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Items: 38

1.

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice.

Wang Y, Su L, Morin MD, Jones BT, Mifune Y, Shi H, Wang KW, Zhan X, Liu A, Wang J, Li X, Tang M, Ludwig S, Hildebrand S, Zhou K, Siegwart DJ, Moresco EMY, Zhang H, Boger DL, Beutler B.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8698-E8706. doi: 10.1073/pnas.1809232115. Epub 2018 Aug 27.

PMID:
30150374
2.

Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database.

Wang T, Bu CH, Hildebrand S, Jia G, Siggs OM, Lyon S, Pratt D, Scott L, Russell J, Ludwig S, Murray AR, Moresco EMY, Beutler B.

Nat Commun. 2018 Jan 30;9(1):441. doi: 10.1038/s41467-017-02806-4.

3.

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.

Sun L, Jiang Z, Acosta-Rodriguez VA, Berger M, Du X, Choi JH, Wang J, Wang KW, Kilaru GK, Mohawk JA, Quan J, Scott L, Hildebrand S, Li X, Tang M, Zhan X, Murray AR, La Vine D, Moresco EMY, Takahashi JS, Beutler B.

J Exp Med. 2017 Nov 6;214(11):3263-3277. doi: 10.1084/jem.20161630. Epub 2017 Oct 2.

4.

An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue.

Tabeta K, Du X, Arimatsu K, Yokoji M, Takahashi N, Amizuka N, Hasegawa T, Crozat K, Maekawa T, Miyauchi S, Matsuda Y, Ida T, Kaku M, Hoebe K, Ohno K, Yoshie H, Yamazaki K, Moresco EMY, Beutler B.

Sci Rep. 2017 Sep 15;7(1):11717. doi: 10.1038/s41598-017-10343-9.

5.

Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.

Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5197-E5206. doi: 10.1073/pnas.1705312114. Epub 2017 Jun 12.

6.

IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.

Choi JH, Wang KW, Zhang D, Zhan X, Wang T, Bu CH, Behrendt CL, Zeng M, Wang Y, Misawa T, Li X, Tang M, Zhan X, Scott L, Hildebrand S, Murray AR, Moresco EM, Hooper LV, Beutler B.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1196-E1204. doi: 10.1073/pnas.1621258114. Epub 2017 Jan 30.

7.

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.

Zhang Z, Turer E, Li X, Zhan X, Choi M, Tang M, Press A, Smith SR, Divoux A, Moresco EM, Beutler B.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6418-E6426. Epub 2016 Oct 5.

8.

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.

Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM, Huang H, Shi H, Choi JH, Wang KW, Moresco EM, Berger M, Zhan X, Zhang H, Boger DL, Beutler B.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E884-93. doi: 10.1073/pnas.1525639113. Epub 2016 Feb 1. Erratum in: Proc Natl Acad Sci U S A. 2016 Apr 5;113(14 ):E2096.

9.

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.

Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, Su L, Pratt D, Bu CH, Hildebrand S, Lyon S, Scott L, Quan J, Sun Q, Russell J, Arnett S, Jurek P, Chen D, Kravchenko VV, Mathison JC, Moresco EM, Monson NL, Ulevitch RJ, Beutler B.

Nat Immunol. 2016 Mar;17(3):250-8. doi: 10.1038/ni.3333. Epub 2015 Dec 7.

10.

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing.

Simon MM, Moresco EM, Bull KR, Kumar S, Mallon AM, Beutler B, Potter PK.

Mamm Genome. 2015 Oct;26(9-10):486-500. doi: 10.1007/s00335-015-9603-x. Epub 2015 Oct 8. Review.

11.

Real-time resolution of point mutations that cause phenovariance in mice.

Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T, Wang Y, Shi H, Wang J, Sun L, SoRelle J, McAlpine W, Hutchins N, Zhan X, Fina M, Gobert R, Quan J, Kreutzer M, Arnett S, Hawkins K, Leach A, Tate C, Daniel C, Reyna C, Prince L, Davis S, Purrington J, Bearden R, Weatherly J, White D, Russell J, Sun Q, Tang M, Li X, Scott L, Moresco EM, McInerney GM, Karlsson Hedestam GB, Xie Y, Beutler B.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E440-9. doi: 10.1073/pnas.1423216112. Epub 2015 Jan 20.

12.

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses.

Zeng M, Hu Z, Shi X, Li X, Zhan X, Li XD, Wang J, Choi JH, Wang KW, Purrington T, Tang M, Fina M, DeBerardinis RJ, Moresco EM, Pedersen G, McInerney GM, Karlsson Hedestam GB, Chen ZJ, Beutler B.

Science. 2014 Dec 19;346(6216):1486-92. doi: 10.1126/science.346.6216.1486. Retraction in: Science. 2017 Oct 27;358(6362):458.

13.

Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling.

Chen Z, Holland W, Shelton JM, Ali A, Zhan X, Won S, Tomisato W, Liu C, Li X, Moresco EM, Beutler B.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7367-72. doi: 10.1073/pnas.1406511111. Epub 2014 May 5.

14.

Going forward with genetics: recent technological advances and forward genetics in mice.

Moresco EM, Li X, Beutler B.

Am J Pathol. 2013 May;182(5):1462-73. doi: 10.1016/j.ajpath.2013.02.002. Review.

15.

Linking membrane trafficking and intestinal homeostasis.

Moresco EM, Brandl K.

Tissue Barriers. 2013 Jan 1;1(1):e23119. doi: 10.4161/tisb.23119.

16.

ENU-induced phenovariance in mice: inferences from 587 mutations.

Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Webster V, Tomisato W, Won S, Xia Y, Xiao N, Beutler B.

BMC Res Notes. 2012 Oct 24;5:577. doi: 10.1186/1756-0500-5-577.

17.

Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice.

Brandl K, Tomisato W, Li X, Neppl C, Pirie E, Falk W, Xia Y, Moresco EM, Baccala R, Theofilopoulos AN, Schnabl B, Beutler B.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12650-5. doi: 10.1073/pnas.1210366109. Epub 2012 Jul 16.

18.

Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice.

Rutschmann S, Crozat K, Li X, Du X, Hanselman JC, Shigeoka AA, Brandl K, Popkin DL, McKay DB, Xia Y, Moresco EM, Beutler B.

G3 (Bethesda). 2012 Apr;2(4):499-504. doi: 10.1534/g3.112.002196. Epub 2012 Apr 1.

19.

Resisting viral infection: the gene by gene approach.

Moresco EM, Beutler B.

Curr Opin Virol. 2011 Dec;1(6):513-8. doi: 10.1016/j.coviro.2011.10.005. Epub 2011 Nov 6. Review.

20.

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.

Won S, Eidenschenk C, Arnold CN, Siggs OM, Sun L, Brandl K, Mullen TM, Nemerow GR, Moresco EM, Beutler B.

J Virol. 2012 Feb;86(3):1802-8. doi: 10.1128/JVI.05660-11. Epub 2011 Nov 23.

21.

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet.

Krebs P, Fan W, Chen YH, Tobita K, Downes MR, Wood MR, Sun L, Li X, Xia Y, Ding N, Spaeth JM, Moresco EM, Boyer TG, Lo CW, Yen J, Evans RM, Beutler B.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19678-82. doi: 10.1073/pnas.1117835108. Epub 2011 Nov 21.

22.

Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype.

Blasius AL, Dubin AE, Petrus MJ, Lim BK, Narezkina A, Criado JR, Wills DN, Xia Y, Moresco EM, Ehlers C, Knowlton KU, Patapoutian A, Beutler B.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19413-8. doi: 10.1073/pnas.1117020108. Epub 2011 Nov 15.

23.

Prion-like behavior of MAVS in RIG-I signaling.

Moresco EM, Vine DL, Beutler B.

Cell Res. 2011 Dec;21(12):1643-5. doi: 10.1038/cr.2011.155. Epub 2011 Sep 20. No abstract available.

24.

Toll-like receptors.

Moresco EM, LaVine D, Beutler B.

Curr Biol. 2011 Jul 12;21(13):R488-93. doi: 10.1016/j.cub.2011.05.039. Review. No abstract available.

25.

Special delivery: granulin brings CpG DNA to Toll-like receptor 9.

Moresco EM, Beutler B.

Immunity. 2011 Apr 22;34(4):453-5. doi: 10.1016/j.immuni.2011.04.001.

26.

Bulk segregation mapping of mutations in closely related strains of mice.

Xia Y, Won S, Du X, Lin P, Ross C, La Vine D, Wiltshire S, Leiva G, Vidal SM, Whittle B, Goodnow CC, Koziol J, Moresco EM, Beutler B.

Genetics. 2010 Dec;186(4):1139-46. doi: 10.1534/genetics.110.121160. Epub 2010 Oct 5.

27.

Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells.

Eidenschenk C, Crozat K, Krebs P, Arens R, Popkin D, Arnold CN, Blasius AL, Benedict CA, Moresco EM, Xia Y, Beutler B.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9759-64. doi: 10.1073/pnas.1005186107. Epub 2010 May 10.

28.

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

Berger M, Krebs P, Crozat K, Li X, Croker BA, Siggs OM, Popkin D, Du X, Lawson BR, Theofilopoulos AN, Xia Y, Khovananth K, Moresco EM, Satoh T, Takeuchi O, Akira S, Beutler B.

Nat Immunol. 2010 Apr;11(4):335-43. doi: 10.1038/ni.1847. Epub 2010 Feb 28.

29.

LGP2: positive about viral sensing.

Moresco EM, Beutler B.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1261-2. doi: 10.1073/pnas.0914011107. No abstract available.

30.

Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.

Barnes MJ, Krebs P, Harris N, Eidenschenk C, Gonzalez-Quintial R, Arnold CN, Crozat K, Sovath S, Moresco EM, Theofilopoulos AN, Beutler B, Hoebe K.

PLoS Biol. 2009 Mar 3;7(3):e51. doi: 10.1371/journal.pbio.1000051.

31.

Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.

Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15028-33. doi: 10.1073/pnas.0806619105. Epub 2008 Sep 19. Erratum in: Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19561. Rutschmann, Sophie [added].

32.

A catechol-O-methyltransferase that is essential for auditory function in mice and humans.

Du X, Schwander M, Moresco EM, Viviani P, Haller C, Hildebrand MS, Pak K, Tarantino L, Roberts A, Richardson H, Koob G, Najmabadi H, Ryan AF, Smith RJ, Müller U, Beutler B.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14609-14. doi: 10.1073/pnas.0807219105. Epub 2008 Sep 15.

33.

The forward genetic dissection of afferent innate immunity.

Beutler B, Moresco EM.

Curr Top Microbiol Immunol. 2008;321:3-26. Review.

PMID:
18727485
34.

The serine protease TMPRSS6 is required to sense iron deficiency.

Du X, She E, Gelbart T, Truksa J, Lee P, Xia Y, Khovananth K, Mudd S, Mann N, Moresco EM, Beutler E, Beutler B.

Science. 2008 May 23;320(5879):1088-92. doi: 10.1126/science.1157121. Epub 2008 May 1.

35.

Akirins versus infection.

Beutler B, Moresco EM.

Nat Immunol. 2008 Jan;9(1):7-9. No abstract available.

PMID:
18087247
36.

Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases.

Moresco EM, Donaldson S, Williamson A, Koleske AJ.

J Neurosci. 2005 Jun 29;25(26):6105-18.

37.

Regulation of neuronal morphogenesis and synaptic function by Abl family kinases.

Moresco EM, Koleske AJ.

Curr Opin Neurobiol. 2003 Oct;13(5):535-44. Review.

PMID:
14630215
38.

Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity.

Moresco EM, Scheetz AJ, Bornmann WG, Koleske AJ, Fitzsimonds RM.

J Neurophysiol. 2003 Mar;89(3):1678-87. Erratum in: J Neurophysiol. 2003 Aug;90(2):1362.

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