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Impact of Early Life Antibiotic Exposure and Neonatal Hyperoxia on the Murine Microbiome and Lung Injury.

Althouse MH, Stewart C, Jiang W, Moorthy B, Lingappan K.

Sci Rep. 2019 Oct 18;9(1):14992. doi: 10.1038/s41598-019-51506-0.


Lung Genotoxicity of Benzo(a)Pyrene in Vivo Involves Reactivation of LINE-1 Retrotransposon and Reprogramming ofOncogenic Regulatory Networks.

Hassanin AA, Tavera-Garcia M, Moorthy B, Zhang GD, Ramos KS.

Am J Physiol Lung Cell Mol Physiol. 2019 Oct 9. doi: 10.1152/ajplung.00304.2019. [Epub ahead of print]


Insertion/deletion-activated frame-shift fluorescence protein is a sensitive reporter for genomic DNA editing.

Kumar A, Birnbaum MD, Moorthy BT, Singh J, Palovcak A, Patel DM, Zhang F.

BMC Genomics. 2019 Jul 24;20(1):609. doi: 10.1186/s12864-019-5963-z.


Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB).

Suter MA, Aagaard KM, Coarfa C, Robertson M, Zhou G, Jackson BP, Thompson D, Putluri V, Putluri N, Hagan J, Wang L, Jiang W, Lingappan K, Moorthy B.

Biochem Biophys Res Commun. 2019 Aug 20;516(2):344-349. doi: 10.1016/j.bbrc.2019.06.049. Epub 2019 Jun 14.


Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene.

Taneja G, Maity S, Jiang W, Moorthy B, Coarfa C, Ghose R.

Sci Rep. 2019 Apr 30;9(1):6663. doi: 10.1038/s41598-019-43248-w.


Pilot-Scale Pyrolytic Remediation of Crude-Oil-Contaminated Soil in a Continuously-Fed Reactor: Treatment Intensity Trade-Offs.

Song W, Vidonish JE, Kamath R, Yu P, Chu C, Moorthy B, Gao B, Zygourakis K, Alvarez PJJ.

Environ Sci Technol. 2019 Feb 19;53(4):2045-2053. doi: 10.1021/acs.est.8b05825. Epub 2019 Feb 8.


Identification of Suppressor of Clathrin Deficiency-1 (SCD1) and Its Connection to Clathrin-Mediated Endocytosis in Saccharomyces cerevisiae.

Moorthy BT, Sharma A, Boettner DR, Wilson TE, Lemmon SK.

G3 (Bethesda). 2019 Mar 7;9(3):867-877. doi: 10.1534/g3.118.200782.


Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis.

Birnbaum MD, Zhao N, Moorthy BT, Patel DM, Kryvenko ON, Heidman L, Kumar A, Morgan WM, Ban Y, Reis IM, Chen X, Gonzalgo ML, Jorda M, Burnstein KL, Zhang F.

Oncogene. 2019 Feb;38(6):838-851. doi: 10.1038/s41388-018-0462-2. Epub 2018 Sep 3.


Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type.

Veith AC, Bou Aram B, Jiang W, Wang L, Zhou G, Jefcoate CR, Couroucli XI, Lingappan K, Moorthy B.

Toxicol Sci. 2018 Oct 1;165(2):462-474. doi: 10.1093/toxsci/kfy154.


Signal sequence-independent targeting of MID2 mRNA to the endoplasmic reticulum by the yeast RNA-binding protein Khd1p.

Syed MI, Moorthy BT, Jenner A, Fetka I, Jansen RP.

FEBS Lett. 2018 Jun;592(11):1870-1881. doi: 10.1002/1873-3468.13098. Epub 2018 May 28.



Veith A, Moorthy B.

Curr Opin Toxicol. 2018 Feb;7:44-51. doi: 10.1016/j.cotox.2017.10.003. Epub 2017 Oct 12.


Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro.

Taneja G, Chu C, Maturu P, Moorthy B, Ghose R.

Drug Metab Dispos. 2018 Apr;46(4):397-404. doi: 10.1124/dmd.117.079160. Epub 2018 Feb 12.


Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations.

Moorthy BS, Zarraga IE, Kumar L, Walters BT, Goldbach P, Topp EM, Allmendinger A.

Mol Pharm. 2018 Jan 2;15(1):1-11. doi: 10.1021/acs.molpharmaceut.7b00504. Epub 2017 Nov 28.


β-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice.

Lingappan K, Maturu P, Liang YW, Jiang W, Wang L, Moorthy B, Couroucli XI.

Toxicol Appl Pharmacol. 2018 Jan 15;339:133-142. doi: 10.1016/j.taap.2017.11.017. Epub 2017 Nov 26.


Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway.

Coarfa C, Zhang Y, Maity S, Perera DN, Jiang W, Wang L, Couroucli X, Moorthy B, Lingappan K.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L991-L1005. doi: 10.1152/ajplung.00230.2017. Epub 2017 Aug 17.


Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions.

Mallick P, Taneja G, Moorthy B, Ghose R.

Expert Opin Drug Metab Toxicol. 2017 Jun;13(6):605-616. doi: 10.1080/17425255.2017.1292251. Epub 2017 Feb 22. Review.


Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome.

Lingappan K, Maity S, Jiang W, Wang L, Couroucli X, Veith A, Zhou G, Coarfa C, Moorthy B.

Sci Rep. 2017 Apr 4;7(1):642. doi: 10.1038/s41598-017-00516-x.


Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome.

Abbas MMK, Patel B, Chen Q, Jiang W, Moorthy B, Barrios R, Puschett JB.

Lung. 2017 Jun;195(3):323-332. doi: 10.1007/s00408-017-9989-1. Epub 2017 Mar 4.


Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro.

Mallick P, Basu S, Moorthy B, Ghose R.

Toxicol In Vitro. 2017 Jun;41:75-82. doi: 10.1016/j.tiv.2017.02.019. Epub 2017 Feb 27.


Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants.

Maturu P, Wei-Liang Y, Jiang W, Wang L, Lingappan K, Barrios R, Liang Y, Moorthy B, Couroucli XI.

Toxicol Sci. 2017 May 1;157(1):260-271. doi: 10.1093/toxsci/kfx036.


Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice.

Shrestha AK, Patel A, Menon RT, Jiang W, Wang L, Moorthy B, Shivanna B.

Biochem Biophys Res Commun. 2017 Mar 25;485(1):195-200. doi: 10.1016/j.bbrc.2017.02.051. Epub 2017 Feb 10.


Omeprazole induces heme oxygenase-1 in fetal human pulmonary microvascular endothelial cells via hydrogen peroxide-independent Nrf2 signaling pathway.

Patel A, Zhang S, Shrestha AK, Maturu P, Moorthy B, Shivanna B.

Toxicol Appl Pharmacol. 2016 Nov 15;311:26-33. doi: 10.1016/j.taap.2016.10.002. Epub 2016 Oct 8.


Sex-specific differences in neonatal hyperoxic lung injury.

Lingappan K, Jiang W, Wang L, Moorthy B.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L481-93. doi: 10.1152/ajplung.00047.2016. Epub 2016 Jun 24.


Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury.

Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B.

Biochem Biophys Res Commun. 2016 Aug 5;476(4):346-351. doi: 10.1016/j.bbrc.2016.05.125. Epub 2016 May 25.


Gene Expression Profiling Identifies Cell Proliferation and Inflammation as the Predominant Pathways Regulated by Aryl Hydrocarbon Receptor in Primary Human Fetal Lung Cells Exposed to Hyperoxia.

Shivanna B, Maity S, Zhang S, Patel A, Jiang W, Wang L, Welty SE, Belmont J, Coarfa C, Moorthy B.

Toxicol Sci. 2016 Jul;152(1):155-68. doi: 10.1093/toxsci/kfw071. Epub 2016 Apr 21.


Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain.

Boettner DR, Segarra VA, Moorthy BT, de León N, Creagh J, Collette JR, Malhotra A, Lemmon SK.

Traffic. 2016 Jul;17(7):754-68. doi: 10.1111/tra.12401. Epub 2016 May 11.


Process and Formulation Effects on Protein Structure in Lyophilized Solids Using Mass Spectrometric Methods.

Iyer LK, Sacha GA, Moorthy BS, Nail SL, Topp EM.

J Pharm Sci. 2016 May;105(5):1684-1692. doi: 10.1016/j.xphs.2016.02.033. Epub 2016 Apr 1.


In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.

Ghose R, Mallick P, Taneja G, Chu C, Moorthy B.

Methods Mol Biol. 2016;1395:55-68. doi: 10.1007/978-1-4939-3347-1_4.


Thiol-Disulfide Exchange in Human Growth Hormone.

Chandrasekhar S, Moorthy BS, Xie R, Topp EM.

Pharm Res. 2016 Jun;33(6):1370-82. doi: 10.1007/s11095-016-1879-3. Epub 2016 Feb 17.


Immunogenicity of Therapeutic Protein Aggregates.

Moussa EM, Panchal JP, Moorthy BS, Blum JS, Joubert MK, Narhi LO, Topp EM.

J Pharm Sci. 2016 Feb;105(2):417-430. doi: 10.1016/j.xphs.2015.11.002. Review.


Omeprazole does not Potentiate Acute Oxygen Toxicity in Fetal Human Pulmonary Microvascular Endothelial Cells Exposed to Hyperoxia.

Patel A, Zhang S, Moorthy B, Shivanna B.

Pharm Anal Acta. 2015 Oct;6(10). pii: 424. Epub 2015 Oct 9.


Characterizing Protein Structure, Dynamics and Conformation in Lyophilized Solids.

Moorthy BS, Iyer LK, Topp EM.

Curr Pharm Des. 2015;21(40):5845-53. Review.


Omeprazole induces NAD(P)H quinone oxidoreductase 1 via aryl hydrocarbon receptor-independent mechanisms: Role of the transcription factor nuclear factor erythroid 2-related factor 2.

Zhang S, Patel A, Moorthy B, Shivanna B.

Biochem Biophys Res Commun. 2015 Nov 13;467(2):282-7. doi: 10.1016/j.bbrc.2015.09.173. Epub 2015 Oct 9.


Leflunomide Induces Pulmonary and Hepatic CYP1A Enzymes via Aryl Hydrocarbon Receptor.

Patel A, Zhang S, Paramahamsa M, Jiang W, Wang L, Moorthy B, Shivanna B.

Drug Metab Dispos. 2015 Dec;43(12):1966-70. doi: 10.1124/dmd.115.066084. Epub 2015 Sep 28.


Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury?

Lingappan K, Moorthy B.

Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1383-6. doi: 10.1152/ajplung.00313.2015. Epub 2015 Sep 11. Review.


Detection of Bulky Endogenous Oxidative DNA Lesions Derived from 8,5'-Cyclo-2'-deoxyadenosine by ³²P-Postlabeling Assay.

Zhou GD, Moorthy B.

Curr Protoc Toxicol. 2015 May 4;64:17.17.1-14. doi: 10.1002/0471140856.tx1717s64.


Omeprazole Attenuates Pulmonary Aryl Hydrocarbon Receptor Activation and Potentiates Hyperoxia-Induced Developmental Lung Injury in Newborn Mice.

Shivanna B, Zhang S, Patel A, Jiang W, Wang L, Welty SE, Moorthy B.

Toxicol Sci. 2015 Nov;148(1):276-87. doi: 10.1093/toxsci/kfv183. Epub 2015 Aug 13.


Photolytic Cross-Linking to Probe Protein-Protein and Protein-Matrix Interactions in Lyophilized Powders.

Iyer LK, Moorthy BS, Topp EM.

Mol Pharm. 2015 Sep 8;12(9):3237-49. doi: 10.1021/acs.molpharmaceut.5b00183. Epub 2015 Aug 7.


Adrenomedullin deficiency potentiates hyperoxic injury in fetal human pulmonary microvascular endothelial cells.

Zhang S, Patel A, Moorthy B, Shivanna B.

Biochem Biophys Res Commun. 2015 Sep 4;464(4):1048-1053. doi: 10.1016/j.bbrc.2015.07.067. Epub 2015 Jul 18.


Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity.

Tiwari KK, Moorthy B, Lingappan K.

Toxicol In Vitro. 2015 Oct;29(7):1369-76. doi: 10.1016/j.tiv.2015.05.008. Epub 2015 May 21.


Mass spectrometric approaches to study protein structure and interactions in lyophilized powders.

Moorthy BS, Iyer LK, Topp EM.

J Vis Exp. 2015 Apr 14;(98):52503. doi: 10.3791/52503.


Polycyclic aromatic hydrocarbons: from metabolism to lung cancer.

Moorthy B, Chu C, Carlin DJ.

Toxicol Sci. 2015 May;145(1):5-15. doi: 10.1093/toxsci/kfv040. Review.


Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB.

Zhang S, Patel A, Chu C, Jiang W, Wang L, Welty SE, Moorthy B, Shivanna B.

Toxicol Appl Pharmacol. 2015 Jul 15;286(2):92-101. doi: 10.1016/j.taap.2015.03.023. Epub 2015 Mar 29.


Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A.

Lingappan K, Jiang W, Wang L, Couroucli XI, Moorthy B.

Toxicology. 2015 May 4;331:14-23. doi: 10.1016/j.tox.2015.01.019. Epub 2015 Feb 19.


Structural transitions and interactions in the early stages of human glucagon amyloid fibrillation.

Moorthy BS, Ghomi HT, Lill MA, Topp EM.

Biophys J. 2015 Feb 17;108(4):937-948. doi: 10.1016/j.bpj.2015.01.004.


Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury.

Wang L, Lingappan K, Jiang W, Couroucli XI, Welty SE, Shivanna B, Barrios R, Wang G, Firoze Khan M, Gonzalez FJ, Jackson Roberts L, Moorthy B.

Free Radic Biol Med. 2015 May;82:147-59. doi: 10.1016/j.freeradbiomed.2015.01.019. Epub 2015 Feb 10.


Adenosine promotes vascular barrier function in hyperoxic lung injury.

Davies J, Karmouty-Quintana H, Le TT, Chen NY, Weng T, Luo F, Molina J, Moorthy B, Blackburn MR.

Physiol Rep. 2014 Sep 28;2(9). pii: e12155. doi: 10.14814/phy2.12155. Print 2014 Sep 1.


Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.

Krishnamurthy S, Moorthy BS, Xin Xiang L, Xin Shan L, Bharatham K, Tulsian NK, Mihalek I, Anand GS.

Biophys J. 2014 Sep 16;107(6):1426-40. doi: 10.1016/j.bpj.2014.07.050.


Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression.

Lingappan K, Srinivasan C, Jiang W, Wang L, Couroucli XI, Moorthy B.

PLoS One. 2014 Jul 8;9(7):e101581. doi: 10.1371/journal.pone.0101581. eCollection 2014.

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