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Combined action of type I and type III interferon restricts initial replication of severe acute respiratory syndrome coronavirus in the lung but fails to inhibit systemic virus spread.

Mahlakõiv T, Ritz D, Mordstein M, DeDiego ML, Enjuanes L, Müller MA, Drosten C, Staeheli P.

J Gen Virol. 2012 Dec;93(Pt 12):2601-5. doi: 10.1099/vir.0.046284-0. Epub 2012 Sep 5.


IFN-lambda determines the intestinal epithelial antiviral host defense.

Pott J, Mahlakõiv T, Mordstein M, Duerr CU, Michiels T, Stockinger S, Staeheli P, Hornef MW.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7944-9. doi: 10.1073/pnas.1100552108. Epub 2011 Apr 25.


Both nonstructural proteins NS1 and NS2 of pneumonia virus of mice are inhibitors of the interferon type I and type III responses in vivo.

Heinze B, Frey S, Mordstein M, Schmitt-Gräff A, Ehl S, Buchholz UJ, Collins PL, Staeheli P, Krempl CD.

J Virol. 2011 May;85(9):4071-84. doi: 10.1128/JVI.01365-10. Epub 2011 Feb 9.


Transcription factor redundancy ensures induction of the antiviral state.

Schmid S, Mordstein M, Kochs G, García-Sastre A, Tenoever BR.

J Biol Chem. 2010 Dec 31;285(53):42013-22. doi: 10.1074/jbc.M110.165936. Epub 2010 Oct 13.


Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response.

Steidle S, Martínez-Sobrido L, Mordstein M, Lienenklaus S, García-Sastre A, Stäheli P, Kochs G.

J Virol. 2010 Dec;84(24):12761-70. doi: 10.1128/JVI.00701-10. Epub 2010 Oct 6.


What have we learned from the IL28 receptor knockout mouse?

Mordstein M, Michiels T, Staeheli P.

J Interferon Cytokine Res. 2010 Aug;30(8):579-84. doi: 10.1089/jir.2010.0061. Review.


Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections.

Mordstein M, Neugebauer E, Ditt V, Jessen B, Rieger T, Falcone V, Sorgeloos F, Ehl S, Mayer D, Kochs G, Schwemmle M, Günther S, Drosten C, Michiels T, Staeheli P.

J Virol. 2010 Jun;84(11):5670-7. doi: 10.1128/JVI.00272-10. Epub 2010 Mar 24.


Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses.

Mordstein M, Kochs G, Dumoutier L, Renauld JC, Paludan SR, Klucher K, Staeheli P.

PLoS Pathog. 2008 Sep 12;4(9):e1000151. doi: 10.1371/journal.ppat.1000151.

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