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Items: 47


Regulation of the Hsf1-dependent transcriptome via conserved bipartite contacts with Hsp70 promotes survival in yeast.

Peffer S, Gonçalves D, Morano KA.

J Biol Chem. 2019 Aug 9;294(32):12191-12202. doi: 10.1074/jbc.RA119.008822. Epub 2019 Jun 25.


Aromatic Residues at the Dimer-Dimer Interface in the Peroxiredoxin Tsa1 Facilitate Decamer Formation and Biological Function.

Loberg MA, Hurtig JE, Graff AH, Allan KM, Buchan JA, Spencer MK, Kelly JE, Clodfelter JE, Morano KA, Lowther WT, West JD.

Chem Res Toxicol. 2019 Mar 18;32(3):474-483. doi: 10.1021/acs.chemrestox.8b00346. Epub 2019 Feb 11.


Thiol stress-dependent aggregation of the glycolytic enzyme triose phosphate isomerase in yeast and human cells.

Ford AE, Denicourt C, Morano KA.

Mol Biol Cell. 2019 Mar 1;30(5):554-565. doi: 10.1091/mbc.E18-10-0616. Epub 2019 Jan 2.


Roles of the nucleotide exchange factor and chaperone Hsp110 in cellular proteostasis and diseases of protein misfolding.

Yakubu UM, Morano KA.

Biol Chem. 2018 Sep 25;399(10):1215-1221. doi: 10.1515/hsz-2018-0209. Review.


Substrate binding by the yeast Hsp110 nucleotide exchange factor and molecular chaperone Sse1 is not obligate for its biological activities.

Garcia VM, Nillegoda NB, Bukau B, Morano KA.

Mol Biol Cell. 2017 Jul 15;28(15):2066-2075. doi: 10.1091/mbc.E17-01-0070. Epub 2017 May 24.


Trapping redox partnerships in oxidant-sensitive proteins with a small, thiol-reactive cross-linker.

Allan KM, Loberg MA, Chepngeno J, Hurtig JE, Tripathi S, Kang MG, Allotey JK, Widdershins AH, Pilat JM, Sizek HJ, Murphy WJ, Naticchia MR, David JB, Morano KA, West JD.

Free Radic Biol Med. 2016 Dec;101:356-366. doi: 10.1016/j.freeradbiomed.2016.10.506. Epub 2016 Nov 2.


Semi-automated microplate monitoring of protein polymerization and aggregation.

Garcia VM, Rowlett VW, Margolin W, Morano KA.

Anal Biochem. 2016 Sep 1;508:9-11. doi: 10.1016/j.ab.2016.05.016. Epub 2016 May 29.


Groupthink: chromosomal clustering during transcriptional memory.

Morano KA.

Microb Cell. 2015 Nov 26;2(12):454-457. doi: 10.15698/mic2015.12.244. No abstract available.


Unraveling protein misfolding diseases using model systems.

Peffer S, Cope K, Morano KA.

Future Sci OA. 2015 Sep 1;1(2):FSO41. doi: 10.4155/fso.15.41. eCollection 2015 Sep. Review.


Anhydrobiosis: drying out with sugar.

Morano KA.

Curr Biol. 2014 Dec 1;24(23):R1121-3. doi: 10.1016/j.cub.2014.10.022. Epub 2014 Dec 1.


Heat shock in the springtime.

Morano KA, Sistonen L, Mezger V.

Cell Stress Chaperones. 2014 Nov;19(6):753-61. doi: 10.1007/s12192-014-0539-y. Epub 2014 Sep 9.


Hierarchical functional specificity of cytosolic heat shock protein 70 (Hsp70) nucleotide exchange factors in yeast.

Abrams JL, Verghese J, Gibney PA, Morano KA.

J Biol Chem. 2014 May 9;289(19):13155-67. doi: 10.1074/jbc.M113.530014. Epub 2014 Mar 26.


Coupled assays for monitoring protein refolding in Saccharomyces cerevisiae.

Abrams JL, Morano KA.

J Vis Exp. 2013 Jul 9;(77):e50432. doi: 10.3791/50432.


Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells.

Naticchia MR, Brown HA, Garcia FJ, Lamade AM, Justice SL, Herrin RP, Morano KA, West JD.

Chem Res Toxicol. 2013 Mar 18;26(3):490-7. doi: 10.1021/tx4000123. Epub 2013 Mar 4.


The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds.

Wang Y, Gibney PA, West JD, Morano KA.

Mol Biol Cell. 2012 Sep;23(17):3290-8. doi: 10.1091/mbc.E12-06-0447. Epub 2012 Jul 18.


Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.

West JD, Wang Y, Morano KA.

Chem Res Toxicol. 2012 Oct 15;25(10):2036-53. doi: 10.1021/tx300264x. Epub 2012 Jul 31. Review.


Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.

Verghese J, Abrams J, Wang Y, Morano KA.

Microbiol Mol Biol Rev. 2012 Jun;76(2):115-58. doi: 10.1128/MMBR.05018-11. Review.


A lysine-rich region within fungal BAG domain-containing proteins mediates a novel association with ribosomes.

Verghese J, Morano KA.

Eukaryot Cell. 2012 Aug;11(8):1003-11. doi: 10.1128/EC.00146-12. Epub 2012 May 25.


The response to heat shock and oxidative stress in Saccharomyces cerevisiae.

Morano KA, Grant CM, Moye-Rowley WS.

Genetics. 2012 Apr;190(4):1157-95. doi: 10.1534/genetics.111.128033. Epub 2011 Dec 29. Review.


Enhanced toxicity of the protein cross-linkers divinyl sulfone and diethyl acetylenedicarboxylate in comparison to related monofunctional electrophiles.

West JD, Stamm CE, Brown HA, Justice SL, Morano KA.

Chem Res Toxicol. 2011 Sep 19;24(9):1457-9. doi: 10.1021/tx200302w. Epub 2011 Aug 8.


Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system.

Mandal AK, Gibney PA, Nillegoda NB, Theodoraki MA, Caplan AJ, Morano KA.

Mol Biol Cell. 2010 May 1;21(9):1439-48. doi: 10.1091/mbc.E09-09-0779. Epub 2010 Mar 17.


Hsp90 nuclear accumulation in quiescence is linked to chaperone function and spore development in yeast.

Tapia H, Morano KA.

Mol Biol Cell. 2010 Jan 1;21(1):63-72. doi: 10.1091/mbc.E09-05-0376. Epub 2009 Nov 4.


Structure of the Hsp110:Hsc70 nucleotide exchange machine.

Schuermann JP, Jiang J, Cuellar J, Llorca O, Wang L, Gimenez LE, Jin S, Taylor AB, Demeler B, Morano KA, Hart PJ, Valpuesta JM, Lafer EM, Sousa R.

Mol Cell. 2008 Jul 25;31(2):232-43. doi: 10.1016/j.molcel.2008.05.006. Epub 2008 Jun 12.


The Hsp110 protein chaperone Sse1 is required for yeast cell wall integrity and morphogenesis.

Shaner L, Gibney PA, Morano KA.

Curr Genet. 2008 Jul;54(1):1-11. doi: 10.1007/s00294-008-0193-y. Epub 2008 May 14.


Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins.

Gibney PA, Fries T, Bailer SM, Morano KA.

Eukaryot Cell. 2008 Jun;7(6):938-48. doi: 10.1128/EC.00042-08. Epub 2008 Apr 11.


Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule.

Trott A, West JD, Klaić L, Westerheide SD, Silverman RB, Morimoto RI, Morano KA.

Mol Biol Cell. 2008 Mar;19(3):1104-12. doi: 10.1091/mbc.E07-10-1004. Epub 2008 Jan 16.


The role of Sse1 in the de novo formation and variant determination of the [PSI+] prion.

Fan Q, Park KW, Du Z, Morano KA, Li L.

Genetics. 2007 Nov;177(3):1583-93.


New tricks for an old dog: the evolving world of Hsp70.

Morano KA.

Ann N Y Acad Sci. 2007 Oct;1113:1-14. Epub 2007 May 18. Review.


All in the family: atypical Hsp70 chaperones are conserved modulators of Hsp70 activity.

Shaner L, Morano KA.

Cell Stress Chaperones. 2007 Spring;12(1):1-8. Review.


Characterization of Hsp70 binding and nucleotide exchange by the yeast Hsp110 chaperone Sse1.

Shaner L, Sousa R, Morano KA.

Biochemistry. 2006 Dec 19;45(50):15075-84.


The yeast Hsp110 Sse1 functionally interacts with the Hsp70 chaperones Ssa and Ssb.

Shaner L, Wegele H, Buchner J, Morano KA.

J Biol Chem. 2005 Dec 16;280(50):41262-9. Epub 2005 Oct 12.


Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe.

Pelletier B, Trott A, Morano KA, Labbé S.

J Biol Chem. 2005 Jul 1;280(26):25146-61. Epub 2005 May 2.


Indirect immunofluorescence microscopy for direct detection of Xylella fastidiosa in xylem sap.

Carbajal D, Morano KA, Morano LD.

Curr Microbiol. 2004 Nov;49(5):372-5.


The function of the yeast molecular chaperone Sse1 is mechanistically distinct from the closely related hsp70 family.

Shaner L, Trott A, Goeckeler JL, Brodsky JL, Morano KA.

J Biol Chem. 2004 May 21;279(21):21992-2001. Epub 2004 Mar 17.


The Hsp90 molecular chaperone complex regulates maltose induction and stability of the Saccharomyces MAL gene transcription activator Mal63p.

Bali M, Zhang B, Morano KA, Michels CA.

J Biol Chem. 2003 Nov 28;278(48):47441-8. Epub 2003 Sep 18.


Ctr6, a vacuolar membrane copper transporter in Schizosaccharomyces pombe.

Bellemare DR, Shaner L, Morano KA, Beaudoin J, Langlois R, Labbe S.

J Biol Chem. 2002 Nov 29;277(48):46676-86. Epub 2002 Sep 18.


The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone.

Liu XD, Morano KA, Thiele DJ.

J Biol Chem. 1999 Sep 17;274(38):26654-60.


Protein chaperones and the heat shock response in Saccharomyces cerevisiae.

Morano KA, Liu PC, Thiele DJ.

Curr Opin Microbiol. 1998 Apr;1(2):197-203. Review.


Dipeptidyl aminopeptidase processing and biosynthesis of alkaline extracellular protease from Yarrowia lipolytica.

Matoba S, Morano KA, Klionsky DJ, Kim K, Ogrydziak DM.

Microbiology. 1997 Oct;143 ( Pt 10):3263-72.


Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.

Scott SV, Hefner-Gravink A, Morano KA, Noda T, Ohsumi Y, Klionsky DJ.

Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12304-8.


Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway.

Harding TM, Morano KA, Scott SV, Klionsky DJ.

J Cell Biol. 1995 Nov;131(3):591-602.

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