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Items: 24

1.

Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques.

Goonawardena AV, Morairty SR, Orellana GA, Willoughby AR, Wallace TL, Kilduff TS.

Neurobiol Sleep Circadian Rhythms. 2018 Aug 22;6:9-23. doi: 10.1016/j.nbscr.2018.08.001. eCollection 2019 Jan.

2.

Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques.

Goonawardena AV, Morairty SR, Dell R, Orellana GA, Hoener MC, Wallace TL, Kilduff TS.

Neuropsychopharmacology. 2019 Jul;44(8):1485-1493. doi: 10.1038/s41386-019-0386-8. Epub 2019 Apr 6.

PMID:
30954024
3.

Validation of 'Somnivore', a Machine Learning Algorithm for Automated Scoring and Analysis of Polysomnography Data.

Allocca G, Ma S, Martelli D, Cerri M, Del Vecchio F, Bastianini S, Zoccoli G, Amici R, Morairty SR, Aulsebrook AE, Blackburn S, Lesku JA, Rattenborg NC, Vyssotski AL, Wams E, Porcheret K, Wulff K, Foster R, Chan JKM, Nicholas CL, Freestone DR, Johnston LA, Gundlach AL.

Front Neurosci. 2019 Mar 18;13:207. doi: 10.3389/fnins.2019.00207. eCollection 2019.

4.

Trace Amine-Associated Receptor 1 Regulates Wakefulness and EEG Spectral Composition.

Schwartz MD, Black SW, Fisher SP, Palmerston JB, Morairty SR, Hoener MC, Kilduff TS.

Neuropsychopharmacology. 2017 May;42(6):1305-1314. doi: 10.1038/npp.2016.216. Epub 2016 Sep 23.

5.

Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep.

Schwartz MD, Nguyen AT, Warrier DR, Palmerston JB, Thomas AM, Morairty SR, Neylan TC, Kilduff TS.

eNeuro. 2016 Mar 21;3(2). pii: ENEURO.0018-16.2016. doi: 10.1523/ENEURO.0018-16.2016. eCollection 2016 Mar-Apr.

6.

Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease.

Fisher SP, Schwartz MD, Wurts-Black S, Thomas AM, Chen TM, Miller MA, Palmerston JB, Kilduff TS, Morairty SR.

Sleep. 2016 Feb 1;39(2):379-91. doi: 10.5665/sleep.5448.

7.

The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.

Parks GS, Warrier DR, Dittrich L, Schwartz MD, Palmerston JB, Neylan TC, Morairty SR, Kilduff TS.

Neuropsychopharmacology. 2016 Mar;41(4):1144-55. doi: 10.1038/npp.2015.256. Epub 2015 Aug 20.

8.

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.

Lindemann L, Porter RH, Scharf SH, Kuennecke B, Bruns A, von Kienlin M, Harrison AC, Paehler A, Funk C, Gloge A, Schneider M, Parrott NJ, Polonchuk L, Niederhauser U, Morairty SR, Kilduff TS, Vieira E, Kolczewski S, Wichmann J, Hartung T, Honer M, Borroni E, Moreau JL, Prinssen E, Spooren W, Wettstein JG, Jaeschke G.

J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. doi: 10.1124/jpet.114.222463. Epub 2015 Feb 9.

PMID:
25665805
9.

Homeostatic sleep pressure is the primary factor for activation of cortical nNOS/NK1 neurons.

Dittrich L, Morairty SR, Warrier DR, Kilduff TS.

Neuropsychopharmacology. 2015 Feb;40(3):632-9. doi: 10.1038/npp.2014.212. Epub 2014 Aug 20.

10.

GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy.

Black SW, Morairty SR, Chen TM, Leung AK, Wisor JP, Yamanaka A, Kilduff TS.

J Neurosci. 2014 May 7;34(19):6485-94. doi: 10.1523/JNEUROSCI.0080-14.2014.

11.

The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats.

Morairty SR, Wilk AJ, Lincoln WU, Neylan TC, Kilduff TS.

Front Neurosci. 2014 Jan 31;8:3. doi: 10.3389/fnins.2014.00003. eCollection 2014.

12.

A role for cortical nNOS/NK1 neurons in coupling homeostatic sleep drive to EEG slow wave activity.

Morairty SR, Dittrich L, Pasumarthi RK, Valladao D, Heiss JE, Gerashchenko D, Kilduff TS.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20272-7. doi: 10.1073/pnas.1314762110. Epub 2013 Nov 4.

13.

Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington's disease.

Fisher SP, Black SW, Schwartz MD, Wilk AJ, Chen TM, Lincoln WU, Liu HW, Kilduff TS, Morairty SR.

Brain. 2013 Jul;136(Pt 7):2159-72. doi: 10.1093/brain/awt132.

PMID:
23801738
14.

Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy.

Black SW, Morairty SR, Fisher SP, Chen TM, Warrier DR, Kilduff TS.

Sleep. 2013 Mar 1;36(3):325-36. doi: 10.5665/sleep.2442.

15.

Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.

Morairty SR, Revel FG, Malherbe P, Moreau JL, Valladao D, Wettstein JG, Kilduff TS, Borroni E.

PLoS One. 2012;7(7):e39131. doi: 10.1371/journal.pone.0039131. Epub 2012 Jul 2.

16.

Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics.

Revel FG, Moreau JL, Gainetdinov RR, Ferragud A, Velázquez-Sánchez C, Sotnikova TD, Morairty SR, Harmeier A, Groebke Zbinden K, Norcross RD, Bradaia A, Kilduff TS, Biemans B, Pouzet B, Caron MG, Canales JJ, Wallace TL, Wettstein JG, Hoener MC.

Biol Psychiatry. 2012 Dec 1;72(11):934-42. doi: 10.1016/j.biopsych.2012.05.014. Epub 2012 Jun 16.

PMID:
22705041
17.

A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.

Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR, Kilduff TS, Wallace TL, Risterucci C, Wettstein JG, Hoener MC.

Mol Psychiatry. 2013 May;18(5):543-56. doi: 10.1038/mp.2012.57. Epub 2012 May 29.

PMID:
22641180
18.

Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia.

Teegarden BR, Li H, Jayakumar H, Strah-Pleynet S, Dosa PI, Selaya SD, Kato N, Elwell KH, Davidson J, Cheng K, Saldana H, Frazer JM, Whelan K, Foster J, Espitia S, Webb RR, Beeley NR, Thomsen W, Morairty SR, Kilduff TS, Al-Shamma HA.

J Med Chem. 2010 Mar 11;53(5):1923-36. doi: 10.1021/jm9007328.

PMID:
20143782
19.

The wake-promoting effects of hypocretin-1 are attenuated in old rats.

Morairty SR, Wisor J, Silveira K, Sinko W, Kilduff TS.

Neurobiol Aging. 2011 Aug;32(8):1514-27. doi: 10.1016/j.neurobiolaging.2009.07.017. Epub 2009 Sep 24.

20.

Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats.

Morairty SR, Hedley L, Flores J, Martin R, Kilduff TS.

Sleep. 2008 Jan;31(1):34-44.

21.

Gene expression in the rat cerebral cortex: comparison of recovery sleep and hypnotic-induced sleep.

Wisor JP, Morairty SR, Huynh NT, Steininger TL, Kilduff TS.

Neuroscience. 2006 Aug 11;141(1):371-8. Epub 2006 May 11.

22.

GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus.

Xie X, Crowder TL, Yamanaka A, Morairty SR, Lewinter RD, Sakurai T, Kilduff TS.

J Physiol. 2006 Jul 15;574(Pt 2):399-414. Epub 2006 Apr 20.

23.

Age-related changes in histamine receptor mRNA levels in the mouse brain.

Terao A, Steininger TL, Morairty SR, Kilduff TS.

Neurosci Lett. 2004 Jan 23;355(1-2):81-4.

PMID:
14729240
24.

Selective increases in non-rapid eye movement sleep following whole body heating in rats.

Morairty SR, Szymusiak R, Thomson D, McGinty DJ.

Brain Res. 1993 Jul 16;617(1):10-6.

PMID:
8374732

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