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Isolation and Characterization of Acidocalcisomes from Trypanosomatids.

Huang G, Moreno SNJ, Docampo R.

Methods Mol Biol. 2020;2116:673-688. doi: 10.1007/978-1-0716-0294-2_40.


An Endoplasmic Reticulum CREC Family Protein Regulates the Egress Proteolytic Cascade in Malaria Parasites.

Fierro MA, Asady B, Brooks CF, Cobb DW, Villegas A, Moreno SNJ, Muralidharan V.

mBio. 2020 Feb 25;11(1). pii: e03078-19. doi: 10.1128/mBio.03078-19.


Genetic Indicators for Calcium Signaling Studies in Toxoplasma gondii.

Vella SA, Calixto A, Asady B, Li ZH, Moreno SNJ.

Methods Mol Biol. 2020;2071:187-207. doi: 10.1007/978-1-4939-9857-9_11.


Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii.

Galaka T, Falcone BN, Li C, Szajnman SH, Moreno SNJ, Docampo R, Rodriguez JB.

Bioorg Med Chem. 2019 Aug 15;27(16):3663-3673. doi: 10.1016/j.bmc.2019.07.004. Epub 2019 Jul 4.


An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion.

Thornton LB, Teehan P, Floyd K, Cochrane C, Bergmann A, Riegel B, Stasic AJ, Di Cristina M, Moreno SNJ, Roepe PD, Dou Z.

PLoS Pathog. 2019 Jun 6;15(6):e1007775. doi: 10.1371/journal.ppat.1007775. eCollection 2019 Jun.


The Vacuolar Zinc Transporter TgZnT Protects Toxoplasma gondii from Zinc Toxicity.

Chasen NM, Stasic AJ, Asady B, Coppens I, Moreno SNJ.

mSphere. 2019 May 22;4(3). pii: e00086-19. doi: 10.1128/mSphere.00086-19.


The Toxoplasma Vacuolar H+-ATPase Regulates Intracellular pH and Impacts the Maturation of Essential Secretory Proteins.

Stasic AJ, Chasen NM, Dykes EJ, Vella SA, Asady B, Starai VJ, Moreno SNJ.

Cell Rep. 2019 May 14;27(7):2132-2146.e7. doi: 10.1016/j.celrep.2019.04.038.


Calcium signaling and the lytic cycle of the Apicomplexan parasite Toxoplasma gondii.

Hortua Triana MA, Márquez-Nogueras KM, Vella SA, Moreno SNJ.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1846-1856. doi: 10.1016/j.bbamcr.2018.08.004. Epub 2018 Aug 10. Review.


Characterization of Two EF-hand Domain-containing Proteins from Toxoplasma gondii.

Chang L, Dykes EJ, Li J, Moreno SNJ, Hortua Triana MA.

J Eukaryot Microbiol. 2019 Mar;66(2):343-353. doi: 10.1111/jeu.12675. Epub 2018 Aug 16.


Tagging of Weakly Expressed Toxoplasma gondii Calcium-Related Genes with High-Affinity Tags.

Hortua Triana MA, Márquez-Nogueras KM, Chang L, Stasic AJ, Li C, Spiegel KA, Sharma A, Li ZH, Moreno SNJ.

J Eukaryot Microbiol. 2018 Jul;65(5):709-721. doi: 10.1111/jeu.12626. Epub 2018 May 11.


Detection of Weakly Expressed Trypanosoma cruzi Membrane Proteins Using High-Performance Probes.

Cruz-Bustos T, Moreno SNJ, Docampo R.

J Eukaryot Microbiol. 2018 Jul;65(5):722-728. doi: 10.1111/jeu.12517. Epub 2018 Mar 30.


Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation.

Chao MN, Storey M, Li C, Rodríguez MG, Di Salvo F, Szajnman SH, Moreno SNJ, Docampo R, Rodriguez JB.

Bioorg Med Chem. 2017 Dec 15;25(24):6435-6449. doi: 10.1016/j.bmc.2017.10.016. Epub 2017 Oct 16.


Synergistic Activity between Statins and Bisphosphonates against Acute Experimental Toxoplasmosis.

Li ZH, Li C, Szajnman SH, Rodriguez JB, Moreno SNJ.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e02628-16. doi: 10.1128/AAC.02628-16. Print 2017 Aug.


A Glycosylphosphatidylinositol-Anchored Carbonic Anhydrase-Related Protein of Toxoplasma gondii Is Important for Rhoptry Biogenesis and Virulence.

Chasen NM, Asady B, Lemgruber L, Vommaro RC, Kissinger JC, Coppens I, Moreno SNJ.

mSphere. 2017 May 17;2(3). pii: e00027-17. doi: 10.1128/mSphere.00027-17. eCollection 2017 May-Jun.


A novel dense granule protein, GRA41, regulates timing of egress and calcium sensitivity in Toxoplasma gondii.

LaFavers KA, Márquez-Nogueras KM, Coppens I, Moreno SNJ, Arrizabalaga G.

Cell Microbiol. 2017 Sep;19(9). doi: 10.1111/cmi.12749. Epub 2017 May 17.


Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites.

Galaka T, Ferrer Casal M, Storey M, Li C, Chao MN, Szajnman SH, Docampo R, Moreno SN, Rodriguez JB.

Molecules. 2017 Jan 4;22(1). pii: E82. doi: 10.3390/molecules22010082.


In Vitro and In Vivo Activities of Sulfur-Containing Linear Bisphosphonates against Apicomplexan Parasites.

Szajnman SH, Galaka T, Li ZH, Li C, Howell NM, Chao MN, Striepen B, Muralidharan V, Moreno SN, Rodriguez JB.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01590-16. doi: 10.1128/AAC.01590-16. Print 2017 Feb.


Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii.

Chao MN, Li C, Storey M, Falcone BN, Szajnman SH, Bonesi SM, Docampo R, Moreno SN, Rodriguez JB.

ChemMedChem. 2016 Dec 16;11(24):2690-2702. doi: 10.1002/cmdc.201600505. Epub 2016 Nov 25.


Keep Up the Good (Bench) Work!

Moreno SNJ.

Trends Parasitol. 2016 Aug;32(8):579-580. doi: 10.1016/ Epub 2016 Apr 28.


Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling.

Sidik SM, Hortua Triana MA, Paul AS, El Bakkouri M, Hackett CG, Tran F, Westwood NJ, Hui R, Zuercher WJ, Duraisingh MT, Moreno SN, Lourido S.

J Biol Chem. 2016 Apr 29;291(18):9566-80. doi: 10.1074/jbc.M115.703546. Epub 2016 Mar 1.


Calcium Signaling throughout the Toxoplasma gondii Lytic Cycle: A STUDY USING GENETICALLY ENCODED CALCIUM INDICATORS.

Borges-Pereira L, Budu A, McKnight CA, Moore CA, Vella SA, Hortua Triana MA, Liu J, Garcia CR, Pace DA, Moreno SN.

J Biol Chem. 2015 Nov 6;290(45):26914-26. doi: 10.1074/jbc.M115.652511. Epub 2015 Sep 15.


Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii.

Chao MN, Matiuzzi CE, Storey M, Li C, Szajnman SH, Docampo R, Moreno SN, Rodriguez JB.

ChemMedChem. 2015 Jun;10(6):1094-108. doi: 10.1002/cmdc.201500100. Epub 2015 Apr 27.


Ca2+ Regulation of Trypanosoma brucei Phosphoinositide Phospholipase C.

King-Keller S, Moore CA, Docampo R, Moreno SN.

Eukaryot Cell. 2015 May;14(5):486-94. doi: 10.1128/EC.00019-15. Epub 2015 Mar 13.


The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp.

Lourido S, Moreno SN.

Cell Calcium. 2015 Mar;57(3):186-93. doi: 10.1016/j.ceca.2014.12.010. Epub 2014 Dec 31. Review.


Proteomic analysis of the acidocalcisome, an organelle conserved from bacteria to human cells.

Huang G, Ulrich PN, Storey M, Johnson D, Tischer J, Tovar JA, Moreno SN, Orlando R, Docampo R.

PLoS Pathog. 2014 Dec 11;10(12):e1004555. doi: 10.1371/journal.ppat.1004555. eCollection 2014 Dec.


Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondii.

Tang Q, Andenmatten N, Hortua Triana MA, Deng B, Meissner M, Moreno SN, Ballif BA, Ward GE.

Mol Biol Cell. 2014 Sep 1;25(17):2579-91. doi: 10.1091/mbc.E13-11-0648. Epub 2014 Jul 2.


A vacuolar-H(+) -pyrophosphatase (TgVP1) is required for microneme secretion, host cell invasion, and extracellular survival of Toxoplasma gondii.

Liu J, Pace D, Dou Z, King TP, Guidot D, Li ZH, Carruthers VB, Moreno SN.

Mol Microbiol. 2014 Aug;93(4):698-712. doi: 10.1111/mmi.12685. Epub 2014 Jul 16.


Calcium entry in Toxoplasma gondii and its enhancing effect of invasion-linked traits.

Pace DA, McKnight CA, Liu J, Jimenez V, Moreno SN.

J Biol Chem. 2014 Jul 11;289(28):19637-47. doi: 10.1074/jbc.M114.565390. Epub 2014 May 27.


New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase.

Ferrer-Casal M, Li C, Galizzi M, Stortz CA, Szajnman SH, Docampo R, Moreno SN, Rodriguez JB.

Bioorg Med Chem. 2014 Jan 1;22(1):398-405. doi: 10.1016/j.bmc.2013.11.010. Epub 2013 Nov 13.


Intracellular calcium channels in protozoa.

Docampo R, Moreno SN, Plattner H.

Eur J Pharmacol. 2014 Sep 15;739:4-18. doi: 10.1016/j.ejphar.2013.11.015. Epub 2013 Nov 28. Review.


Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin.

Li ZH, Ramakrishnan S, Striepen B, Moreno SN.

PLoS Pathog. 2013;9(10):e1003665. doi: 10.1371/journal.ppat.1003665. Epub 2013 Oct 17.


Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents.

Elicio PD, Chao MN, Galizzi M, Li C, Szajnman SH, Docampo R, Moreno SN, Rodriguez JB.

Eur J Med Chem. 2013 Nov;69:480-9. doi: 10.1016/j.ejmech.2013.09.009. Epub 2013 Sep 18.


Polyphosphate and its diverse functions in host cells and pathogens.

Moreno SN, Docampo R.

PLoS Pathog. 2013;9(5):e1003230. doi: 10.1371/journal.ppat.1003230. Epub 2013 May 2. Review. No abstract available.


N-terminal palmitoylation is required for Toxoplasma gondii HSP20 inner membrane complex localization.

De Napoli MG, de Miguel N, Lebrun M, Moreno SN, Angel SO, Corvi MM.

Biochim Biophys Acta. 2013 Jun;1833(6):1329-37. doi: 10.1016/j.bbamcr.2013.02.022. Epub 2013 Feb 26.


Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Cai G, Deng L, Xue J, Moreno SN, Striepen B, Song Y.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2158-61. doi: 10.1016/j.bmcl.2013.01.097. Epub 2013 Jan 30.


Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity.

Huang G, Bartlett PJ, Thomas AP, Moreno SN, Docampo R.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1887-92. doi: 10.1073/pnas.1216955110. Epub 2013 Jan 14.


Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.

Recher M, Barboza AP, Li ZH, Galizzi M, Ferrer-Casal M, Szajnman SH, Docampo R, Moreno SN, Rodriguez JB.

Eur J Med Chem. 2013 Feb;60:431-40. doi: 10.1016/j.ejmech.2012.12.015. Epub 2012 Dec 20.


1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase.

Szajnman SH, Rosso VS, Malayil L, Smith A, Moreno SN, Docampo R, Rodriguez JB.

Org Biomol Chem. 2012 Feb 21;10(7):1424-33. doi: 10.1039/c1ob06602a. Epub 2012 Jan 3.


Calcium storage and function in apicomplexan parasites.

Moreno SN, Ayong L, Pace DA.

Essays Biochem. 2011;51:97-110. doi: 10.1042/bse0510097. Review.


Overexpression of a cytosolic pyrophosphatase (TgPPase) reveals a regulatory role of PP(i) in glycolysis for Toxoplasma gondii.

Pace DA, Fang J, Cintron R, Docampo MD, Moreno SN.

Biochem J. 2011 Dec 1;440(2):229-40. doi: 10.1042/BJ20110641.


The role of acidocalcisomes in the stress response of Trypanosoma cruzi.

Docampo R, Jimenez V, King-Keller S, Li ZH, Moreno SN.

Adv Parasitol. 2011;75:307-24. doi: 10.1016/B978-0-12-385863-4.00014-9.



Docampo R, Moreno SN.

Cell Calcium. 2011 Aug;50(2):113-9. doi: 10.1016/j.ceca.2011.05.012. Epub 2011 Jul 12. Review.


Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii.

Nair SC, Brooks CF, Goodman CD, Sturm A, McFadden GI, Sundriyal S, Anglin JL, Song Y, Moreno SN, Striepen B.

J Exp Med. 2011 Jul 4;208(7):1547-59. doi: 10.1084/jem.20110039. Epub 2011 Jun 20. Erratum in: J Exp Med. 2012 May 7;209(5):1051. Strurm, Angelika [corrected to Sturm, Angelika].


Calcium uptake and proton transport by acidocalcisomes of Toxoplasma gondii.

Rohloff P, Miranda K, Rodrigues JC, Fang J, Galizzi M, Plattner H, Hentschel J, Moreno SN.

PLoS One. 2011 Apr 25;6(4):e18390. doi: 10.1371/journal.pone.0018390.


A Toxoplasma gondii protein with homology to intracellular type Na⁺/H⁺ exchangers is important for osmoregulation and invasion.

Francia ME, Wicher S, Pace DA, Sullivan J, Moreno SN, Arrizabalaga G.

Exp Cell Res. 2011 Jun 10;317(10):1382-96. doi: 10.1016/j.yexcr.2011.03.020. Epub 2011 Apr 9.


Identification of contractile vacuole proteins in Trypanosoma cruzi.

Ulrich PN, Jimenez V, Park M, Martins VP, Atwood J 3rd, Moles K, Collins D, Rohloff P, Tarleton R, Moreno SN, Orlando R, Docampo R.

PLoS One. 2011 Mar 18;6(3):e18013. doi: 10.1371/journal.pone.0018013.


Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.

Rosso VS, Szajnman SH, Malayil L, Galizzi M, Moreno SN, Docampo R, Rodriguez JB.

Bioorg Med Chem. 2011 Apr 1;19(7):2211-7. doi: 10.1016/j.bmc.2011.02.037.


TgVTC2 is involved in polyphosphate accumulation in Toxoplasma gondii.

Rooney PJ, Ayong L, Tobin CM, Moreno SN, Knoll LJ.

Mol Biochem Parasitol. 2011 Apr;176(2):121-6. doi: 10.1016/j.molbiopara.2010.12.012. Epub 2010 Dec 30.


Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes.

de Paulo Martins V, Okura M, Maric D, Engman DM, Vieira M, Docampo R, Moreno SN.

J Biol Chem. 2010 Oct 1;285(40):30906-17. doi: 10.1074/jbc.M110.142190. Epub 2010 Jul 20.

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