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Emerging structural insights into glycosyltransferase-mediated synthesis of glycans.

Moremen KW, Haltiwanger RS.

Nat Chem Biol. 2019 Sep;15(9):853-864. doi: 10.1038/s41589-019-0350-2. Epub 2019 Aug 19. Review.


Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide.

't Hart IME, Li T, Wolfert MA, Wang S, Moremen KW, Boons GJ.

Org Biomol Chem. 2019 Aug 7;17(31):7304-7308. doi: 10.1039/c9ob01368g.


Direct Visualization of Live Zebrafish Glycans via Single-Step Metabolic Labeling with Fluorophore-Tagged Nucleotide Sugars.

Hong S, Sahai-Hernandez P, Chapla DG, Moremen KW, Traver D, Wu P.

Angew Chem Int Ed Engl. 2019 Oct 1;58(40):14327-14333. doi: 10.1002/anie.201907410. Epub 2019 Aug 28. Review.


Measurement of residual dipolar couplings in methyl groups via carbon detection.

Williams RV, Yang JY, Moremen KW, Amster IJ, Prestegard JH.

J Biomol NMR. 2019 Apr;73(3-4):191-198. doi: 10.1007/s10858-019-00245-5. Epub 2019 Apr 30.


NMR Resonance Assignment Methodology: Characterizing Large Sparsely Labeled Glycoproteins.

Chalmers GR, Eletsky A, Morris LC, Yang JY, Tian F, Woods RJ, Moremen KW, Prestegard JH.

J Mol Biol. 2019 May 31;431(12):2369-2382. doi: 10.1016/j.jmb.2019.04.029. Epub 2019 Apr 26.


An automated platform for the enzyme-mediated assembly of complex oligosaccharides.

Li T, Liu L, Wei N, Yang JY, Chapla DG, Moremen KW, Boons GJ.

Nat Chem. 2019 Mar;11(3):229-236. doi: 10.1038/s41557-019-0219-8. Epub 2019 Feb 21.


Recombinant Sialyltransferase Infusion Mitigates Infection-Driven Acute Lung Inflammation.

Nasirikenari M, Lugade AA, Neelamegham S, Gao Z, Moremen KW, Bogner PN, Thanavala Y, Lau JTY.

Front Immunol. 2019 Feb 4;10:48. doi: 10.3389/fimmu.2019.00048. eCollection 2019.


Selective Engineering of Linkage-Specific α2,6-N-Linked Sialoproteins Using Sydnone-Modified Sialic Acid Bioorthogonal Reporters.

Chinoy ZS, Bodineau C, Favre C, Moremen KW, Durán RV, Friscourt F.

Angew Chem Int Ed Engl. 2019 Mar 22;58(13):4281-4285. doi: 10.1002/anie.201814266. Epub 2019 Feb 19.


A Single-Step Chemoenzymatic Reaction for the Construction of Antibody-Cell Conjugates.

Li J, Chen M, Liu Z, Zhang L, Felding BH, Moremen KW, Lauvau G, Abadier M, Ley K, Wu P.

ACS Cent Sci. 2018 Dec 26;4(12):1633-1641. doi: 10.1021/acscentsci.8b00552. Epub 2018 Dec 7.


Streamlining the chemoenzymatic synthesis of complex N-glycans by a stop and go strategy.

Liu L, Prudden AR, Capicciotti CJ, Bosman GP, Yang JY, Chapla DG, Moremen KW, Boons GJ.

Nat Chem. 2019 Feb;11(2):161-169. doi: 10.1038/s41557-018-0188-3. Epub 2018 Dec 10.


A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships.

Qiu H, Shi S, Yue J, Xin M, Nairn AV, Lin L, Liu X, Li G, Archer-Hartmann SA, Dela Rosa M, Galizzi M, Wang S, Zhang F, Azadi P, van Kuppevelt TH, Cardoso WV, Kimata K, Ai X, Moremen KW, Esko JD, Linhardt RJ, Wang L.

Nat Methods. 2018 Nov;15(11):889-899. doi: 10.1038/s41592-018-0189-6. Epub 2018 Oct 30.


Association mapping, transcriptomics, and transient expression identify candidate genes mediating plant-pathogen interactions in a tree.

Muchero W, Sondreli KL, Chen JG, Urbanowicz BR, Zhang J, Singan V, Yang Y, Brueggeman RS, Franco-Coronado J, Abraham N, Yang JY, Moremen KW, Weisberg AJ, Chang JH, Lindquist E, Barry K, Ranjan P, Jawdy S, Schmutz J, Tuskan GA, LeBoldus JM.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11573-11578. doi: 10.1073/pnas.1804428115. Epub 2018 Oct 18.


A two-phase model for the non-processive biosynthesis of homogalacturonan polysaccharides by the GAUT1:GAUT7 complex.

Amos RA, Pattathil S, Yang JY, Atmodjo MA, Urbanowicz BR, Moremen KW, Mohnen D.

J Biol Chem. 2018 Dec 7;293(49):19047-19063. doi: 10.1074/jbc.RA118.004463. Epub 2018 Oct 16.


Identification of Key Enzymes for Pectin Synthesis in Seed Mucilage.

Voiniciuc C, Engle KA, Günl M, Dieluweit S, Schmidt MH, Yang JY, Moremen KW, Mohnen D, Usadel B.

Plant Physiol. 2018 Nov;178(3):1045-1064. doi: 10.1104/pp.18.00584. Epub 2018 Sep 18.


Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase.

Thieker DF, Xu Y, Chapla D, Nora C, Qiu H, Felix T, Wang L, Moremen KW, Liu J, Esko JD, Woods RJ.

Sci Rep. 2018 Aug 7;8(1):11832. doi: 10.1038/s41598-018-29602-4.


Paramagnetic Tag for Glycosylation Sites in Glycoproteins: Structural Constraints on Heparan Sulfate Binding to Robo1.

Moure MJ, Eletsky A, Gao Q, Morris LC, Yang JY, Chapla D, Zhao Y, Zong C, Amster IJ, Moremen KW, Boons GJ, Prestegard JH.

ACS Chem Biol. 2018 Sep 21;13(9):2560-2567. doi: 10.1021/acschembio.8b00511. Epub 2018 Aug 16.


Defective mucin-type glycosylation on α-dystroglycan in COG-deficient cells increases its susceptibility to bacterial proteases.

Yu SH, Zhao P, Prabhakar PK, Sun T, Beedle A, Boons GJ, Moremen KW, Wells L, Steet R.

J Biol Chem. 2018 Sep 14;293(37):14534-14544. doi: 10.1074/jbc.RA118.003014. Epub 2018 Jul 26.


Integration of genetic and metabolic features related to sialic acid metabolism distinguishes human breast cell subtypes.

Saeui CT, Nairn AV, Galizzi M, Douville C, Gowda P, Park M, Dharmarha V, Shah SR, Clarke A, Austin M, Moremen KW, Yarema KJ.

PLoS One. 2018 May 30;13(5):e0195812. doi: 10.1371/journal.pone.0195812. eCollection 2018.


Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite.

Kadirvelraj R, Yang JY, Sanders JH, Liu L, Ramiah A, Prabhakar PK, Boons GJ, Wood ZA, Moremen KW.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4637-4642. doi: 10.1073/pnas.1716988115. Epub 2018 Apr 16.


Structural Characterization of a Heparan Sulfate Pentamer Interacting with LAR-Ig1-2.

Gao Q, Yang JY, Moremen KW, Flanagan JG, Prestegard JH.

Biochemistry. 2018 Apr 17;57(15):2189-2199. doi: 10.1021/acs.biochem.8b00241. Epub 2018 Apr 3.


Sialyltransferase-Based Chemoenzymatic Histology for the Detection of N- and O-Glycans.

Lopez Aguilar A, Meng L, Hou X, Li W, Moremen KW, Wu P.

Bioconjug Chem. 2018 Apr 18;29(4):1231-1239. doi: 10.1021/acs.bioconjchem.8b00021. Epub 2018 Mar 23.


A Traveling Wave Ion Mobility Spectrometry (TWIMS) Study of the Robo1-Heparan Sulfate Interaction.

Zhao Y, Yang JY, Thieker DF, Xu Y, Zong C, Boons GJ, Liu J, Woods RJ, Moremen KW, Amster IJ.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1153-1165. doi: 10.1007/s13361-018-1903-4. Epub 2018 Mar 8.


Cell-based glycan arrays for probing glycan-glycan binding protein interactions.

Briard JG, Jiang H, Moremen KW, Macauley MS, Wu P.

Nat Commun. 2018 Feb 28;9(1):880. doi: 10.1038/s41467-018-03245-5.


Identification of an algal xylan synthase indicates that there is functional orthology between algal and plant cell wall biosynthesis.

Jensen JK, Busse-Wicher M, Poulsen CP, Fangel JU, Smith PJ, Yang JY, Peña MJ, Dinesen MH, Martens HJ, Melkonian M, Wong GK, Moremen KW, Wilkerson CG, Scheller HV, Dupree P, Ulvskov P, Urbanowicz BR, Harholt J.

New Phytol. 2018 May;218(3):1049-1060. doi: 10.1111/nph.15050. Epub 2018 Feb 20.


Publisher Correction: Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway.

Benedetti E, Pučić-Baković M, Keser T, Wahl A, Hassinen A, Yang JY, Liu L, Trbojević-Akmačić I, Razdorov G, Štambuk J, Klarić L, Ugrina I, Selman MHJ, Wuhrer M, Rudan I, Polasek O, Hayward C, Grallert H, Strauch K, Peters A, Meitinger T, Gieger C, Vilaj M, Boons GJ, Moremen KW, Ovchinnikova T, Bovin N, Kellokumpu S, Theis FJ, Lauc G, Krumsiek J.

Nat Commun. 2018 Feb 13;9(1):706. doi: 10.1038/s41467-017-02379-2.


Engineered Glycocalyx Regulates Stem Cell Proliferation in Murine Crypt Organoids.

Rouhanifard SH, Lopez Aguilar A, Meng L, Moremen KW, Wu P.

Cell Chem Biol. 2018 Apr 19;25(4):439-446.e5. doi: 10.1016/j.chembiol.2018.01.010. Epub 2018 Feb 8.


Isotopic labeling with cellular O-glycome reporter/amplification (ICORA) for comparative O-glycomics of cultured cells.

Kudelka MR, Nairn AV, Sardar MY, Sun X, Chaikof EL, Ju T, Moremen KW, Cummings RD.

Glycobiology. 2018 Apr 1;28(4):214-222. doi: 10.1093/glycob/cwy005.


Modulating Cell-Surface Receptor Signaling and Ion Channel Functions by In Situ Glycan Editing.

Jiang H, López-Aguilar A, Meng L, Gao Z, Liu Y, Tian X, Yu G, Ovryn B, Moremen KW, Wu P.

Angew Chem Int Ed Engl. 2018 Jan 22;57(4):967-971. doi: 10.1002/anie.201706535. Epub 2018 Jan 2.


Expression system for structural and functional studies of human glycosylation enzymes.

Moremen KW, Ramiah A, Stuart M, Steel J, Meng L, Forouhar F, Moniz HA, Gahlay G, Gao Z, Chapla D, Wang S, Yang JY, Prabhakar PK, Johnson R, Rosa MD, Geisler C, Nairn AV, Seetharaman J, Wu SC, Tong L, Gilbert HJ, LaBaer J, Jarvis DL.

Nat Chem Biol. 2018 Feb;14(2):156-162. doi: 10.1038/nchembio.2539. Epub 2017 Dec 18.


Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway.

Benedetti E, Pučić-Baković M, Keser T, Wahl A, Hassinen A, Yang JY, Liu L, Trbojević-Akmačić I, Razdorov G, Štambuk J, Klarić L, Ugrina I, Selman MHJ, Wuhrer M, Rudan I, Polasek O, Hayward C, Grallert H, Strauch K, Peters A, Meitinger T, Gieger C, Vilaj M, Boons GJ, Moremen KW, Ovchinnikova T, Bovin N, Kellokumpu S, Theis FJ, Lauc G, Krumsiek J.

Nat Commun. 2017 Nov 14;8(1):1483. doi: 10.1038/s41467-017-01525-0. Erratum in: Nat Commun. 2018 Feb 13;9(1):706.


RElative QUantitation Inferred by Evaluating Mixtures (REQUIEM).

Tuomivaara ST, Schliekelman P, Nairn AV, Moremen KW, York WS.

Anal Chim Acta. 2017 Nov 15;993:22-37. doi: 10.1016/j.aca.2017.09.023. Epub 2017 Oct 4.


Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain.

Tong W, Dwyer CA, Thacker BE, Glass CA, Brown JR, Hamill K, Moremen KW, Sarrazin S, Gordts PLSM, Dozier LE, Patrick GN, Tor Y, Esko JD.

Mol Ther. 2017 Dec 6;25(12):2743-2752. doi: 10.1016/j.ymthe.2017.08.007. Epub 2017 Aug 12.


Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions.

Epp A, Hobusch J, Bartsch YC, Petry J, Lilienthal GM, Koeleman CAM, Eschweiler S, Möbs C, Hall A, Morris SC, Braumann D, Engellenner C, Bitterling J, Rahmöller J, Leliavski A, Thurmann R, Collin M, Moremen KW, Strait RT, Blanchard V, Petersen A, Gemoll T, Habermann JK, Petersen F, Nandy A, Kahlert H, Hertl M, Wuhrer M, Pfützner W, Jappe U, Finkelman FD, Ehlers M.

J Allergy Clin Immunol. 2018 Jan;141(1):399-402.e8. doi: 10.1016/j.jaci.2017.06.021. Epub 2017 Jul 18. No abstract available.


Structural, mutagenic and in silico studies of xyloglucan fucosylation in Arabidopsis thaliana suggest a water-mediated mechanism.

Urbanowicz BR, Bharadwaj VS, Alahuhta M, Peña MJ, Lunin VV, Bomble YJ, Wang S, Yang JY, Tuomivaara ST, Himmel ME, Moremen KW, York WS, Crowley MF.

Plant J. 2017 Sep;91(6):931-949. doi: 10.1111/tpj.13628. Epub 2017 Aug 28.


Biochemical characterization of functional domains of the chaperone Cosmc.

Hanes MS, Moremen KW, Cummings RD.

PLoS One. 2017 Jun 30;12(6):e0180242. doi: 10.1371/journal.pone.0180242. eCollection 2017.


Synthesis of asymmetrical multiantennary human milk oligosaccharides.

Prudden AR, Liu L, Capicciotti CJ, Wolfert MA, Wang S, Gao Z, Meng L, Moremen KW, Boons GJ.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):6954-6959. doi: 10.1073/pnas.1701785114. Epub 2017 Jun 19.


NMR assignments of sparsely labeled proteins using a genetic algorithm.

Gao Q, Chalmers GR, Moremen KW, Prestegard JH.

J Biomol NMR. 2017 Apr;67(4):283-294. doi: 10.1007/s10858-017-0101-1. Epub 2017 Mar 13.


Rapid screening of sugar-nucleotide donor specificities of putative glycosyltransferases.

Sheikh MO, Halmo SM, Patel S, Middleton D, Takeuchi H, Schafer CM, West CM, Haltiwanger RS, Avci FY, Moremen KW, Wells L.

Glycobiology. 2017 Mar 1;27(3):206-212. doi: 10.1093/glycob/cww114.


O-Linked N-Acetylglucosamine (O-GlcNAc) Expression Levels Epigenetically Regulate Colon Cancer Tumorigenesis by Affecting the Cancer Stem Cell Compartment via Modulating Expression of Transcriptional Factor MYBL1.

Guo H, Zhang B, Nairn AV, Nagy T, Moremen KW, Buckhaults P, Pierce M.

J Biol Chem. 2017 Mar 10;292(10):4123-4137. doi: 10.1074/jbc.M116.763201. Epub 2017 Jan 17.


Protein O-Linked Mannose β-1,4-N-Acetylglucosaminyl-transferase 2 (POMGNT2) Is a Gatekeeper Enzyme for Functional Glycosylation of α-Dystroglycan.

Halmo SM, Singh D, Patel S, Wang S, Edlin M, Boons GJ, Moremen KW, Live D, Wells L.

J Biol Chem. 2017 Feb 10;292(6):2101-2109. doi: 10.1074/jbc.M116.764712. Epub 2016 Dec 8.


Substrate recognition and catalysis by GH47 α-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway.

Xiang Y, Karaveg K, Moremen KW.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7890-E7899. Epub 2016 Nov 17.


Divergent Chemoenzymatic Synthesis of Asymmetrical-Core-Fucosylated and Core-Unmodified N-Glycans.

Li T, Huang M, Liu L, Wang S, Moremen KW, Boons GJ.

Chemistry. 2016 Dec 23;22(52):18742-18746. doi: 10.1002/chem.201604999. Epub 2016 Nov 22.


Structural Aspects of Heparan Sulfate Binding to Robo1-Ig1-2.

Gao Q, Chen CY, Zong C, Wang S, Ramiah A, Prabhakar P, Morris LC, Boons GJ, Moremen KW, Prestegard JH.

ACS Chem Biol. 2016 Nov 18;11(11):3106-3113. Epub 2016 Sep 29.


Integrated Approach to Identify Heparan Sulfate Ligand Requirements of Robo1.

Zong C, Huang R, Condac E, Chiu Y, Xiao W, Li X, Lu W, Ishihara M, Wang S, Ramiah A, Stickney M, Azadi P, Amster IJ, Moremen KW, Wang L, Sharp JS, Boons GJ.

J Am Chem Soc. 2016 Oct 5;138(39):13059-13067. Epub 2016 Sep 27.


One-Step Selective Exoenzymatic Labeling (SEEL) Strategy for the Biotinylation and Identification of Glycoproteins of Living Cells.

Sun T, Yu SH, Zhao P, Meng L, Moremen KW, Wells L, Steet R, Boons GJ.

J Am Chem Soc. 2016 Sep 14;138(36):11575-11582. doi: 10.1021/jacs.6b04049. Epub 2016 Sep 1.


Glycosylation Alters Dimerization Properties of a Cell-surface Signaling Protein, Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 (CEACAM1).

Zhuo Y, Yang JY, Moremen KW, Prestegard JH.

J Biol Chem. 2016 Sep 16;291(38):20085-95. doi: 10.1074/jbc.M116.740050. Epub 2016 Jul 28.


NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length.

Deligny A, Dierker T, Dagälv A, Lundequist A, Eriksson I, Nairn AV, Moremen KW, Merry CLR, Kjellén L.

J Biol Chem. 2016 Sep 2;291(36):18600-18607. doi: 10.1074/jbc.M116.744433. Epub 2016 Jul 7.


Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.

Zhang C, Zhang T, Zou J, Miller CL, Gorkhali R, Yang JY, Schilmiller A, Wang S, Huang K, Brown EM, Moremen KW, Hu J, Yang JJ.

Sci Adv. 2016 May 27;2(5):e1600241. doi: 10.1126/sciadv.1600241. eCollection 2016 May.


Differentiation-related glycan epitopes identify discrete domains of the muscle glycocalyx.

McMorran BJ, McCarthy FE, Gibbs EM, Pang M, Marshall JL, Nairn AV, Moremen KW, Crosbie-Watson RH, Baum LG.

Glycobiology. 2016 Oct;26(10):1120-1132. doi: 10.1093/glycob/cww061. Epub 2016 May 28.


The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition.

Praissman JL, Willer T, Sheikh MO, Toi A, Chitayat D, Lin YY, Lee H, Stalnaker SH, Wang S, Prabhakar PK, Nelson SF, Stemple DL, Moore SA, Moremen KW, Campbell KP, Wells L.

Elife. 2016 Apr 29;5. pii: e14473. doi: 10.7554/eLife.14473.

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