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Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity.

Cao X, Zhang W, Moore PK, Bian J.

Int J Mol Sci. 2019 Jan 14;20(2). pii: E313. doi: 10.3390/ijms20020313. Review.


Hydrogen sulfide inhibits ATP-induced neuroinflammation and Aβ1-42 synthesis by suppressing the activation of STAT3 and cathepsin S.

Cao L, Cao X, Zhou Y, Nagpure BV, Wu ZY, Hu LF, Yang Y, Sethi G, Moore PK, Bian JS.

Brain Behav Immun. 2018 Oct;73:603-614. doi: 10.1016/j.bbi.2018.07.005. Epub 2018 Jul 5.


Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis.

Wu W, Qin M, Jia W, Huang Z, Li Z, Yang D, Huang M, Xiao C, Long F, Mao J, Moore PK, Liu X, Zhu YZ.

Cell Mol Immunol. 2018 May 29. doi: 10.1038/s41423-018-0037-8. [Epub ahead of print]


A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?

Cao X, Ding L, Xie ZZ, Yang Y, Whiteman M, Moore PK, Bian JS.

Antioxid Redox Signal. 2019 Jul 1;31(1):1-38. doi: 10.1089/ars.2017.7058. Epub 2018 Jun 29.


Garlic and Gaseous Mediators.

Rose P, Moore PK, Zhu YZ.

Trends Pharmacol Sci. 2018 Jul;39(7):624-634. doi: 10.1016/ Epub 2018 Apr 26. Review.


Management of Acute Kidney Injury: Core Curriculum 2018.

Moore PK, Hsu RK, Liu KD.

Am J Kidney Dis. 2018 Jul;72(1):136-148. doi: 10.1053/j.ajkd.2017.11.021. Epub 2018 Feb 22.


Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity.

Cao X, Nie X, Xiong S, Cao L, Wu Z, Moore PK, Bian JS.

Redox Biol. 2018 May;15:513-521. doi: 10.1016/j.redox.2018.01.012. Epub 2018 Feb 2.


Is there a role of H2S in mediating health span benefits of caloric restriction?

Ng LT, Gruber J, Moore PK.

Biochem Pharmacol. 2018 Mar;149:91-100. doi: 10.1016/j.bcp.2018.01.030. Epub 2018 Jan 31. Review.


Renal Protective Effect of Hydrogen Sulfide in Cisplatin-Induced Nephrotoxicity.

Cao X, Xiong S, Zhou Y, Wu Z, Ding L, Zhu Y, Wood ME, Whiteman M, Moore PK, Bian JS.

Antioxid Redox Signal. 2018 Aug 10;29(5):455-470. doi: 10.1089/ars.2017.7157. Epub 2018 Feb 21.


Intracellular Hyper-Acidification Potentiated by Hydrogen Sulfide Mediates Invasive and Therapy Resistant Cancer Cell Death.

Lee ZW, Teo XY, Song ZJ, Nin DS, Novera W, Choo BA, Dymock BW, Moore PK, Huang RY, Deng LW.

Front Pharmacol. 2017 Oct 31;8:763. doi: 10.3389/fphar.2017.00763. eCollection 2017.


Macroscopic T-Wave Alternans: A Red Flag for Code Blue.

Moore PK, Raffel KE, Whitman IR.

JAMA Intern Med. 2017 Oct 1;177(10):1520-1522. doi: 10.1001/jamainternmed.2017.3191. No abstract available.


Hydrogen Sulfide As a Potential Target in Preventing Spermatogenic Failure and Testicular Dysfunction.

Wang J, Wang W, Li S, Han Y, Zhang P, Meng G, Xiao Y, Xie L, Wang X, Sha J, Chen Q, Moore PK, Wang R, Xiang W, Ji Y.

Antioxid Redox Signal. 2018 Jun 1;28(16):1447-1462. doi: 10.1089/ars.2016.6968. Epub 2017 Oct 16.


Higher prevalence of detectable troponin I among cocaine-users without known cardiovascular disease.

Riley ED, Hsue PY, Vittinghoff E, Wu AH, Coffin PO, Moore PK, Lynch KL.

Drug Alcohol Depend. 2017 Mar 1;172:88-93. doi: 10.1016/j.drugalcdep.2016.11.039. Epub 2017 Jan 19.


Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents.

Feng W, Novera W, Peh K, Neo D, Ramanujulu PM, Moore PK, Deng LW, Dymock BW.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):967-972. doi: 10.1016/j.bmcl.2016.12.079. Epub 2017 Jan 2.


Identification of a previously undetected metabolic defect in the Complex II Caenorhabditis elegans mev-1 mutant strain using respiratory control analysis.

Fong S, Ng LF, Ng LT, Moore PK, Halliwell B, Gruber J.

Biogerontology. 2017 Apr;18(2):189-200. doi: 10.1007/s10522-016-9672-6. Epub 2016 Dec 30.


H2S biosynthesis and catabolism: new insights from molecular studies.

Rose P, Moore PK, Zhu YZ.

Cell Mol Life Sci. 2017 Apr;74(8):1391-1412. doi: 10.1007/s00018-016-2406-8. Epub 2016 Nov 14. Review.


A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo.

Huang CW, Feng W, Peh MT, Peh K, Dymock BW, Moore PK.

Pharmacol Res. 2016 Nov;113(Pt A):533-546. doi: 10.1016/j.phrs.2016.09.032. Epub 2016 Sep 27.


Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model.

Fong S, Teo E, Ng LF, Chen CB, Lakshmanan LN, Tsoi SY, Moore PK, Inoue T, Halliwell B, Gruber J.

Sci Rep. 2016 Sep 22;6:33781. doi: 10.1038/srep33781.


Hydrogen Sulfide Regulates Krüppel-Like Factor 5 Transcription Activity via Specificity Protein 1 S-Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy.

Meng G, Xiao Y, Ma Y, Tang X, Xie L, Liu J, Gu Y, Yu Y, Park CM, Xian M, Wang X, Ferro A, Wang R, Moore PK, Zhang Z, Wang H, Han Y, Ji Y.

J Am Heart Assoc. 2016 Sep 16;5(9). pii: e004160. doi: 10.1161/JAHA.116.004160.


Overnight Extubation in Patients With Mechanical Ventilation: Is It Harmful?

Moore PK, Matthay MA.

JAMA Intern Med. 2016 Nov 1;176(11):1660-1661. doi: 10.1001/jamainternmed.2016.5280. No abstract available.


Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation.

Xie L, Gu Y, Wen M, Zhao S, Wang W, Ma Y, Meng G, Han Y, Wang Y, Liu G, Moore PK, Wang X, Wang H, Zhang Z, Yu Y, Ferro A, Huang Z, Ji Y.

Diabetes. 2016 Oct;65(10):3171-84. doi: 10.2337/db16-0020. Epub 2016 Jun 22.


Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages.

Miao L, Shen X, Whiteman M, Xin H, Shen Y, Xin X, Moore PK, Zhu YZ.

Antioxid Redox Signal. 2016 Aug 10;25(5):268-81. doi: 10.1089/ars.2015.6577.


SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells.

Xie L, Feng H, Li S, Meng G, Liu S, Tang X, Ma Y, Han Y, Xiao Y, Gu Y, Shao Y, Park CM, Xian M, Huang Y, Ferro A, Wang R, Moore PK, Wang H, Ji Y.

Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.


GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia.

Lilyanna S, Peh MT, Liew OW, Wang P, Moore PK, Richards AM, Martinez EC.

J Mol Cell Cardiol. 2015 Oct;87:27-37. doi: 10.1016/j.yjmcc.2015.07.028. Epub 2015 Aug 4.


H2S Synthesizing Enzymes: Biochemistry and Molecular Aspects.

Huang CW, Moore PK.

Handb Exp Pharmacol. 2015;230:3-25. doi: 10.1007/978-3-319-18144-8_1. Review.


Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity.

Feng W, Teo XY, Novera W, Ramanujulu PM, Liang D, Huang D, Moore PK, Deng LW, Dymock BW.

J Med Chem. 2015 Aug 27;58(16):6456-80. doi: 10.1021/acs.jmedchem.5b00848. Epub 2015 Aug 5.


Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis.

Meng G, Zhu J, Xiao Y, Huang Z, Zhang Y, Tang X, Xie L, Chen Y, Shao Y, Ferro A, Wang R, Moore PK, Ji Y.

Oxid Med Cell Longev. 2015;2015:691070. doi: 10.1155/2015/691070. Epub 2015 May 11.


GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats.

Meng G, Wang J, Xiao Y, Bai W, Xie L, Shan L, Moore PK, Ji Y.

J Biomed Res. 2015 May;29(3):203-13. doi: 10.7555/JBR.28.20140037. Epub 2014 Oct 10.


Hydrogen sulfide promotes adipogenesis in 3T3L1 cells.

Tsai CY, Peh MT, Feng W, Dymock BW, Moore PK.

PLoS One. 2015 Mar 30;10(3):e0119511. doi: 10.1371/journal.pone.0119511. eCollection 2015.


GYY4137, a novel water-soluble, H2S-releasing molecule.

Rose P, Dymock BW, Moore PK.

Methods Enzymol. 2015;554:143-67. doi: 10.1016/bs.mie.2014.11.014. Epub 2015 Jan 10. Review.


A unique role for p53 in the regulation of M2 macrophage polarization.

Li L, Ng DS, Mah WC, Almeida FF, Rahmat SA, Rao VK, Leow SC, Laudisi F, Peh MT, Goh AM, Lim JS, Wright GD, Mortellaro A, Taneja R, Ginhoux F, Lee CG, Moore PK, Lane DP.

Cell Death Differ. 2015 Jul;22(7):1081-93. doi: 10.1038/cdd.2014.212. Epub 2014 Dec 19.


Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance.

Lee ZW, Teo XY, Tay EY, Tan CH, Hagen T, Moore PK, Deng LW.

Br J Pharmacol. 2014 Sep;171(18):4322-36. doi: 10.1111/bph.12773. Epub 2014 Jul 2.


Effect of feeding a high fat diet on hydrogen sulfide (H2S) metabolism in the mouse.

Peh MT, Anwar AB, Ng DS, Atan MS, Kumar SD, Moore PK.

Nitric Oxide. 2014 Sep 15;41:138-45. doi: 10.1016/j.niox.2014.03.002. Epub 2014 Mar 15.


The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.


A case of swallow syncope.

Moore PK, Lee JK, Garcia JA, Krantz MJ.

Tex Heart Inst J. 2013;40(5):606-7.


C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.

Qabazard B, Ahmed S, Li L, Arlt VM, Moore PK, Stürzenbaum SR.

PLoS One. 2013 Nov 8;8(11):e80135. doi: 10.1371/journal.pone.0080135. eCollection 2013.


Could hydrogen sulfide be the next blockbuster treatment for inflammatory disease?

Li L, Moore PK.

Expert Rev Clin Pharmacol. 2013 Nov;6(6):593-5. doi: 10.1586/17512433.2013.842126. No abstract available.


Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans.

Qabazard B, Li L, Gruber J, Peh MT, Ng LF, Kumar SD, Rose P, Tan CH, Dymock BW, Wei F, Swain SC, Halliwell B, Stürzenbaum SR, Moore PK.

Antioxid Redox Signal. 2014 Jun 1;20(16):2621-30. doi: 10.1089/ars.2013.5448. Epub 2013 Nov 21.


Signs of stress: deep symmetric T-wave inversions.

Moore PK, Marzec LN, Krantz MJ.

Am J Med. 2013 Aug;126(8):682-4. doi: 10.1016/j.amjmed.2013.03.005. Epub 2013 Jun 10. No abstract available.


The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E(-/-) mice.

Liu Z, Han Y, Li L, Lu H, Meng G, Li X, Shirhan M, Peh MT, Xie L, Zhou S, Wang X, Chen Q, Dai W, Tan CH, Pan S, Moore PK, Ji Y.

Br J Pharmacol. 2013 Aug;169(8):1795-809. doi: 10.1111/bph.12246.


The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells.

Li L, Fox B, Keeble J, Salto-Tellez M, Winyard PG, Wood ME, Moore PK, Whiteman M.

J Cell Mol Med. 2013 Mar;17(3):365-76. doi: 10.1111/jcmm.12016. Epub 2013 Jan 28.


Remember why we went into this field in the first place...

Moore PK.

J Trauma Acute Care Surg. 2012 Sep;73(3):539-41. doi: 10.1097/TA.0b013e318267ce55. No abstract available.


Endogenous hydrogen sulfide insufficiency as a predictor of sexual dysfunction in aging rats.

Srilatha B, Muthulakshmi P, Adaikan PG, Moore PK.

Aging Male. 2012 Sep;15(3):153-8. doi: 10.3109/13685538.2012.668722. Epub 2012 Mar 29.


Future of acute care surgery: a perspective from the next generation.

Moore HB, Moore PK, Grant AR, Tello TL, Knudson MM, Kornblith LZ, Song TE, Sauaia A, Zuckerbahn B, Moore EE.

J Trauma Acute Care Surg. 2012 Jan;72(1):94-9. doi: 10.1097/TA.0b013e31823b990a.


The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo.

Lee ZW, Zhou J, Chen CS, Zhao Y, Tan CH, Li L, Moore PK, Deng LW.

PLoS One. 2011;6(6):e21077. doi: 10.1371/journal.pone.0021077. Epub 2011 Jun 20.


Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint?

Fox B, Schantz JT, Haigh R, Wood ME, Moore PK, Viner N, Spencer JP, Winyard PG, Whiteman M.

J Cell Mol Med. 2012 Apr;16(4):896-910. doi: 10.1111/j.1582-4934.2011.01357.x.


Multifaceted role of nitric oxide in an in vitro mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signalling cascades.

Peng ZF, Chen MJ, Manikandan J, Melendez AJ, Shui G, Russo-Marie F, Whiteman M, Beart PM, Moore PK, Cheung NS.

J Cell Mol Med. 2012 Jan;16(1):41-58. doi: 10.1111/j.1582-4934.2011.01288.x.


Hydrogen sulfide and cell signaling.

Li L, Rose P, Moore PK.

Annu Rev Pharmacol Toxicol. 2011;51:169-87. doi: 10.1146/annurev-pharmtox-010510-100505. Review.


Gene profiling reveals hydrogen sulphide recruits death signaling via the N-methyl-D-aspartate receptor identifying commonalities with excitotoxicity.

Chen MJ, Peng ZF, Manikandan J, Melendez AJ, Tan GS, Chung CM, Li QT, Tan TM, Deng LW, Whiteman M, Beart PM, Moore PK, Cheung NS.

J Cell Physiol. 2011 May;226(5):1308-22. doi: 10.1002/jcp.22459.


The plasma fraction of stored erythrocytes augments pancreatic cancer metastasis in male versus female mice.

Moore PK, Benson D, Kehler M, Moore EE, Fragoso M, Silliman CC, Barnett CC Jr.

J Surg Res. 2010 Nov;164(1):23-7. doi: 10.1016/j.jss.2010.05.047. Epub 2010 Jun 13.

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