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Items: 1 to 50 of 70

1.

Cysteine, glutathione and a new genetic code: biochemical adaptations of the primordial cells that spread into open water and survived biospheric oxygenation.

Moosmann B, Schindeldecker M, Hajieva P.

Biol Chem. 2019 Aug 13. pii: /j/bchm.ahead-of-print/hsz-2019-0232/hsz-2019-0232.xml. doi: 10.1515/hsz-2019-0232. [Epub ahead of print] Review.

PMID:
31318686
2.

Neutrophils mediate early cerebral cortical hypoperfusion in a murine model of subarachnoid haemorrhage.

Neulen A, Pantel T, Kosterhon M, Kramer A, Kunath S, Petermeyer M, Moosmann B, Lotz J, Kantelhardt SR, Ringel F, Thal SC.

Sci Rep. 2019 Jun 11;9(1):8460. doi: 10.1038/s41598-019-44906-9.

3.

What is the rate-limiting step towards aging? Chemical reaction kinetics might reconcile contradictory observations in experimental aging research.

Kunath S, Moosmann B.

Geroscience. 2019 Feb 27. doi: 10.1007/s11357-019-00058-2. [Epub ahead of print]

PMID:
30809734
5.

Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines: An update comprising flunitrazolam, norflurazepam, and 4'-chlorodiazepam (Ro5-4864).

Moosmann B, Bisel P, Westphal F, Wilde M, Kempf J, Angerer V, Auwärter V.

Drug Test Anal. 2019 Mar;11(3):541-549. doi: 10.1002/dta.2561. Epub 2019 Feb 5.

PMID:
30578721
6.

Designer Benzodiazepines: Another Class of New Psychoactive Substances.

Moosmann B, Auwärter V.

Handb Exp Pharmacol. 2018;252:383-410. doi: 10.1007/164_2018_154.

PMID:
30367253
7.

Phase I metabolism of the carbazole-derived synthetic cannabinoids EG-018, EG-2201, and MDMB-CHMCZCA and detection in human urine samples.

Mogler L, Franz F, Wilde M, Huppertz LM, Halter S, Angerer V, Moosmann B, Auwärter V.

Drug Test Anal. 2018 Sep;10(9):1417-1429. doi: 10.1002/dta.2398. Epub 2018 May 23.

PMID:
29726116
8.

The role of Plasma Membrane Calcium ATPases (PMCAs) in neurodegenerative disorders.

Hajieva P, Baeken MW, Moosmann B.

Neurosci Lett. 2018 Jan 10;663:29-38. doi: 10.1016/j.neulet.2017.09.033. Review.

PMID:
29452613
9.

Modern diversification of the amino acid repertoire driven by oxygen.

Granold M, Hajieva P, Toşa MI, Irimie FD, Moosmann B.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):41-46. doi: 10.1073/pnas.1717100115. Epub 2017 Dec 19.

10.

Flubromazolam - Basic pharmacokinetic evaluation of a highly potent designer benzodiazepine.

Huppertz LM, Moosmann B, Auwärter V.

Drug Test Anal. 2018 Jan;10(1):206-211. doi: 10.1002/dta.2203. Epub 2017 May 19.

PMID:
28378533
11.

Detection of the recently emerged synthetic cannabinoid 5F-MDMB-PICA in 'legal high' products and human urine samples.

Mogler L, Franz F, Rentsch D, Angerer V, Weinfurtner G, Longworth M, Banister SD, Kassiou M, Moosmann B, Auwärter V.

Drug Test Anal. 2018 Jan;10(1):196-205. doi: 10.1002/dta.2201. Epub 2017 May 24.

PMID:
28371476
12.

Immunoassay screening in urine for synthetic cannabinoids - an evaluation of the diagnostic efficiency.

Franz F, Angerer V, Jechle H, Pegoro M, Ertl H, Weinfurtner G, Janele D, Schlögl C, Friedl M, Gerl S, Mielke R, Zehnle R, Wagner M, Moosmann B, Auwärter V.

Clin Chem Lab Med. 2017 Aug 28;55(9):1375-1384. doi: 10.1515/cclm-2016-0831.

PMID:
28130957
13.

Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection.

Ohlow MJ, Sohre S, Granold M, Schreckenberger M, Moosmann B.

Pharm Res. 2017 Feb;34(2):378-393. doi: 10.1007/s11095-016-2068-0. Epub 2016 Nov 28.

PMID:
27896592
14.
15.

Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.

Allison SE, Chen Y, Petrovic N, Zimmermann S, Moosmann B, Jansch M, Cui PH, Dunstan CR, Mackenzie PI, Murray M.

Int J Biochem Cell Biol. 2016 Nov;80:173-178. doi: 10.1016/j.biocel.2016.10.004. Epub 2016 Oct 5.

PMID:
27720933
16.

Reply to Restolho et al. 'Contactless decontamination of hair samples: cannabinoids'.

Moosmann B, Auwärter V.

Drug Test Anal. 2017 Feb;9(2):289-290. doi: 10.1002/dta.2125. Epub 2016 Nov 18. No abstract available.

PMID:
27783890
17.

Phase I metabolism of the highly potent synthetic cannabinoid MDMB-CHMICA and detection in human urine samples.

Franz F, Angerer V, Moosmann B, Auwärter V.

Drug Test Anal. 2017 May;9(5):744-753. doi: 10.1002/dta.2049. Epub 2016 Sep 21.

PMID:
27504870
18.

Separation and structural characterization of the new synthetic cannabinoid JWH-018 cyclohexyl methyl derivative "NE-CHMIMO" using flash chromatography, GC-MS, IR and NMR spectroscopy.

Angerer V, Bisel P, Moosmann B, Westphal F, Auwärter V.

Forensic Sci Int. 2016 Sep;266:e93-e98. doi: 10.1016/j.forsciint.2016.05.031. Epub 2016 Jun 3.

PMID:
27297324
19.

Metabolites of synthetic cannabinoids in hair--proof of consumption or false friends for interpretation?

Franz F, Angerer V, Hermanns-Clausen M, Auwärter V, Moosmann B.

Anal Bioanal Chem. 2016 May;408(13):3445-52. doi: 10.1007/s00216-016-9422-2. Epub 2016 Mar 2.

PMID:
26935933
20.

In vitro metabolism of the synthetic cannabinoid 3,5-AB-CHMFUPPYCA and its 5,3-regioisomer and investigation of their thermal stability.

Franz F, Angerer V, Brandt SD, McLaughlin G, Kavanagh PV, Moosmann B, Auwärter V.

Drug Test Anal. 2017 Feb;9(2):311-316. doi: 10.1002/dta.1950. Epub 2016 Feb 17.

PMID:
26888282
21.

Reply to 'Sudden Cardiac Death Following Use of the Synthetic Cannabinoid MDMB-CHMICA'.

Angerer V, Franz F, Schwarze B, Moosmann B, Auwärter V.

J Anal Toxicol. 2016 Apr;40(3):240-2. doi: 10.1093/jat/bkw004. Epub 2016 Jan 27. No abstract available.

22.

Brain protein oxidation: what does it reflect?

Hajieva P, Moosmann B.

Neural Regen Res. 2015 Nov;10(11):1729-30. doi: 10.4103/1673-5374.170294. No abstract available.

23.

Finding cannabinoids in hair does not prove cannabis consumption.

Moosmann B, Roth N, Auwärter V.

Sci Rep. 2015 Oct 7;5:14906. doi: 10.1038/srep14906.

24.

Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro-Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice.

Sebastiani A, Granold M, Ditter A, Sebastiani P, Gölz C, Pöttker B, Luh C, Schaible EV, Radyushkin K, Timaru-Kast R, Werner C, Schäfer MK, Engelhard K, Moosmann B, Thal SC.

Crit Care Med. 2016 Feb;44(2):e70-82. doi: 10.1097/CCM.0000000000001284.

PMID:
26317567
25.

Hair analysis for Δ(9) -tetrahydrocannabinolic acid A (THCA-A) and Δ(9) -tetrahydrocannabinol (THC) after handling cannabis plant material.

Moosmann B, Roth N, Auwärter V.

Drug Test Anal. 2016 Jan;8(1):128-32. doi: 10.1002/dta.1830. Epub 2015 Jun 21.

PMID:
26097164
26.

Designer benzodiazepines: A new challenge.

Moosmann B, King LA, Auwärter V.

World Psychiatry. 2015 Jun;14(2):248. doi: 10.1002/wps.20236. No abstract available.

27.

Inhalation therapy with the synthetic TIP-like peptide AP318 attenuates pulmonary inflammation in a porcine sepsis model.

Hartmann EK, Ziebart A, Thomas R, Liu T, Schad A, Tews M, Moosmann B, Kamuf J, Duenges B, Thal SC, David M.

BMC Pulm Med. 2015 Feb 7;15:7. doi: 10.1186/s12890-015-0002-6.

28.

Protein-borne methionine residues as structural antioxidants in mitochondria.

Schindeldecker M, Moosmann B.

Amino Acids. 2015 Jul;47(7):1421-32. doi: 10.1007/s00726-015-1955-8. Epub 2015 Apr 10.

PMID:
25859649
29.

High membrane protein oxidation in the human cerebral cortex.

Granold M, Moosmann B, Staib-Lasarzik I, Arendt T, Del Rey A, Engelhard K, Behl C, Hajieva P.

Redox Biol. 2015;4:200-7. doi: 10.1016/j.redox.2014.12.013. Epub 2014 Dec 24.

30.

RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy.

Spang N, Feldmann A, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, Koziollek-Drechsler I, Clement AM, Moosmann B, Jung J, Behrends C, Dikic I, Kern A, Behl C.

Autophagy. 2014;10(12):2297-309. doi: 10.4161/15548627.2014.994359.

31.

The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in mice.

Songarj P, Luh C, Staib-Lasarzik I, Engelhard K, Moosmann B, Thal SC.

Neurosci Lett. 2015 Jan 1;584:253-8. doi: 10.1016/j.neulet.2014.10.037. Epub 2014 Oct 28.

PMID:
25449871
32.

Membrane protein oxidation determines neuronal degeneration.

Hajieva P, Bayatti N, Granold M, Behl C, Moosmann B.

J Neurochem. 2015 May;133(3):352-67. doi: 10.1111/jnc.12987. Epub 2015 Feb 4.

33.

Cannabinoid findings in children hair - what do they really tell us? An assessment in the light of three different analytical methods with focus on interpretation of Δ9-tetrahydrocannabinolic acid A concentrations.

Moosmann B, Roth N, Hastedt M, Jacobsen-Bauer A, Pragst F, Auwärter V.

Drug Test Anal. 2015 May;7(5):349-57. doi: 10.1002/dta.1692. Epub 2014 Jul 28.

PMID:
25069954
34.

Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis.

Liebl MP, Kaya AM, Tenzer S, Mittenzwei R, Koziollek-Drechsler I, Schild H, Moosmann B, Behl C, Clement AM.

Free Radic Biol Med. 2014 Jul;72:41-54. doi: 10.1016/j.freeradbiomed.2014.04.008. Epub 2014 Apr 15.

35.

Investigation of the in vitro toxicological properties of the synthetic cannabimimetic drug CP-47,497-C8.

Koller VJ, Auwärter V, Grummt T, Moosmann B, Mišík M, Knasmüller S.

Toxicol Appl Pharmacol. 2014 Jun 1;277(2):164-71. doi: 10.1016/j.taap.2014.03.014. Epub 2014 Mar 28.

PMID:
24686252
36.

Characterization of the designer benzodiazepine diclazepam and preliminary data on its metabolism and pharmacokinetics.

Moosmann B, Bisel P, Auwärter V.

Drug Test Anal. 2014 Jul-Aug;6(7-8):757-63. doi: 10.1002/dta.1628. Epub 2014 Mar 6.

PMID:
24604775
37.

Detection and identification of the designer benzodiazepine flubromazepam and preliminary data on its metabolism and pharmacokinetics.

Moosmann B, Huppertz LM, Hutter M, Buchwald A, Ferlaino S, Auwärter V.

J Mass Spectrom. 2013 Nov;48(11):1150-9. doi: 10.1002/jms.3279.

PMID:
24259203
38.

Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism.

Hutter M, Moosmann B, Kneisel S, Auwärter V.

J Mass Spectrom. 2013 Jul;48(7):885-94. doi: 10.1002/jms.3229.

PMID:
23832945
39.

Stability of 11 prevalent synthetic cannabinoids in authentic neat oral fluid samples: glass versus polypropylene containers at different temperatures.

Kneisel S, Speck M, Moosmann B, Auwärter V.

Drug Test Anal. 2013 Jul;5(7):602-6. doi: 10.1002/dta.1497. Epub 2013 May 22.

PMID:
23704054
40.

Hair analysis for THCA-A, THC and CBN after passive in vivo exposure to marijuana smoke.

Moosmann B, Roth N, Auwärter V.

Drug Test Anal. 2014 Jan-Feb;6(1-2):119-25. doi: 10.1002/dta.1474. Epub 2013 Apr 15.

PMID:
23589391
41.

LC/ESI-MS/MS method for quantification of 28 synthetic cannabinoids in neat oral fluid and its application to preliminary studies on their detection windows.

Kneisel S, Speck M, Moosmann B, Corneillie TM, Butlin NG, Auwärter V.

Anal Bioanal Chem. 2013 May;405(14):4691-706. doi: 10.1007/s00216-013-6887-0. Epub 2013 Mar 28.

PMID:
23535743
42.

Development and validation of an LC-MS/MS method for quantification of Δ9-tetrahydrocannabinolic acid A (THCA-A), THC, CBN and CBD in hair.

Roth N, Moosmann B, Auwärter V.

J Mass Spectrom. 2013 Feb;48(2):227-33. doi: 10.1002/jms.3152.

PMID:
23378095
43.

Prooxidative toxicity and selenoprotein suppression by cerivastatin in muscle cells.

Fuhrmeister J, Tews M, Kromer A, Moosmann B.

Toxicol Lett. 2012 Dec 17;215(3):219-27. doi: 10.1016/j.toxlet.2012.10.010. Epub 2012 Oct 22.

PMID:
23092657
44.

A fast and inexpensive procedure for the isolation of synthetic cannabinoids from 'Spice' products using a flash chromatography system.

Moosmann B, Kneisel S, Wohlfarth A, Brecht V, Auwärter V.

Anal Bioanal Chem. 2013 May;405(12):3929-35. doi: 10.1007/s00216-012-6462-0. Epub 2012 Oct 14.

PMID:
23064708
45.

Is the chromanol head group of vitamin E nature's final truth on chain-breaking antioxidants?

Ohlow MJ, Granold M, Schreckenberger M, Moosmann B.

FEBS Lett. 2012 Mar 23;586(6):711-6. doi: 10.1016/j.febslet.2012.01.022. Epub 2012 Jan 24.

46.

Separation and structural characterization of the synthetic cannabinoids JWH-412 and 1-[(5-fluoropentyl)-1H-indol-3yl]-(4-methylnaphthalen-1-yl)methanone using GC-MS, NMR analysis and a flash chromatography system.

Moosmann B, Kneisel S, Girreser U, Brecht V, Westphal F, Auwärter V.

Forensic Sci Int. 2012 Jul 10;220(1-3):e17-22. doi: 10.1016/j.forsciint.2011.12.010. Epub 2012 Jan 20.

PMID:
22264627
47.

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation.

Meng F, Yao D, Shi Y, Kabakoff J, Wu W, Reicher J, Ma Y, Moosmann B, Masliah E, Lipton SA, Gu Z.

Mol Neurodegener. 2011 May 19;6:34. doi: 10.1186/1750-1326-6-34.

48.

Differential cysteine depletion in respiratory chain complexes enables the distinction of longevity from aerobicity.

Schindeldecker M, Stark M, Behl C, Moosmann B.

Mech Ageing Dev. 2011 Apr;132(4):171-9. doi: 10.1016/j.mad.2011.03.002. Epub 2011 Mar 29.

PMID:
21453719
49.

Phenothiazine: the seven lives of pharmacology's first lead structure.

Ohlow MJ, Moosmann B.

Drug Discov Today. 2011 Feb;16(3-4):119-31. doi: 10.1016/j.drudis.2011.01.001. Epub 2011 Jan 13. Review.

PMID:
21237283
50.

Respiratory chain cysteine and methionine usage indicate a causal role for thiyl radicals in aging.

Moosmann B.

Exp Gerontol. 2011 Feb-Mar;46(2-3):164-9. doi: 10.1016/j.exger.2010.08.034. Epub 2010 Sep 16. Review.

PMID:
20850516

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