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Items: 1 to 50 of 126

1.

Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers.

Motea EA, Fattah FJ, Xiao L, Girard L, Rommel A, Morales JC, Patidar P, Zhou Y, Porter A, Xie Y, Minna JD, Boothman DA.

Clin Cancer Res. 2018 Aug 14. doi: 10.1158/1078-0432.CCR-17-1118. [Epub ahead of print]

PMID:
30108102
2.

Enzymatic Synthesis of a Novel Pterostilbene α-Glucoside by the Combination of Cyclodextrin Glucanotransferase and Amyloglucosidase.

González-Alfonso JL, Rodrigo-Frutos D, Belmonte-Reche E, Peñalver P, Poveda A, Jiménez-Barbero J, Ballesteros AO, Hirose Y, Polaina J, Morales JC, Fernández-Lobato M, Plou FJ.

Molecules. 2018 May 25;23(6). pii: E1271. doi: 10.3390/molecules23061271.

3.

Glucose-nucleobase pairs within DNA: impact of hydrophobicity, alternative linking unit and DNA polymerase nucleotide insertion studies.

Vengut-Climent E, Peñalver P, Lucas R, Gómez-Pinto I, Aviñó A, Muro-Pastor AM, Galbis E, de Paz MV, Fonseca Guerra C, Bickelhaupt FM, Eritja R, González C, Morales JC.

Chem Sci. 2018 Mar 5;9(14):3544-3554. doi: 10.1039/c7sc04850e. eCollection 2018 Apr 14.

4.

Amino acid profiles of young adults differ by sex, body mass index and insulin resistance.

Guevara-Cruz M, Vargas-Morales JM, Méndez-García AL, López-Barradas AM, Granados-Portillo O, Ordaz-Nava G, Rocha-Viggiano AK, Gutierrez-Leyte CA, Medina-Cerda E, Rosado JL, Morales JC, Torres N, Tovar AR, Noriega LG.

Nutr Metab Cardiovasc Dis. 2018 Apr;28(4):393-401. doi: 10.1016/j.numecd.2018.01.001. Epub 2018 Jan 10.

PMID:
29422298
5.

Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases.

Peñalver P, Belmonte-Reche E, Adán N, Caro M, Mateos-Martín ML, Delgado M, González-Rey E, Morales JC.

Eur J Med Chem. 2018 Feb 25;146:123-138. doi: 10.1016/j.ejmech.2018.01.037. Epub 2018 Jan 17.

PMID:
29407944
6.

G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.

Belmonte-Reche E, Martínez-García M, Guédin A, Zuffo M, Arévalo-Ruiz M, Doria F, Campos-Salinas J, Maynadier M, López-Rubio JJ, Freccero M, Mergny JL, Pérez-Victoria JM, Morales JC.

J Med Chem. 2018 Feb 8;61(3):1231-1240. doi: 10.1021/acs.jmedchem.7b01672. Epub 2018 Jan 27.

7.

Enzymatic Synthesis of a Novel Neuroprotective Hydroxytyrosyl Glycoside.

Nieto-Domínguez M, de Eugenio LI, Peñalver P, Belmonte-Reche E, Morales JC, Poveda A, Jiménez-Barbero J, Prieto A, Plou FJ, Martínez MJ.

J Agric Food Chem. 2017 Dec 6;65(48):10526-10533. doi: 10.1021/acs.jafc.7b04176. Epub 2017 Nov 21.

PMID:
29119794
8.

Space Creation Dynamics in Basketball Small-Sided Games.

Bredt SGT, Morales JCP, Andrade AGP, Torres JO, Peixoto GH, Greco PJ, Praça GM, Chagas MH.

Percept Mot Skills. 2018 Feb;125(1):162-176. doi: 10.1177/0031512517725445. Epub 2017 Aug 11.

PMID:
28799865
9.

Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells.

Muriana FJG, Montserrat-de la Paz S, Lucas R, Bermudez B, Jaramillo S, Morales JC, Abia R, Lopez S.

Food Funct. 2017 Aug 1;8(8):2905-2914. doi: 10.1039/c7fo00641a. Epub 2017 Jul 25.

PMID:
28740975
10.

Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K+ Buffer.

Street STG, Chin DN, Hollingworth GJ, Berry M, Morales JC, Galan MC.

Chemistry. 2017 May 23;23(29):6953-6958. doi: 10.1002/chem.201700140. Epub 2017 Mar 30.

11.

Synthesis, Binding Properties, and Differences in Cell Uptake of G-Quadruplex Ligands Based on Carbohydrate Naphthalene Diimide Conjugates.

Arévalo-Ruiz M, Doria F, Belmonte-Reche E, De Rache A, Campos-Salinas J, Lucas R, Falomir E, Carda M, Pérez-Victoria JM, Mergny JL, Freccero M, Morales JC.

Chemistry. 2017 Feb 10;23(9):2157-2164. doi: 10.1002/chem.201604886. Epub 2017 Jan 16.

PMID:
27925323
12.

Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA, and 2'-Amino-LNA Monomers.

Ries A, Kumar R, Lou C, Kosbar T, Vengut-Climent E, Jørgensen PT, Morales JC, Wengel J.

J Org Chem. 2016 Nov 18;81(22):10845-10856. Epub 2016 Oct 25.

PMID:
27736097
13.

The effect of l-thymidine, acyclic thymine and 8-bromoguanine on the stability of model G-quadruplex structures.

Aviñó A, Mazzini S, Fàbrega C, Peñalver P, Gargallo R, Morales JC, Eritja R.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1205-1212. doi: 10.1016/j.bbagen.2016.09.030. Epub 2016 Oct 2.

14.

XRN2 Links Transcription Termination to DNA Damage and Replication Stress.

Morales JC, Richard P, Patidar PL, Motea EA, Dang TT, Manley JL, Boothman DA.

PLoS Genet. 2016 Jul 20;12(7):e1006107. doi: 10.1371/journal.pgen.1006107. eCollection 2016 Jul.

15.

Glucose-Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA.

Vengut-Climent E, Gómez-Pinto I, Lucas R, Peñalver P, Aviñó A, Fonseca Guerra C, Bickelhaupt FM, Eritja R, González C, Morales JC.

Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8643-7. doi: 10.1002/anie.201603510. Epub 2016 Jun 22.

PMID:
27328804
16.

Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer.

Tang KJ, Constanzo JD, Venkateswaran N, Melegari M, Ilcheva M, Morales JC, Skoulidis F, Heymach JV, Boothman DA, Scaglioni PP.

Clin Cancer Res. 2016 Dec 1;22(23):5851-5863. Epub 2016 May 24.

17.

Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents.

Belmonte-Reche E, Martínez-García M, Peñalver P, Gómez-Pérez V, Lucas R, Gamarro F, Pérez-Victoria JM, Morales JC.

Eur J Med Chem. 2016 Aug 25;119:132-40. doi: 10.1016/j.ejmech.2016.04.047. Epub 2016 Apr 26.

PMID:
27155468
18.

Cytotoxic, Antiangiogenic and Antitelomerase Activity of Glucosyl- and Acyl- Resveratrol Prodrugs and Resveratrol Sulfate Metabolites.

Falomir E, Lucas R, Peñalver P, Martí-Centelles R, Dupont A, Zafra-Gómez A, Carda M, Morales JC.

Chembiochem. 2016 Jul 15;17(14):1343-8. doi: 10.1002/cbic.201600084. Epub 2016 Jun 20.

PMID:
27147200
19.

The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair.

Patidar PL, Motea EA, Fattah FJ, Zhou Y, Morales JC, Xie Y, Garner HR, Boothman DA.

Nucleic Acids Res. 2016 Feb 29;44(4):1718-31. doi: 10.1093/nar/gkv1492. Epub 2016 Jan 26.

20.

Hydroxytyrosol and tyrosol sulfate metabolites protect against the oxidized cholesterol pro-oxidant effect in Caco-2 human enterocyte-like cells.

Atzeri A, Lucas R, Incani A, Peñalver P, Zafra-Gómez A, Melis MP, Pizzala R, Morales JC, Deiana M.

Food Funct. 2016 Jan;7(1):337-46. doi: 10.1039/c5fo00074b.

PMID:
26488801
21.

Improved sample treatment for the determination of fructooligosaccharides in milk related products by liquid chromatography with electrochemical and refractive index detection.

Rodríguez-Gómez R, Jiménez-Díaz I, Zafra-Gómez A, Morales JC.

Talanta. 2015 Nov 1;144:883-9. doi: 10.1016/j.talanta.2015.07.042. Epub 2015 Jul 15.

PMID:
26452904
22.

Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitors.

Serrano-Heras G, Cuenca-López MD, Montero JC, Corrales-Sanchez V, Morales JC, Núñez LE, Morís F, Pandiella A, Ocaña A.

Oncotarget. 2015 Oct 13;6(31):31272-83. doi: 10.18632/oncotarget.5211.

23.

Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer.

Cuenca-López MD, Serrano-Heras G, Montero JC, Corrales-Sánchez V, Gomez-Juarez M, Gascón-Escribano MJ, Morales JC, Voisin V, Núñez LE, Morís F, Bader GD, Pandiella A, Ocaña A.

Oncotarget. 2015 Sep 29;6(29):27923-37. doi: 10.18632/oncotarget.4736.

24.

Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength in the epileptic brain.

Álvarez-Ferradas C, Morales JC, Wellmann M, Nualart F, Roncagliolo M, Fuenzalida M, Bonansco C.

Glia. 2015 Sep;63(9):1507-21. doi: 10.1002/glia.22817. Epub 2015 May 15.

PMID:
25980474
25.

Antioxidant activity of alkyl gallates and glycosyl alkyl gallates in fish oil in water emulsions: relevance of their surface active properties and of the type of emulsifier.

González MJ, Medina I, Maldonado OS, Lucas R, Morales JC.

Food Chem. 2015 Sep 15;183:190-6. doi: 10.1016/j.foodchem.2015.03.035. Epub 2015 Mar 17.

PMID:
25863628
26.

Hemolytic activity and solubilizing capacity of raffinose and melezitose fatty acid monoesters prepared by enzymatic synthesis.

Carvalho L, Morales JC, Pérez-Victoria JM, Pérez-Victoria I.

Eur J Pharm Biopharm. 2015 May;92:139-45. doi: 10.1016/j.ejpb.2015.02.023. Epub 2015 Mar 6.

PMID:
25753196
27.

Glucose conjugation of anti-HIV-1 oligonucleotides containing unmethylated CpG motifs reduces their immunostimulatory activity.

Reyes-Darias JA, Sánchez-Luque FJ, Morales JC, Pérez-Rentero S, Eritja R, Berzal-Herranz A.

Chembiochem. 2015 Mar 2;16(4):584-91. doi: 10.1002/cbic.201402574. Epub 2015 Feb 11.

PMID:
25683851
28.

Skin delivery of antioxidant surfactants based on gallic acid and hydroxytyrosol.

Alonso C, Lucas R, Barba C, Marti M, Rubio L, Comelles F, Morales JC, Coderch L, Parra JL.

J Pharm Pharmacol. 2015 Jul;67(7):900-8. doi: 10.1111/jphp.12382. Epub 2015 Feb 3.

PMID:
25645286
29.

Sensory evaluation of dairy supplements enriched with reduced iron, ferrous sulfate or ferrous fumarate.

Morales JC, Sánchez-Vargas E, García-Zepeda R, Villalpando S.

Salud Publica Mex. 2015 Jan-Feb;57(1):14-21.

30.

A patient care program for adjusting the autoinjector needle depth according to subcutaneous tissue thickness in patients with multiple sclerosis receiving subcutaneous injections of glatiramer acetate.

Masid ML, Ocaña RH, Gil MJ, Ramos MC, Roig ME, Carreño MR, Morales JC, Carrasco ML, Hidalgo LM, Felices AM, Castaño AH, Romero PC, Martinez PF, Sánchez-De la Rosa R.

J Neurosci Nurs. 2015 Feb;47(1):E22-30. doi: 10.1097/JNN.0000000000000086.

31.

A new rapid kindling variant for induction of cortical epileptogenesis in freely moving rats.

Morales JC, Alvarez-Ferradas C, Roncagliolo M, Fuenzalida M, Wellmann M, Nualart FJ, Bonansco C.

Front Cell Neurosci. 2014 Jul 23;8:200. doi: 10.3389/fncel.2014.00200. eCollection 2014.

32.

Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling.

Cuenca-López MD, Montero JC, Morales JC, Prat A, Pandiella A, Ocana A.

BMC Cancer. 2014 Apr 30;14:302. doi: 10.1186/1471-2407-14-302.

33.

Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair.

Morales JC, Richard P, Rommel A, Fattah FJ, Motea EA, Patidar PL, Xiao L, Leskov K, Wu SY, Hittelman WN, Chiang CM, Manley JL, Boothman DA.

Nucleic Acids Res. 2014 Apr;42(8):4996-5006. doi: 10.1093/nar/gku160. Epub 2014 Mar 3.

34.

Effects of sugar functional groups, hydrophobicity, and fluorination on carbohydrate-DNA stacking interactions in water.

Lucas R, Peñalver P, Gómez-Pinto I, Vengut-Climent E, Mtashobya L, Cousin J, Maldonado OS, Perez V, Reynes V, Aviñó A, Eritja R, González C, Linclau B, Morales JC.

J Org Chem. 2014 Mar 21;79(6):2419-29. doi: 10.1021/jo402700y. Epub 2014 Mar 5.

PMID:
24552250
35.

Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers.

Cao L, Li LS, Spruell C, Xiao L, Chakrabarti G, Bey EA, Reinicke KE, Srougi MC, Moore Z, Dong Y, Vo P, Kabbani W, Yang CR, Wang X, Fattah F, Morales JC, Motea EA, Bornmann WG, Yordy JS, Boothman DA.

Antioxid Redox Signal. 2014 Jul 10;21(2):237-50. doi: 10.1089/ars.2013.5462. Epub 2014 Apr 3.

36.

Lack of population genetic structure and host specificity in the bat fly, Cyclopodia horsfieldi, across species of Pteropus bats in Southeast Asia.

Olival KJ, Dick CW, Simmons NB, Morales JC, Melnick DJ, Dittmar K, Perkins SL, Daszak P, Desalle R.

Parasit Vectors. 2013 Aug 8;6:231. doi: 10.1186/1756-3305-6-231.

37.

Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates.

Vengut-Climent E, Terrazas M, Lucas R, Arévalo-Ruiz M, Eritja R, Morales JC.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4048-51. doi: 10.1016/j.bmcl.2013.05.065. Epub 2013 May 28.

PMID:
23764303
38.

The gut microbiota ellagic acid-derived metabolite urolithin A and its sulfate conjugate are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP).

González-Sarrías A, Miguel V, Merino G, Lucas R, Morales JC, Tomás-Barberán F, Alvarez AI, Espín JC.

J Agric Food Chem. 2013 May 8;61(18):4352-9. doi: 10.1021/jf4007505. Epub 2013 Apr 24.

PMID:
23586460
39.

Carbohydrate-DNA interactions at G-quadruplexes: folding and stability changes by attaching sugars at the 5'-end.

Gómez-Pinto I, Vengut-Climent E, Lucas R, Aviñó A, Eritja R, González C, Morales JC.

Chemistry. 2013 Feb 4;19(6):1920-7. doi: 10.1002/chem.201203902. Epub 2013 Jan 11.

PMID:
23315826
40.

Histopathologic, immunohistochemical and ultrastructural features of a granular cell tumour in an Australian parakeet (Melopsittacus undulatus).

Hernández V, Carrera E, Méndez A, Morales JC, Morales E, Sánchez FD.

Avian Pathol. 2012 Oct;41(5):437-40. doi: 10.1080/03079457.2012.711463. Epub 2012 Aug 22.

PMID:
22913601
41.

Resveratrol and some glucosyl, glucosylacyl, and glucuronide derivatives reduce Escherichia coli O157:H7, Salmonella Typhimurium, and Listeria monocytogenes Scott A adhesion to colonic epithelial cell lines.

Selma MV, Larrosa M, Beltrán D, Lucas R, Morales JC, Tomás-Barberán F, Espín JC.

J Agric Food Chem. 2012 Aug 1;60(30):7367-74. doi: 10.1021/jf203967u. Epub 2012 Jul 18.

PMID:
22762450
42.

Apolar carbohydrates as DNA capping agents.

Lucas R, Vengut-Climent E, Gómez-Pinto I, Aviñó A, Eritja R, González C, Morales JC.

Chem Commun (Camb). 2012 Mar 21;48(24):2991-3. doi: 10.1039/c2cc17093k. Epub 2012 Feb 7.

PMID:
22314313
43.

Effects of long-term consumption of low doses of resveratrol on diet-induced mild hypercholesterolemia in pigs: a transcriptomic approach to disease prevention.

Azorín-Ortuño M, Yáñez-Gascón MJ, González-Sarrías A, Larrosa M, Vallejo F, Pallarés FJ, Lucas R, Morales JC, Tomás-Barberán FA, García-Conesa MT, Espín JC.

J Nutr Biochem. 2012 Jul;23(7):829-37. doi: 10.1016/j.jnutbio.2011.04.007. Epub 2011 Aug 17.

PMID:
21852083
44.

Hydroxytyrosol glucuronides protect renal tubular epithelial cells against H(2)O(2) induced oxidative damage.

Deiana M, Incani A, Rosa A, Atzeri A, Loru D, Cabboi B, Paola Melis M, Lucas R, Morales JC, Assunta Dessì M.

Chem Biol Interact. 2011 Sep 30;193(3):232-9. doi: 10.1016/j.cbi.2011.07.002. Epub 2011 Jul 21.

PMID:
21798251
45.

Usefulness of retropubic tape for recurrent stress incontinence after transobturator tape failure.

Sabadell J, Poza JL, Esgueva A, Morales JC, Sánchez-Iglesias JL, Xercavins J.

Int Urogynecol J. 2011 Dec;22(12):1543-7. doi: 10.1007/s00192-011-1490-4. Epub 2011 Jul 6.

PMID:
21732099
46.

Metabolites and tissue distribution of resveratrol in the pig.

Azorín-Ortuño M, Yáñez-Gascón MJ, Vallejo F, Pallarés FJ, Larrosa M, Lucas R, Morales JC, Tomás-Barberán FA, García-Conesa MT, Espín JC.

Mol Nutr Food Res. 2011 Aug;55(8):1154-68. doi: 10.1002/mnfr.201100140. Epub 2011 Jun 28.

PMID:
21710561
47.

ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability.

Goetz EM, Shankar B, Zou Y, Morales JC, Luo X, Araki S, Bachoo R, Mayo LD, Boothman DA.

Oncogene. 2011 Sep 1;30(35):3745-54. doi: 10.1038/onc.2011.92. Epub 2011 Apr 4.

48.

The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells.

Ruiz-Magaña MJ, Rodríguez-Vargas JM, Morales JC, Saldivia MA, Schulze-Osthoff K, Ruiz-Ruiz C.

Int J Cancer. 2012 Mar 1;130(5):1195-207. doi: 10.1002/ijc.26107. Epub 2011 Jul 21.

49.

Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations.

Aviñó A, Ocampo SM, Lucas R, Reina JJ, Morales JC, Perales JC, Eritja R.

Mol Divers. 2011 Aug;15(3):751-7. doi: 10.1007/s11030-011-9305-6. Epub 2011 Jan 26.

PMID:
21267652
50.

Highly polar carbohydrates stack onto DNA duplexes via CH/π interactions.

Lucas R, Gómez-Pinto I, Aviñó A, Reina JJ, Eritja R, González C, Morales JC.

J Am Chem Soc. 2011 Feb 16;133(6):1909-16. doi: 10.1021/ja108962j. Epub 2011 Jan 18.

PMID:
21244028

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