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Items: 39


Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues.

Graves PR, Aponte-Collazo LJ, Fennell EMJ, Graves AC, Hale AE, Dicheva N, Herring LE, Gilbert TSK, East MP, McDonald IM, Lockett MR, Ashamalla H, Moorman NJ, Karanewsky DS, Iwanowicz EJ, Holmuhamedov E, Graves LM.

ACS Chem Biol. 2019 May 17;14(5):1020-1029. doi: 10.1021/acschembio.9b00222. Epub 2019 May 1.


GSK2801, A BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer.

Bevill SM, Olivares-Quintero JF, Sciaky N, Golitz BT, Singh D, Beltran AS, Rashid NU, Stuhlmiller TJ, Hale A, Moorman NJ, Santos CM, Angus SP, Zawistowski JS, Johnson GL.

Mol Cancer Res. 2019 Apr 18. doi: 10.1158/1541-7786.MCR-18-1121. [Epub ahead of print]


The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models.

Fowler KA, Li K, Whitehurst CB, Bruce DW, Moorman NJ, Aubé J, Coghill JM.

Biol Blood Marrow Transplant. 2019 Jun;25(6):1062-1074. doi: 10.1016/j.bbmt.2019.01.022. Epub 2019 Jan 19.


mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a.

Monteith AJ, Vincent HA, Kang S, Li P, Claiborne TM, Rajfur Z, Jacobson K, Moorman NJ, Vilen BJ.

J Immunol. 2018 Jul 15;201(2):371-382. doi: 10.4049/jimmunol.1701712. Epub 2018 Jun 4.


Structural divergence creates new functional features in alphavirus genomes.

Kutchko KM, Madden EA, Morrison C, Plante KS, Sanders W, Vincent HA, Cruz Cisneros MC, Long KM, Moorman NJ, Heise MT, Laederach A.

Nucleic Acids Res. 2018 Apr 20;46(7):3657-3670. doi: 10.1093/nar/gky012.


The 5' Untranslated Region of the Major Immediate Early mRNA Is Necessary for Efficient Human Cytomegalovirus Replication.

Arend KC, Lenarcic EM, Moorman NJ.

J Virol. 2018 Mar 14;92(7). pii: e02128-17. doi: 10.1128/JVI.02128-17. Print 2018 Apr 1.


An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression.

Corley M, Solem A, Phillips G, Lackey L, Ziehr B, Vincent HA, Mustoe AM, Ramos SBV, Weeks KM, Moorman NJ, Laederach A.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10244-E10253. doi: 10.1073/pnas.1706539114. Epub 2017 Nov 6.


NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.

Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM.

Nat Immunol. 2017 Dec;18(12):1299-1309. doi: 10.1038/ni.3853. Epub 2017 Oct 2.


Mutations in the E2 Glycoprotein and the 3' Untranslated Region Enhance Chikungunya Virus Virulence in Mice.

Hawman DW, Carpentier KS, Fox JM, May NA, Sanders W, Montgomery SA, Moorman NJ, Diamond MS, Morrison TE.

J Virol. 2017 Sep 27;91(20). pii: e00816-17. doi: 10.1128/JVI.00816-17. Print 2017 Oct 15.


Complete Genome Sequences of 15 Chikungunya Virus Isolates from Puerto Rico.

Sanders WA, Long K, Rivera B, Vincent HA, Heise MT, Rodriguez-Orengo JF, Moorman NJ.

Genome Announc. 2017 Jul 6;5(27). pii: e00561-17. doi: 10.1128/genomeA.00561-17.


Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection.

Westdorp KN, Sand A, Moorman NJ, Terhune SS.

J Virol. 2017 Aug 24;91(18). pii: e00593-17. doi: 10.1128/JVI.00593-17. Print 2017 Sep 15.


Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals.

Arend KC, Lenarcic EM, Vincent HA, Rashid N, Lazear E, McDonald IM, Gilbert TS, East MP, Herring LE, Johnson GL, Graves LM, Moorman NJ.

Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S263-S276. doi: 10.1074/mcp.M116.065375. Epub 2017 Feb 25.


Inducing circular RNA formation using the CRISPR endoribonuclease Csy4.

Borchardt EK, Meganck RM, Vincent HA, Ball CB, Ramos SBV, Moorman NJ, Marzluff WF, Asokan A.

RNA. 2017 May;23(5):619-627. doi: 10.1261/rna.056838.116. Epub 2017 Feb 21.


Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1.

Vincent HA, Ziehr B, Moorman NJ.

J Virol. 2017 Feb 14;91(5). pii: e01574-16. doi: 10.1128/JVI.01574-16. Print 2017 Mar 1.


Multiple Transcripts Encode Full-Length Human Cytomegalovirus IE1 and IE2 Proteins during Lytic Infection.

Arend KC, Ziehr B, Vincent HA, Moorman NJ.

J Virol. 2016 Sep 12;90(19):8855-65. doi: 10.1128/JVI.00741-16. Print 2016 Oct 1.


Human Cytomegalovirus Strategies to Maintain and Promote mRNA Translation.

Vincent HA, Ziehr B, Moorman NJ.

Viruses. 2016 Apr 13;8(4):97. doi: 10.3390/v8040097. Review.


Human Cytomegalovirus pTRS1 and pIRS1 Antagonize Protein Kinase R To Facilitate Virus Replication.

Ziehr B, Vincent HA, Moorman NJ.

J Virol. 2016 Mar 28;90(8):3839-3848. doi: 10.1128/JVI.02714-15. Print 2016 Apr.


The eIF4AIII RNA helicase is a critical determinant of human cytomegalovirus replication.

Ziehr B, Lenarcic E, Cecil C, Moorman NJ.

Virology. 2016 Feb;489:194-201. doi: 10.1016/j.virol.2015.12.009. Epub 2016 Jan 8.


Human Cytomegalovirus Stimulates the Synthesis of Select Akt-Dependent Antiapoptotic Proteins during Viral Entry To Promote Survival of Infected Monocytes.

Peppenelli MA, Arend KC, Cojohari O, Moorman NJ, Chan GC.

J Virol. 2016 Jan 6;90(6):3138-47. doi: 10.1128/JVI.02879-15.


Human cytomegalovirus TRS1 protein associates with the 7-methylguanosine mRNA cap and facilitates translation.

Ziehr B, Lenarcic E, Vincent HA, Cecil C, Garcia B, Shenk T, Moorman NJ.

Proteomics. 2015 Jun;15(12):1983-94. doi: 10.1002/pmic.201400616. Epub 2015 May 12.


An unbiased proteomics approach to identify human cytomegalovirus RNA-associated proteins.

Lenarcic EM, Ziehr BJ, Moorman NJ.

Virology. 2015 Jul;481:13-23. doi: 10.1016/j.virol.2015.02.008. Epub 2015 Mar 9.


miR-122 stimulates hepatitis C virus RNA synthesis by altering the balance of viral RNAs engaged in replication versus translation.

Masaki T, Arend KC, Li Y, Yamane D, McGivern DR, Kato T, Wakita T, Moorman NJ, Lemon SM.

Cell Host Microbe. 2015 Feb 11;17(2):217-28. doi: 10.1016/j.chom.2014.12.014. Epub 2015 Feb 5.


Roseomics: a blank slate.

Moorman NJ, Murphy EA.

Curr Opin Virol. 2014 Dec;9:188-93. doi: 10.1016/j.coviro.2014.09.021. Epub 2014 Nov 28. Review.


miniMAVS, You Complete Me!

Rayamajhi M, Miao EA, Moorman NJ.

Cell. 2014 Feb 13;156(4):629-30. doi: 10.1016/j.cell.2014.01.045.


Differential role for host translation factors in host and viral protein synthesis during human cytomegalovirus infection.

Lenarcic EM, Ziehr B, De Leon G, Mitchell D, Moorman NJ.

J Virol. 2014 Feb;88(3):1473-83. doi: 10.1128/JVI.02321-13. Epub 2013 Nov 6.


HCMV targets the metabolic stress response through activation of AMPK whose activity is important for viral replication.

McArdle J, Moorman NJ, Munger J.

PLoS Pathog. 2012 Jan;8(1):e1002502. doi: 10.1371/journal.ppat.1002502. Epub 2012 Jan 26.


Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication.

Spencer CM, Schafer XL, Moorman NJ, Munger J.

J Virol. 2011 Jun;85(12):5814-24. doi: 10.1128/JVI.02630-10. Epub 2011 Apr 6.


Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA.

Terhune SS, Moorman NJ, Cristea IM, Savaryn JP, Cuevas-Bennett C, Rout MP, Chait BT, Shenk T.

PLoS Pathog. 2010 Jun 24;6(6):e1000965. doi: 10.1371/journal.ppat.1000965.


Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein.

Cristea IM, Moorman NJ, Terhune SS, Cuevas CD, O'Keefe ES, Rout MP, Chait BT, Shenk T.

J Virol. 2010 Aug;84(15):7803-14. doi: 10.1128/JVI.00139-10. Epub 2010 May 26.


Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome.

Paden CR, Forrest JC, Moorman NJ, Speck SH.

J Virol. 2010 Jul;84(14):7214-24. doi: 10.1128/JVI.00133-10. Epub 2010 May 5.


Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication.

Moorman NJ, Shenk T.

J Virol. 2010 May;84(10):5260-9. doi: 10.1128/JVI.02733-09. Epub 2010 Feb 24.


A targeted spatial-temporal proteomics approach implicates multiple cellular trafficking pathways in human cytomegalovirus virion maturation.

Moorman NJ, Sharon-Friling R, Shenk T, Cristea IM.

Mol Cell Proteomics. 2010 May;9(5):851-60. doi: 10.1074/mcp.M900485-MCP200. Epub 2009 Dec 20.


Human cytomegalovirus UL28 and UL29 open reading frames encode a spliced mRNA and stimulate accumulation of immediate-early RNAs.

Mitchell DP, Savaryn JP, Moorman NJ, Shenk T, Terhune SS.

J Virol. 2009 Oct;83(19):10187-97. doi: 10.1128/JVI.00396-09. Epub 2009 Jul 22.


Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex.

Moorman NJ, Cristea IM, Terhune SS, Rout MP, Chait BT, Shenk T.

Cell Host Microbe. 2008 Apr 17;3(4):253-62. doi: 10.1016/j.chom.2008.03.002.


The M4 gene of gammaHV68 encodes a secreted glycoprotein and is required for the efficient establishment of splenic latency.

Evans AG, Moorman NJ, Willer DO, Speck SH.

Virology. 2006 Jan 20;344(2):520-31. Epub 2005 Sep 26.


Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo.

Leib DA, Harrison TE, Laslo KM, Machalek MA, Moorman NJ, Virgin HW.

J Exp Med. 1999 Feb 15;189(4):663-72.

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