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Items: 1 to 50 of 96

1.

Evaluation of Targeted Delivery to the Brain Using Magnetic Immunoliposomes and Magnetic Force.

Thomsen LB, Linemann T, Birkelund S, Tarp GA, Moos T.

Materials (Basel). 2019 Oct 31;12(21). pii: E3576. doi: 10.3390/ma12213576.

2.

Impairment of the Developing Human Brain in Iron Deficiency: Correlations to Findings in Experimental Animals and Prospects for Early Intervention Therapy.

Markova V, Holm C, Pinborg AB, Thomsen LL, Moos T.

Pharmaceuticals (Basel). 2019 Aug 14;12(3). pii: E120. doi: 10.3390/ph12030120. Review.

3.

Targeting the transferrin receptor for brain drug delivery.

Johnsen KB, Burkhart A, Thomsen LB, Andresen TL, Moos T.

Prog Neurobiol. 2019 Oct;181:101665. doi: 10.1016/j.pneurobio.2019.101665. Epub 2019 Jul 31. Review.

PMID:
31376426
4.

Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo.

Johnsen KB, Bak M, Melander F, Thomsen MS, Burkhart A, Kempen PJ, Andresen TL, Moos T.

J Control Release. 2019 Feb 10;295:237-249. doi: 10.1016/j.jconrel.2019.01.005. Epub 2019 Jan 10.

PMID:
30633947
5.

Correction to: Hepcidin Mediates Transcriptional Changes in Ferroportin mRNA in Differentiated Neuronal-like PC12 Cells Subjected to Iron Challenge.

Helgudottir SS, Lichota J, Burkhart A, Moos T.

Mol Neurobiol. 2019 Apr;56(4):2375-2378. doi: 10.1007/s12035-018-1282-7.

PMID:
30128649
6.

Hepcidin Mediates Transcriptional Changes in Ferroportin mRNA in Differentiated Neuronal-Like PC12 Cells Subjected to Iron Challenge.

Helgudottir SS, Lichota J, Burkhart A, Moos T.

Mol Neurobiol. 2019 Apr;56(4):2362-2374. doi: 10.1007/s12035-018-1241-3. Epub 2018 Jul 20. Erratum in: Mol Neurobiol. 2018 Aug 20;:.

PMID:
30027341
7.

Iron deficiency and iron treatment in the fetal developing brain - a pilot study introducing an experimental rat model.

Moos T, Skjørringe T, Thomsen LL.

Reprod Health. 2018 Jun 22;15(Suppl 1):93. doi: 10.1186/s12978-018-0537-0.

8.

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles.

Johnsen KB, Bak M, Kempen PJ, Melander F, Burkhart A, Thomsen MS, Nielsen MS, Moos T, Andresen TL.

Theranostics. 2018 May 24;8(12):3416-3436. doi: 10.7150/thno.25228. eCollection 2018.

9.

[The blood-brain barrier in ageing persons].

Haaning N, Damsgaard EM, Moos T.

Ugeskr Laeger. 2018 Mar 26;180(13). pii: V08170576. Review. Danish.

PMID:
29587956
10.

The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro.

Toth AE, Siupka P, P Augustine TJ, Venø ST, Thomsen LB, Moos T, Lohi HT, Madsen P, Lykke-Hartmann K, Nielsen MS.

Mol Neurobiol. 2018 Nov;55(11):8522-8537. doi: 10.1007/s12035-018-0988-x. Epub 2018 Mar 20.

PMID:
29560581
11.

On the use of liposome controls in studies investigating the clinical potential of extracellular vesicle-based drug delivery systems - A commentary.

Johnsen KB, Gudbergsson JM, Duroux M, Moos T, Andresen TL, Simonsen JB.

J Control Release. 2018 Jan 10;269:10-14. doi: 10.1016/j.jconrel.2017.11.002. Epub 2017 Nov 7. Review.

PMID:
29126999
12.

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma.

Johnsen KB, Burkhart A, Melander F, Kempen PJ, Vejlebo JB, Siupka P, Nielsen MS, Andresen TL, Moos T.

Sci Rep. 2017 Sep 4;7(1):10396. doi: 10.1038/s41598-017-11220-1.

13.

The vascular basement membrane in the healthy and pathological brain.

Thomsen MS, Routhe LJ, Moos T.

J Cereb Blood Flow Metab. 2017 Oct;37(10):3300-3317. doi: 10.1177/0271678X17722436. Epub 2017 Jul 28. Review.

14.

The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury.

Xiang J, Routhe LJ, Wilkinson DA, Hua Y, Moos T, Xi G, Keep RF.

Fluids Barriers CNS. 2017 Mar 28;14(1):8. doi: 10.1186/s12987-017-0056-3. Review.

15.

Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells.

Siupka P, Hersom MN, Lykke-Hartmann K, Johnsen KB, Thomsen LB, Andresen TL, Moos T, Abbott NJ, Brodin B, Nielsen MS.

J Cereb Blood Flow Metab. 2017 Jul;37(7):2598-2613. doi: 10.1177/0271678X17700665. Epub 2017 Mar 24.

16.

Transfection of primary brain capillary endothelial cells for protein synthesis and secretion of recombinant erythropoietin: a strategy to enable protein delivery to the brain.

Burkhart A, Andresen TL, Aigner A, Thomsen LB, Moos T.

Cell Mol Life Sci. 2017 Jul;74(13):2467-2485. doi: 10.1007/s00018-017-2501-5. Epub 2017 Mar 14.

PMID:
28293718
17.

Metal-Dependent Regulation of ATP7A and ATP7B in Fibroblast Cultures.

Lenartowicz M, Moos T, Ogórek M, Jensen TG, Møller LB.

Front Mol Neurosci. 2016 Aug 18;9:68. doi: 10.3389/fnmol.2016.00068. eCollection 2016.

18.

Geographical Variation in Antipsychotic Drug Use in Elderly Patients with Dementia: A Nationwide Study.

Zakarias JK, Jensen-Dahm C, Nørgaard A, Stevnsborg L, Gasse C, Andersen BG, Søren J, Waldorff FB, Moos T, Waldemar G.

J Alzheimers Dis. 2016 Oct 4;54(3):1183-1192.

PMID:
27567863
19.

Targeted Vascular Drug Delivery in Cerebral Cancer.

Humle N, Johnsen KB, Arendt GA, Nielsen RP, Moos T, Thomsen LB.

Curr Pharm Des. 2016;22(35):5487-5504. Review.

PMID:
27464719
20.

Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier.

Thomsen MS, Birkelund S, Burkhart A, Stensballe A, Moos T.

J Neurochem. 2017 Mar;140(5):741-754. doi: 10.1111/jnc.13747. Epub 2016 Sep 8.

21.

Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes.

Johnsen KB, Gudbergsson JM, Skov MN, Christiansen G, Gurevich L, Moos T, Duroux M.

Cytotechnology. 2016 Oct;68(5):2125-38. doi: 10.1007/s10616-016-9952-7. Epub 2016 Feb 8.

22.

Handling iron in restorative neuroscience.

Routhe LJ, Moos T.

Neural Regen Res. 2015 Oct;10(10):1558-9. doi: 10.4103/1673-5374.165316. No abstract available.

23.

Expression of Iron-Related Proteins at the Neurovascular Unit Supports Reduction and Reoxidation of Iron for Transport Through the Blood-Brain Barrier.

Burkhart A, Skjørringe T, Johnsen KB, Siupka P, Thomsen LB, Nielsen MS, Thomsen LL, Moos T.

Mol Neurobiol. 2016 Dec;53(10):7237-7253. Epub 2015 Dec 21.

PMID:
26687231
24.

Revisiting nanoparticle technology for blood-brain barrier transport: Unfolding at the endothelial gate improves the fate of transferrin receptor-targeted liposomes.

Johnsen KB, Moos T.

J Control Release. 2016 Jan 28;222:32-46. doi: 10.1016/j.jconrel.2015.11.032. Epub 2015 Dec 3. Review.

PMID:
26658072
25.

Targeted drug delivery to the brain using magnetic nanoparticles.

Thomsen LB, Thomsen MS, Moos T.

Ther Deliv. 2015;6(10):1145-55. doi: 10.4155/tde.15.56. Epub 2015 Oct 8. Review.

26.

Transfection of brain capillary endothelial cells in primary culture with defined blood-brain barrier properties.

Burkhart A, Thomsen LB, Thomsen MS, Lichota J, Fazakas C, Krizbai I, Moos T.

Fluids Barriers CNS. 2015 Aug 7;12:19. doi: 10.1186/s12987-015-0015-9.

27.

A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial cells, Astrocytes and Pericytes.

Thomsen LB, Burkhart A, Moos T.

PLoS One. 2015 Aug 4;10(8):e0134765. doi: 10.1371/journal.pone.0134765. eCollection 2015.

28.

Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology.

Skjørringe T, Burkhart A, Johnsen KB, Moos T.

Front Mol Neurosci. 2015 Jun 8;8:19. doi: 10.3389/fnmol.2015.00019. eCollection 2015. Review.

29.

Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons.

Thomsen MS, Andersen MV, Christoffersen PR, Jensen MD, Lichota J, Moos T.

Neurobiol Dis. 2015 Sep;81:108-18. doi: 10.1016/j.nbd.2015.03.013. Epub 2015 Mar 20.

PMID:
25801802
30.

Accessing targeted nanoparticles to the brain: the vascular route.

Burkhart A, Azizi M, Thomsen MS, Thomsen LB, Moos T.

Curr Med Chem. 2014;21(36):4092-9. Review.

PMID:
25039779
31.

A comprehensive overview of exosomes as drug delivery vehicles - endogenous nanocarriers for targeted cancer therapy.

Johnsen KB, Gudbergsson JM, Skov MN, Pilgaard L, Moos T, Duroux M.

Biochim Biophys Acta. 2014 Aug;1846(1):75-87. doi: 10.1016/j.bbcan.2014.04.005. Epub 2014 Apr 18. Review.

PMID:
24747178
32.

Cripto-1 expression in glioblastoma multiforme.

Pilgaard L, Mortensen JH, Henriksen M, Olesen P, Sørensen P, Laursen R, Vyberg M, Agger R, Zachar V, Moos T, Duroux M.

Brain Pathol. 2014 Jul;24(4):360-70. doi: 10.1111/bpa.12131. Epub 2014 Mar 28.

PMID:
24521322
33.

Development of a novel lipophilic, magnetic nanoparticle for in vivo drug delivery.

Linemann T, Thomsen LB, Jardin KG, Laursen JC, Jensen JB, Lichota J, Moos T.

Pharmaceutics. 2013 Apr 23;5(2):246-60. doi: 10.3390/pharmaceutics5020246.

34.

Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration.

Andersen HH, Johnsen KB, Moos T.

Cell Mol Life Sci. 2014 May;71(9):1607-22. doi: 10.1007/s00018-013-1509-8. Epub 2013 Nov 12. Review.

35.

Targeted antiepidermal growth factor receptor (cetuximab) immunoliposomes enhance cellular uptake in vitro and exhibit increased accumulation in an intracranial model of glioblastoma multiforme.

Mortensen JH, Jeppesen M, Pilgaard L, Agger R, Duroux M, Zachar V, Moos T.

J Drug Deliv. 2013;2013:209205. doi: 10.1155/2013/209205. Epub 2013 Sep 23.

36.

Uptake and transport of superparamagnetic iron oxide nanoparticles through human brain capillary endothelial cells.

Thomsen LB, Linemann T, Pondman KM, Lichota J, Kim KS, Pieters RJ, Visser GM, Moos T.

ACS Chem Neurosci. 2013 Oct 16;4(10):1352-60. doi: 10.1021/cn400093z. Epub 2013 Aug 26.

37.

Impairment of interrelated iron- and copper homeostatic mechanisms in brain contributes to the pathogenesis of neurodegenerative disorders.

Skjørringe T, Møller LB, Moos T.

Front Pharmacol. 2012 Sep 25;3:169. doi: 10.3389/fphar.2012.00169. eCollection 2012.

38.

Brain delivery systems via mechanism independent of receptor-mediated endocytosis and adsorptive-mediated endocytosis.

Thomsen LB, Lichota J, Eskehave TN, Linemann T, Mortensen JH, du Jardin KG, Moos T.

Curr Pharm Biotechnol. 2012 Sep;13(12):2349-54. Review.

PMID:
23016641
39.

Chronic vitamin C deficiency does not accelerate oxidative stress in ageing brains of guinea pigs.

Tveden-Nyborg P, Hasselholt S, Miyashita N, Moos T, Poulsen HE, Lykkesfeldt J.

Basic Clin Pharmacol Toxicol. 2012 Jun;110(6):524-9. doi: 10.1111/j.1742-7843.2011.00852.x. Epub 2012 Jan 20.

41.

Gene delivery by pullulan derivatives in brain capillary endothelial cells for protein secretion.

Thomsen LB, Lichota J, Kim KS, Moos T.

J Control Release. 2011 Apr 10;151(1):45-50. doi: 10.1016/j.jconrel.2011.01.002. Epub 2011 Jan 18.

PMID:
21251935
42.

Heterogenous distribution of ferroportin-containing neurons in mouse brain.

Boserup MW, Lichota J, Haile D, Moos T.

Biometals. 2011 Apr;24(2):357-75. doi: 10.1007/s10534-010-9405-2. Epub 2011 Jan 7.

PMID:
21213119
43.

Developmental iron uptake and axonal transport in the retina of the rat.

Moos T, Bernth N, Courtois Y, Morgan EH.

Mol Cell Neurosci. 2011 Mar;46(3):607-13. doi: 10.1016/j.mcn.2010.12.013. Epub 2011 Jan 3.

PMID:
21211566
44.

Macromolecular drug transport into the brain using targeted therapy.

Lichota J, Skjørringe T, Thomsen LB, Moos T.

J Neurochem. 2010 Apr;113(1):1-13. doi: 10.1111/j.1471-4159.2009.06544.x. Epub 2009 Dec 14. Review.

45.

Fulminant lymphocytic choriomeningitis virus-induced inflammation of the CNS involves a cytokine-chemokine-cytokine-chemokine cascade.

Christensen JE, Simonsen S, Fenger C, Sørensen MR, Moos T, Christensen JP, Finsen B, Thomsen AR.

J Immunol. 2009 Jan 15;182(2):1079-87.

46.

Ubxd1 is a novel co-factor of the human p97 ATPase.

Madsen L, Andersen KM, Prag S, Moos T, Semple CA, Seeger M, Hartmann-Petersen R.

Int J Biochem Cell Biol. 2008;40(12):2927-42. doi: 10.1016/j.biocel.2008.06.008. Epub 2008 Jul 5.

PMID:
18656546
47.

VCAM-1 directed immunoliposomes selectively target tumor vasculature in vivo.

Gosk S, Moos T, Gottstein C, Bendas G.

Biochim Biophys Acta. 2008 Apr;1778(4):854-63. doi: 10.1016/j.bbamem.2007.12.021. Epub 2008 Jan 5.

48.

Iron trafficking inside the brain.

Moos T, Rosengren Nielsen T, Skjørringe T, Morgan EH.

J Neurochem. 2007 Dec;103(5):1730-40. Epub 2007 Oct 22. Review.

49.
50.

Ferroportin in the postnatal rat brain: implications for axonal transport and neuronal export of iron.

Moos T, Rosengren Nielsen T.

Semin Pediatr Neurol. 2006 Sep;13(3):149-57.

PMID:
17101453

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