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Items: 17

1.

Immunological Lessons from Respiratory Syncytial Virus Vaccine Development.

Ruckwardt TJ, Morabito KM, Graham BS.

Immunity. 2019 Sep 17;51(3):429-442. doi: 10.1016/j.immuni.2019.08.007. Review.

PMID:
31533056
2.

A proof of concept for structure-based vaccine design targeting RSV in humans.

Crank MC, Ruckwardt TJ, Chen M, Morabito KM, Phung E, Costner PJ, Holman LA, Hickman SP, Berkowitz NM, Gordon IJ, Yamshchikov GV, Gaudinski MR, Kumar A, Chang LA, Moin SM, Hill JP, DiPiazza AT, Schwartz RM, Kueltzo L, Cooper JW, Chen P, Stein JA, Carlton K, Gall JG, Nason MC, Kwong PD, Chen GL, Mascola JR, McLellan JS, Ledgerwood JE, Graham BS; VRC 317 Study Team.

Science. 2019 Aug 2;365(6452):505-509. doi: 10.1126/science.aav9033.

PMID:
31371616
3.

Epitope-Specific Serological Assays for RSV: Conformation Matters.

Phung E, Chang LA, Morabito KM, Kanekiyo M, Chen M, Nair D, Kumar A, Chen GL, Ledgerwood JE, Graham BS, Ruckwardt TJ.

Vaccines (Basel). 2019 Feb 23;7(1). pii: E23. doi: 10.3390/vaccines7010023.

4.

Memory Inflation Drives Tissue-Resident Memory CD8+ T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus.

Morabito KM, Ruckwardt TJ, Bar-Haim E, Nair D, Moin SM, Redwood AJ, Price DA, Graham BS.

Front Immunol. 2018 Aug 14;9:1861. doi: 10.3389/fimmu.2018.01861. eCollection 2018.

5.

Zika Virus Vaccine Development.

Morabito KM, Graham BS.

J Infect Dis. 2017 Dec 16;216(suppl_10):S957-S963. doi: 10.1093/infdis/jix464. Review.

6.

Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials.

Gaudinski MR, Houser KV, Morabito KM, Hu Z, Yamshchikov G, Rothwell RS, Berkowitz N, Mendoza F, Saunders JG, Novik L, Hendel CS, Holman LA, Gordon IJ, Cox JH, Edupuganti S, McArthur MA, Rouphael NG, Lyke KE, Cummings GE, Sitar S, Bailer RT, Foreman BM, Burgomaster K, Pelc RS, Gordon DN, DeMaso CR, Dowd KA, Laurencot C, Schwartz RM, Mascola JR, Graham BS, Pierson TC, Ledgerwood JE, Chen GL; VRC 319; VRC 320 study teams.

Lancet. 2018 Feb 10;391(10120):552-562. doi: 10.1016/S0140-6736(17)33105-7. Epub 2017 Dec 5.

7.

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage.

Shan C, Muruato AE, Jagger BW, Richner J, Nunes BTD, Medeiros DBA, Xie X, Nunes JGC, Morabito KM, Kong WP, Pierson TC, Barrett AD, Weaver SC, Rossi SL, Vasconcelos PFC, Graham BS, Diamond MS, Shi PY.

Nat Commun. 2017 Sep 22;8(1):676. doi: 10.1038/s41467-017-00737-8.

8.

Neonatal mice possess two phenotypically and functionally distinct lung-migratory CD103+ dendritic cell populations following respiratory infection.

Ruckwardt TJ, Morabito KM, Bar-Haim E, Nair D, Graham BS.

Mucosal Immunol. 2018 Jan;11(1):186-198. doi: 10.1038/mi.2017.28. Epub 2017 Apr 5.

9.

Pulmonary Dendritic Cell Subsets Shape the Respiratory Syncytial Virus-Specific CD8+ T Cell Immunodominance Hierarchy in Neonates.

Malloy AM, Ruckwardt TJ, Morabito KM, Lau-Kilby AW, Graham BS.

J Immunol. 2017 Jan 1;198(1):394-403. Epub 2016 Nov 28.

10.

Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant.

Francica JR, Lynn GM, Laga R, Joyce MG, Ruckwardt TJ, Morabito KM, Chen M, Chaudhuri R, Zhang B, Sastry M, Druz A, Ko K, Choe M, Pechar M, Georgiev IS, Kueltzo LA, Seymour LW, Mascola JR, Kwong PD, Graham BS, Seder RA.

Bioconjug Chem. 2016 Oct 19;27(10):2372-2385. Epub 2016 Sep 22.

PMID:
27583777
11.

Rapid development of a DNA vaccine for Zika virus.

Dowd KA, Ko SY, Morabito KM, Yang ES, Pelc RS, DeMaso CR, Castilho LR, Abbink P, Boyd M, Nityanandam R, Gordon DN, Gallagher JR, Chen X, Todd JP, Tsybovsky Y, Harris A, Huang YS, Higgs S, Vanlandingham DL, Andersen H, Lewis MG, De La Barrera R, Eckels KH, Jarman RG, Nason MC, Barouch DH, Roederer M, Kong WP, Mascola JR, Pierson TC, Graham BS.

Science. 2016 Oct 14;354(6309):237-240. Epub 2016 Sep 22.

12.

Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung.

Morabito KM, Ruckwardt TR, Redwood AJ, Moin SM, Price DA, Graham BS.

Mucosal Immunol. 2017 Mar;10(2):545-554. doi: 10.1038/mi.2016.48. Epub 2016 May 25.

13.

Determinants of early life immune responses to RSV infection.

Ruckwardt TJ, Morabito KM, Graham BS.

Curr Opin Virol. 2016 Feb;16:151-157. doi: 10.1016/j.coviro.2016.01.003. Epub 2016 Mar 15. Review.

14.

A Numerically Subdominant CD8 T Cell Response to Matrix Protein of Respiratory Syncytial Virus Controls Infection with Limited Immunopathology.

Liu J, Haddad EK, Marceau J, Morabito KM, Rao SS, Filali-Mouhim A, Sekaly RP, Graham BS.

PLoS Pathog. 2016 Mar 4;12(3):e1005486. doi: 10.1371/journal.ppat.1005486. eCollection 2016 Mar.

15.

Phenotype and Hierarchy of Two Transgenic T Cell Lines Targeting the Respiratory Syncytial Virus KdM282-90 Epitope Is Transfer Dose-Dependent.

Morabito KM, Erez N, Graham BS, Ruckwardt TJ.

PLoS One. 2016 Jan 11;11(1):e0146781. doi: 10.1371/journal.pone.0146781. eCollection 2016.

16.

Viruslike Particles Encapsidating Respiratory Syncytial Virus M and M2 Proteins Induce Robust T Cell Responses.

Schwarz B, Morabito KM, Ruckwardt TJ, Patterson DP, Avera J, Miettinen HM, Graham BS, Douglas T.

ACS Biomater Sci Eng. 2016;2(12):2324-2332. doi: 10.1021/acsbiomaterials.6b00532. Epub 2016 Nov 3.

17.

Quantitative and qualitative deficits in neonatal lung-migratory dendritic cells impact the generation of the CD8+ T cell response.

Ruckwardt TJ, Malloy AM, Morabito KM, Graham BS.

PLoS Pathog. 2014 Feb 13;10(2):e1003934. doi: 10.1371/journal.ppat.1003934. eCollection 2014 Feb.

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