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Items: 1 to 50 of 55

1.

Evaluation of the Drug-Drug Interaction Potential of Acalabrutinib and Its Active Metabolite, ACP-5862, Using a Physiologically-Based Pharmacokinetic Modeling Approach.

Zhou D, Podoll T, Xu Y, Moorthy G, Vishwanathan K, Ware J, Slatter JG, Al-Huniti N.

CPT Pharmacometrics Syst Pharmacol. 2019 May 1. doi: 10.1002/psp4.12408. [Epub ahead of print]

2.

Morphine Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.

Zuppa AF, Benitez GR, Zane NR, Curley MAQ, Bradfield J, Hakonarson H, Gastonguay MS, Moorthy G, Prodell J, Gastonguay MR.

Crit Care Med. 2019 Jun;47(6):e485-e494. doi: 10.1097/CCM.0000000000003741.

PMID:
30920410
3.

Midazolam Dose Optimization in Critically Ill Pediatric Patients With Acute Respiratory Failure: A Population Pharmacokinetic-Pharmacogenomic Study.

Zuppa AF, Conrado DJ, Zane NR, Curley MAQ, Bradfield J, Hakonarson H, Gastonguay MS, Moorthy G, Prodell J, Gastonguay MR.

Crit Care Med. 2019 Apr;47(4):e301-e309. doi: 10.1097/CCM.0000000000003638.

PMID:
30672747
4.

An improved ultra-high-performance liquid chromatography-tandem mass spectrometric method for the quantitation of dexmedetomidine in small volume of pediatric plasma.

Moorthy GS, Vedar C, Moorthy AS, Prodell JL, Zuppa AF.

Biomed Chromatogr. 2019 Jun;33(6):e4487. doi: 10.1002/bmc.4487. Epub 2019 Feb 7.

PMID:
30664276
5.

Development and validation of a volumetric absorptive microsampling assay for analysis of voriconazole and voriconazole N-oxide in human whole blood.

Moorthy GS, Vedar C, Zane N, Prodell JL, Zuppa AF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jan 15;1105:67-75. doi: 10.1016/j.jchromb.2018.12.007. Epub 2018 Dec 8.

PMID:
30572203
6.

A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children.

Zuppa AF, Zane NR, Moorthy G, Dalton HJ, Abraham A, Reeder RW, Carcillo JA, Yates AR, Meert KL, Berg RA, Sapru A, Mourani P, Notterman DA, Dean JM, Gastonguay MR; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).

Pediatr Crit Care Med. 2019 Jan;20(1):62-70. doi: 10.1097/PCC.0000000000001786.

PMID:
30431557
7.

A validated HPLC-MS/MS method for estimating the concentration of the ganglioside, GD2, in human plasma or serum.

Busch CM, Desai AV, Moorthy GS, Fox E, Balis FM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Dec 1;1102-1103:60-65. doi: 10.1016/j.jchromb.2018.10.010. Epub 2018 Oct 12.

PMID:
30368044
8.

The Management of Nausea at the End of Life.

Moorthy GS, Letizia M.

J Hosp Palliat Nurs. 2018 Oct;20(5):442-449. doi: 10.1097/NJH.0000000000000453.

PMID:
30188436
9.

Effect of gastrocystoplasty on height and bone density in children.

Singh A, Moorthy G, Bajpai M.

Urol Ann. 2018 Jul-Sep;10(3):313-316. doi: 10.4103/0974-7796.236524.

10.

Delivery of TDF/FTC for Pre-exposure Prophylaxis to Prevent HIV-1 Acquisition in Young Adult Men Who Have Sex With Men and Transgender Women of Color Using a Urine Adherence Assay.

Lalley-Chareczko L, Clark D, Conyngham C, Zuppa A, Moorthy G, Mounzer K, Koenig H.

J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):173-178. doi: 10.1097/QAI.0000000000001772.

PMID:
29905593
11.

Polymorphisms in cytochrome P450 are associated with extensive efavirenz pharmacokinetics and CNS toxicities in an HIV cohort in Botswana.

Vujkovic M, Bellamy SL, Zuppa AF, Gastonguay MR, Moorthy GS, Ratshaa B, Han X, Steenhoff AP, Mosepele M, Strom BL, Bisson GP, Aplenc R, Gross R.

Pharmacogenomics J. 2018 Sep;18(5):678-688. doi: 10.1038/s41397-018-0028-2. Epub 2018 Jun 1.

12.

Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model.

Nguyen F, Alferiev I, Guan P, Guerrero DT, Kolla V, Moorthy GS, Chorny M, Brodeur GM.

Clin Cancer Res. 2018 Jun 1;24(11):2585-2593. doi: 10.1158/1078-0432.CCR-17-3811. Epub 2018 Mar 7.

13.

Development of reduced graphene oxide (rGO)-isabgol nanocomposite dressings for enhanced vascularization and accelerated wound healing in normal and diabetic rats.

Thangavel P, Kannan R, Ramachandran B, Moorthy G, Suguna L, Muthuvijayan V.

J Colloid Interface Sci. 2018 May 1;517:251-264. doi: 10.1016/j.jcis.2018.01.110. Epub 2018 Feb 2.

PMID:
29428812
14.

Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling.

Elia J, Ungal G, Kao C, Ambrosini A, De Jesus-Rosario N, Larsen L, Chiavacci R, Wang T, Kurian C, Titchen K, Sykes B, Hwang S, Kumar B, Potts J, Davis J, Malatack J, Slattery E, Moorthy G, Zuppa A, Weller A, Byrne E, Li YR, Kraft WK, Hakonarson H.

Nat Commun. 2018 Jan 16;9(1):4. doi: 10.1038/s41467-017-02244-2.

15.

Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice.

Chikara S, Mamidi S, Sreedasyam A, Chittem K, Pietrofesa R, Zuppa A, Moorthy G, Dyer N, Christofidou-Solomidou M, Reindl KM.

Cancer Prev Res (Phila). 2018 Jan;11(1):27-37. doi: 10.1158/1940-6207.CAPR-17-0119. Epub 2017 Oct 26.

16.

Harnessing Meta-analysis to Refine an Oncology Patient Population for Physiology-Based Pharmacokinetic Modeling of Drugs.

Schwenger E, Reddy VP, Moorthy G, Sharma P, Tomkinson H, Masson E, Vishwanathan K.

Clin Pharmacol Ther. 2018 Feb;103(2):271-280. doi: 10.1002/cpt.917. Epub 2017 Nov 20. Review.

PMID:
29063606
17.

Development and validation of a sensitive assay for analysis of midazolam, free and conjugated 1-hydroxymidazolam and 4-hydroxymidazolam in pediatric plasma: Application to Pediatric Pharmacokinetic Study.

Moorthy GS, Jogiraju H, Vedar C, Zuppa AF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 1;1067:1-9. doi: 10.1016/j.jchromb.2017.09.030. Epub 2017 Sep 28.

18.

Ketamine and norketamine stability in whole blood at ambient and 4°C conditions.

Tran BD, Moorthy GS, Zuppa AF.

Biomed Chromatogr. 2018 Mar;32(3). doi: 10.1002/bmc.4104. Epub 2017 Nov 9.

19.

CYP2B6 genotypes and early efavirenz-based HIV treatment outcomes in Botswana.

Gross R, Bellamy SL, Ratshaa B, Han X, Vujkovic M, Aplenc R, Steenhoff AP, Mosepele M, Moorthy G, Zuppa AF, Strom BL, Bisson GP.

AIDS. 2017 Sep 24;31(15):2107-2113. doi: 10.1097/QAD.0000000000001593.

20.

Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles.

Gupta KH, Goldufsky JW, Wood SJ, Tardi NJ, Moorthy GS, Gilbert DZ, Zayas JP, Hahm E, Altintas MM, Reiser J, Shafikhani SH.

Dev Cell. 2017 Jun 19;41(6):674-684.e5. doi: 10.1016/j.devcel.2017.05.014.

21.

Brief Report: CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-Treated HIV-Infected Patients in Botswana.

Vujkovic M, Bellamy SL, Zuppa AF, Gastonguay M, Moorthy GS, Ratshaa BR, Han X, Steenhoff AP, Mosepele M, Strom BL, Aplenc R, Bisson GP, Gross R.

J Acquir Immune Defic Syndr. 2017 Aug 1;75(4):488-491. doi: 10.1097/QAI.0000000000001442.

22.

Urine assay for tenofovir to monitor adherence in real time to tenofovir disoproxil fumarate/emtricitabine as pre-exposure prophylaxis.

Koenig HC, Mounzer K, Daughtridge GW, Sloan CE, Lalley-Chareczko L, Moorthy GS, Conyngham SC, Zuppa AF, Montaner LJ, Tebas P.

HIV Med. 2017 Jul;18(6):412-418. doi: 10.1111/hiv.12518. Epub 2017 Apr 26.

23.

A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies.

Wise-Draper TM, Moorthy G, Salkeni MA, Karim NA, Thomas HE, Mercer CA, Beg MS, O'Gara S, Olowokure O, Fathallah H, Kozma SC, Thomas G, Rixe O, Desai P, Morris JC.

Target Oncol. 2017 Jun;12(3):323-332. doi: 10.1007/s11523-017-0482-9.

24.

A case study of chewed Truvada® for PrEP maintaining protective drug levels as measured by a novel urine tenofovir assay.

Lalley-Chareczko L, Clark D, Zuppa AF, Moorthy G, Conyngham C, Mounzer K, Koenig H.

Antivir Ther. 2017;22(7):639-641. doi: 10.3851/IMP3151. Epub 2017 Mar 6.

PMID:
28260694
25.

Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn.

Giaccone A, Zuppa AF, Sood B, Cohen MS, O'Byrne ML, Moorthy G, Mathur A, Kirpalani H.

Am J Perinatol. 2017 Jul;34(8):749-758. doi: 10.1055/s-0036-1597996. Epub 2017 Jan 18.

26.

Sacrococcygeal Teratoma: Mistreated With Repeated Aspirations.

G R, R G, P S, G M, Lu D.

APSP J Case Rep. 2016 Jun 15;7(3):26. doi: 10.21699/ajcr.v7i3.422. eCollection 2016 Jul-Aug. No abstract available.

27.

A Rare Association of Non-Compaction of the Ventricular Myocardium, and Non-Immune Hydrops Fetalis.

Nandyal R, Moorthy G.

J Okla State Med Assoc. 2016 Apr-May;109(4-5):146-50.

PMID:
27328555
28.

Skeletal muscle and plasma concentrations of cefazolin during complex paediatric spinal surgery.

Himebauch AS, Sankar WN, Flynn JM, Sisko MT, Moorthy GS, Gerber JS, Zuppa AF, Fox E, Dormans JP, Kilbaugh TJ.

Br J Anaesth. 2016 Jul;117(1):87-94. doi: 10.1093/bja/aew032.

29.

Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV.

Barrett JS, Spitsin S, Moorthy G, Barrett K, Baker K, Lackner A, Tulic F, Winters A, Evans DL, Douglas SD.

J Transl Med. 2016 May 26;14(1):148. doi: 10.1186/s12967-016-0904-y.

30.

Renal Function Descriptors in Neonates: Which Creatinine-Based Formula Best Describes Vancomycin Clearance?

Bhongsatiern J, Stockmann C, Yu T, Constance JE, Moorthy G, Spigarelli MG, Desai PB, Sherwin CM.

J Clin Pharmacol. 2016 May;56(5):528-40. doi: 10.1002/jcph.650. Epub 2015 Dec 18. Review.

PMID:
26412385
31.

Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents.

van Rongen A, Vaughns JD, Moorthy GS, Barrett JS, Knibbe CA, van den Anker JN.

Br J Clin Pharmacol. 2015 Nov;80(5):1185-96. doi: 10.1111/bcp.12693. Epub 2015 Sep 10.

32.

Safety, tolerability and pharmacokinetics of 2-pyridylacetic acid, a major metabolite of betahistine, in a phase 1 dose escalation study in subjects with ADHD.

Moorthy G, Sallee F, Gabbita P, Zemlan F, Sallans L, Desai PB.

Biopharm Drug Dispos. 2015 Oct;36(7):429-39. doi: 10.1002/bdd.1955. Epub 2015 May 22.

PMID:
25904220
33.

A liquid chromatography/tandem mass spectrometry method for determination of obatoclax in human plasma.

Moorthy GS, Norris RE, Adamson PC, Fox E.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Nov 15;971:30-4. doi: 10.1016/j.jchromb.2014.09.005. Epub 2014 Sep 16.

34.

Skeletal muscle and plasma concentrations of cefazolin during cardiac surgery in infants.

Himebauch AS, Nicolson SC, Sisko M, Moorthy G, Fuller S, Gaynor JW, Zuppa AF, Fox E, Kilbaugh TJ.

J Thorac Cardiovasc Surg. 2014 Dec;148(6):2634-41. doi: 10.1016/j.jtcvs.2014.06.064. Epub 2014 Jul 22.

35.

Modeling and simulation approach to support dosing and study design requirements for treating HIV-related neuropsychiatric disease with the NK1-R antagonist aprepitant.

Barrett JS, Bajaj G, McGuire J, Wu D, Spitsin S, Moorthy G, Zhao X, Tebas P, Evans DL, Douglas SD.

Curr HIV Res. 2014;12(2):121-31.

PMID:
24862330
36.

A sensitive and selective liquid chromatography/tandem mass spectrometry method for quantitative analysis of efavirenz in human plasma.

Srivastava P, Moorthy GS, Gross R, Barrett JS.

PLoS One. 2013 Jun 5;8(6):e63305. doi: 10.1371/journal.pone.0063305. Print 2013.

37.

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors.

Rheault TR, Stellwagen JC, Adjabeng GM, Hornberger KR, Petrov KG, Waterson AG, Dickerson SH, Mook RA Jr, Laquerre SG, King AJ, Rossanese OW, Arnone MR, Smitheman KN, Kane-Carson LS, Han C, Moorthy GS, Moss KG, Uehling DE.

ACS Med Chem Lett. 2013 Feb 7;4(3):358-62. doi: 10.1021/ml4000063. eCollection 2013 Mar 14.

38.

Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation.

Watt KM, Benjamin DK Jr, Cheifetz IM, Moorthy G, Wade KC, Smith PB, Brouwer KL, Capparelli EV, Cohen-Wolkowiez M.

Pediatr Infect Dis J. 2012 Oct;31(10):1042-7. doi: 10.1097/INF.0b013e31825d3091.

39.

Mining relational paths in integrated biomedical data.

He B, Tang J, Ding Y, Wang H, Sun Y, Shin JH, Chen B, Moorthy G, Qiu J, Desai P, Wild DJ.

PLoS One. 2011;6(12):e27506. doi: 10.1371/journal.pone.0027506. Epub 2011 Dec 6.

40.

Fluconazole loading dose pharmacokinetics and safety in infants.

Piper L, Smith PB, Hornik CP, Cheifetz IM, Barrett JS, Moorthy G, Hope WW, Wade KC, Cohen-Wolkowiez M, Benjamin DK Jr.

Pediatr Infect Dis J. 2011 May;30(5):375-8. doi: 10.1097/INF.0b013e318202cbb3.

41.

A sensitive and selective liquid chromatography/tandem mass spectrometry method for determination of MLN8237 in human plasma.

Lipsitz E, Moorthy G, Mosse Y, Fox E, Adamson PC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2369-73. doi: 10.1016/j.jchromb.2010.06.037. Epub 2010 Jul 3.

42.

Validation of an HPLC method for determination of imatinib mesylate in rat serum and its application in a pharmacokinetic study.

Bende G, Kollipara S, Movva S, Moorthy G, Saha R.

J Chromatogr Sci. 2010 May-Jun;48(5):334-41.

PMID:
20515524
43.

Cytogenetic evaluation of neuroblastoma using fine needle aspiration cultures.

Moorthy G, Agarwala S, Sharma A, Iyer VK, Srinivas M, Bajpai M, Bhatnagar V, Gupta DK.

Pediatr Surg Int. 2009 Nov;25(11):939-43. doi: 10.1007/s00383-009-2446-3.

PMID:
19680663
44.

Lactobacilli inhibit Shigella dysenteriae 1 induced pro-inflammatory response and cytotoxicity in host cells via impediment of Shigella-host interactions.

Moorthy G, Murali MR, Niranjali Devaraj S.

Dig Liver Dis. 2010 Jan;42(1):33-9. doi: 10.1016/j.dld.2009.04.021. Epub 2009 Jun 16.

PMID:
19535308
45.

Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).

Emmitte KA, Wilson BJ, Baum EW, Emerson HK, Kuntz KW, Nailor KE, Salovich JM, Smith SC, Cheung M, Gerding RM, Stevens KL, Uehling DE, Mook RA Jr, Moorthy GS, Dickerson SH, Hassell AM, Leesnitzer MA, Shewchuk LM, Groy A, Rowand JL, Anderson K, Atkins CL, Yang J, Sabbatini P, Kumar R.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):1004-8. doi: 10.1016/j.bmcl.2008.11.058. Epub 2008 Nov 20.

PMID:
19101143
46.

Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R: elimination of an acid-mediated decomposition pathway.

Chamberlain SD, Redman AM, Patnaik S, Brickhouse K, Chew YC, Deanda F, Gerding R, Lei H, Moorthy G, Patrick M, Stevens KL, Wilson JW, Brad Shotwell J.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):373-7. doi: 10.1016/j.bmcl.2008.11.065. Epub 2008 Nov 24.

PMID:
19081716
47.

Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.

Chamberlain SD, Redman AM, Wilson JW, Deanda F, Shotwell JB, Gerding R, Lei H, Yang B, Stevens KL, Hassell AM, Shewchuk LM, Leesnitzer MA, Smith JL, Sabbatini P, Atkins C, Groy A, Rowand JL, Kumar R, Mook RA Jr, Moorthy G, Patnaik S.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):360-4. doi: 10.1016/j.bmcl.2008.11.077. Epub 2008 Nov 24.

PMID:
19071018
48.

Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase.

Chamberlain SD, Wilson JW, Deanda F, Patnaik S, Redman AM, Yang B, Shewchuk L, Sabbatini P, Leesnitzer MA, Groy A, Atkins C, Gerding R, Hassell AM, Lei H, Mook RA Jr, Moorthy G, Rowand JL, Stevens KL, Kumar R, Shotwell JB.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):469-73. doi: 10.1016/j.bmcl.2008.11.046. Epub 2008 Nov 18.

PMID:
19056263
49.

Lactobacilli facilitate maintenance of intestinal membrane integrity during Shigella dysenteriae 1 infection in rats.

Moorthy G, Murali MR, Devaraj SN.

Nutrition. 2009 Mar;25(3):350-8. doi: 10.1016/j.nut.2008.09.004. Epub 2008 Nov 26.

PMID:
19036564
50.

Reversible carboxamide-mediated internal activation at C(6) of 2-chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines.

Chamberlain SD, Gerding RM, Lei H, Moorthy G, Patnaik S, Redman AM, Stevens KL, Wilson JW, Yang B, Shotwell JB.

J Org Chem. 2008 Dec 5;73(23):9511-4. doi: 10.1021/jo8020693.

PMID:
18998728

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