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Evolutionary history of human colitis-associated colorectal cancer.

Baker AM, Cross W, Curtius K, Al Bakir I, Choi CR, Davis HL, Temko D, Biswas S, Martinez P, Williams MJ, Lindsay JO, Feakins R, Vega R, Hayes SJ, Tomlinson IPM, McDonald SAC, Moorghen M, Silver A, East JE, Wright NA, Wang LM, Rodriguez-Justo M, Jansen M, Hart AL, Leedham SJ, Graham TA.

Gut. 2019 Jun;68(6):985-995. doi: 10.1136/gutjnl-2018-316191. Epub 2018 Jul 10.


Resection of large sessile serrated polyps by cold piecemeal endoscopic mucosal resection: Serrated COld Piecemeal Endoscopic mucosal resection (SCOPE).

Rameshshanker R, Tsiamoulos Z, Latchford A, Moorghen M, Saunders BP.

Endoscopy. 2018 Jul;50(7):E165-E167. doi: 10.1055/a-0599-0346. Epub 2018 May 9. No abstract available.


Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study.

Choi CR, Al Bakir I, Ding NJ, Lee GH, Askari A, Warusavitarne J, Moorghen M, Humphries A, Ignjatovic-Wilson A, Thomas-Gibson S, Saunders BP, Rutter MD, Graham TA, Hart AL.

Gut. 2017 Nov 17. pii: gutjnl-2017-314190. doi: 10.1136/gutjnl-2017-314190. [Epub ahead of print]


A pilot study to assess near infrared laparoscopy with indocyanine green (ICG) for intraoperative sentinel lymph node mapping in early colon cancer.

Currie AC, Brigic A, Thomas-Gibson S, Suzuki N, Moorghen M, Jenkins JT, Faiz OD, Kennedy RH.

Eur J Surg Oncol. 2017 Nov;43(11):2044-2051. doi: 10.1016/j.ejso.2017.05.026. Epub 2017 Aug 23.


Role of SMAD proteins in colitis-associated cancer: from known to the unknown.

Chandrasinghe P, Cereser B, Moorghen M, Al Bakir I, Tabassum N, Hart A, Stebbing J, Warusavitarne J.

Oncogene. 2018 Jan 4;37(1):1-7. doi: 10.1038/onc.2017.300. Epub 2017 Sep 4. Review.


Burden and Profile of Somatic Mutation in Duodenal Adenomas from Patients with Familial Adenomatous- and MUTYH-associated Polyposis.

Thomas LE, Hurley JJ, Meuser E, Jose S, Ashelford KE, Mort M, Idziaszczyk S, Maynard J, Brito HL, Harry M, Walters A, Raja M, Walton SJ, Dolwani S, Williams GT, Morgan M, Moorghen M, Clark SK, Sampson JR.

Clin Cancer Res. 2017 Nov 1;23(21):6721-6732. doi: 10.1158/1078-0432.CCR-17-1269. Epub 2017 Aug 8.


Narrow band imaging optical diagnosis of small colorectal polyps in routine clinical practice: the Detect Inspect Characterise Resect and Discard 2 (DISCARD 2) study.

Rees CJ, Rajasekhar PT, Wilson A, Close H, Rutter MD, Saunders BP, East JE, Maier R, Moorghen M, Muhammad U, Hancock H, Jayaprakash A, MacDonald C, Ramadas A, Dhar A, Mason JM.

Gut. 2017 May;66(5):887-895. doi: 10.1136/gutjnl-2015-310584. Epub 2016 Apr 19.


Outcomes following laparoscopic rectal cancer resection by supervised trainees.

Currie AC, White I, Malietzis G, Moorghen M, Jenkins JT, Kennedy RH.

Br J Surg. 2016 Jul;103(8):1076-83. doi: 10.1002/bjs.10193. Epub 2016 May 11.


Body composition of the host influences dendritic cell phenotype in patients treated for colorectal cancer.

Malietzis G, Lee GH, Al-Hassi HO, Bernardo D, Blakemore AI, Kennedy RH, Moorghen M, Jenkins JT, Knight SC.

Tumour Biol. 2016 Aug;37(8):11359-64. doi: 10.1007/s13277-016-5009-y. Epub 2016 Mar 10.


An analysis of the accuracy of computed tomography colonography when defining anatomy for novel full-thickness colonic excision techniques in early colonic neoplasia.

Currie AC, Burling D, Mainta E, Ilangovan R, Moorghen M, Lung P, Faiz O, Kennedy RH.

Colorectal Dis. 2016 Oct;18(10):983-988. doi: 10.1111/codi.13316.


Low-grade dysplasia in ulcerative colitis: risk factors for developing high-grade dysplasia or colorectal cancer.

Choi CH, Ignjatovic-Wilson A, Askari A, Lee GH, Warusavitarne J, Moorghen M, Thomas-Gibson S, Saunders BP, Rutter MD, Graham TA, Hart AL.

Am J Gastroenterol. 2015 Oct;110(10):1461-71; quiz 1472. doi: 10.1038/ajg.2015.248. Epub 2015 Sep 29.


The prognostic significance and relationship with body composition of CCR7-positive cells in colorectal cancer.

Malietzis G, Lee GH, Bernardo D, Blakemore AI, Knight SC, Moorghen M, Al-Hassi HO, Jenkins JT.

J Surg Oncol. 2015 Jul;112(1):86-92. doi: 10.1002/jso.23959. Epub 2015 Jul 14.


Prognostic Value of the Tumour-Infiltrating Dendritic Cells in Colorectal Cancer: A Systematic Review.

Malietzis G, Lee GH, Jenkins JT, Bernardo D, Moorghen M, Knight SC, Al-Hassi HO.

Cell Commun Adhes. 2015;22(1):9-14. doi: 10.3109/15419061.2015.1036859. Epub 2015 May 30. Review.


Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview.

Choi CH, Rutter MD, Askari A, Lee GH, Warusavitarne J, Moorghen M, Thomas-Gibson S, Saunders BP, Graham TA, Hart AL.

Am J Gastroenterol. 2015 Jul;110(7):1022-34. doi: 10.1038/ajg.2015.65. Epub 2015 Mar 31.


Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells.

Ortiz ML, Kumar V, Martner A, Mony S, Donthireddy L, Condamine T, Seykora J, Knight SC, Malietzis G, Lee GH, Moorghen M, Lenox B, Luetteke N, Celis E, Gabrilovich D.

J Exp Med. 2015 Mar 9;212(3):351-67. doi: 10.1084/jem.20140835. Epub 2015 Feb 9.


IL-13 promotes collagen accumulation in Crohn's disease fibrosis by down-regulation of fibroblast MMP synthesis: a role for innate lymphoid cells?

Bailey JR, Bland PW, Tarlton JF, Peters I, Moorghen M, Sylvester PA, Probert CS, Whiting CV.

PLoS One. 2012;7(12):e52332. doi: 10.1371/journal.pone.0052332. Epub 2012 Dec 31.


Endoscopic features of mesenteric panniculitis by double-balloon enteroscopy.

Bourikas LA, Despott EJ, Moorghen M, Fraser C.

Dig Liver Dis. 2012 Nov;44(11):961. doi: 10.1016/j.dld.2012.06.001. Epub 2012 Jul 15. No abstract available.


Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation.

Banu NA, Daly RS, Buda A, Moorghen M, Baker J, Pignatelli M.

Cell Commun Adhes. 2011 Feb;18(1-2):1-8. doi: 10.3109/15419061.2011.586754. Epub 2011 Jun 16.


Liver disease and cirrhosis because of Khat chewing in UK Somali men: a case series.

Peevers CG, Moorghen M, Collins PL, Gordon FH, McCune CA.

Liver Int. 2010 Sep;30(8):1242-3. doi: 10.1111/j.1478-3231.2010.02228.x. Epub 2010 Apr 8. No abstract available.


The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells.

Greenhough A, Wallam CA, Hicks DJ, Moorghen M, Williams AC, Paraskeva C.

Oncogene. 2010 Jun 10;29(23):3398-410. doi: 10.1038/onc.2010.94. Epub 2010 Mar 29.


BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity.

Clemo NK, Collard TJ, Southern SL, Edwards KD, Moorghen M, Packham G, Hague A, Paraskeva C, Williams AC.

Carcinogenesis. 2008 Apr;29(4):849-57. doi: 10.1093/carcin/bgn004. Epub 2008 Jan 19.


Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia?

Kaidi A, Moorghen M, Williams AC, Paraskeva C.

Gut. 2007 Nov;56(11):1637-8. No abstract available.


Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy.

Banu N, Buda A, Chell S, Elder D, Moorghen M, Paraskeva C, Qualtrough D, Pignatelli M.

Cell Prolif. 2007 Oct;40(5):768-79.


Adult transmural intestinal ganglioneuromatosis is not always associated with multiple endocrine neoplasia or neurofibromatosis: a case report.

Ledwidge SF, Moorghen M, Longman RJ, Thomas MG.

J Clin Pathol. 2007 Feb;60(2):222-3. No abstract available.


Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease.

Creed TJ, Probert CS, Norman MN, Moorghen M, Shepherd NA, Hearing SD, Dayan CM; BASBUC INVESTIGATORS.

Aliment Pharmacol Ther. 2006 May 15;23(10):1435-42.


Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence.

Chell SD, Witherden IR, Dobson RR, Moorghen M, Herman AA, Qualtrough D, Williams AC, Paraskeva C.

Cancer Res. 2006 Mar 15;66(6):3106-13.


The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival.

Clemo NK, Arhel NJ, Barnes JD, Baker J, Moorghen M, Packham GK, Paraskeva C, Williams AC.

Biochem Soc Trans. 2005 Aug;33(Pt 4):676-8. Review.


Refractory coeliac disease: remission with infliximab and immunomodulators.

Turner SM, Moorghen M, Probert CS.

Eur J Gastroenterol Hepatol. 2005 Jun;17(6):667-9. Review.


Upper gastrointestinal cancer pathology reporting: a regional audit to compare standards with minimum datasets.

King PM, Blazeby JM, Gupta J, Alderson D, Moorghen M.

J Clin Pathol. 2004 Jul;57(7):702-5.


Insulin-like growth factor binding protein-3: relationship to the development of gastric pre-malignancy and gastric adenocarcinoma (United Kingdom).

Zhang ZW, Newcomb PV, Moorghen M, Gupta J, Feakins R, Savage P, Hollowood A, Alderson D, Holly JM.

Cancer Causes Control. 2004 Mar;15(2):211-8.


Prognostic value of TP53 codon 72 polymorphism in advanced gastric adenocarcinoma.

Zhang ZW, Laurence NJ, Hollowood A, Newcomb P, Moorghen M, Gupta J, Feakins R, Farthing MJ, Alderson D, Holly J.

Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):131-5.


Epstein-Barr virus infection in colorectal neoplasms associated with inflammatory bowel disease: detection of the virus in lymphomas but not in adenocarcinomas.

Wong NA, Herbst H, Herrmann K, Kirchner T, Krajewski AS, Moorghen M, Niedobitek F, Rooney N, Shepherd NA, Niedobitek G.

J Pathol. 2003 Oct;201(2):312-8.


Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis.

Creed TJ, Norman MR, Probert CS, Harvey RF, Shaw IS, Smithson J, Anderson J, Moorghen M, Gupta J, Shepherd NA, Dayan CM, Hearing SD.

Aliment Pharmacol Ther. 2003 Jul 1;18(1):65-75.


Age-associated increase of codon 72 Arginine p53 frequency in gastric cardia and non-cardia adenocarcinoma.

Zhang ZW, Newcomb P, Hollowood A, Feakins R, Moorghen M, Storey A, Farthing MJ, Alderson D, Holly J.

Clin Cancer Res. 2003 Jun;9(6):2151-6.


Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression.

Elder DJ, Baker JA, Banu NA, Moorghen M, Paraskeva C.

J Pathol. 2002 Dec;198(4):428-34.


Mucin gene expression in Barrett's oesophagus: an in situ hybridisation and immunohistochemical study.

Arul GS, Moorghen M, Myerscough N, Alderson DA, Spicer RD, Corfield AP.

Gut. 2000 Dec;47(6):753-61.


Cost-effective strategy for the serological investigation of coeliac disease.

Bowron A, Moorghen M, Morgan JE, Osborne JR, Stansbie D, Stone JE.

Ann Clin Biochem. 2000 Jul;37 ( Pt 4):467-70.


Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells.

Williams AC, Collard TJ, Perks CM, Newcomb P, Moorghen M, Holly JM, Paraskeva C.

Cancer Res. 2000 Jan 1;60(1):22-7.


Plexiform neurofibroma of the small bowel infiltrated with metastatic adenocarcinoma.

Leslie A, Virjee JP, Moorghen M.

Br J Radiol. 1999 Jun;72(858):604-6.


Primary yolk sac tumour of the liver in adulthood.

Wong NA, D'Costa H, Barry RE, Alderson D, Moorghen M.

J Clin Pathol. 1998 Dec;51(12):939-40. Review.


Sulindac enhances cell proliferation in DMH-treated mouse colonic mucosa.

Moorghen M, Orde M, Finney KJ, Appleton DR, Watson AJ.

Cell Prolif. 1998 Apr;31(2):59-70.


An organ-culture method for human colorectal mucosa using serum-free medium.

Moorghen M, Chapman M, Appleton DR.

J Pathol. 1996 Sep;180(1):102-5.


c-erbB-2 overexpression in the dysplasia/carcinoma sequence of Barrett's oesophagus.

Hardwick RH, Shepherd NA, Moorghen M, Newcomb PV, Alderson D.

J Clin Pathol. 1995 Feb;48(2):129-32.


BCL-2 expression in human colorectal adenomas and carcinomas.

Hague A, Moorghen M, Hicks D, Chapman M, Paraskeva C.

Oncogene. 1994 Nov;9(11):3367-70.


TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.

Avery A, Paraskeva C, Hall P, Flanders KC, Sporn M, Moorghen M.

Br J Cancer. 1993 Jul;68(1):137-9.


Effects of gastrointestinal peptides on azoxymethane-treated colonic mucosa in vitro.

Finney KJ, Appleton DR, Ince P, Moorghen M, Elliott K, Watson AJ.

Carcinogenesis. 1991 Nov;12(11):2017-22.


Organ culture as a model for investigating the effects of antimetabolites and nucleoside transport inhibitors on rodent colonic mucosa.

Moorghen M, Ince P, Finney KJ, Watson AJ, Harris AL.

In Vitro Cell Dev Biol. 1991 Nov;27A(11):873-7.


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