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Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts.

Hughes AD, Zhao D, Dai H, Abou-Daya KI, Tieu R, Rammal R, Williams AL, Landsittel DP, Shlomchik WD, Morelli AE, Oberbarnscheidt MH, Lakkis FG.

J Clin Invest. 2020 Jan 2;130(1):287-294. doi: 10.1172/JCI125773.


Impact of extracellular vesicles on innate immunity.

Chen Z, Larregina AT, Morelli AE.

Curr Opin Organ Transplant. 2019 Dec;24(6):670-678. doi: 10.1097/MOT.0000000000000701.


Platelet Extracellular Vesicles Drive Inflammasome-IL-1β-Dependent Lung Injury in Sickle Cell Disease.

Vats R, Brzoska T, Bennewitz MF, Jimenez MA, Pradhan-Sundd T, Tutuncuoglu E, Jonassaint J, Gutierrez E, Watkins SC, Shiva S, Scott MJ, Morelli AE, Neal MD, Kato GJ, Gladwin MT, Sundd P.

Am J Respir Crit Care Med. 2020 Jan 1;201(1):33-46. doi: 10.1164/rccm.201807-1370OC.


Oral administration of lipoteichoic acid from Lactobacillus rhamnosus GG overcomes UVB-induced immunosuppression and impairs skin tumor growth in mice.

Friedrich AD, Campo VE, Cela EM, Morelli AE, Shufesky WJ, Tckacheva OA, Leoni J, Paz ML, Larregina AT, González Maglio DH.

Eur J Immunol. 2019 Nov;49(11):2095-2102. doi: 10.1002/eji.201848024. Epub 2019 Jul 31.


Promise of Regulatory Macrophage (Mreg)-induced T-cell Immunosuppression.

Morelli AE.

Transplantation. 2019 Jul;103(7):1291-1292. doi: 10.1097/TP.0000000000002637. No abstract available.


Extracellular vesicle-mediated MHC cross-dressing in immune homeostasis, transplantation, infectious diseases, and cancer.

Zeng F, Morelli AE.

Semin Immunopathol. 2018 Sep;40(5):477-490. doi: 10.1007/s00281-018-0679-8. Epub 2018 Mar 28. Review.


Donor-Derived Regulatory Dendritic Cell Infusion Maintains Donor-Reactive CD4+CTLA4hi T Cells in Non-Human Primate Renal Allograft Recipients Treated with CD28 Co-Stimulation Blockade.

Ezzelarab MB, Lu L, Shufesky WF, Morelli AE, Thomson AW.

Front Immunol. 2018 Feb 19;9:250. doi: 10.3389/fimmu.2018.00250. eCollection 2018.


Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice.

Zettel K, Korff S, Zamora R, Morelli AE, Darwiche S, Loughran PA, Elson G, Shang L, Salgado-Pires S, Scott MJ, Vodovotz Y, Billiar TR.

Front Immunol. 2017 Nov 28;8:1672. doi: 10.3389/fimmu.2017.01672. eCollection 2017.


Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury.

Yang MQ, Du Q, Goswami J, Varley PR, Chen B, Wang RH, Morelli AE, Stolz DB, Billiar TR, Li J, Geller DA.

Hepatology. 2018 Mar;67(3):1056-1070. doi: 10.1002/hep.29605. Epub 2018 Jan 24.


Graft-infiltrating PD-L1hi cross-dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance.

Ono Y, Perez-Gutierrez A, Nakao T, Dai H, Camirand G, Yoshida O, Yokota S, Stolz DB, Ross MA, Morelli AE, Geller DA, Thomson AW.

Hepatology. 2018 Apr;67(4):1499-1515. doi: 10.1002/hep.29529. Epub 2018 Feb 18.


Exosomes: From Cell Debris to Potential Biomarkers in Transplantation.

Morelli AE.

Transplantation. 2017 Oct;101(10):2275-2276. doi: 10.1097/TP.0000000000001856. No abstract available.


Renal Allograft Survival in Nonhuman Primates Infused With Donor Antigen-Pulsed Autologous Regulatory Dendritic Cells.

Ezzelarab MB, Raich-Regue D, Lu L, Zahorchak AF, Perez-Gutierrez A, Humar A, Wijkstrom M, Minervini M, Wiseman RW, Cooper DKC, Morelli AE, Thomson AW.

Am J Transplant. 2017 Jun;17(6):1476-1489. doi: 10.1111/ajt.14182. Epub 2017 Feb 2.


Donor-derived exosomes: the trick behind the semidirect pathway of allorecognition.

Morelli AE, Bracamonte-Baran W, Burlingham WJ.

Curr Opin Organ Transplant. 2017 Feb;22(1):46-54. doi: 10.1097/MOT.0000000000000372. Review.


Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity.

Ouyang Y, Bayer A, Chu T, Tyurin VA, Kagan VE, Morelli AE, Coyne CB, Sadovsky Y.

Placenta. 2016 Nov;47:86-95. doi: 10.1016/j.placenta.2016.09.008. Epub 2016 Sep 14.


Antigen Presentation in Transplantation.

Alegre ML, Lakkis FG, Morelli AE.

Trends Immunol. 2016 Dec;37(12):831-843. doi: 10.1016/ Epub 2016 Oct 12. Review.


Graft-infiltrating host dendritic cells play a key role in organ transplant rejection.

Zhuang Q, Liu Q, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE.

Nat Commun. 2016 Aug 24;7:12623. doi: 10.1038/ncomms12623.


Donor dendritic cell-derived exosomes promote allograft-targeting immune response.

Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, Sullivan ML, Gibson GA, Watkins SC, Larregina AT, Morelli AE.

J Clin Invest. 2016 Aug 1;126(8):2805-20. doi: 10.1172/JCI84577. Epub 2016 Jun 27.


Strategically Altering the Balance of Macrophage Subpopulations to Inhibit Chronic Rejection.

Baldwin WM 3rd, Morelli AE.

Am J Transplant. 2016 Sep;16(9):2510-1. doi: 10.1111/ajt.13849. Epub 2016 Jun 9. No abstract available.


HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension.

Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HH, Shapiro S, Zhao Y, Goncharova EA.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):866-877.


Concise Review: Mechanisms Behind Apoptotic Cell-Based Therapies Against Transplant Rejection and Graft versus Host Disease.

Morelli AE, Larregina AT.

Stem Cells. 2016 May;34(5):1142-50. doi: 10.1002/stem.2326. Epub 2016 Feb 29. Review.


Toll-like Receptor 4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin 10 During Intra-abdominal Sepsis.

Deng M, Ma T, Yan Z, Zettel KR, Scott MJ, Liao H, Frank A, Morelli AE, Sodhi CP, Hackam DJ, Billiar TR.

J Infect Dis. 2016 Apr 15;213(8):1280-8. doi: 10.1093/infdis/jiv562. Epub 2015 Nov 24.


Clinical implications of basic science discoveries: nociceptive neurons as targets to control immunity--potential relevance for transplantation.

Larregina AT, Divito SJ, Morelli AE.

Am J Transplant. 2015 Jun;15(6):1472-4. doi: 10.1111/ajt.13158. Epub 2015 Apr 6. Review.


Autocrine hemokinin-1 functions as an endogenous adjuvant for IgE-mediated mast cell inflammatory responses.

Sumpter TL, Ho CH, Pleet AR, Tkacheva OA, Shufesky WJ, Rojas-Canales DM, Morelli AE, Larregina AT.

J Allergy Clin Immunol. 2015 Apr;135(4):1019-30.e8. doi: 10.1016/j.jaci.2014.07.036. Epub 2014 Sep 4.


Methods of purification of CTL-derived exosomes.

Montecalvo A, Larregina AT, Morelli AE.

Methods Mol Biol. 2014;1186:87-102. doi: 10.1007/978-1-4939-1158-5_7.


Orchestration of transplantation tolerance by regulatory dendritic cell therapy or in-situ targeting of dendritic cells.

Morelli AE, Thomson AW.

Curr Opin Organ Transplant. 2014 Aug;19(4):348-56. doi: 10.1097/MOT.0000000000000097. Review.


The secret behind non-antigen-pulsed autologous dendritic cell therapy in transplantation.

Morelli AE, Thomson AW.

Am J Transplant. 2014 May;14(5):989-90. doi: 10.1111/ajt.12705. Epub 2014 Apr 14. No abstract available.


Regulation of immune responses by extracellular vesicles.

Robbins PD, Morelli AE.

Nat Rev Immunol. 2014 Mar;14(3):195-208. doi: 10.1038/nri3622. Review.


Increased soluble CD154 (CD40 ligand) levels in xenograft recipients correlate with the development of de novo anti-pig IgG antibodies.

Ezzelarab MB, Ekser B, Isse K, Iwase H, Morelli AE, Ayares D, Cooper DK.

Transplantation. 2014 Mar 15;97(5):502-8. doi: 10.1097/TP.0000000000000042.


Dendritic cells of myeloid lineage: the masterminds behind acute allograft rejection.

Morelli AE.

Curr Opin Organ Transplant. 2014 Feb;19(1):20-7. doi: 10.1097/MOT.0000000000000039. Review.


Human placental trophoblasts confer viral resistance to recipient cells.

Delorme-Axford E, Donker RB, Mouillet JF, Chu T, Bayer A, Ouyang Y, Wang T, Stolz DB, Sarkar SN, Morelli AE, Sadovsky Y, Coyne CB.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12048-53. doi: 10.1073/pnas.1304718110. Epub 2013 Jul 1.


Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates.

Ezzelarab MB, Zahorchak AF, Lu L, Morelli AE, Chalasani G, Demetris AJ, Lakkis FG, Wijkstrom M, Murase N, Humar A, Shapiro R, Cooper DK, Thomson AW.

Am J Transplant. 2013 Aug;13(8):1989-2005. doi: 10.1111/ajt.12310. Epub 2013 Jun 11.


Methods of analysis of dendritic cell-derived exosome-shuttle microRNA and its horizontal propagation between dendritic cells.

Montecalvo A, Larregina AT, Morelli AE.

Methods Mol Biol. 2013;1024:19-40. doi: 10.1007/978-1-62703-453-1_3.


Galectin-1, immune regulation and liver allograft survival.

Morelli AE, Thomson AW.

Am J Transplant. 2013 Mar;13(3):535-6. doi: 10.1111/ajt.12092. No abstract available.


Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12.

Janelsins BM, Sumpter TL, Tkacheva OA, Rojas-Canales DM, Erdos G, Mathers AR, Shufesky WJ, Storkus WJ, Falo LD Jr, Morelli AE, Larregina AT.

Blood. 2013 Apr 11;121(15):2923-33. doi: 10.1182/blood-2012-07-446054. Epub 2013 Jan 30.


Dendritic cell therapies in transplantation revisited: deletion of recipient DCs deters the effect of therapeutic DCs.

Wang Z, Divito SJ, Shufesky WJ, Sumpter T, Wang H, Tkacheva OA, Wang W, Liu C, Larregina AT, Morelli AE.

Am J Transplant. 2012 Jun;12(6):1398-408. doi: 10.1111/j.1600-6143.2012.04060.x. Epub 2012 Apr 14.


The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes.

Donker RB, Mouillet JF, Chu T, Hubel CA, Stolz DB, Morelli AE, Sadovsky Y.

Mol Hum Reprod. 2012 Aug;18(8):417-24. doi: 10.1093/molehr/gas013. Epub 2012 Feb 29.


Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.

Montecalvo A, Larregina AT, Shufesky WJ, Stolz DB, Sullivan ML, Karlsson JM, Baty CJ, Gibson GA, Erdos G, Wang Z, Milosevic J, Tkacheva OA, Divito SJ, Jordan R, Lyons-Weiler J, Watkins SC, Morelli AE.

Blood. 2012 Jan 19;119(3):756-66. doi: 10.1182/blood-2011-02-338004. Epub 2011 Oct 26.


Role of neurokinin-1 receptor in the initiation and maintenance of skin chronic inflammatory diseases.

Divito SJ, Morelli AE, Larregina AT.

Immunol Res. 2011 Aug;50(2-3):195-201. doi: 10.1007/s12026-011-8219-9.


Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation.

Divito SJ, Wang Z, Shufesky WJ, Liu Q, Tkacheva OA, Montecalvo A, Erdos G, Larregina AT, Morelli AE.

Blood. 2010 Oct 14;116(15):2694-705. doi: 10.1182/blood-2009-10-251058. Epub 2010 Jun 24.


Apoptotic cell-based therapies against transplant rejection: role of recipient's dendritic cells.

Morelli AE, Larregina AT.

Apoptosis. 2010 Sep;15(9):1083-97. doi: 10.1007/s10495-010-0469-9. Review.


Disease-modifying immunotherapy for the management of autoimmune diabetes.

Castro CN, Barcala Tabarrozi AE, Noguerol MA, Liberman AC, Dewey RA, Arzt E, Morelli AE, Perone MJ.

Neuroimmunomodulation. 2010;17(3):173-6. doi: 10.1159/000258716. Epub 2010 Feb 4. Review.


In situ-targeting of dendritic cells with donor-derived apoptotic cells restrains indirect allorecognition and ameliorates allograft vasculopathy.

Wang Z, Shufesky WJ, Montecalvo A, Divito SJ, Larregina AT, Morelli AE.

PLoS One. 2009;4(3):e4940. doi: 10.1371/journal.pone.0004940. Epub 2009 Mar 31.


Suppression of autoimmune diabetes by soluble galectin-1.

Perone MJ, Bertera S, Shufesky WJ, Divito SJ, Montecalvo A, Mathers AR, Larregina AT, Pang M, Seth N, Wucherpfennig KW, Trucco M, Baum LG, Morelli AE.

J Immunol. 2009 Mar 1;182(5):2641-53. doi: 10.4049/jimmunol.0800839.


Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responses.

Mathers AR, Janelsins BM, Rubin JP, Tkacheva OA, Shufesky WJ, Watkins SC, Morelli AE, Larregina AT.

J Immunol. 2009 Jan 15;182(2):921-33.


Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection.

Bierly AL, Shufesky WJ, Sukhumavasi W, Morelli AE, Denkers EY.

J Immunol. 2008 Dec 15;181(12):8485-91.


Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses.

Lin YJ, Hara H, Tai HC, Long C, Tokita D, Yeh P, Ayares D, Morelli AE, Cooper DK.

Transplantation. 2008 Nov 27;86(10):1452-62. doi: 10.1097/TP.0b013e318188acb0.


Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity.

Janelsins BM, Mathers AR, Tkacheva OA, Erdos G, Shufesky WJ, Morelli AE, Larregina AT.

Blood. 2009 Mar 26;113(13):3017-26. doi: 10.1182/blood-2008-06-163121. Epub 2008 Nov 5.


Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition.

Montecalvo A, Shufesky WJ, Stolz DB, Sullivan MG, Wang Z, Divito SJ, Papworth GD, Watkins SC, Robbins PD, Larregina AT, Morelli AE.

J Immunol. 2008 Mar 1;180(5):3081-90.

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