostaglandins.2013.02.001. Epub 2013 Feb 19.

PMID:
23434473
25.

Modeling recent human evolution in mice by expression of a selected EDAR variant.

Kamberov YG, Wang S, Tan J, Gerbault P, Wark A, Tan L, Yang Y, Li S, Tang K, Chen H, Powell A, Itan Y, Fuller D, Lohmueller J, Mao J, Schachar A, Paymer M, Hostetter E, Byrne E, Burnett M, McMahon AP, Thomas MG, Lieberman DE, Jin L, Tabin CJ, Morgan BA, Sabeti PC.

Cell. 2013 Feb 14;152(4):691-702. doi: 10.1016/j.cell.2013.01.016.

26.

Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity.

Arico-Muendel CC, Belanger B, Benjamin D, Blanchette HS, Caiazzo TM, Centrella PA, DeLorey J, Doyle EG, Gradhand U, Griffin ST, Hill S, Labenski MT, Morgan BA, O'Donovan G, Prasad K, Skinner S, Taghizadeh N, Thompson CD, Wakefield J, Westlin W, White KF.

Drug Metab Dispos. 2013 Apr;41(4):814-26. doi: 10.1124/dmd.112.048355. Epub 2013 Jan 25.

PMID:
23355637
27.

An Atg10-like E2 enzyme is essential for cell cycle progression but not autophagy in Schizosaccharomyces pombe.

Flanagan MD, Whitehall SK, Morgan BA.

Cell Cycle. 2013 Jan 15;12(2):271-7. doi: 10.4161/cc.23055. Epub 2012 Jan 15.

28.

Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1.

Evindar G, Deng H, Bernier SG, Doyle E, Lorusso J, Morgan BA, Westlin WF.

Bioorg Med Chem Lett. 2013 Jan 15;23(2):472-5. doi: 10.1016/j.bmcl.2012.11.053. Epub 2012 Nov 27.

PMID:
23245510
29.

Protein kinase C regulates late cell cycle-dependent gene expression.

Darieva Z, Han N, Warwood S, Doris KS, Morgan BA, Sharrocks AD.

Mol Cell Biol. 2012 Nov;32(22):4651-61. doi: 10.1128/MCB.06000-11. Epub 2012 Sep 10.

30.

Oxidative stress responses involve oxidation of a conserved ubiquitin pathway enzyme.

Doris KS, Rumsby EL, Morgan BA.

Mol Cell Biol. 2012 Nov;32(21):4472-81. doi: 10.1128/MCB.00559-12. Epub 2012 Sep 4.

31.

Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).

Deng H, O'Keefe H, Davie CP, Lind KE, Acharya RA, Franklin GJ, Larkin J, Matico R, Neeb M, Thompson MM, Lohr T, Gross JW, Centrella PA, O'Donovan GK, Bedard KL, van Vloten K, Mataruse S, Skinner SR, Belyanskaya SL, Carpenter TY, Shearer TW, Clark MA, Cuozzo JW, Arico-Muendel CC, Morgan BA.

J Med Chem. 2012 Aug 23;55(16):7061-79. doi: 10.1021/jm300449x. Epub 2012 Aug 14.

PMID:
22891645
32.

Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.

Day AM, Brown JD, Taylor SR, Rand JD, Morgan BA, Veal EA.

Mol Cell. 2012 Feb 10;45(3):398-408. doi: 10.1016/j.molcel.2011.11.027. Epub 2012 Jan 12.

33.

Dynasplint for the management of trismus after treatment of upper aerodigestive tract cancer: a retrospective study.

Barañano CF, Rosenthal EL, Morgan BA, McColloch NL, Magnuson JS.

Ear Nose Throat J. 2011 Dec;90(12):584-90.

PMID:
22180114
34.

Identification of a novel response regulator, Crr1, that is required for hydrogen peroxide resistance in Candida albicans.

Bruce CR, Smith DA, Rodgers D, da Silva Dantas A, MacCallum DM, Morgan BA, Quinn J.

PLoS One. 2011;6(12):e27979. doi: 10.1371/journal.pone.0027979. Epub 2011 Dec 2.

35.

Developmental biology: a hair-raising tale.

Morgan BA.

Nature. 2011 Mar 31;471(7340):586-7. doi: 10.1038/471586a. No abstract available.

PMID:
21455169
36.

A homeodomain transcription factor regulates the DNA replication checkpoint in yeast.

Purtill FS, Whitehall SK, Williams ES, McInerny CJ, Sharrocks AD, Morgan BA.

Cell Cycle. 2011 Feb 15;10(4):664-70. Epub 2011 Feb 15.

37.

Beta-catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching.

Enshell-Seijffers D, Lindon C, Wu E, Taketo MM, Morgan BA.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21564-9. doi: 10.1073/pnas.1007326107. Epub 2010 Nov 22.

38.

Two-component mediated peroxide sensing and signal transduction in fission yeast.

Quinn J, Malakasi P, Smith DA, Cheetham J, Buck V, Millar JB, Morgan BA.

Antioxid Redox Signal. 2011 Jul 1;15(1):153-65. doi: 10.1089/ars.2010.3345. Epub 2011 Mar 31.

PMID:
20919928
39.

Thioredoxin regulates multiple hydrogen peroxide-induced signaling pathways in Candida albicans.

da Silva Dantas A, Patterson MJ, Smith DA, Maccallum DM, Erwig LP, Morgan BA, Quinn J.

Mol Cell Biol. 2010 Oct;30(19):4550-63. doi: 10.1128/MCB.00313-10. Epub 2010 Aug 2.

40.

De novo production of dermal papilla cells during the anagen phase of the hair cycle.

Chi WY, Enshell-Seijffers D, Morgan BA.

J Invest Dermatol. 2010 Nov;130(11):2664-6. doi: 10.1038/jid.2010.176. Epub 2010 Jun 24. No abstract available.

41.

beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair.

Enshell-Seijffers D, Lindon C, Kashiwagi M, Morgan BA.

Dev Cell. 2010 Apr 20;18(4):633-42. doi: 10.1016/j.devcel.2010.01.016.

42.

A competitive transcription factor binding mechanism determines the timing of late cell cycle-dependent gene expression.

Darieva Z, Clancy A, Bulmer R, Williams E, Pic-Taylor A, Morgan BA, Sharrocks AD.

Mol Cell. 2010 Apr 9;38(1):29-40. doi: 10.1016/j.molcel.2010.02.030.

43.

Stress signalling to fungal stress-activated protein kinase pathways.

Smith DA, Morgan BA, Quinn J.

FEMS Microbiol Lett. 2010 May;306(1):1-8. doi: 10.1111/j.1574-6968.2010.01937.x. Epub 2010 Feb 24. Review.

44.

Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.

Evindar G, Bernier SG, Doyle E, Kavarana MJ, Satz AL, Lorusso J, Blanchette HS, Saha AK, Hannig G, Morgan BA, Westlin WF.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2520-4. doi: 10.1016/j.bmcl.2010.02.098. Epub 2010 Mar 3.

PMID:
20304639
45.

Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.

Arico-Muendel CC, Benjamin DR, Caiazzo TM, Centrella PA, Contonio BD, Cook CM, Doyle EG, Hannig G, Labenski MT, Searle LL, Lind K, Morgan BA, Olson G, Paradise CL, Self C, Skinner SR, Sluboski B, Svendsen JL, Thompson CD, Westlin W, White KF.

J Med Chem. 2009 Dec 24;52(24):8047-56. doi: 10.1021/jm901260k.

PMID:
19929003
46.

Design, synthesis and selection of DNA-encoded small-molecule libraries.

Clark MA, Acharya RA, Arico-Muendel CC, Belyanskaya SL, Benjamin DR, Carlson NR, Centrella PA, Chiu CH, Creaser SP, Cuozzo JW, Davie CP, Ding Y, Franklin GJ, Franzen KD, Gefter ML, Hale SP, Hansen NJ, Israel DI, Jiang J, Kavarana MJ, Kelley MS, Kollmann CS, Li F, Lind K, Mataruse S, Medeiros PF, Messer JA, Myers P, O'Keefe H, Oliff MC, Rise CE, Satz AL, Skinner SR, Svendsen JL, Tang L, van Vloten K, Wagner RW, Yao G, Zhao B, Morgan BA.

Nat Chem Biol. 2009 Sep;5(9):647-54. doi: 10.1038/nchembio.211. Epub 2009 Aug 2. Erratum in: Nat Chem Biol. 2009 Oct;5(10):772.

PMID:
19648931
47.

Antiparasitic activities of novel, orally available fumagillin analogs.

Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, Rosenthal PJ, Chiang PK.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5128-31. doi: 10.1016/j.bmcl.2009.07.029. Epub 2009 Jul 10.

48.

Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.

Evindar G, Satz AL, Bernier SG, Kavarana MJ, Doyle E, Lorusso J, Taghizadeh N, Halley K, Hutchings A, Kelley MS, Wright AD, Saha AK, Hannig G, Morgan BA, Westlin WF.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2315-9. doi: 10.1016/j.bmcl.2009.02.073. Epub 2009 Feb 23.

PMID:
19282175
49.

Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.

Evindar G, Bernier SG, Kavarana MJ, Doyle E, Lorusso J, Kelley MS, Halley K, Hutchings A, Wright AD, Saha AK, Hannig G, Morgan BA, Westlin WF.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):369-72. doi: 10.1016/j.bmcl.2008.11.072. Epub 2008 Nov 24.

PMID:
19081720
50.

A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.

Oláhová M, Taylor SR, Khazaipoul S, Wang J, Morgan BA, Matsumoto K, Blackwell TK, Veal EA.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19839-44. doi: 10.1073/pnas.0805507105. Epub 2008 Dec 8.

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