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Items: 17

1.

Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer.

Chantarasriwong O, Milcarek AT, Morales TH, Settle AL, Rezende CO Jr, Althufairi BD, Theodoraki MA, Alpaugh ML, Theodorakis EA.

Eur J Med Chem. 2019 Apr 15;168:405-413. doi: 10.1016/j.ejmech.2019.02.047. Epub 2019 Feb 20.

PMID:
30831408
2.

A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.

Drilon A, Nagasubramanian R, Blake JF, Ku N, Tuch BB, Ebata K, Smith S, Lauriault V, Kolakowski GR, Brandhuber BJ, Larsen PD, Bouhana KS, Winski SL, Hamor R, Wu WI, Parker A, Morales TH, Sullivan FX, DeWolf WE, Wollenberg LA, Gordon PR, Douglas-Lindsay DN, Scaltriti M, Benayed R, Raj S, Hanusch B, Schram AM, Jonsson P, Berger MF, Hechtman JF, Taylor BS, Andrews S, Rothenberg SM, Hyman DM.

Cancer Discov. 2017 Sep;7(9):963-972. doi: 10.1158/2159-8290.CD-17-0507. Epub 2017 Jun 3.

3.

An ATP-site on-off switch that restricts phosphatase accessibility of Akt.

Lin K, Lin J, Wu WI, Ballard J, Lee BB, Gloor SL, Vigers GP, Morales TH, Friedman LS, Skelton N, Brandhuber BJ.

Sci Signal. 2012 May 8;5(223):ra37. doi: 10.1126/scisignal.2002618.

4.

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.

Xu R, Banka A, Blake JF, Mitchell IS, Wallace EM, Bencsik JR, Kallan NC, Spencer KL, Gloor SL, Martinson M, Risom T, Gross SD, Morales TH, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2335-40. doi: 10.1016/j.bmcl.2011.02.098. Epub 2011 Feb 26.

PMID:
21420856
5.

Discovery and SAR of spirochromane Akt inhibitors.

Kallan NC, Spencer KL, Blake JF, Xu R, Heizer J, Bencsik JR, Mitchell IS, Gloor SL, Martinson M, Risom T, Gross SD, Morales TH, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2410-4. doi: 10.1016/j.bmcl.2011.02.073. Epub 2011 Feb 18.

PMID:
21392984
6.

Discovery of pyrrolopyrimidine inhibitors of Akt.

Blake JF, Kallan NC, Xiao D, Xu R, Bencsik JR, Skelton NJ, Spencer KL, Mitchell IS, Woessner RD, Gloor SL, Risom T, Gross SD, Martinson M, Morales TH, Vigers GP, Brandhuber BJ.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5607-12. doi: 10.1016/j.bmcl.2010.08.053. Epub 2010 Aug 13.

PMID:
20810279
7.

Cloning and preliminary characterization of a novel cuticular antigen from the filarial parasite Dirofilaria immitis.

Tsuji N, Morales TH, Ozols VV, Carmody AB, Chandrashekar R.

Parasitol Int. 2000 Dec;49(4):321-5.

PMID:
11077266
8.

Removal of hydrogen peroxide by a 1-cysteine peroxiredoxin enzyme of the filarial parasite Dirofilaria immitis.

Chandrashekar R, Tsuji N, Morales TH, Carmody AB, Ozols VO, Welton J, Tang L.

Parasitol Res. 2000 Mar;86(3):200-6.

PMID:
10726990
9.

Identification of an asparagine amidohydrolase from the filarial parasite Dirofilaria immitis.

Tsuji N, Morales TH, Ozols VV, Carmody AB, Chandrashekar R.

Int J Parasitol. 1999 Sep;29(9):1451-5.

PMID:
10579432
10.

Molecular characterization of a calcium-binding protein from the filarial parasite Dirofilaria immitis.

Tsuji N, Morales TH, Ozols VV, Carmody AB, Chandrashekar R.

Mol Biochem Parasitol. 1998 Nov 30;97(1-2):69-79.

PMID:
9879888
11.

The formation of mitochondrial ribonucleoprotein complexes involving guide RNA molecules in Trypanosoma brucei.

Göringer HU, Koslowsky DJ, Morales TH, Stuart K.

Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1776-80.

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In vitro guide RNA/mRNA chimaera formation in Trypanosoma brucei RNA editing.

Koslowsky DJ, Göringer HU, Morales TH, Stuart K.

Nature. 1992 Apr 30;356(6372):807-9.

PMID:
1374163
15.

Ubiquitin-EP52 fusion protein homologs from Trypanosoma brucei.

Wong S, Morales TH, Campbell DA.

Nucleic Acids Res. 1990 Dec 11;18(23):7181. No abstract available. Erratum in: Nucleic Acids Res 1991 Feb 25;19(4):980.

16.

An abnormal pattern of embryonic development during early pregnancy in aging rats.

Day JR, La Polt PS, Morales TH, Lu JK.

Biol Reprod. 1989 Nov;41(5):933-9.

PMID:
2624857
17.

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