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Items: 33

1.

A strategy for the selection of monovalent antibodies that span protein dimer interfaces.

Spangler JB, Moraga I, Jude KM, Savvides CS, Garcia KC.

J Biol Chem. 2019 Sep 20;294(38):13876-13886. doi: 10.1074/jbc.RA119.009213. Epub 2019 Aug 6.

2.

A Mediterranean Diet with an Enhanced Consumption of Extra Virgin Olive Oil and Pistachios Improves Pregnancy Outcomes in Women Without Gestational Diabetes Mellitus: A Sub-Analysis of the St. Carlos Gestational Diabetes Mellitus Prevention Study.

Assaf-Balut C, García de la Torre N, Duran A, Fuentes M, Bordiú E, Del Valle L, Familiar C, Valerio J, Jiménez I, Herraiz MA, Izquierdo N, Torrejon MJ, Cuadrado MÁ, Ortega I, Illana FJ, Runkle I, de Miguel P, Moraga I, Montañez C, Barabash A, Cuesta M, Rubio MA, Calle-Pascual AL.

Ann Nutr Metab. 2019;74(1):69-79. doi: 10.1159/000495793. Epub 2018 Dec 14.

3.

Medical nutrition therapy for gestational diabetes mellitus based on Mediterranean Diet principles: a subanalysis of the St Carlos GDM Prevention Study.

Assaf-Balut C, Garcia de la Torre N, Durán A, Fuentes M, Bordiú E, Del Valle L, Valerio J, Familiar C, Jiménez I, Herraiz MA, Izquierdo N, Torrejón MJ, Runkle I, de Miguel MP, Moraga I, Montañez MC, Barabash A, Cuesta M, Rubio MA, Calle-Pascual AL.

BMJ Open Diabetes Res Care. 2018 Oct 11;6(1):e000550. doi: 10.1136/bmjdrc-2018-000550. eCollection 2018.

4.

Mapping Determinants of Cytokine Signaling via Protein Engineering.

Gorby C, Martinez-Fabregas J, Wilmes S, Moraga I.

Front Immunol. 2018 Sep 27;9:2143. doi: 10.3389/fimmu.2018.02143. eCollection 2018. Review.

5.

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.

Richter D, Moraga I, Winkelmann H, Birkholz O, Wilmes S, Schulte M, Kraich M, Kenneweg H, Beutel O, Selenschik P, Paterok D, Gavutis M, Schmidt T, Garcia KC, Müller TD, Piehler J.

Nat Commun. 2017 Jul 14;8:15976. doi: 10.1038/ncomms15976.

6.

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.

Moraga I, Spangler JB, Mendoza JL, Gakovic M, Wehrman TS, Krutzik P, Garcia KC.

Elife. 2017 May 12;6. pii: e22882. doi: 10.7554/eLife.22882.

7.

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.

Mendoza JL, Schneider WM, Hoffmann HH, Vercauteren K, Jude KM, Xiong A, Moraga I, Horton TM, Glenn JS, de Jong YP, Rice CM, Garcia KC.

Immunity. 2017 Mar 21;46(3):379-392. doi: 10.1016/j.immuni.2017.02.017.

8.

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.

Kim AR, Ulirsch JC, Wilmes S, Unal E, Moraga I, Karakukcu M, Yuan D, Kazerounian S, Abdulhay NJ, King DS, Gupta N, Gabriel SB, Lander ES, Patiroglu T, Ozcan A, Ozdemir MA, Garcia KC, Piehler J, Gazda HT, Klein DE, Sankaran VG.

Cell. 2017 Mar 9;168(6):1053-1064.e15. doi: 10.1016/j.cell.2017.02.026.

9.

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.

Ho CCM, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, Weissman IL, Galli SJ, Shizuru JA, Garcia KC.

Cell. 2017 Mar 9;168(6):1041-1052.e18. doi: 10.1016/j.cell.2017.02.011.

10.

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.

You C, Marquez-Lago TT, Richter CP, Wilmes S, Moraga I, Garcia KC, Leier A, Piehler J.

Sci Adv. 2016 Dec 2;2(12):e1600452. eCollection 2016 Dec.

11.

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.

Moraga I, Richter D, Wilmes S, Winkelmann H, Jude K, Thomas C, Suhoski MM, Engleman EG, Piehler J, Garcia KC.

Sci Signal. 2015 Nov 10;8(402):ra114. doi: 10.1126/scisignal.aab2677.

12.

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.

Moraga I, Wernig G, Wilmes S, Gryshkova V, Richter CP, Hong WJ, Sinha R, Guo F, Fabionar H, Wehrman TS, Krutzik P, Demharter S, Plo I, Weissman IL, Minary P, Majeti R, Constantinescu SN, Piehler J, Garcia KC.

Cell. 2015 Mar 12;160(6):1196-208. doi: 10.1016/j.cell.2015.02.011. Epub 2015 Feb 26.

13.

Insights into cytokine-receptor interactions from cytokine engineering.

Spangler JB, Moraga I, Mendoza JL, Garcia KC.

Annu Rev Immunol. 2015;33:139-67. doi: 10.1146/annurev-immunol-032713-120211. Epub 2014 Dec 10. Review.

14.

Multifarious determinants of cytokine receptor signaling specificity.

Moraga I, Spangler J, Mendoza JL, Garcia KC.

Adv Immunol. 2014;121:1-39. doi: 10.1016/B978-0-12-800100-4.00001-5. Review.

15.

[Superkines: cytokines displaying better targeted functions].

Creusot RJ, Moraga I.

Med Sci (Paris). 2013 Apr;29(4):345-9. doi: 10.1051/medsci/2013294004. Epub 2013 Apr 26. French. No abstract available.

16.

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.

Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, Ozkan E, Leonard WJ, Garcia KC.

Nat Immunol. 2012 Dec;13(12):1187-95. doi: 10.1038/ni.2449. Epub 2012 Oct 28.

17.

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.

Junttila IS, Creusot RJ, Moraga I, Bates DL, Wong MT, Alonso MN, Suhoski MM, Lupardus P, Meier-Schellersheim M, Engleman EG, Utz PJ, Fathman CG, Paul WE, Garcia KC.

Nat Chem Biol. 2012 Dec;8(12):990-8. doi: 10.1038/nchembio.1096. Epub 2012 Oct 28.

18.

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.

Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC.

Nature. 2012 Mar 25;484(7395):529-33. doi: 10.1038/nature10975.

19.

The role of RPGR in cilia formation and actin stability.

Gakovic M, Shu X, Kasioulis I, Carpanini S, Moraga I, Wright AF.

Hum Mol Genet. 2011 Dec 15;20(24):4840-50. doi: 10.1093/hmg/ddr423. Epub 2011 Sep 20.

PMID:
21933838
20.

Structural linkage between ligand discrimination and receptor activation by type I interferons.

Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS, Nolan GP, Piehler J, Schreiber G, Garcia KC.

Cell. 2011 Aug 19;146(4):621-32. doi: 10.1016/j.cell.2011.06.048.

21.

[About a case of multiple endocrine neoplasia type 1. Review of some clinical manifestations and treatment controversies].

Familiar C, Antón T, Moraga I, Ramos A, Marco A.

Endocrinol Nutr. 2011 Feb;58(2):84-9. doi: 10.1016/j.endonu.2010.10.011. Epub 2011 Feb 20. Review. Spanish.

PMID:
21339088
22.

CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism.

Lalanne AI, Moraga I, Hao Y, Pereira JP, Alves NL, Huntington ND, Freitas AA, Cumano A, Vieira P.

J Immunol. 2010 May 15;184(10):5678-85. doi: 10.4049/jimmunol.0903854. Epub 2010 Apr 16.

23.

[Risk factors of persistent disease at 5 years from diagnosis in differentiated thyroid cancer: study of 63 patients].

Familiar C, Moraga I, Antón T, Gargallo MA, Ramos A, Marco AL, Villa M, Tapia MA.

Endocrinol Nutr. 2009 Aug-Sep;56(7):361-8. doi: 10.1016/S1575-0922(09)72455-6. Spanish.

PMID:
19883896
24.

Receptor density is key to the alpha2/beta interferon differential activities.

Moraga I, Harari D, Schreiber G, Uzé G, Pellegrini S.

Mol Cell Biol. 2009 Sep;29(17):4778-87. doi: 10.1128/MCB.01808-08. Epub 2009 Jun 29.

25.

Effectiveness of retinoic acid treatment for redifferentiation of thyroid cancer in relation to recovery of radioiodine uptake.

Fernández CA, Puig-Domingo M, Lomeña F, Estorch M, Camacho Martí V, Bittini AL, Marazuela M, Santamaría J, Castro J, Martínez de Icaya P, Moraga I, Martín T, Megía A, Porta M, Mauricio D, Halperin I.

J Endocrinol Invest. 2009 Mar;32(3):228-33.

PMID:
19542739
26.

Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells.

Merino E, Avila-Flores A, Shirai Y, Moraga I, Saito N, Mérida I.

J Immunol. 2008 May 1;180(9):5805-15.

27.

Cardiovascular risk factor management is poorer in diabetic patients with undiagnosed peripheral arterial disease than in those with known coronary heart disease or cerebrovascular disease. Results of a nationwide study in tertiary diabetes centres.

González-Clemente JM, Piniés JA, Calle-Pascual A, Saavedra A, Sánchez C, Bellido D, Martín-Folgueras T, Moraga I, Recasens A, Girbés J, Sánchez-Zamorano MA, Mauricio D; PADiD Study Group.

Diabet Med. 2008 Apr;25(4):427-34. doi: 10.1111/j.1464-5491.2008.02402.x. Epub 2008 Mar 13.

PMID:
18341592
28.

Role of the diacylglycerol kinase alpha-conserved domains in membrane targeting in intact T cells.

Merino E, Sanjuán MA, Moraga I, Ciprés A, Mérida I.

J Biol Chem. 2007 Nov 30;282(48):35396-404. Epub 2007 Oct 2.

29.

Epidemiology of nontraumatic lower-extremity amputation in area 7, Madrid, between 1989 and 1999: a population-based study.

Calle-Pascual AL, Garcia-Torre N, Moraga I, Diaz JA, Duran A, Moñux G, Serrano FJ, Martín-Alvarez PJ, Charro A, Marañes JP.

Diabetes Care. 2001 Sep;24(9):1686-9. No abstract available.

PMID:
11522722
30.

Comparison of peripheral arterial reconstruction in diabetic and non-diabetic patients: a prospective clinic-based study.

Calle-Pascual AL, Durán A, Diaz A, Moñux G, Serrano FJ, de la Torre NG, Moraga I, Calle JR, Charro A, Marañes JP.

Diabetes Res Clin Pract. 2001 Aug;53(2):129-36.

PMID:
11403862
31.

[Care and complications of tracheotomy].

Manzano JL, Moraga I, Martínez Gálvez J, Guerra J, Manzano JJ, Bolaños J, Güemes B.

Rev Esp Anestesiol Reanim. 1975 Nov;22(6):490-503. Spanish. No abstract available.

PMID:
1208932
32.

[Decanulation of tracheostomised children (author's transl)].

Manzano JL, Moraga I, Manzano JJ, Guerra J, Güemes B, Bolaños J.

An Esp Pediatr. 1975 May-Jun;8(3):297-302. Spanish.

PMID:
1155860
33.

[Prolonged intubation in children (author's transl)].

Manzano JL, Moraga I, Losa J, Rogues M, Escribano J, De la Fuente J.

An Esp Pediatr. 1975 May-Jun;8(3):259-66. Spanish.

PMID:
1155856

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