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Items: 24


Detection of vancomycin-resistant Enterococcus faecium hospital-adapted lineages in municipal wastewater treatment plants indicates widespread distribution and release into the environment.

Gouliouris T, Raven KE, Moradigaravand D, Ludden C, Coll F, Blane B, Naydenova P, Horner C, Brown NM, Corander J, Limmathurotsakul D, Parkhill J, Peacock SJ.

Genome Res. 2019 Apr;29(4):626-634. doi: 10.1101/gr.232629.117. Epub 2019 Mar 21.


A One Health study of the genetic relatedness of Klebsiella pneumoniae and their mobile elements in the East of England.

Ludden C, Moradigaravand D, Jamrozy D, Gouliouris T, Blane B, Naydenova P, Hernandez-Garcia J, Wood P, Hadjirin N, Radakovic M, Crawley C, Brown NM, Holmes M, Parkhill J, Peacock SJ.

Clin Infect Dis. 2019 Mar 7. pii: ciz174. doi: 10.1093/cid/ciz174. [Epub ahead of print]


Prediction of antibiotic resistance in Escherichia coli from large-scale pan-genome data.

Moradigaravand D, Palm M, Farewell A, Mustonen V, Warringer J, Parts L.

PLoS Comput Biol. 2018 Dec 14;14(12):e1006258. doi: 10.1371/journal.pcbi.1006258. eCollection 2018 Dec.


Reply to Dookie et al., "Whole-Genome Sequencing To Guide the Selection of Treatment for Drug-Resistant Tuberculosis".

Köser CU, Heyckendorf J, Andres S, Olaru ID, Schön T, Sturegård E, Beckert P, Schleusener V, Kohl TA, Hillemann D, Moradigaravand D, Parkhill J, Peacock SJ, Niemann S, Lange C, Merker M.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00616-18. doi: 10.1128/AAC.00616-18. Print 2018 Aug. No abstract available.


Genomic survey of Clostridium difficile reservoirs in the East of England implicates environmental contamination of wastewater treatment plants by clinical lineages.

Moradigaravand D, Gouliouris T, Ludden C, Reuter S, Jamrozy D, Blane B, Naydenova P, Judge K, H Aliyu S, F Hadjirin N, A Holmes M, Török E, M Brown N, Parkhill J, Peacock S.

Microb Genom. 2018 Mar;4(3). doi: 10.1099/mgen.0.000162. Epub 2018 Mar 2.


Within-host evolution of Enterococcus faecium during longitudinal carriage and transition to bloodstream infection in immunocompromised patients.

Moradigaravand D, Gouliouris T, Blane B, Naydenova P, Ludden C, Crawley C, Brown NM, Török ME, Parkhill J, Peacock SJ.

Genome Med. 2017 Dec 27;9(1):119. doi: 10.1186/s13073-017-0507-0.


What Is Resistance? Impact of Phenotypic versus Molecular Drug Resistance Testing on Therapy for Multi- and Extensively Drug-Resistant Tuberculosis.

Heyckendorf J, Andres S, Köser CU, Olaru ID, Schön T, Sturegård E, Beckert P, Schleusener V, Kohl TA, Hillemann D, Moradigaravand D, Parkhill J, Peacock SJ, Niemann S, Lange C, Merker M.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01550-17. doi: 10.1128/AAC.01550-17. Print 2018 Feb.


Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.

Nakatani Y, Opel-Reading HK, Merker M, Machado D, Andres S, Kumar SS, Moradigaravand D, Coll F, Perdigão J, Portugal I, Schön T, Nair D, Devi KRU, Kohl TA, Beckert P, Clark TG, Maphalala G, Khumalo D, Diel R, Klaos K, Aung HL, Cook GM, Parkhill J, Peacock SJ, Swaminathan S, Viveiros M, Niemann S, Krause KL, Köser CU.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01575-17. doi: 10.1128/AAC.01575-17. Print 2017 Dec.


Evolution of the Staphylococcus argenteus ST2250 Clone in Northeastern Thailand Is Linked with the Acquisition of Livestock-Associated Staphylococcal Genes.

Moradigaravand D, Jamrozy D, Mostowy R, Anderson A, Nickerson EK, Thaipadungpanit J, Wuthiekanun V, Limmathurotsakul D, Tandhavanant S, Wikraiphat C, Wongsuvan G, Teerawattanasook N, Jutrakul Y, Srisurat N, Chaimanee P, Eoin West T, Blane B, Parkhill J, Chantratita N, Peacock SJ.

MBio. 2017 Jul 5;8(4). pii: e00802-17. doi: 10.1128/mBio.00802-17.


Evolution and Epidemiology of Multidrug-Resistant Klebsiella pneumoniae in the United Kingdom and Ireland.

Moradigaravand D, Martin V, Peacock SJ, Parkhill J.

MBio. 2017 Feb 21;8(1). pii: e01976-16. doi: 10.1128/mBio.01976-16.


Population structure of multidrug resistant Klebsiella oxytoca within hospitals across the UK and Ireland identifies sharing of virulence and resistance genes with K. pneumoniae.

Moradigaravand D, Martin V, Peacock SJ, Parkhill J.

Genome Biol Evol. 2017 Feb 8. doi: 10.1093/gbe/evx019. [Epub ahead of print] No abstract available.


Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays.

Ajileye A, Alvarez N, Merker M, Walker TM, Akter S, Brown K, Moradigaravand D, Schön T, Andres S, Schleusener V, Omar SV, Coll F, Huang H, Diel R, Ismail N, Parkhill J, de Jong BC, Peto TE, Crook DW, Niemann S, Robledo J, Smith EG, Peacock SJ, Köser CU.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02169-16. doi: 10.1128/AAC.02169-16. Print 2017 Apr.


Whole genome sequencing reveals high-resolution epidemiological links between clinical and environmental Klebsiella pneumoniae.

Runcharoen C, Moradigaravand D, Blane B, Paksanont S, Thammachote J, Anun S, Parkhill J, Chantratita N, Peacock SJ.

Genome Med. 2017 Jan 24;9(1):6. doi: 10.1186/s13073-017-0397-1.


The essential mycobacterial amidotransferase GatCAB is a modulator of specific translational fidelity.

Su HW, Zhu JH, Li H, Cai RJ, Ealand C, Wang X, Chen YX, Kayani MU, Zhu TF, Moradigaravand D, Huang H, Kana BD, Javid B.

Nat Microbiol. 2016 Aug 26;1(11):16147. doi: 10.1038/nmicrobiol.2016.147.


The dissemination of multidrug-resistant Enterobacter cloacae throughout the UK and Ireland.

Moradigaravand D, Reuter S, Martin V, Peacock SJ, Parkhill J.

Nat Microbiol. 2016 Sep 26;1:16173. doi: 10.1038/nmicrobiol.2016.173.


Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.

Aung HL, Tun T, Moradigaravand D, Köser CU, Nyunt WW, Aung ST, Lwin T, Thinn KK, Crump JA, Parkhill J, Peacock SJ, Cook GM, Hill PC.

J Glob Antimicrob Resist. 2016 Sep;6:113-117. doi: 10.1016/j.jgar.2016.04.008. Epub 2016 May 30.


Recent independent emergence of multiple multidrug-resistant Serratia marcescens clones within the United Kingdom and Ireland.

Moradigaravand D, Boinett CJ, Martin V, Peacock SJ, Parkhill J.

Genome Res. 2016 Aug;26(8):1101-9. doi: 10.1101/gr.205245.116. Epub 2016 Jul 18.


Wild-Type and Non-Wild-Type Mycobacterium tuberculosis MIC Distributions for the Novel Fluoroquinolone Antofloxacin Compared with Those for Ofloxacin, Levofloxacin, and Moxifloxacin.

Yu X, Wang G, Chen S, Wei G, Shang Y, Dong L, Schön T, Moradigaravand D, Parkhill J, Peacock SJ, Köser CU, Huang H.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5232-7. doi: 10.1128/AAC.00393-16. Print 2016 Sep.


dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains.

Moradigaravand D, Grandjean L, Martinez E, Li H, Zheng J, Coronel J, Moore D, Török ME, Sintchenko V, Huang H, Javid B, Parkhill J, Peacock SJ, Köser CU.

Antimicrob Agents Chemother. 2016 May 23;60(6):3864-7. doi: 10.1128/AAC.00253-16. Print 2016 Jun. No abstract available.


Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1.

Moradigaravand D, Kouyos R, Hinkley T, Haddad M, Petropoulos CJ, Engelstädter J, Bonhoeffer S.

PLoS Genet. 2014 Jun 26;10(6):e1004439. doi: 10.1371/journal.pgen.1004439. eCollection 2014 Jun.


The impact of natural transformation on adaptation in spatially structured bacterial populations.

Moradigaravand D, Engelstädter J.

BMC Evol Biol. 2014 Jun 20;14:141. doi: 10.1186/1471-2148-14-141.


Adaptation through genetic time travel? Fluctuating selection can drive the evolution of bacterial transformation.

Engelstädter J, Moradigaravand D.

Proc Biol Sci. 2013 Nov 27;281(1775):20132609. doi: 10.1098/rspb.2013.2609. Print 2014 Jan 22.


The evolution of natural competence: disentangling costs and benefits of sex in bacteria.

Moradigaravand D, Engelstädter J.

Am Nat. 2013 Oct;182(4):E112-26. doi: 10.1086/671909. Epub 2013 Aug 20.


The effect of bacterial recombination on adaptation on fitness landscapes with limited peak accessibility.

Moradigaravand D, Engelstädter J.

PLoS Comput Biol. 2012;8(10):e1002735. doi: 10.1371/journal.pcbi.1002735. Epub 2012 Oct 25.

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