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HGSNAT enzyme deficiency results in accumulation of heparan sulfate in podocytes and basement membranes.

Nagel L, Oliveira R, Pshezhetsky AV, Morales CR.

Histol Histopathol. 2019 Jun 3:18131. doi: 10.14670/HH-18-131. [Epub ahead of print]


Proprioceptive Stabilizer™ training of the abdominal wall muscles in healthy subjects: a quasi-experimental study.

Morales CR, Sanz DR, Reguera MC, Martínez SF, González PT, Pascual BM.

Rev Assoc Med Bras (1992). 2018 Dec;64(12):1134-1138. doi: 10.1590/1806-9282.64.12.1134.


Ultrasonography features of abdominal perimuscular connective tissue in elite and amateur basketball players: an observational study.

Morales CR, Polo JA, Sanz DR, López DL, González SV, Buría JLA, Lobo CC.

Rev Assoc Med Bras (1992). 2018 Oct;64(10):936-941. doi: 10.1590/1806-9282.64.10.936.


Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.

Rotter D, Peiris H, Grinsfelder DB, Martin AM, Burchfield J, Parra V, Hull C, Morales CR, Jessup CF, Matusica D, Parks BW, Lusis AJ, Nguyen NUN, Oh M, Iyoke I, Jakkampudi T, McMillan DR, Sadek HA, Watt MJ, Gupta RK, Pritchard MA, Keating DJ, Rothermel BA.

EMBO Rep. 2018 Dec;19(12). pii: e44706. doi: 10.15252/embr.201744706. Epub 2018 Nov 2.


Presence of aberrant epididymal tubules revealing undifferentiated epithelial cells and absence of spermatozoa in a combined neuraminidase-3 and -4 deficient adult mouse model.

Oliveira R, Hermo L, Pshezhetsky AV, Morales CR.

PLoS One. 2018 Oct 25;13(10):e0206173. doi: 10.1371/journal.pone.0206173. eCollection 2018.


Effectiveness of median nerve neural mobilization versus oral ibuprofen treatment in subjects who suffer from cervicobrachial pain: a randomized clinical trial.

Sanz DR, Solano FU, López DL, Corbalan IS, Morales CR, Lobo CC.

Arch Med Sci. 2018 Jun;14(4):871-879. doi: 10.5114/aoms.2017.70328. Epub 2017 Sep 26.


Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides.

Pan X, De Aragão CBP, Velasco-Martin JP, Priestman DA, Wu HY, Takahashi K, Yamaguchi K, Sturiale L, Garozzo D, Platt FM, Lamarche-Vane N, Morales CR, Miyagi T, Pshezhetsky AV.

FASEB J. 2017 Aug;31(8):3467-3483. doi: 10.1096/fj.201601299R. Epub 2017 Apr 25.


Atypical juvenile presentation of GM2 gangliosidosis AB in a patient compound-heterozygote for c.259G > T and c.164C > T mutations in the GM2A gene.

Martins C, Brunel-Guitton C, Lortie A, Gauvin F, Morales CR, Mitchell GA, Pshezhetsky AV.

Mol Genet Metab Rep. 2017 Apr 7;11:24-29. doi: 10.1016/j.ymgmr.2017.01.017. eCollection 2017 Jun.


Targeting exogenous β-Defensin to the endolysosomal compartment via a vehicle guided system.

Carvelli L, Libin Y, Esfandnia S, Zhang Y, Presley JF, Morales CR.

Histol Histopathol. 2017 Oct;32(10):1017-1027. doi: 10.14670/HH-11-862. Epub 2016 Dec 29.


Increased Brain Neurotensin and NTSR2 Lead to Weak Nociception in NTSR3/Sortilin Knockout Mice.

Devader C, Moreno S, Roulot M, Deval E, Dix T, Morales CR, Mazella J.

Front Neurosci. 2016 Nov 24;10:542. eCollection 2016.


Ultrasound evaluation of intrinsic plantar muscles and fascia in hallux valgus: A case-control study.

Lobo CC, Marín AG, Sanz DR, López DL, López PP, Morales CR, Corbalán IS.

Medicine (Baltimore). 2016 Nov;95(45):e5243.


Interrater Reliability in the Clinical Evaluation of Myofascial Trigger Points in Three Ankle Muscles.

Sanz DR, Lobo CC, López DL, Morales CR, Marín CS, Corbalán IS.

J Manipulative Physiol Ther. 2016 Nov - Dec;39(9):623-634. doi: 10.1016/j.jmpt.2016.09.002. Epub 2016 Nov 2.


Ultrasonography Comparison of Peroneus Muscle Cross-sectional Area in Subjects With or Without Lateral Ankle Sprains.

Lobo CC, Morales CR, Sanz DR, Corbalán IS, Marín AG, López DL.

J Manipulative Physiol Ther. 2016 Nov - Dec;39(9):635-644. doi: 10.1016/j.jmpt.2016.09.001. Epub 2016 Oct 25.


Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns.

Gassmann NN, van Elteren HA, Goos TG, Morales CR, Rivera-Ch M, Martin DS, Cabala Peralta P, Passano Del Carpio A, Aranibar Machaca S, Huicho L, Reiss IK, Gassmann M, de Jonge RC.

J Appl Physiol (1985). 2016 Sep 1;121(3):709-15. doi: 10.1152/japplphysiol.00561.2016. Epub 2016 Jul 21.


Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression.

Morales CR, Li DL, Pedrozo Z, May HI, Jiang N, Kyrychenko V, Cho GW, Kim SY, Wang ZV, Rotter D, Rothermel BA, Schneider JW, Lavandero S, Gillette TG, Hill JA.

Sci Signal. 2016 Apr 5;9(422):ra34. doi: 10.1126/scisignal.aad5736.


Epigenetic regulation in heart failure.

Kim SY, Morales CR, Gillette TG, Hill JA.

Curr Opin Cardiol. 2016 May;31(3):255-65. doi: 10.1097/HCO.0000000000000276. Review.


Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability.

Pedrozo Z, Criollo A, Battiprolu PK, Morales CR, Contreras-Ferrat A, Fernández C, Jiang N, Luo X, Caplan MJ, Somlo S, Rothermel BA, Gillette TG, Lavandero S, Hill JA.

Circulation. 2015 Jun 16;131(24):2131-42. doi: 10.1161/CIRCULATIONAHA.114.013537. Epub 2015 Apr 17.


Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis.

Patel KM, Strong A, Tohyama J, Jin X, Morales CR, Billheimer J, Millar J, Kruth H, Rader DJ.

Circ Res. 2015 Feb 27;116(5):789-96. doi: 10.1161/CIRCRESAHA.116.305811. Epub 2015 Jan 15.


Prosaposin: a protein with differential sorting and multiple functions.

Carvelli L, Libin Y, Morales CR.

Histol Histopathol. 2015 Jun;30(6):647-60. doi: 10.14670/HH-30.647. Epub 2014 Dec 18. Review.


Mitochondrial damage and cholesterol storage in human hepatocellular carcinoma cells with silencing of UBIAD1 gene expression.

Morales CR, Grigoryeva LS, Pan X, Bruno L, Hickson G, Ngo MH, McMaster CR, Samuels ME, Pshezhetsky AV.

Mol Genet Metab Rep. 2014 Sep 19;1:407-411. eCollection 2014.


Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway.

Wang ZV, Deng Y, Gao N, Pedrozo Z, Li DL, Morales CR, Criollo A, Luo X, Tan W, Jiang N, Lehrman MA, Rothermel BA, Lee AH, Lavandero S, Mammen PPA, Ferdous A, Gillette TG, Scherer PE, Hill JA.

Cell. 2014 Mar 13;156(6):1179-1192. doi: 10.1016/j.cell.2014.01.014.


A man for all seasons: celebrating the scientific career of Yves Clermont.

Morales CR, Hermo L, Robaire B.

Biol Reprod. 2014 Mar 13;90(3):51. doi: 10.1095/biolreprod.113.116822. Print 2014 Mar. No abstract available.


The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft trafficking.

Yang M, Virassamy B, Vijayaraj SL, Lim Y, Saadipour K, Wang YJ, Han YC, Zhong JH, Morales CR, Zhou XF.

PLoS One. 2013 May 21;8(5):e63049. doi: 10.1371/journal.pone.0063049. Print 2013.


Oxidative stress and autophagy in cardiovascular homeostasis.

Morales CR, Pedrozo Z, Lavandero S, Hill JA.

Antioxid Redox Signal. 2014 Jan 20;20(3):507-18. doi: 10.1089/ars.2013.5359. Epub 2013 Jun 27. Review.


Screening for severe obstructive sleep apnea syndrome in hypertensive outpatients.

Gurubhagavatula I, Fields BG, Morales CR, Hurley S, Pien GW, Wick LC, Staley BA, Townsend RR, Maislin G.

J Clin Hypertens (Greenwich). 2013 Apr;15(4):279-88. doi: 10.1111/jch.12073. Epub 2013 Feb 12.


In-home, self-assembled sleep studies are useful in diagnosing sleep apnea in the elderly.

Morales CR, Hurley S, Wick LC, Staley B, Pack FM, Gooneratne NS, Maislin G, Pack A, Gurubhagavatula I.

Sleep. 2012 Nov 1;35(11):1491-501. doi: 10.5665/sleep.2196.


Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.

Strong A, Ding Q, Edmondson AC, Millar JS, Sachs KV, Li X, Kumaravel A, Wang MY, Ai D, Guo L, Alexander ET, Nguyen D, Lund-Katz S, Phillips MC, Morales CR, Tall AR, Kathiresan S, Fisher EA, Musunuru K, Rader DJ.

J Clin Invest. 2012 Aug;122(8):2807-16. doi: 10.1172/JCI63563. Epub 2012 Jul 2.


ABCA17 mediates sterol efflux from mouse spermatozoa plasma membranes.

Morales CR, Ni X, Smith CE, Inagaki N, Hermo L.

Histol Histopathol. 2012 Mar;27(3):317-28. doi: 10.14670/HH-27.317.


NADPH oxidase-dependent and -independent mechanisms of reported inhibitors of reactive oxygen generation.

Gatto GJ Jr, Ao Z, Kearse MG, Zhou M, Morales CR, Daniels E, Bradley BT, Goserud MT, Goodman KB, Douglas SA, Harpel MR, Johns DG.

J Enzyme Inhib Med Chem. 2013 Feb;28(1):95-104. doi: 10.3109/14756366.2011.636360. Epub 2011 Dec 3.


Prosaposin sorting is mediated by oligomerization.

Yuan L, Morales CR.

Exp Cell Res. 2011 Oct 15;317(17):2456-67. doi: 10.1016/j.yexcr.2011.07.017. Epub 2011 Jul 29.


Tuning flux: autophagy as a target of heart disease therapy.

Xie M, Morales CR, Lavandero S, Hill JA.

Curr Opin Cardiol. 2011 May;26(3):216-22. doi: 10.1097/HCO.0b013e328345980a. Review.


Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy.

Cao DJ, Wang ZV, Battiprolu PK, Jiang N, Morales CR, Kong Y, Rothermel BA, Gillette TG, Hill JA.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4123-8. doi: 10.1073/pnas.1015081108. Epub 2011 Feb 18.


Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss.

Seyrantepe V, Lema P, Caqueret A, Dridi L, Bel Hadj S, Carpentier S, Boucher F, Levade T, Carmant L, Gravel RA, Hamel E, Vachon P, Di Cristo G, Michaud JL, Morales CR, Pshezhetsky AV.

PLoS Genet. 2010 Sep 16;6(9):e1001118. doi: 10.1371/journal.pgen.1001118.


From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.

Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S, Rader DJ.

Nature. 2010 Aug 5;466(7307):714-9. doi: 10.1038/nature09266.


Castration induces changes in the cation-dependent mannose-6-phosphate receptor in rat epididymis: possible implications in secretion of lysosomal enzymes.

Carvelli LF, Bannoud N, Aguilera CA, Morales CR, Sosa MA.

J Cell Biochem. 2010 Aug 1;110(5):1101-10. doi: 10.1002/jcb.22622.


ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway.

Lebrun-Julien F, Bertrand MJ, De Backer O, Stellwagen D, Morales CR, Di Polo A, Barker PA.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3817-22. doi: 10.1073/pnas.0909276107. Epub 2010 Feb 3.


A stretch of 17 amino acids in the prosaposin C terminus is critical for its binding to sortilin and targeting to lysosomes.

Yuan L, Morales CR.

J Histochem Cytochem. 2010 Mar;58(3):287-300. doi: 10.1369/jhc.2009.955203. Epub 2009 Nov 24.


The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes.

Zeng J, Racicott J, Morales CR.

Exp Cell Res. 2009 Nov 1;315(18):3112-24. doi: 10.1016/j.yexcr.2009.08.016. Epub 2009 Sep 2.


Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells.

Morales CR, Fox A, El-Alfy M, Ni X, Argraves WS.

Microsc Res Tech. 2009 Nov;72(11):809-15. doi: 10.1002/jemt.20733.


The interactomics of sortilin: an ancient lysosomal receptor evolving new functions.

Canuel M, Libin Y, Morales CR.

Histol Histopathol. 2009 Apr;24(4):481-92. doi: 10.14670/HH-24.481. Review.


Sortilin and prosaposin localize to detergent-resistant membrane microdomains.

Canuel M, Bhattacharyya N, Balbis A, Yuan L, Morales CR.

Exp Cell Res. 2009 Jan 15;315(2):240-7. doi: 10.1016/j.yexcr.2008.10.009. Epub 2008 Oct 22.


ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa.

Morales CR, Marat AL, Ni X, Yu Y, Oko R, Smith BT, Argraves WS.

Biochem Biophys Res Commun. 2008 Nov 21;376(3):472-7. doi: 10.1016/j.bbrc.2008.09.009. Epub 2008 Sep 13.


Sortilin mediates the lysosomal targeting of cathepsins D and H.

Canuel M, Korkidakis A, Konnyu K, Morales CR.

Biochem Biophys Res Commun. 2008 Aug 22;373(2):292-7. doi: 10.1016/j.bbrc.2008.06.021. Epub 2008 Jun 16.


Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1.

Seyrantepe V, Hinek A, Peng J, Fedjaev M, Ernest S, Kadota Y, Canuel M, Itoh K, Morales CR, Lavoie J, Tremblay J, Pshezhetsky AV.

Circulation. 2008 Apr 15;117(15):1973-81. doi: 10.1161/CIRCULATIONAHA.107.733212. Epub 2008 Apr 7.


Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage.

Seyrantepe V, Canuel M, Carpentier S, Landry K, Durand S, Liang F, Zeng J, Caqueret A, Gravel RA, Marchesini S, Zwingmann C, Michaud J, Morales CR, Levade T, Pshezhetsky AV.

Hum Mol Genet. 2008 Jun 1;17(11):1556-68. doi: 10.1093/hmg/ddn043. Epub 2008 Feb 11.


AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes.

Canuel M, Lefrancois S, Zeng J, Morales CR.

Biochem Biophys Res Commun. 2008 Feb 15;366(3):724-30. Epub 2007 Dec 17.


SGP-1 increases dendritic and synaptic development dependent on synaptic activity.

Cove J, Morales CR, Baranes D.

Neurosci Res. 2006 Dec;56(4):372-85. Epub 2006 Oct 16.


Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility.

Lupien M, Diévart A, Morales CR, Hermo L, Calvo E, Kay DG, Hu C, Jolicoeur P.

Dev Biol. 2006 Dec 15;300(2):497-511. Epub 2006 Sep 14.


In the absence of the mouse DNA/RNA-binding protein MSY2, messenger RNA instability leads to spermatogenic arrest.

Yang J, Morales CR, Medvedev S, Schultz RM, Hecht NB.

Biol Reprod. 2007 Jan;76(1):48-54. Epub 2006 Oct 11.


Epithelial trafficking of Sonic hedgehog by megalin.

Morales CR, Zeng J, El Alfy M, Barth JL, Chintalapudi MR, McCarthy RA, Incardona JP, Argraves WS.

J Histochem Cytochem. 2006 Oct;54(10):1115-27. Epub 2006 Jun 26.

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