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Items: 1 to 50 of 183

1.

Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice.

Willetts L, Felix LC, Jacobsen EA, Puttagunta L, Condjella RM, Zellner KR, Ochkur SI, Kim JD, Luo H, Lee NA, Lee JJ, Moqbel R, Lacy P.

Commun Biol. 2018 Jun 29;1:83. doi: 10.1038/s42003-018-0081-z. eCollection 2018.

2.

Neurotransmitter signalling via NMDA receptors leads to decreased T helper type 1-like and enhanced T helper type 2-like immune balance in humans.

Orihara K, Odemuyiwa SO, Stefura WP, Ilarraza R, HayGlass KT, Moqbel R.

Immunology. 2018 Mar;153(3):368-379. doi: 10.1111/imm.12846. Epub 2017 Nov 3.

3.

Tumor necrosis factor regulates NMDA receptor-mediated airway smooth muscle contractile function and airway responsiveness.

Anaparti V, Pascoe CD, Jha A, Mahood TH, Ilarraza R, Unruh H, Moqbel R, Halayko AJ.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L467-80. doi: 10.1152/ajplung.00382.2015. Epub 2016 Jul 1.

4.

NMDA receptors mediate contractile responses in human airway smooth muscle cells.

Anaparti V, Ilarraza R, Orihara K, Stelmack GL, Ojo OO, Mahood TH, Unruh H, Halayko AJ, Moqbel R.

Am J Physiol Lung Cell Mol Physiol. 2015 Jun 15;308(12):L1253-64. doi: 10.1152/ajplung.00402.2014. Epub 2015 Apr 17.

5.

Respiratory syncytial virus induces indoleamine 2,3-dioxygenase activity: a potential novel role in the development of allergic disease.

Ajamian F, Wu Y, Ebeling C, Ilarraza R, Odemuyiwa SO, Moqbel R, Adamko DJ.

Clin Exp Allergy. 2015 Mar;45(3):644-59. doi: 10.1111/cea.12498.

PMID:
25627660
6.

Cyclin-dependent kinase 5 regulates degranulation in human eosinophils.

Odemuyiwa SO, Ilarraza R, Davoine F, Logan MR, Shayeganpour A, Wu Y, Majaesic C, Adamko DJ, Moqbel R, Lacy P.

Immunology. 2015 Apr;144(4):641-8. doi: 10.1111/imm.12416.

7.

Connexin 43 expression on peripheral blood eosinophils: role of gap junctions in transendothelial migration.

Vliagoftis H, Ebeling C, Ilarraza R, Mahmudi-Azer S, Abel M, Adamko D, Befus AD, Moqbel R.

Biomed Res Int. 2014;2014:803257. doi: 10.1155/2014/803257. Epub 2014 Jul 6.

8.

Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice.

Jacobsen EA, Lesuer WE, Willetts L, Zellner KR, Mazzolini K, Antonios N, Beck B, Protheroe C, Ochkur SI, Colbert D, Lacy P, Moqbel R, Appleton J, Lee NA, Lee JJ.

Allergy. 2014 Mar;69(3):315-27. doi: 10.1111/all.12321. Epub 2013 Nov 25.

9.

An essential role for Rab27a GTPase in eosinophil exocytosis.

Kim JD, Willetts L, Ochkur S, Srivastava N, Hamburg R, Shayeganpour A, Seabra MC, Lee JJ, Moqbel R, Lacy P.

J Leukoc Biol. 2013 Dec;94(6):1265-74. doi: 10.1189/jlb.0812431. Epub 2013 Aug 28.

10.

Fragrance materials in asthma: a pilot study using a surrogate aerosol product.

Vethanayagam D, Vliagoftis H, Mah D, Beach J, Smith L, Moqbel R.

J Asthma. 2013 Nov;50(9):975-82. doi: 10.3109/02770903.2013.822079. Epub 2013 Aug 20.

PMID:
23829679
11.

Osteocalcin expression in pulp inflammation.

Abd-Elmeguid A, Abdeldayem M, Kline LW, Moqbel R, Vliagoftis H, Yu DC.

J Endod. 2013 Jul;39(7):865-72. doi: 10.1016/j.joen.2012.12.035. Epub 2013 Feb 28.

PMID:
23791253
12.

Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils.

Doyle AD, Jacobsen EA, Ochkur SI, Willetts L, Shim K, Neely J, Kloeber J, Lesuer WE, Pero RS, Lacy P, Moqbel R, Lee NA, Lee JJ.

J Leukoc Biol. 2013 Jul;94(1):17-24. doi: 10.1189/jlb.0213089. Epub 2013 Apr 29.

13.

Eosinophils in human oral squamous carcinoma; role of prostaglandin D2.

Davoine F, Sim A, Tang C, Fisher S, Ethier C, Puttagunta L, Wu Y, McGaw WT, Yu D, Cameron L, Adamko DJ, Moqbel R.

J Inflamm (Lond). 2013 Jan 31;10(1):4. doi: 10.1186/1476-9255-10-4.

14.

Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD).

Bochner BS, Book W, Busse WW, Butterfield J, Furuta GT, Gleich GJ, Klion AD, Lee JJ, Leiferman KM, Minnicozzi M, Moqbel R, Rothenberg ME, Schwartz LB, Simon HU, Wechsler ME, Weller PF.

J Allergy Clin Immunol. 2012 Sep;130(3):587-96. doi: 10.1016/j.jaci.2012.07.024.

15.

Human versus mouse eosinophils: "that which we call an eosinophil, by any other name would stain as red".

Lee JJ, Jacobsen EA, Ochkur SI, McGarry MP, Condjella RM, Doyle AD, Luo H, Zellner KR, Protheroe CA, Willetts L, Lesuer WE, Colbert DC, Helmers RA, Lacy P, Moqbel R, Lee NA.

J Allergy Clin Immunol. 2012 Sep;130(3):572-84. doi: 10.1016/j.jaci.2012.07.025. Review.

16.

A sensitive high throughput ELISA for human eosinophil peroxidase: a specific assay to quantify eosinophil degranulation from patient-derived sources.

Ochkur SI, Kim JD, Protheroe CA, Colbert D, Condjella RM, Bersoux S, Helmers RA, Moqbel R, Lacy P, Kelly EA, Jarjour NN, Kern R, Peters A, Schleimer RP, Furuta GT, Nair P, Lee JJ, Lee NA.

J Immunol Methods. 2012 Oct 31;384(1-2):10-20. doi: 10.1016/j.jim.2012.06.011. Epub 2012 Jun 28.

17.

Dentin matrix protein-1 activates dental pulp fibroblasts.

Abd-Elmeguid A, Yu DC, Kline LW, Moqbel R, Vliagoftis H.

J Endod. 2012 Jan;38(1):75-80. doi: 10.1016/j.joen.2011.10.005. Epub 2011 Nov 21.

PMID:
22152625
18.

Changes in thymic regulatory T-cell maturation from birth to puberty: differences in atopic children.

Tulic MK, Andrews D, Crook ML, Charles A, Tourigny MR, Moqbel R, Prescott SL.

J Allergy Clin Immunol. 2012 Jan;129(1):199-206.e1-4. doi: 10.1016/j.jaci.2011.10.016. Epub 2011 Nov 21.

PMID:
22104606
19.

The development of a sensitive and specific ELISA for mouse eosinophil peroxidase: assessment of eosinophil degranulation ex vivo and in models of human disease.

Ochkur SI, Kim JD, Protheroe CA, Colbert D, Moqbel R, Lacy P, Lee JJ, Lee NA.

J Immunol Methods. 2012 Jan 31;375(1-2):138-47. doi: 10.1016/j.jim.2011.10.002. Epub 2011 Oct 12.

20.

Extracellular 14-3-3 from human lung epithelial cells enhances MMP-1 expression.

Asdaghi N, Kilani RT, Hosseini-Tabatabaei A, Odemuyiwa SO, Hackett TL, Knight DA, Ghahary A, Moqbel R.

Mol Cell Biochem. 2012 Jan;360(1-2):261-70. doi: 10.1007/s11010-011-1065-1. Epub 2011 Sep 25.

PMID:
21948273
21.

Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury.

Willetts L, Parker K, Wesselius LJ, Protheroe CA, Jaben E, Graziano P, Moqbel R, Leslie KO, Lee NA, Lee JJ.

Respir Res. 2011 Aug 26;12:116. doi: 10.1186/1465-9921-12-116.

22.

Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2.

Lacy P, Willetts L, Kim JD, Lo AN, Lam B, Maclean EI, Moqbel R, Rothenberg ME, Zimmermann N.

Int Arch Allergy Immunol. 2011;156(2):137-47. doi: 10.1159/000322597. Epub 2011 May 16.

23.

Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy.

Saude EJ, Skappak CD, Regush S, Cook K, Ben-Zvi A, Becker A, Moqbel R, Sykes BD, Rowe BH, Adamko DJ.

J Allergy Clin Immunol. 2011 Mar;127(3):757-64.e1-6. doi: 10.1016/j.jaci.2010.12.1077.

PMID:
21377043
24.

What's new in asthma pathophysiology and immunopathology?

Orihara K, Dil N, Anaparti V, Moqbel R.

Expert Rev Respir Med. 2010 Oct;4(5):605-29. doi: 10.1586/ers.10.57. Review.

PMID:
20923340
25.

Intelligent granules: are eosinophil crystalloid granules inimitable?

Mahmudi-Azer S, Odemuyiwa SO, Moqbel R.

J Allergy Clin Immunol. 2010 Jul;126(1):28-30. doi: 10.1016/j.jaci.2010.04.008. Epub 2010 Jun 9. No abstract available.

PMID:
20538325
26.

Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor.

Dyer KD, Percopo CM, Xie Z, Yang Z, Kim JD, Davoine F, Lacy P, Druey KM, Moqbel R, Rosenberg HF.

J Immunol. 2010 Jun 1;184(11):6327-34. doi: 10.4049/jimmunol.0904043. Epub 2010 Apr 26.

27.

Thymic indoleamine 2,3-dioxygenase-positive eosinophils in young children: potential role in maturation of the naive immune system.

Tulic MK, Sly PD, Andrews D, Crook M, Davoine F, Odemuyiwa SO, Charles A, Hodder ML, Prescott SL, Holt PG, Moqbel R.

Am J Pathol. 2009 Nov;175(5):2043-52. doi: 10.2353/ajpath.2009.090015. Epub 2009 Oct 8.

28.

Allergy, asthma, and inflammation: which inflammatory cell type is more important?

Moqbel R, Odemuyiwa SO.

Allergy Asthma Clin Immunol. 2008 Dec 15;4(4):150-6. doi: 10.1186/1710-1492-4-4-150. Epub 2008 Dec 15.

29.

Eosinophil granules function extracellularly as receptor-mediated secretory organelles.

Neves JS, Perez SA, Spencer LA, Melo RC, Reynolds L, Ghiran I, Mahmudi-Azer S, Odemuyiwa SO, Dvorak AM, Moqbel R, Weller PF.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18478-83. doi: 10.1073/pnas.0804547105. Epub 2008 Nov 18.

30.

Metabolomic biomarkers in a model of asthma exacerbation: urine nuclear magnetic resonance.

Saude EJ, Obiefuna IP, Somorjai RL, Ajamian F, Skappak C, Ahmad T, Dolenko BK, Sykes BD, Moqbel R, Adamko DJ.

Am J Respir Crit Care Med. 2009 Jan 1;179(1):25-34. doi: 10.1164/rccm.200711-1716OC. Epub 2008 Oct 17.

PMID:
18931331
31.

Tryptophan catabolites regulate mucosal sensitization to ovalbumin in respiratory airways.

Odemuyiwa SO, Ebeling C, Duta V, Abel M, Puttagunta L, Cravetchi O, Majaesic C, Vliagoftis H, Moqbel R.

Allergy. 2009 Mar;64(3):488-92. doi: 10.1111/j.1398-9995.2008.01809.x. Epub 2008 Aug 21.

PMID:
18721245
32.

Differential expression and activation of Rab27A in human eosinophils: relationship to blood eosinophilia.

Coughlin JJ, Odemuyiwa SO, Davidson CE, Moqbel R.

Biochem Biophys Res Commun. 2008 Aug 29;373(3):382-6. doi: 10.1016/j.bbrc.2008.06.033. Epub 2008 Jun 20.

PMID:
18571497
33.

Virus-induced eosinophil mediator release requires antigen-presenting and CD4+ T cells.

Davoine F, Cao M, Wu Y, Ajamian F, Ilarraza R, Kokaji AI, Moqbel R, Adamko DJ.

J Allergy Clin Immunol. 2008 Jul;122(1):69-77, 77.e1-2. doi: 10.1016/j.jaci.2008.03.028. Epub 2008 May 9.

PMID:
18472150
34.

The effect of cationic charge on release of eosinophil mediators.

Adamko DJ, Wu Y, Ajamian F, Ilarraza R, Moqbel R, Gleich GJ.

J Allergy Clin Immunol. 2008 Aug;122(2):383-90, 390.e1-4. doi: 10.1016/j.jaci.2008.03.020. Epub 2008 May 2.

PMID:
18455220
35.

Eosinophils: biological properties and role in health and disease.

Hogan SP, Rosenberg HF, Moqbel R, Phipps S, Foster PS, Lacy P, Kay AB, Rothenberg ME.

Clin Exp Allergy. 2008 May;38(5):709-50. doi: 10.1111/j.1365-2222.2008.02958.x. Epub 2008 Apr 1. Review.

PMID:
18384431
36.

Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line.

Marcet-Palacios M, Odemuyiwa SO, Coughlin JJ, Garofoli D, Ewen C, Davidson CE, Ghaffari M, Kane KP, Lacy P, Logan MR, Befus AD, Bleackley RC, Moqbel R.

Biochem Biophys Res Commun. 2008 Feb 15;366(3):617-23. Epub 2007 Nov 26.

PMID:
18042464
37.

Human lymphocytes express the transcriptional regulator, Wilms tumor 1: the role of WT1 in mediating nitric oxide-dependent repression of lymphocyte proliferation.

Marcet-Palacios M, Davoine F, Adamko DJ, Moqbel R, Befus AD.

Biochem Biophys Res Commun. 2007 Nov 16;363(2):283-7. Epub 2007 Sep 4.

PMID:
17869219
38.

Differential secretion of cytokines.

Moqbel R, Coughlin JJ.

Sci STKE. 2006 Jun 6;2006(338):pe26. Review.

PMID:
16757734
39.

Interleukin-12 inhibits eosinophil degranulation and migration but does not promote eosinophil apoptosis.

Davoine F, Ferland C, Chakir J, Lee JE, Adamko DJ, Moqbel R, Laviolette M.

Int Arch Allergy Immunol. 2006;140(4):277-84. Epub 2006 May 20.

PMID:
16735797
40.

A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils.

Logan MR, Lacy P, Odemuyiwa SO, Steward M, Davoine F, Kita H, Moqbel R.

Allergy. 2006 Jun;61(6):777-84.

PMID:
16677249
41.

Effects of clarithromycin on inflammatory cell mediator release and survival.

Borszcz PD, Befus D, Moqbel R, Sin DD, Adamko DJ, Man SF, Lacy P.

Chemotherapy. 2005 Jul;51(4):206-10. Epub 2005 Jul 6.

PMID:
16006767
42.

12th Annual Canadian Resident-Fellow Competition in Respiratory Research.

Marciniuk DD, Aaron S, Maltais F, Moqbel R.

Can Respir J. 2005 Jan-Feb;12(1):46. No abstract available.

43.

The rise of the phoenix: the expanding role of the eosinophil in health and disease.

Adamko DJ, Odemuyiwa SO, Vethanayagam D, Moqbel R.

Allergy. 2005 Jan;60(1):13-22. Review.

PMID:
15575925
44.

Cutting edge: human eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenase.

Odemuyiwa SO, Ghahary A, Li Y, Puttagunta L, Lee JE, Musat-Marcu S, Ghahary A, Moqbel R.

J Immunol. 2004 Nov 15;173(10):5909-13.

45.

Mast cell tryptase activates peripheral blood eosinophils to release granule-associated enzymes.

Vliagoftis H, Lacy P, Luy B, Adamko D, Hollenberg M, Befus D, Moqbel R.

Int Arch Allergy Immunol. 2004 Nov;135(3):196-204. Epub 2004 Oct 4.

PMID:
15467372
46.

NMR analysis of neutrophil activation in sputum samples from patients with cystic fibrosis.

Saude EJ, Lacy P, Musat-Marcu S, Mayes DC, Bagu J, Man SF, Sykes BD, Moqbel R.

Magn Reson Med. 2004 Oct;52(4):807-14.

47.

The induction of eosinophil peroxidase release: improved methods of measurement and stimulation.

Adamko DJ, Wu Y, Gleich GJ, Lacy P, Moqbel R.

J Immunol Methods. 2004 Aug;291(1-2):101-8.

PMID:
15345309
48.

Eosinophil function in allergic inflammation: from bone marrow to tissue response.

Adamko D, Lacy P, Moqbel R.

Curr Allergy Asthma Rep. 2004 Mar;4(2):149-58. Review.

PMID:
14769265
49.

Molecular mechanisms in eosinophil activation.

Moqbel R, Lacy P.

Chem Immunol. 2000;78:189-98. Review. No abstract available.

PMID:
12847730
50.

The eosinophil as a therapeutic target in asthma: beginning of the end, or end of the beginning?

Adamko D, Odemuyiwa SO, Moqbel R.

Curr Opin Pharmacol. 2003 Jun;3(3):227-32. Review.

PMID:
12810184

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