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Items: 1 to 50 of 336

1.

A revisited version of the apo structure of the ligand-binding domain of the human nuclear receptor retinoic X receptor α.

Eberhardt J, McEwen AG, Bourguet W, Moras D, Dejaegere A.

Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;75(Pt 2):98-104. doi: 10.1107/S2053230X18018022. Epub 2019 Jan 23.

PMID:
30713160
2.

Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor.

Mohideen-Abdul K, Tazibt K, Bourguet M, Hazemann I, Lebars I, Takacs M, Cianférani S, Klaholz BP, Moras D, Billas IML.

Front Endocrinol (Lausanne). 2017 Jun 20;8:140. doi: 10.3389/fendo.2017.00140. eCollection 2017.

3.

Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen.

Markov GV, Gutierrez-Mazariegos J, Pitrat D, Billas IML, Bonneton F, Moras D, Hasserodt J, Lecointre G, Laudet V.

Sci Adv. 2017 Mar 31;3(3):e1601778. doi: 10.1126/sciadv.1601778. eCollection 2017 Mar.

4.

Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases.

Valencia-Sánchez MI, Rodríguez-Hernández A, Ferreira R, Santamaría-Suárez HA, Arciniega M, Dock-Bregeon AC, Moras D, Beinsteiner B, Mertens H, Svergun D, Brieba LG, Grøtli M, Torres-Larios A.

J Biol Chem. 2016 Jul 8;291(28):14430-46. doi: 10.1074/jbc.M116.730382. Epub 2016 May 23.

5.

Structure-function relationships in nuclear receptors: the facts.

Moras D, Billas IM, Rochel N, Klaholz BP.

Trends Biochem Sci. 2015 Jun;40(6):287-90. doi: 10.1016/j.tibs.2015.03.009. Epub 2015 Apr 19. No abstract available.

PMID:
25899756
6.

Structural basis of natural promoter recognition by the retinoid X nuclear receptor.

Osz J, McEwen AG, Poussin-Courmontagne P, Moutier E, Birck C, Davidson I, Moras D, Rochel N.

Sci Rep. 2015 Feb 3;5:8216. doi: 10.1038/srep08216.

7.

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.

Huet T, Laverny G, Ciesielski F, Molnár F, Ramamoorthy TG, Belorusova AY, Antony P, Potier N, Metzger D, Moras D, Rochel N.

Cell Rep. 2015 Feb 3;10(4):516-26. doi: 10.1016/j.celrep.2014.12.045. Epub 2015 Jan 22.

8.

Architecture of DNA Bound RAR heterodimers.

Rochel N, Moras D.

Subcell Biochem. 2014;70:21-36. doi: 10.1007/978-94-017-9050-5_2. Review.

PMID:
24962879
9.

The palindromic DNA-bound USP/EcR nuclear receptor adopts an asymmetric organization with allosteric domain positioning.

Maletta M, Orlov I, Roblin P, Beck Y, Moras D, Billas IM, Klaholz BP.

Nat Commun. 2014 Jun 19;5:4139. doi: 10.1038/ncomms5139.

PMID:
24942373
10.

Reconstruction of quaternary structure from X-ray scattering by equilibrium mixtures of biological macromolecules.

Petoukhov MV, Billas IM, Takacs M, Graewert MA, Moras D, Svergun DI.

Biochemistry. 2013 Oct 1;52(39):6844-55. doi: 10.1021/bi400731u. Epub 2013 Sep 19.

PMID:
24000896
11.

The asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanism.

Takacs M, Petoukhov MV, Atkinson RA, Roblin P, Ogi FX, Demeler B, Potier N, Chebaro Y, Dejaegere A, Svergun DI, Moras D, Billas IM.

PLoS One. 2013 Jul 9;8(7):e67810. doi: 10.1371/journal.pone.0067810. Print 2013.

12.

Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex.

Maillot B, Lévy N, Eiler S, Crucifix C, Granger F, Richert L, Didier P, Godet J, Pradeau-Aubreton K, Emiliani S, Nazabal A, Lesbats P, Parissi V, Mely Y, Moras D, Schultz P, Ruff M.

PLoS One. 2013 Apr 11;8(4):e60734. doi: 10.1371/journal.pone.0060734. Print 2013.

13.

Allosteric controls of nuclear receptor function in the regulation of transcription.

Billas I, Moras D.

J Mol Biol. 2013 Jul 10;425(13):2317-29. doi: 10.1016/j.jmb.2013.03.017. Epub 2013 Mar 15. Review.

PMID:
23499886
14.

Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.

Nardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C, Bolognesi M, Mantovani R.

Cell. 2013 Jan 17;152(1-2):132-43. doi: 10.1016/j.cell.2012.11.047.

15.

Solution Structures of PPARγ2/RXRα Complexes.

Osz J, Pethoukhov MV, Sirigu S, Svergun DI, Moras D, Rochel N.

PPAR Res. 2012;2012:701412. doi: 10.1155/2012/701412. Epub 2012 Dec 18.

16.

Functional insights into the core-TFIIH from a comparative survey.

Bedez F, Linard B, Brochet X, Ripp R, Thompson JD, Moras D, Lecompte O, Poch O.

Genomics. 2013 Mar;101(3):178-86. doi: 10.1016/j.ygeno.2012.11.003. Epub 2012 Nov 10.

17.

Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin D nuclear receptor.

Ciesielski F, Sato Y, Chebaro Y, Moras D, Dejaegere A, Rochel N.

J Med Chem. 2012 Oct 11;55(19):8440-9. doi: 10.1021/jm300858s. Epub 2012 Sep 19.

PMID:
22957834
18.

Synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition.

Fischer J, Wang TT, Kaldre D, Rochel N, Moras D, White JH, Gleason JL.

Chem Biol. 2012 Aug 24;19(8):963-71. doi: 10.1016/j.chembiol.2012.05.024.

19.

TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.

Scheer E, Delbac F, Tora L, Moras D, Romier C.

J Biol Chem. 2012 Aug 10;287(33):27580-92. doi: 10.1074/jbc.M112.379206. Epub 2012 Jun 13.

20.

Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology.

Moutier E, Ye T, Choukrallah MA, Urban S, Osz J, Chatagnon A, Delacroix L, Langer D, Rochel N, Moras D, Benoit G, Davidson I.

J Biol Chem. 2012 Jul 27;287(31):26328-41. doi: 10.1074/jbc.M112.361790. Epub 2012 Jun 1.

21.

Expression of functional full-length hSRC-1 in eukaryotic cells using modified vaccinia virus Ankara and baculovirus.

Osz J, Pradeau-Aubreton K, Drillien R, Troffer-Charlier N, Kolb-Cheynel I, Poterszman A, Ruff M, Moras D, Rochel N.

Anal Biochem. 2012 Jul 15;426(2):106-8. doi: 10.1016/j.ab.2012.04.006. Epub 2012 Apr 7.

PMID:
22490469
22.

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.

Osz J, Brélivet Y, Peluso-Iltis C, Cura V, Eiler S, Ruff M, Bourguet W, Rochel N, Moras D.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):E588-94. doi: 10.1073/pnas.1118192109. Epub 2012 Feb 21.

23.

Crystal structure of a vitamin D3 analog, ZK203278, showing dissociated profile.

Rochel N, Moras D.

Anticancer Res. 2012 Jan;32(1):335-9.

PMID:
22213324
24.

Structure-function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097.

Huet T, Maehr H, Lee HJ, Uskokovic MR, Suh N, Moras D, Rochel N.

Medchemcomm. 2011;2(5):424-429.

25.

Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA.

Orlov I, Rochel N, Moras D, Klaholz BP.

EMBO J. 2012 Jan 18;31(2):291-300. doi: 10.1038/emboj.2011.445. Epub 2011 Dec 16.

26.

Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chains.

Fraga R, Zacconi F, Sussman F, Ordóñez-Morán P, Muñoz A, Huet T, Molnár F, Moras D, Rochel N, Maestro M, Mouriño A.

Chemistry. 2012 Jan 9;18(2):603-12. doi: 10.1002/chem.201102695. Epub 2011 Dec 8.

PMID:
22162241
27.

In vivo topoisomerase I inhibition attenuates the expression of hypoxia-inducible factor 1α target genes and decreases tumor angiogenesis.

Guérin E, Raffelsberger W, Pencreach E, Maier A, Neuville A, Schneider A, Bachellier P, Rohr S, Petitprez A, Poch O, Moras D, Oudet P, Larsen AK, Gaub MP, Guenot D.

Mol Med. 2012 Feb 10;18:83-94. doi: 10.2119/molmed.2011.00120.

28.

Structural analysis of nuclear receptors: from isolated domains to integral proteins.

Brélivet Y, Rochel N, Moras D.

Mol Cell Endocrinol. 2012 Jan 30;348(2):466-73. doi: 10.1016/j.mce.2011.08.015. Epub 2011 Aug 25. Review.

PMID:
21888944
29.

Structural insights into transcription complexes.

Berger I, Blanco AG, Boelens R, Cavarelli J, Coll M, Folkers GE, Nie Y, Pogenberg V, Schultz P, Wilmanns M, Moras D, Poterszman A.

J Struct Biol. 2011 Aug;175(2):135-46. doi: 10.1016/j.jsb.2011.04.015. Epub 2011 May 6. Review.

PMID:
21571073
30.

Synthesis, structure, and biological activity of des-side chain analogues of 1α,25-dihydroxyvitamin D3 with substituents at C18.

Verlinden L, Verstuyf A, Eelen G, Bouillon R, Ordóñez-Morán P, Larriba MJ, Muñoz A, Rochel N, Sato Y, Moras D, Maestro M, Seoane S, Dominguez F, Eduardo-Canosa S, Nicoletti D, Moman E, Mouriño A.

ChemMedChem. 2011 May 2;6(5):788-93. doi: 10.1002/cmdc.201100021. Epub 2011 Mar 29.

31.

1α,25(OH)2-3-epi-vitamin D3, a natural physiological metabolite of vitamin D3: its synthesis, biological activity and crystal structure with its receptor.

Molnár F, Sigüeiro R, Sato Y, Araujo C, Schuster I, Antony P, Peluso J, Muller C, Mouriño A, Moras D, Rochel N.

PLoS One. 2011 Mar 31;6(3):e18124. doi: 10.1371/journal.pone.0018124.

32.

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings.

Rochel N, Ciesielski F, Godet J, Moman E, Roessle M, Peluso-Iltis C, Moulin M, Haertlein M, Callow P, Mély Y, Svergun DI, Moras D.

Nat Struct Mol Biol. 2011 May;18(5):564-70. doi: 10.1038/nsmb.2054. Epub 2011 Apr 10.

PMID:
21478865
33.

Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors.

Leproult E, Barluenga S, Moras D, Wurtz JM, Winssinger N.

J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.

PMID:
21322567
34.

The "Phantom Effect" of the Rexinoid LG100754: structural and functional insights.

Sato Y, Ramalanjaona N, Huet T, Potier N, Osz J, Antony P, Peluso-Iltis C, Poussin-Courmontagne P, Ennifar E, Mély Y, Dejaegere A, Moras D, Rochel N.

PLoS One. 2010 Nov 30;5(11):e15119. doi: 10.1371/journal.pone.0015119.

35.

Proofreading in translation: dynamics of the double-sieve model.

Moras D.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):21949-50. doi: 10.1073/pnas.1016083107. Epub 2010 Dec 13. No abstract available.

36.

Insights into metazoan evolution from Alvinella pompejana cDNAs.

Gagnière N, Jollivet D, Boutet I, Brélivet Y, Busso D, Da Silva C, Gaill F, Higuet D, Hourdez S, Knoops B, Lallier F, Leize-Wagner E, Mary J, Moras D, Perrodou E, Rees JF, Segurens B, Shillito B, Tanguy A, Thierry JC, Weissenbach J, Wincker P, Zal F, Poch O, Lecompte O.

BMC Genomics. 2010 Nov 16;11:634. doi: 10.1186/1471-2164-11-634.

37.

M-ORBIS: mapping of molecular binding sites and surfaces.

Albou LP, Poch O, Moras D.

Nucleic Acids Res. 2011 Jan;39(1):30-43. doi: 10.1093/nar/gkq736. Epub 2010 Sep 2.

38.

Analysis of recombinant phosphoprotein complexes with complementary mass spectrometry approaches.

Fouillen L, Abdulrahman W, Moras D, Dorsselaer AV, Poterszman A, Sanglier-Cianférani S.

Anal Biochem. 2010 Dec 1;407(1):34-43. doi: 10.1016/j.ab.2010.07.006. Epub 2010 Aug 3.

PMID:
20624369
39.

Quantitative cell-based reporter gene assays using droplet-based microfluidics.

Baret JC, Beck Y, Billas-Massobrio I, Moras D, Griffiths AD.

Chem Biol. 2010 May 28;17(5):528-36. doi: 10.1016/j.chembiol.2010.04.010.

40.

Dynamic correlation networks in human peroxisome proliferator-activated receptor-γ nuclear receptor protein.

Fidelak J, Ferrer S, Oberlin M, Moras D, Dejaegere A, Stote RH.

Eur Biophys J. 2010 Oct;39(11):1503-12. doi: 10.1007/s00249-010-0608-9. Epub 2010 May 23.

PMID:
20496064
41.

Crystal structure of hereditary vitamin D-resistant rickets--associated mutant H305Q of vitamin D nuclear receptor bound to its natural ligand.

Rochel N, Hourai S, Moras D.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):84-7. doi: 10.1016/j.jsbmb.2010.04.008. Epub 2010 Apr 18.

PMID:
20403435
42.

Design and synthesis of active vitamin D analogs.

Eduardo-Canosa S, Fraga R, Sigüeiro R, Marco M, Rochel N, Moras D, Mouriño A.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):7-12. doi: 10.1016/j.jsbmb.2010.03.036. Epub 2010 Mar 24. Review.

PMID:
20346396
43.

Detection of nucleic acid-nuclear hormone receptor complexes with mass spectrometry.

Bich C, Bovet C, Rochel N, Peluso-Iltis C, Panagiotidis A, Nazabal A, Moras D, Zenobi R.

J Am Soc Mass Spectrom. 2010 Apr;21(4):635-45. doi: 10.1016/j.jasms.2009.12.004. Epub 2009 Dec 28.

44.

Structure-function relationships and crystal structures of the vitamin D receptor bound 2 alpha-methyl-(20S,23S)- and 2 alpha-methyl-(20S,23R)-epoxymethano-1 alpha,25-dihydroxyvitamin D3.

Antony P, Sigüeiro R, Huet T, Sato Y, Ramalanjaona N, Rodrigues LC, Mouriño A, Moras D, Rochel N.

J Med Chem. 2010 Feb 11;53(3):1159-71. doi: 10.1021/jm9014636.

PMID:
20070104
45.

SM2PH-db: an interactive system for the integrated analysis of phenotypic consequences of missense mutations in proteins involved in human genetic diseases.

Friedrich A, Garnier N, Gagnière N, Nguyen H, Albou LP, Biancalana V, Bettler E, Deléage G, Lecompte O, Muller J, Moras D, Mandel JL, Toursel T, Moulinier L, Poch O.

Hum Mutat. 2010 Feb;31(2):127-35. doi: 10.1002/humu.21155.

PMID:
19921752
46.

Two complementary enzymes for threonylation of tRNA in crenarchaeota: crystal structure of Aeropyrum pernix threonyl-tRNA synthetase lacking a cis-editing domain.

Shimizu S, Juan EC, Sato Y, Miyashita Y, Hoque MM, Suzuki K, Sagara T, Tsunoda M, Sekiguchi T, Dock-Bregeon AC, Moras D, Takénaka A.

J Mol Biol. 2009 Nov 27;394(2):286-96. doi: 10.1016/j.jmb.2009.09.018. Epub 2009 Sep 15.

PMID:
19761773
47.

Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology.

Lippert WP, Burschka C, Götz K, Kaupp M, Ivanova D, Gaudon C, Sato Y, Antony P, Rochel N, Moras D, Gronemeyer H, Tacke R.

ChemMedChem. 2009 Jul;4(7):1143-52. doi: 10.1002/cmdc.200900090.

PMID:
19496083
48.

The ligand-binding domains of the three RXR-USP nuclear receptor types support distinct tissue and ligand specific hormonal responses in transgenic Drosophila.

Beck Y, Delaporte C, Moras D, Richards G, Billas IM.

Dev Biol. 2009 Jun 1;330(1):1-11. doi: 10.1016/j.ydbio.2008.12.042. Epub 2009 Mar 4.

49.

Towards high-throughput identification of endocrine disrupting compounds with mass spectrometry.

Bovet C, Plet B, Ruff M, Eiler S, Granger F, Panagiotidis A, Wenzel R, Nazabal A, Moras D, Zenobi R.

Toxicol In Vitro. 2009 Jun;23(4):704-9. doi: 10.1016/j.tiv.2009.02.004. Epub 2009 Feb 20.

PMID:
19233257
50.

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor.

Michel F, Crucifix C, Granger F, Eiler S, Mouscadet JF, Korolev S, Agapkina J, Ziganshin R, Gottikh M, Nazabal A, Emiliani S, Benarous R, Moras D, Schultz P, Ruff M.

EMBO J. 2009 Apr 8;28(7):980-91. doi: 10.1038/emboj.2009.41. Epub 2009 Feb 19.

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