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Items: 44


Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.

Adib R, Montgomery JM, Atherton J, O'Regan L, Richards MW, Straatman KR, Roth D, Straube A, Bayliss R, Moores CA, Fry AM.

Sci Signal. 2019 Aug 13;12(594). pii: eaaw2939. doi: 10.1126/scisignal.aaw2939.


Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission.

Zeeshan M, Ferguson DJ, Abel S, Burrrell A, Rea E, Brady D, Daniel E, Delves M, Vaughan S, Holder AA, Le Roch KG, Moores CA, Tewari R.

Life Sci Alliance. 2019 Aug 13;2(4). pii: e201900488. doi: 10.26508/lsa.201900488. Print 2019 Aug.


Cryo-EM structure of the Ustilago maydis kinesin-5 motor domain bound to microtubules.

von Loeffelholz O, Moores CA.

J Struct Biol. 2019 Sep 1;207(3):312-316. doi: 10.1016/j.jsb.2019.07.003. Epub 2019 Jul 6.


Cryo-EM Structure (4.5-Å) of Yeast Kinesin-5-Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance.

von Loeffelholz O, Peña A, Drummond DR, Cross R, Moores CA.

J Mol Biol. 2019 Feb 15;431(4):864-872. doi: 10.1016/j.jmb.2019.01.011. Epub 2019 Jan 16.


Microtubule structure by cryo-EM: snapshots of dynamic instability.

Manka SW, Moores CA.

Essays Biochem. 2018 Dec 7;62(6):737-751. doi: 10.1042/EBC20180031. Print 2018 Dec 7. Review.


The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability.

Manka SW, Moores CA.

Nat Struct Mol Biol. 2018 Jul;25(7):607-615. doi: 10.1038/s41594-018-0087-8. Epub 2018 Jul 2.


Microtubule architecture in vitro and in cells revealed by cryo-electron tomography.

Atherton J, Stouffer M, Francis F, Moores CA.

Acta Crystallogr D Struct Biol. 2018 Jun 1;74(Pt 6):572-584. doi: 10.1107/S2059798318001948. Epub 2018 Apr 11.


Nucleotide- and Mal3-dependent changes in fission yeast microtubules suggest a structural plasticity view of dynamics.

von Loeffelholz O, Venables NA, Drummond DR, Katsuki M, Cross R, Moores CA.

Nat Commun. 2017 Dec 13;8(1):2110. doi: 10.1038/s41467-017-02241-5.


Structural basis of human kinesin-8 function and inhibition.

Locke J, Joseph AP, Peña A, Möckel MM, Mayer TU, Topf M, Moores CA.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9539-E9548. doi: 10.1073/pnas.1712169114. Epub 2017 Oct 23.


Tubulin isoform composition tunes microtubule dynamics.

Vemu A, Atherton J, Spector JO, Moores CA, Roll-Mecak A.

Mol Biol Cell. 2017 Dec 1;28(25):3564-3572. doi: 10.1091/mbc.E17-02-0124. Epub 2017 Oct 11.


A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.

Atherton J, Jiang K, Stangier MM, Luo Y, Hua S, Houben K, van Hooff JJE, Joseph AP, Scarabelli G, Grant BJ, Roberts AJ, Topf M, Steinmetz MO, Baldus M, Moores CA, Akhmanova A.

Nat Struct Mol Biol. 2017 Nov;24(11):931-943. doi: 10.1038/nsmb.3483. Epub 2017 Oct 9.


The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.

Atherton J, Yu IM, Cook A, Muretta JM, Joseph A, Major J, Sourigues Y, Clause J, Topf M, Rosenfeld SS, Houdusse A, Moores CA.

Elife. 2017 Aug 11;6. pii: e27793. doi: 10.7554/eLife.27793.


Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism.

Britto M, Goulet A, Rizvi S, von Loeffelholz O, Moores CA, Cross RA.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7483-E7489. Epub 2016 Nov 9.


Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin.

Vemu A, Atherton J, Spector JO, Szyk A, Moores CA, Roll-Mecak A.

J Biol Chem. 2016 Jun 17;291(25):12907-15. doi: 10.1074/jbc.C116.731133. Epub 2016 Apr 25.


Mapping the Processivity Determinants of the Kinesin-3 Motor Domain.

Scarabelli G, Soppina V, Yao XQ, Atherton J, Moores CA, Verhey KJ, Grant BJ.

Biophys J. 2015 Oct 20;109(8):1537-40. doi: 10.1016/j.bpj.2015.08.027.


Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins.

Atherton J, Farabella I, Yu IM, Rosenfeld SS, Houdusse A, Topf M, Moores CA.

Elife. 2014 Sep 10;3:e03680. doi: 10.7554/eLife.03680.


Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family.

Goulet A, Major J, Jun Y, Gross SP, Rosenfeld SS, Moores CA.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1837-42. doi: 10.1073/pnas.1319848111. Epub 2014 Jan 21.


Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study.

Muretta JM, Behnke-Parks WM, Major J, Petersen KJ, Goulet A, Moores CA, Thomas DD, Rosenfeld SS.

J Biol Chem. 2013 Nov 29;288(48):34839-49. doi: 10.1074/jbc.M113.518845. Epub 2013 Oct 21.


New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum.

Bahi-Buisson N, Souville I, Fourniol FJ, Toussaint A, Moores CA, Houdusse A, Lemaitre JY, Poirier K, Khalaf-Nazzal R, Hully M, Leger PL, Elie C, Boddaert N, Beldjord C, Chelly J, Francis F; SBH-LIS European Consortium.

Brain. 2013 Jan;136(Pt 1):223-44. doi: 10.1093/brain/aws323.


The structural basis of force generation by the mitotic motor kinesin-5.

Goulet A, Behnke-Parks WM, Sindelar CV, Major J, Rosenfeld SS, Moores CA.

J Biol Chem. 2012 Dec 28;287(53):44654-66. doi: 10.1074/jbc.M112.404228. Epub 2012 Nov 7.


Dynein: a force (generation mechanism) to be reckoned with.

Moores CA.

Structure. 2012 Oct 10;20(10):1611-2. doi: 10.1016/j.str.2012.09.002.


Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins.

Liu JS, Schubert CR, Fu X, Fourniol FJ, Jaiswal JK, Houdusse A, Stultz CM, Moores CA, Walsh CA.

Mol Cell. 2012 Sep 14;47(5):707-21. doi: 10.1016/j.molcel.2012.06.025. Epub 2012 Aug 1.


EBs recognize a nucleotide-dependent structural cap at growing microtubule ends.

Maurer SP, Fourniol FJ, Bohner G, Moores CA, Surrey T.

Cell. 2012 Apr 13;149(2):371-82. doi: 10.1016/j.cell.2012.02.049.


Snapshots of kinesin motors on microtubule tracks.

Fourniol FJ, Moores CA.

Methods Mol Biol. 2011;778:57-70. doi: 10.1007/978-1-61779-261-8_5.


Template-free 13-protofilament microtubule-MAP assembly visualized at 8 A resolution.

Fourniol FJ, Sindelar CV, Amigues B, Clare DK, Thomas G, Perderiset M, Francis F, Houdusse A, Moores CA.

J Cell Biol. 2010 Nov 1;191(3):463-70. doi: 10.1083/jcb.201007081. Epub 2010 Oct 25.


Insight into the molecular mechanism of the multitasking kinesin-8 motor.

Peters C, Brejc K, Belmont L, Bodey AJ, Lee Y, Yu M, Guo J, Sakowicz R, Hartman J, Moores CA.

EMBO J. 2010 Oct 20;29(20):3437-47. doi: 10.1038/emboj.2010.220. Epub 2010 Sep 3.


Kinesin-5 mitotic motors: Is loop5 the on/off switch?

Moores CA.

Cell Cycle. 2010 Apr 1;9(7):1286-90.


Kinesin motor activation: microtubules pull the switches.

Fourniol F, Moores CA.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):3949-50. doi: 10.1073/pnas.0915158107. Epub 2010 Feb 17. No abstract available.


A new model for binding of kinesin 13 to curved microtubule protofilaments.

Mulder AM, Glavis-Bloom A, Moores CA, Wagenbach M, Carragher B, Wordeman L, Milligan RA.

J Cell Biol. 2009 Apr 6;185(1):51-7. doi: 10.1083/jcb.200812052. Epub 2009 Mar 30.


9-Angström structure of a microtubule-bound mitotic motor.

Bodey AJ, Kikkawa M, Moores CA.

J Mol Biol. 2009 May 1;388(2):218-24. doi: 10.1016/j.jmb.2009.03.008. Epub 2009 Mar 10.


Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.

Ciferri C, Pasqualato S, Screpanti E, Varetti G, Santaguida S, Dos Reis G, Maiolica A, Polka J, De Luca JG, De Wulf P, Salek M, Rappsilber J, Moores CA, Salmon ED, Musacchio A.

Cell. 2008 May 2;133(3):427-39. doi: 10.1016/j.cell.2008.03.020.


Visualisation of a kinesin-13 motor on microtubule end mimics.

Moores CA, Milligan RA.

J Mol Biol. 2008 Mar 28;377(3):647-54. doi: 10.1016/j.jmb.2008.01.079. Epub 2008 Feb 4.


Lucky 13-microtubule depolymerisation by kinesin-13 motors.

Moores CA, Milligan RA.

J Cell Sci. 2006 Oct 1;119(Pt 19):3905-13. Review.


Distinct roles of doublecortin modulating the microtubule cytoskeleton.

Moores CA, Perderiset M, Kappeler C, Kain S, Drummond D, Perkins SJ, Chelly J, Cross R, Houdusse A, Francis F.

EMBO J. 2006 Oct 4;25(19):4448-57. Epub 2006 Sep 7.


The role of the kinesin-13 neck in microtubule depolymerization.

Moores CA, Cooper J, Wagenbach M, Ovechkina Y, Wordeman L, Milligan RA.

Cell Cycle. 2006 Aug;5(16):1812-5. Epub 2006 Aug 15.


Mechanism of microtubule stabilization by doublecortin.

Moores CA, Perderiset M, Francis F, Chelly J, Houdusse A, Milligan RA.

Mol Cell. 2004 Jun 18;14(6):833-9.


Regulation of KinI kinesin ATPase activity by binding to the microtubule lattice.

Moores CA, Hekmat-Nejad M, Sakowicz R, Milligan RA.

J Cell Biol. 2003 Dec 8;163(5):963-71.


An atomic model for actin binding by the CH domains and spectrin-repeat modules of utrophin and dystrophin.

Sutherland-Smith AJ, Moores CA, Norwood FL, Hatch V, Craig R, Kendrick-Jones J, Lehman W.

J Mol Biol. 2003 May 23;329(1):15-33.


A double-take on MAPs.

Moores CA, Francis F, Perderiset M, Houdusse A.

Nat Struct Biol. 2003 May;10(5):314-6. No abstract available.


A mechanism for microtubule depolymerization by KinI kinesins.

Moores CA, Yu M, Guo J, Beraud C, Sakowicz R, Milligan RA.

Mol Cell. 2002 Apr;9(4):903-9.


Biochemical characterisation of the actin-binding properties of utrophin.

Moores CA, Kendrick-Jones J.

Cell Motil Cytoskeleton. 2000 Jun;46(2):116-28.


Structure of the utrophin actin-binding domain bound to F-actin reveals binding by an induced fit mechanism.

Moores CA, Keep NH, Kendrick-Jones J.

J Mol Biol. 2000 Mar 24;297(2):465-80.


Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer.

Keep NH, Winder SJ, Moores CA, Walke S, Norwood FL, Kendrick-Jones J.

Structure. 1999 Dec 15;7(12):1539-46.


The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin.

Keep NH, Norwood FL, Moores CA, Winder SJ, Kendrick-Jones J.

J Mol Biol. 1999 Jan 22;285(3):1257-64.


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