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Items: 1 to 50 of 94

1.

Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444-3451.

Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, O'Garra A.

J Immunol. 2016 Sep 1;197(5):1531-8. No abstract available.

2.

FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein.

Smith R, Duguay A, Bakker A, Li P, Weiszmann J, Thomas MR, Alba BM, Wu X, Gupte J, Yang L, Stevens J, Hamburger A, Smith S, Chen J, Komorowski R, Moore KW, Véniant MM, Li Y.

PLoS One. 2013 Apr 22;8(4):e61432. doi: 10.1371/journal.pone.0061432. Print 2013.

3.

Parenting practices, interpretive biases, and anxiety in Latino children.

Varela RE, Niditch LA, Hensley-Maloney L, Moore KW, Creveling CC.

J Anxiety Disord. 2013 Mar;27(2):171-7. doi: 10.1016/j.janxdis.2012.12.004. Epub 2013 Jan 5.

4.

What is your diagnosis? Osteochondroma.

Ickes JC, Moore KW, Morales SC.

J Am Vet Med Assoc. 2012 Nov 1;241(9):1155-6. doi: 10.2460/javma.241.9.1155. No abstract available.

PMID:
23078559
5.

Exploring constrained quantum control landscapes.

Moore KW, Rabitz H.

J Chem Phys. 2012 Oct 7;137(13):134113. doi: 10.1063/1.4757133.

PMID:
23039591
6.

Pillars article: homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science. 1990. 248: 1230-1234.

Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR.

J Immunol. 2012 Sep 1;189(5):2072-6. No abstract available.

7.

NMR landscapes for chemical shift prediction.

Moore KW, Li R, Pelczer I, Rabitz H.

J Phys Chem A. 2012 Sep 13;116(36):9142-57. doi: 10.1021/jp306353b. Epub 2012 Aug 29.

PMID:
22900681
8.

Why is chemical synthesis and property optimization easier than expected?

Moore KW, Pechen A, Feng XJ, Dominy J, Beltrani VJ, Rabitz H.

Phys Chem Chem Phys. 2011 Jun 7;13(21):10048-70. doi: 10.1039/c1cp20353c. Epub 2011 Apr 12.

PMID:
21483988
9.

Correlates of long-term posttraumatic stress symptoms in children following Hurricane Katrina.

Moore KW, Varela RE.

Child Psychiatry Hum Dev. 2010 Apr;41(2):239-50. doi: 10.1007/s10578-009-0165-6.

PMID:
19949973
10.

Parenting practices and childhood anxiety reporting in Mexican, Mexican American, and European American families.

Luis TM, Varela RE, Moore KW.

J Anxiety Disord. 2008 Aug;22(6):1011-20. Epub 2007 Nov 9.

PMID:
18083326
11.

Proteasome-mediated proteolysis of the interleukin-10 receptor is important for signal downregulation.

Wei SH, Ming-Lum A, Liu Y, Wallach D, Ong CJ, Chung SW, Moore KW, Mui AL.

J Interferon Cytokine Res. 2006 May;26(5):281-90.

PMID:
16689656
12.

2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: functionally selective GABAA alpha3-subtype agonists.

Carling RW, Russell MG, Moore KW, Mitchinson A, Guiblin A, Smith A, Wafford KA, Marshall G, Atack JR, Street LJ.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3550-4. Epub 2006 Apr 18.

PMID:
16621541
13.

Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains.

Silverman J, Liu Q, Bakker A, To W, Duguay A, Alba BM, Smith R, Rivas A, Li P, Le H, Whitehorn E, Moore KW, Swimmer C, Perlroth V, Vogt M, Kolkman J, Stemmer WP.

Nat Biotechnol. 2005 Dec;23(12):1556-61. Epub 2005 Nov 20. Erratum in: Nat Biotechnol. 2006 Feb;24(2):220. Lu, Qiang [corrected to Liu, Qiang].

PMID:
16299519
14.

7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.

Carling RW, Madin A, Guiblin A, Russell MG, Moore KW, Mitchinson A, Sohal B, Pike A, Cook SM, Ragan IC, McKernan RM, Quirk K, Ferris P, Marshall G, Thompson SA, Wafford KA, Dawson GR, Atack JR, Harrison T, Castro JL, Street LJ.

J Med Chem. 2005 Nov 17;48(23):7089-92.

PMID:
16279764
15.

Association analysis of CHMP1.5 genetic variation and bipolar disorder.

McNabb LD, Moore KW, Scena JE, Buono RJ, Berrettini WH.

Psychiatr Genet. 2005 Sep;15(3):211-4.

PMID:
16094257
16.

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit.

Russell MG, Carling RW, Atack JR, Bromidge FA, Cook SM, Hunt P, Isted C, Lucas M, McKernan RM, Mitchinson A, Moore KW, Narquizian R, Macaulay AJ, Thomas D, Thompson SA, Wafford KA, Castro JL.

J Med Chem. 2005 Mar 10;48(5):1367-83.

PMID:
15743180
17.

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

Street LJ, Sternfeld F, Jelley RA, Reeve AJ, Carling RW, Moore KW, McKernan RM, Sohal B, Cook S, Pike A, Dawson GR, Bromidge FA, Wafford KA, Seabrook GR, Thompson SA, Marshall G, Pillai GV, Castro JL, Atack JR, MacLeod AM.

J Med Chem. 2004 Jul 1;47(14):3642-57.

PMID:
15214791
18.

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.

Mitchinson A, Atack JR, Blurton P, Carling RW, Castro JL, Curley KS, Russell MG, Marshall G, McKernan RM, Moore KW, Narquizian R, Smith A, Street LJ, Thompson SA, Wafford K.

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3441-4.

PMID:
15177449
19.

Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.

Sternfeld F, Carling RW, Jelley RA, Ladduwahetty T, Merchant KJ, Moore KW, Reeve AJ, Street LJ, O'Connor D, Sohal B, Atack JR, Cook S, Seabrook G, Wafford K, Tattersall FD, Collinson N, Dawson GR, Castro JL, MacLeod AM.

J Med Chem. 2004 Apr 22;47(9):2176-9.

PMID:
15084116
20.

3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.

Carling RW, Moore KW, Street LJ, Wild D, Isted C, Leeson PD, Thomas S, O'Connor D, McKernan RM, Quirk K, Cook SM, Atack JR, Wafford KA, Thompson SA, Dawson GR, Ferris P, Castro JL.

J Med Chem. 2004 Mar 25;47(7):1807-22.

PMID:
15027873
21.

Bilateral ectopic ureters in a male dog with unilateral renal agenesis.

Taney KG, Moore KW, Carro T, Spencer C.

J Am Vet Med Assoc. 2003 Sep 15;223(6):817-20, 810.

PMID:
14507098
22.

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.

Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O'Farrell AM, McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein RA, de Waal Malefyt R, Moore KW.

J Immunol. 2002 Jun 1;168(11):5699-708.

23.

Differential IL-10R1 expression plays a critical role in IL-10-mediated immune regulation.

Ding Y, Qin L, Zamarin D, Kotenko SV, Pestka S, Moore KW, Bromberg JS.

J Immunol. 2001 Dec 15;167(12):6884-92.

24.

Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10.

Crepaldi L, Gasperini S, Lapinet JA, Calzetti F, Pinardi C, Liu Y, Zurawski S, de Waal Malefyt R, Moore KW, Cassatella MA.

J Immunol. 2001 Aug 15;167(4):2312-22.

25.
26.

Interleukin-10 and the interleukin-10 receptor.

Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A.

Annu Rev Immunol. 2001;19:683-765. Review.

PMID:
11244051
27.

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, de Waal-Malefyt R, Hannum C, Bazan JF, Kastelein RA.

Immunity. 2000 Nov;13(5):715-25.

28.

IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.

Debets R, Timans JC, Churakowa T, Zurawski S, de Waal Malefyt R, Moore KW, Abrams JS, O'Garra A, Bazan JF, Kastelein RA.

J Immunol. 2000 Nov 1;165(9):4950-6.

29.
30.

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ, Castro JL, Ragan CI, Dawson GR, Whiting PJ.

Nat Neurosci. 2000 Jun;3(6):587-92.

PMID:
10816315
31.

Stat3-dependent induction of p19INK4D by IL-10 contributes to inhibition of macrophage proliferation.

O'Farrell AM, Parry DA, Zindy F, Roussel MF, Lees E, Moore KW, Mui AL.

J Immunol. 2000 May 1;164(9):4607-15.

32.

1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.

Carling RW, Moore KW, Moyes CR, Jones EA, Bonner K, Emms F, Marwood R, Patel S, Patel S, Fletcher AE, Beer M, Sohal B, Pike A, Leeson PD.

J Med Chem. 1999 Jul 15;42(14):2706-15.

PMID:
10411491
33.

4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors.

Moore KW, Bonner K, Jones EA, Emms F, Leeson PD, Marwood R, Patel S, Patel S, Rowley M, Thomas S, Carling RW.

Bioorg Med Chem Lett. 1999 May 3;9(9):1285-90.

PMID:
10340615
35.

A review of the effects of bromate on aquatic organisms and toxicity of bromate to oyster (Crassostrea gigas) embryos.

Hutchinson TH, Hutchings MJ, Moore KW.

Ecotoxicol Environ Saf. 1997 Dec;38(3):238-43. Review.

PMID:
9469875
36.

Altered immune responses in interleukin 10 transgenic mice.

Hagenbaugh A, Sharma S, Dubinett SM, Wei SH, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M.

J Exp Med. 1997 Jun 16;185(12):2101-10.

37.

Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10.

Zdanov A, Schalk-Hihi C, Menon S, Moore KW, Wlodawer A.

J Mol Biol. 1997 May 2;268(2):460-7.

PMID:
9159483
38.

4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity.

Carling RW, Leeson PD, Moore KW, Moyes CR, Duncton M, Hudson ML, Baker R, Foster AC, Grimwood S, Kemp JA, Marshall GR, Tricklebank MD, Saywell KL.

J Med Chem. 1997 Feb 28;40(5):754-65.

PMID:
9057862
39.

The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor.

Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, Moore KW, Xu J.

J Immunol. 1997 Jan 15;158(2):604-13.

PMID:
8992974
40.

Follicular dendritic cells specifically express the long CR2/CD21 isoform.

Liu YJ, Xu J, de Bouteiller O, Parham CL, Grouard G, Djossou O, de Saint-Vis B, Lebecque S, Banchereau J, Moore KW.

J Exp Med. 1997 Jan 6;185(1):165-70.

41.

Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain.

Weber-Nordt RM, Riley JK, Greenlund AC, Moore KW, Darnell JE, Schreiber RD.

J Biol Chem. 1996 Nov 1;271(44):27954-61.

42.

Functional regions of the mouse interleukin-10 receptor cytoplasmic domain.

Ho AS, Wei SH, Mui AL, Miyajima A, Moore KW.

Mol Cell Biol. 1995 Sep;15(9):5043-53.

43.
44.
45.

The human interleukin-10 receptor gene maps to chromosome 11q23.3.

Taniyama T, Takai S, Miyazaki E, Fukumura R, Sato J, Kobayashi Y, Hirakawa T, Moore KW, Yamada K.

Hum Genet. 1995 Jan;95(1):99-101.

PMID:
7814035
46.

Lymphotactin: a cytokine that represents a new class of chemokine.

Kelner GS, Kennedy J, Bacon KB, Kleyensteuber S, Largaespada DA, Jenkins NA, Copeland NG, Bazan JF, Moore KW, Schall TJ, et al.

Science. 1994 Nov 25;266(5189):1395-9.

PMID:
7973732
47.

Interleukin-10 and its receptor.

Ho AS, Moore KW.

Ther Immunol. 1994 Jun;1(3):173-85. Review.

PMID:
7584493
48.

Expression cloning and characterization of a human IL-10 receptor.

Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW.

J Immunol. 1994 Feb 15;152(4):1821-9.

PMID:
8120391
49.

A receptor for interleukin 10 is related to interferon receptors.

Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW.

Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11267-71.

50.

3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

Carling RW, Leeson PD, Moore KW, Smith JD, Moyes CR, Mawer IM, Thomas S, Chan T, Baker R, Foster AC, et al.

J Med Chem. 1993 Oct 29;36(22):3397-408.

PMID:
8230130

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