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Items: 21


Characterization of In Vivo Resistance to Osimertinib and JNJ-61186372, an EGFR/Met Bispecific Antibody, Reveals Unique and Consensus Mechanisms of Resistance.

Emdal KB, Dittmann A, Reddy RJ, Lescarbeau RS, Moores SL, Laquerre S, White FM.

Mol Cancer Ther. 2017 Nov;16(11):2572-2585. doi: 10.1158/1535-7163.MCT-17-0413. Epub 2017 Aug 22.


Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cells.

Grugan KD, Dorn K, Jarantow SW, Bushey BS, Pardinas JR, Laquerre S, Moores SL, Chiu ML.

MAbs. 2017 Jan;9(1):114-126. doi: 10.1080/19420862.2016.1249079. Epub 2016 Oct 27.


A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors.

Moores SL, Chiu ML, Bushey BS, Chevalier K, Luistro L, Dorn K, Brezski RJ, Haytko P, Kelly T, Wu SJ, Martin PL, Neijssen J, Parren PW, Schuurman J, Attar RM, Laquerre S, Lorenzi MV, Anderson GM.

Cancer Res. 2016 Jul 1;76(13):3942-53. doi: 10.1158/0008-5472.CAN-15-2833. Epub 2016 May 23.


Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody.

Jarantow SW, Bushey BS, Pardinas JR, Boakye K, Lacy ER, Sanders R, Sepulveda MA, Moores SL, Chiu ML.

J Biol Chem. 2015 Oct 9;290(41):24689-704. doi: 10.1074/jbc.M115.651653. Epub 2015 Aug 10.


Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis C virus replication.

Stachulski AV, Pidathala C, Row EC, Sharma R, Berry NG, Lawrenson AS, Moores SL, Iqbal M, Bentley J, Allman SA, Edwards G, Helm A, Hellier J, Korba BE, Semple JE, Rossignol JF.

J Med Chem. 2011 Dec 22;54(24):8670-80. doi: 10.1021/jm201264t. Epub 2011 Nov 21.


Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia.

Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL, Haase VH.

Blood. 2010 Oct 21;116(16):3039-48. doi: 10.1182/blood-2010-02-270322. Epub 2010 Jul 13.


Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo.

Stachulski AV, Berry NG, Lilian Low AC, Moores SL, Row E, Warhurst DC, Adagu IS, Rossignol JF.

J Med Chem. 2006 Feb 23;49(4):1450-4.


In vitro efficacies of nitazoxanide and other thiazolides against Neospora caninum tachyzoites reveal antiparasitic activity independent of the nitro group.

Esposito M, Stettler R, Moores SL, Pidathala C, Müller N, Stachulski A, Berry NG, Rossignol JF, Hemphill A.

Antimicrob Agents Chemother. 2005 Sep;49(9):3715-23.


Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells.

Bill HM, Knudsen B, Moores SL, Muthuswamy SK, Rao VR, Brugge JS, Miranti CK.

Mol Cell Biol. 2004 Oct;24(19):8586-99.


Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.

Gakidis MA, Cullere X, Olson T, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T, Brugge JS.

J Cell Biol. 2004 Jul 19;166(2):273-82. Epub 2004 Jul 12.


Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.

Fujikawa K, Miletic AV, Alt FW, Faccio R, Brown T, Hoog J, Fredericks J, Nishi S, Mildiner S, Moores SL, Brugge J, Rosen FS, Swat W.

J Exp Med. 2003 Nov 17;198(10):1595-608.


Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.

Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ.

J Cell Biol. 2002 Apr 15;157(2):265-75. Epub 2002 Apr 8.


Vav family proteins couple to diverse cell surface receptors.

Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W.

Mol Cell Biol. 2000 Sep;20(17):6364-73.


On the role of myosin-II in cytokinesis: division of Dictyostelium cells under adhesive and nonadhesive conditions.

Zang JH, Cavet G, Sabry JH, Wagner P, Moores SL, Spudich JA.

Mol Biol Cell. 1997 Dec;8(12):2617-29.


Myosin heavy chain phosphorylation sites regulate myosin localization during cytokinesis in live cells.

Sabry JH, Moores SL, Ryan S, Zang JH, Spudich JA.

Mol Biol Cell. 1997 Dec;8(12):2605-15.


Myosin dynamics in live Dictyostelium cells.

Moores SL, Sabry JH, Spudich JA.

Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):443-6.


Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases.

Kohl NE, Diehl RE, Schaber MD, Rands E, Soderman DD, He B, Moores SL, Pompliano DL, Ferro-Novick S, Powers S, et al.

J Biol Chem. 1991 Oct 5;266(28):18884-8.


Sequence dependence of protein isoprenylation.

Moores SL, Schaber MD, Mosser SD, Rands E, O'Hara MB, Garsky VM, Marshall MS, Pompliano DL, Gibbs JB.

J Biol Chem. 1991 Aug 5;266(22):14603-10.


Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.

Schaber MD, O'Hara MB, Garsky VM, Mosser SC, Bergstrom JD, Moores SL, Marshall MS, Friedman PA, Dixon RA, Gibbs JB.

J Biol Chem. 1990 Sep 5;265(25):14701-4.

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