Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 134

1.

Evolutionary mitochondrial biology in titisee.

Gray MW, Mootha VK.

IUBMB Life. 2018 Dec;70(12):1184-1187. doi: 10.1002/iub.1958. Epub 2018 Oct 24. No abstract available.

PMID:
30358089
2.

Author Correction: Cryo-EM structure of a fungal mitochondrial calcium uniporter.

Nguyen NX, Armache JP, Lee C, Yang Y, Zeng W, Mootha VK, Cheng Y, Bai XC, Jiang Y.

Nature. 2018 Oct;562(7728):E25. doi: 10.1038/s41586-018-0427-1.

PMID:
30108362
3.

Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma.

Gopal RK, Kübler K, Calvo SE, Polak P, Livitz D, Rosebrock D, Sadow PM, Campbell B, Donovan SE, Amin S, Gigliotti BJ, Grabarek Z, Hess JM, Stewart C, Braunstein LZ, Arndt PF, Mordecai S, Shih AR, Chaves F, Zhan T, Lubitz CC, Kim J, Iafrate AJ, Wirth L, Parangi S, Leshchiner I, Daniels GH, Mootha VK, Dias-Santagata D, Getz G, McFadden DG.

Cancer Cell. 2018 Aug 13;34(2):242-255.e5. doi: 10.1016/j.ccell.2018.06.013.

PMID:
30107175
4.

MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+.

Kamer KJ, Sancak Y, Fomina Y, Meisel JD, Chaudhuri D, Grabarek Z, Mootha VK.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7960-E7969. doi: 10.1073/pnas.1807811115. Epub 2018 Aug 6.

PMID:
30082385
5.

Cryo-EM structure of a fungal mitochondrial calcium uniporter.

Nguyen NX, Armache JP, Lee C, Yang Y, Zeng W, Mootha VK, Cheng Y, Bai XC, Jiang Y.

Nature. 2018 Jul;559(7715):570-574. doi: 10.1038/s41586-018-0333-6. Epub 2018 Jul 11. Erratum in: Nature. 2018 Oct;562(7728):E25.

PMID:
29995855
6.

Oxygen in mitochondrial disease: can there be too much of a good thing?

Mootha VK, Chinnery PF.

J Inherit Metab Dis. 2018 Sep;41(5):761-763. doi: 10.1007/s10545-018-0210-3. Epub 2018 Jun 8. No abstract available.

PMID:
29948481
7.

Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma.

Gopal RK, Calvo SE, Shih AR, Chaves FL, McGuone D, Mick E, Pierce KA, Li Y, Garofalo A, Van Allen EM, Clish CB, Oliva E, Mootha VK.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6283-E6290. doi: 10.1073/pnas.1711888115. Epub 2018 Jun 18.

8.

A Middle Eastern Founder Mutation Expands the Genotypic and Phenotypic Spectrum of Mitochondrial MICU1 Deficiency: A Report of 13 Patients.

Musa S, Eyaid W, Kamer K, Ali R, Al-Mureikhi M, Shahbeck N, Al Mesaifri F, Makhseed N, Mohamed Z, AlShehhi WA, Mootha VK, Juusola J, Ben-Omran T.

JIMD Rep. 2018 May 3. doi: 10.1007/8904_2018_107. [Epub ahead of print]

PMID:
29721912
9.

Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome.

Lake NJ, Webb BD, Stroud DA, Richman TR, Ruzzenente B, Compton AG, Mountford HS, Pulman J, Zangarelli C, Rio M, Boddaert N, Assouline Z, Sherpa MD, Schadt EE, Houten SM, Byrnes J, McCormick EM, Zolkipli-Cunningham Z, Haude K, Zhang Z, Retterer K, Bai R, Calvo SE, Mootha VK, Christodoulou J, Rötig A, Filipovska A, Cristian I, Falk MJ, Metodiev MD, Thorburn DR.

Am J Hum Genet. 2018 Apr 5;102(4):713. doi: 10.1016/j.ajhg.2018.03.015. No abstract available.

10.

Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism.

Goodman RP, Calvo SE, Mootha VK.

J Biol Chem. 2018 May 18;293(20):7508-7516. doi: 10.1074/jbc.TM117.000258. Epub 2018 Mar 7. Review.

PMID:
29514978
11.

How many human proteoforms are there?

Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.

Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576.

PMID:
29443976
12.

Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.

Bick AG, Wakimoto H, Kamer KJ, Sancak Y, Goldberger O, Axelsson A, DeLaughter DM, Gorham JM, Mootha VK, Seidman JG, Seidman CE.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9096-E9104. doi: 10.1073/pnas.1711303114. Epub 2017 Oct 9.

13.

The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12.

Shen H, Campanello GC, Flicker D, Grabarek Z, Hu J, Luo C, Banerjee R, Mootha VK.

Cell. 2017 Nov 2;171(4):771-782.e11. doi: 10.1016/j.cell.2017.09.051. Epub 2017 Oct 19.

14.

Antibodies to biotin enable large-scale detection of biotinylation sites on proteins.

Udeshi ND, Pedram K, Svinkina T, Fereshetian S, Myers SA, Aygun O, Krug K, Clauser K, Ryan D, Ast T, Mootha VK, Ting AY, Carr SA.

Nat Methods. 2017 Dec;14(12):1167-1170. doi: 10.1038/nmeth.4465. Epub 2017 Oct 16.

PMID:
29039416
15.

Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome.

Garone C, D'Souza AR, Dallabona C, Lodi T, Rebelo-Guiomar P, Rorbach J, Donati MA, Procopio E, Montomoli M, Guerrini R, Zeviani M, Calvo SE, Mootha VK, DiMauro S, Ferrero I, Minczuk M.

Hum Mol Genet. 2017 Nov 1;26(21):4257-4266. doi: 10.1093/hmg/ddx314.

16.

Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies.

Feichtinger RG, Oláhová M, Kishita Y, Garone C, Kremer LS, Yagi M, Uchiumi T, Jourdain AA, Thompson K, D'Souza AR, Kopajtich R, Alston CL, Koch J, Sperl W, Mastantuono E, Strom TM, Wortmann SB, Meitinger T, Pierre G, Chinnery PF, Chrzanowska-Lightowlers ZM, Lightowlers RN, DiMauro S, Calvo SE, Mootha VK, Moggio M, Sciacco M, Comi GP, Ronchi D, Murayama K, Ohtake A, Rebelo-Guiomar P, Kohda M, Kang D, Mayr JA, Taylor RW, Okazaki Y, Minczuk M, Prokisch H.

Am J Hum Genet. 2017 Oct 5;101(4):525-538. doi: 10.1016/j.ajhg.2017.08.015. Epub 2017 Sep 21.

17.

A genetically encoded tool for manipulation of NADP+/NADPH in living cells.

Cracan V, Titov DV, Shen H, Grabarek Z, Mootha VK.

Nat Chem Biol. 2017 Oct;13(10):1088-1095. doi: 10.1038/nchembio.2454. Epub 2017 Aug 7.

18.

Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome.

Lake NJ, Webb BD, Stroud DA, Richman TR, Ruzzenente B, Compton AG, Mountford HS, Pulman J, Zangarelli C, Rio M, Boddaert N, Assouline Z, Sherpa MD, Schadt EE, Houten SM, Byrnes J, McCormick EM, Zolkipli-Cunningham Z, Haude K, Zhang Z, Retterer K, Bai R, Calvo SE, Mootha VK, Christodoulou J, Rötig A, Filipovska A, Cristian I, Falk MJ, Metodiev MD, Thorburn DR.

Am J Hum Genet. 2017 Aug 3;101(2):239-254. doi: 10.1016/j.ajhg.2017.07.005. Erratum in: Am J Hum Genet. 2018 Apr 5;102(4):713.

19.

CLIC, a tool for expanding biological pathways based on co-expression across thousands of datasets.

Li Y, Jourdain AA, Calvo SE, Liu JS, Mootha VK.

PLoS Comput Biol. 2017 Jul 18;13(7):e1005653. doi: 10.1371/journal.pcbi.1005653. eCollection 2017 Jul.

20.

Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy.

Delaney NF, Sharma R, Tadvalkar L, Clish CB, Haller RG, Mootha VK.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8402-8407. doi: 10.1073/pnas.1703338114. Epub 2017 Jul 17.

21.

High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter.

Kamer KJ, Grabarek Z, Mootha VK.

EMBO Rep. 2017 Aug;18(8):1397-1411. doi: 10.15252/embr.201643748. Epub 2017 Jun 14.

22.

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.

Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4241-E4250. doi: 10.1073/pnas.1621511114. Epub 2017 May 8. Erratum in: Proc Natl Acad Sci U S A. 2018 Jan 30;:. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4894-E4896.

23.

Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation.

Hung V, Lam SS, Udeshi ND, Svinkina T, Guzman G, Mootha VK, Carr SA, Ting AY.

Elife. 2017 Apr 25;6. pii: e24463. doi: 10.7554/eLife.24463.

24.

Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast.

Calvo SE, Julien O, Clauser KR, Shen H, Kamer KJ, Wells JA, Mootha VK.

Mol Cell Proteomics. 2017 Apr;16(4):512-523. doi: 10.1074/mcp.M116.063818. Epub 2017 Jan 25.

25.

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation.

Arroyo JD, Jourdain AA, Calvo SE, Ballarano CA, Doench JG, Root DE, Mootha VK.

Cell Metab. 2016 Dec 13;24(6):875-885. doi: 10.1016/j.cmet.2016.08.017. Epub 2016 Sep 22.

26.

Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors.

Vafai SB, Mevers E, Higgins KW, Fomina Y, Zhang J, Mandinova A, Newman D, Shaw SY, Clardy J, Mootha VK.

PLoS One. 2016 Sep 13;11(9):e0162686. doi: 10.1371/journal.pone.0162686. eCollection 2016.

27.

Natural underlying mtDNA heteroplasmy as a potential source of intra-person hiPSC variability.

Perales-Clemente E, Cook AN, Evans JM, Roellinger S, Secreto F, Emmanuele V, Oglesbee D, Mootha VK, Hirano M, Schon EA, Terzic A, Nelson TJ.

EMBO J. 2016 Sep 15;35(18):1979-90. doi: 10.15252/embj.201694892. Epub 2016 Jul 19.

28.

Mitochondrial dysfunction remodels one-carbon metabolism in human cells.

Bao XR, Ong SE, Goldberger O, Peng J, Sharma R, Thompson DA, Vafai SB, Cox AG, Marutani E, Ichinose F, Goessling W, Regev A, Carr SA, Clish CB, Mootha VK.

Elife. 2016 Jun 16;5. pii: e10575. doi: 10.7554/eLife.10575.

29.

Architecture of the mitochondrial calcium uniporter.

Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ.

Nature. 2016 May 12;533(7602):269-73. doi: 10.1038/nature17656. Epub 2016 May 2.

30.

Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio.

Titov DV, Cracan V, Goodman RP, Peng J, Grabarek Z, Mootha VK.

Science. 2016 Apr 8;352(6282):231-5. doi: 10.1126/science.aad4017. Epub 2016 Apr 7.

31.

Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood.

Lewis-Smith D, Kamer KJ, Griffin H, Childs AM, Pysden K, Titov D, Duff J, Pyle A, Taylor RW, Yu-Wai-Man P, Ramesh V, Horvath R, Mootha VK, Chinnery PF.

Neurol Genet. 2016 Mar 3;2(2):e59. doi: 10.1212/NXG.0000000000000059. eCollection 2016 Apr.

32.

Hypoxia as a therapy for mitochondrial disease.

Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK.

Science. 2016 Apr 1;352(6281):54-61. doi: 10.1126/science.aad9642. Epub 2016 Feb 25.

33.

A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome

Thompson Legault J, Strittmatter L, Tardif J, Sharma R, Tremblay-Vaillancourt V, Aubut C, Boucher G, Clish CB, Cyr D, Daneault C, Waters PJ; LSFC Consortium, Vachon L, Morin C, Laprise C, Rioux JD, Mootha VK, Des Rosiers C.

Cell Rep. 2015 Nov 3;13(5):981-9. doi: 10.1016/j.celrep.2015.09.054. Epub 2015 Oct 22.

34.

Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury.

Kishi S, Campanholle G, Gohil VM, Perocchi F, Brooks CR, Morizane R, Sabbisetti V, Ichimura T, Mootha VK, Bonventre JV.

EBioMedicine. 2015 Jul 29;2(9):1090-101. doi: 10.1016/j.ebiom.2015.07.035. eCollection 2015 Sep.

35.

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins.

Calvo SE, Clauser KR, Mootha VK.

Nucleic Acids Res. 2016 Jan 4;44(D1):D1251-7. doi: 10.1093/nar/gkv1003. Epub 2015 Oct 7.

36.

The molecular era of the mitochondrial calcium uniporter.

Kamer KJ, Mootha VK.

Nat Rev Mol Cell Biol. 2015 Sep;16(9):545-53. doi: 10.1038/nrm4039. Epub 2015 Aug 19. Review.

PMID:
26285678
37.

FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy.

Fassone E, Duncan AJ, Taanman JW, Pagnamenta AT, Sadowski MI, Holand T, Qasim W, Rutland P, Calvo SE, Mootha VK, Bitner-Glindzicz M, Rahman S.

Hum Mol Genet. 2015 Jul 15;24(14):4183. doi: 10.1093/hmg/ddv164. Epub 2015 May 28. No abstract available.

38.

IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.

Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J.

Cell Metab. 2015 Apr 7;21(4):609-21. doi: 10.1016/j.cmet.2015.03.006.

39.

Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.

Lennerz BS, Vafai SB, Delaney NF, Clish CB, Deik AA, Pierce KA, Ludwig DS, Mootha VK.

Mol Genet Metab. 2015 Jan;114(1):73-9. doi: 10.1016/j.ymgme.2014.11.010. Epub 2014 Nov 15.

40.

Directed evolution of APEX2 for electron microscopy and proximity labeling.

Lam SS, Martell JD, Kamer KJ, Deerinck TJ, Ellisman MH, Mootha VK, Ting AY.

Nat Methods. 2015 Jan;12(1):51-4. doi: 10.1038/nmeth.3179. Epub 2014 Nov 24.

41.

Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase.

Sinha A, Köhrer C, Weber MH, Masuda I, Mootha VK, Hou YM, RajBhandary UL.

J Biol Chem. 2014 Nov 21;289(47):32729-41. doi: 10.1074/jbc.M114.610626. Epub 2014 Oct 6.

42.

Mutation in the novel nuclear-encoded mitochondrial protein CHCHD10 in a family with autosomal dominant mitochondrial myopathy.

Ajroud-Driss S, Fecto F, Ajroud K, Lalani I, Calvo SE, Mootha VK, Deng HX, Siddique N, Tahmoush AJ, Heiman-Patterson TD, Siddique T.

Neurogenetics. 2015 Jan;16(1):1-9. doi: 10.1007/s10048-014-0421-1. Epub 2014 Sep 6.

43.

Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging.

Hung V, Zou P, Rhee HW, Udeshi ND, Cracan V, Svinkina T, Carr SA, Mootha VK, Ting AY.

Mol Cell. 2014 Jul 17;55(2):332-41. doi: 10.1016/j.molcel.2014.06.003. Epub 2014 Jul 4.

44.

Expansion of biological pathways based on evolutionary inference.

Li Y, Calvo SE, Gutman R, Liu JS, Mootha VK.

Cell. 2014 Jul 3;158(1):213-25. doi: 10.1016/j.cell.2014.05.034.

45.

Reconstitution of the mitochondrial calcium uniporter in yeast.

Kovács-Bogdán E, Sancak Y, Kamer KJ, Plovanich M, Jambhekar A, Huber RJ, Myre MA, Blower MD, Mootha VK.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8985-90. doi: 10.1073/pnas.1400514111. Epub 2014 Jun 2.

46.

The uniporter: from newly identified parts to function.

Kamer KJ, Sancak Y, Mootha VK.

Biochem Biophys Res Commun. 2014 Jul 11;449(4):370-2. doi: 10.1016/j.bbrc.2014.04.143. Epub 2014 May 9. No abstract available.

PMID:
24814702
47.

Functional genomic analysis of human mitochondrial RNA processing.

Wolf AR, Mootha VK.

Cell Rep. 2014 May 8;7(3):918-31. doi: 10.1016/j.celrep.2014.03.035. Epub 2014 Apr 18.

48.

Next generation sequencing with copy number variant detection expands the phenotypic spectrum of HSD17B4-deficiency.

Lieber DS, Hershman SG, Slate NG, Calvo SE, Sims KB, Schmahmann JD, Mootha VK.

BMC Med Genet. 2014 Mar 6;15:30. doi: 10.1186/1471-2350-15-30.

49.

A systematic survey of lipids across mouse tissues.

Jain M, Ngoy S, Sheth SA, Swanson RA, Rhee EP, Liao R, Clish CB, Mootha VK, Nilsson R.

Am J Physiol Endocrinol Metab. 2014 Apr 15;306(8):E854-68. doi: 10.1152/ajpendo.00371.2013. Epub 2014 Feb 11.

50.

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.

Kamer KJ, Mootha VK.

EMBO Rep. 2014 Mar;15(3):299-307. doi: 10.1002/embr.201337946. Epub 2014 Feb 6.

Supplemental Content

Loading ...
Support Center