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Developability assessment of physicochemical properties and stability profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 envelope glycoprotein trimers as candidate vaccine antigens.

Whitaker N, Hickey JM, Kaur K, Xiong J, Sawant N, Cupo A, Lee WH, Ozorowski G, Medina-Ramírez M, Ward AB, Sanders RW, Moore JP, Joshi SB, Volkin DB, Dey AK.

J Pharm Sci. 2019 Feb 15. pii: S0022-3549(19)30083-8. doi: 10.1016/j.xphs.2019.01.033. [Epub ahead of print]


Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide.

Kumar S, Sarkar A, Pugach P, Sanders RW, Moore JP, Ward AB, Wilson IA.

Nat Commun. 2019 Feb 15;10(1):763. doi: 10.1038/s41467-019-08738-5.


Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers.

de Taeye SW, Go EP, Sliepen K, Torrents de la Peña A, Badal K, Medina-Ramirez M, Lee WH, Desaire H, Wilson IA, Moore JP, Ward AB, Sanders RW.

J Biol Chem. 2019 Feb 6. pii: jbc.RA118.005396. doi: 10.1074/jbc.RA118.005396. [Epub ahead of print]


Differential control of muscle sympathetic outflow in single units of humans: a role for pulmonary artery baroreceptors?

Moore JP, Drinkhill MJ.

Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H430-H431. doi: 10.1152/ajpheart.00817.2018. No abstract available.


Deconstructing Wine Grape Cell Walls with Enzymes During Winemaking: New Insights from Glycan Microarray Technology.

Gao Y, Zietsman AJJ, Vivier MA, Moore JP.

Molecules. 2019 Jan 4;24(1). pii: E165. doi: 10.3390/molecules24010165. Review.


Metabolomics as a complement to phylogenetics for assessing intraspecific boundaries in the desiccation-tolerant medicinal shrub Myrothamnus flabellifolia (Myrothamnaceae).

Bentley J, Moore JP, Farrant JM.

Phytochemistry. 2019 Mar;159:127-136. doi: 10.1016/j.phytochem.2018.12.016. Epub 2019 Jan 3.


Safety and outcomes of catheter ablation for atrial fibrillation in adults with congenital heart disease: A multicenter registry study.

Liang JJ, Frankel DS, Parikh V, Lakkireddy D, Mohanty S, Burkhardt JD, Natale A, Szilagyi J, Gerstenfeld EP, Moore JP, Collins KK, Kay JD, Santangeli P, Marchlinski FE, Sauer WH, Nguyen DT.

Heart Rhythm. 2018 Dec 26. pii: S1547-5271(18)31356-0. doi: 10.1016/j.hrthm.2018.12.024. [Epub ahead of print]


Investigating the relationship between grape cell wall polysaccharide composition and the extractability of phenolic compounds into Shiraz wines. Part I: Vintage and ripeness effects.

Garrido-Bañuelos G, Buica A, Schückel J, Zietsman AJJ, Willats WGT, Moore JP, Du Toit WJ.

Food Chem. 2019 Apr 25;278:36-46. doi: 10.1016/j.foodchem.2018.10.134. Epub 2018 Oct 30.


Investigating the relationship between cell wall polysaccharide composition and the extractability of grape phenolic compounds into Shiraz wines. Part II: Extractability during fermentation into wines made from grapes of different ripeness levels.

Garrido-Bañuelos G, Buica A, Schückel J, Zietsman AJJ, Willats WGT, Moore JP, Du Toit WJ.

Food Chem. 2019 Apr 25;278:26-35. doi: 10.1016/j.foodchem.2018.10.136. Epub 2018 Oct 30.


Experimental evolution of Escherichia coli K-12 in the presence of PMF uncoupler CCCP selects for mutations affecting PMF-driven drug efflux pumps.

Griffith JM, Basting PJ, Bischof KM, Wrona EP, Kunka KS, Tancredi AC, Moore JP, Hyman MRL, Slonczewski JL.

Appl Environ Microbiol. 2018 Dec 21. pii: AEM.02792-18. doi: 10.1128/AEM.02792-18. [Epub ahead of print]


Plant Immunity Is Compartmentalized and Specialized in Roots.

Chuberre C, Plancot B, Driouich A, Moore JP, Bardor M, Gügi B, Vicré M.

Front Plant Sci. 2018 Nov 28;9:1692. doi: 10.3389/fpls.2018.01692. eCollection 2018. Review.


A minimally invasive hybrid approach for cardiac resynchronization of the systemic right ventricle.

Moore JP, Gallotti RG, Shannon KM, Biniwale R.

Pacing Clin Electrophysiol. 2019 Feb;42(2):171-177. doi: 10.1111/pace.13568. Epub 2018 Dec 13.


Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes.

Ringe RP, Pugach P, Cottrell CA, LaBranche CC, Seabright GE, Ketas TJ, Ozorowski G, Kumar S, Schorcht A, van Gils MJ, Crispin M, Montefiori DC, Wilson IA, Ward AB, Sanders RW, Klasse PJ, Moore JP.

J Virol. 2019 Feb 5;93(4). pii: e01656-18. doi: 10.1128/JVI.01656-18. Print 2019 Feb 15.


Genetic polymorphism analysis of patients with primary hyperhidrosis.

Simes BC, Moore JP, Brown TC, Rushforth TJ, Bookout AL, Richardson CL.

Clin Cosmet Investig Dermatol. 2018 Oct 11;11:477-483. doi: 10.2147/CCID.S176842. eCollection 2018.


Catheter Ablation of Ventricular Arrhythmia for Ebstein's Anomaly in Unoperated and Post-Surgical Patients.

Moore JP, Shannon KM, Gallotti RG, McLeod CJ, Chiriac A, Walsh EP, Sreeram N, Patel AR, De Groot NM, von Alvensleben J, Balaji S, Frankel DS, Miyake CY, Perry JC, Shivkumar K.

JACC Clin Electrophysiol. 2018 Oct;4(10):1300-1307. doi: 10.1016/j.jacep.2018.05.009. Epub 2018 Jun 27.


Cosmetic outcomes and quality of life in children with cardiac implantable electronic devices.

Gist KM, Marino BS, Palmer C, Fish FA, Moore JP, Czosek RJ, Cassedy A, LaPage MJ, Law IH, Garnreiter J, Cannon BC, Collins KK.

Pacing Clin Electrophysiol. 2019 Jan;42(1):46-57. doi: 10.1111/pace.13522. Epub 2018 Nov 19.


The Reliability of Suprapatellar Transverse Sonographic Assessment of Femoral Trochlear Cartilage Thickness in Healthy Adults.

Roberts HM, Moore JP, Thom JM.

J Ultrasound Med. 2018 Sep 12. doi: 10.1002/jum.14775. [Epub ahead of print]


Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen.

Struwe WB, Chertova E, Allen JD, Seabright GE, Watanabe Y, Harvey DJ, Medina-Ramirez M, Roser JD, Smith R, Westcott D, Keele BF, Bess JW Jr, Sanders RW, Lifson JD, Moore JP, Crispin M.

Cell Rep. 2018 Aug 21;24(8):1958-1966.e5. doi: 10.1016/j.celrep.2018.07.080.


Implantation techniques and outcomes after cardiac resynchronization therapy for congenitally corrected transposition of the great arteries.

Moore JP, Cho D, Lin JP, Lluri G, Reardon LC, Aboulhosn JA, Hageman A, Shannon KM.

Heart Rhythm. 2018 Dec;15(12):1808-1815. doi: 10.1016/j.hrthm.2018.08.017. Epub 2018 Aug 18.


Cryoballoon pulmonary vein isolation after extracardiac Fontan operation.

Small AJ, Buch EF, Sanchez DR, Moore JP.

HeartRhythm Case Rep. 2018 Apr 27;4(8):336-338. doi: 10.1016/j.hrcr.2018.04.008. eCollection 2018 Aug. No abstract available.


Life-Threatening Event Risk in Children With Wolff-Parkinson-White Syndrome: A Multicenter International Study.

Etheridge SP, Escudero CA, Blaufox AD, Law IH, Dechert-Crooks BE, Stephenson EA, Dubin AM, Ceresnak SR, Motonaga KS, Skinner JR, Marcondes LD, Perry JC, Collins KK, Seslar SP, Cabrera M, Uzun O, Cannon BC, Aziz PF, Kubuš P, Tanel RE, Valdes SO, Sami S, Kertesz NJ, Maldonado J, Erickson C, Moore JP, Asakai H, Mill L, Abcede M, Spector ZZ, Menon S, Shwayder M, Bradley DJ, Cohen MI, Sanatani S.

JACC Clin Electrophysiol. 2018 Apr;4(4):433-444. doi: 10.1016/j.jacep.2017.10.009. Epub 2017 Nov 15.


Allostasis and sedation practices in intensive care evaluation: an observational pilot study.

Moore JPR, Anstey C, Murray L, Fraser JF, Singer M.

Intensive Care Med Exp. 2018 Jun 20;6(1):13. doi: 10.1186/s40635-018-0179-0.


Clinical and electrophysiological properties of atrial tachycardia after pediatric heart transplantation.

Drogalis-Kim DE, Gallotti RG, Blais BA, Perens G, Moore JP.

Pacing Clin Electrophysiol. 2018 Sep;41(9):1093-1100. doi: 10.1111/pace.13415. Epub 2018 Jul 11.


Electrophysiology and structural interventions in adults with congenital heart disease: Comparison of combined versus separate procedures.

Lindsay I, Nik-Ahd F, Aboulhosn JA, Moore JP.

J Cardiovasc Electrophysiol. 2018 Sep;29(9):1280-1286. doi: 10.1111/jce.13637. Epub 2018 Jun 6.


Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.

Schiffner T, Pallesen J, Russell RA, Dodd J, de Val N, LaBranche CC, Montefiori D, Tomaras GD, Shen X, Harris SL, Moghaddam AE, Kalyuzhniy O, Sanders RW, McCoy LE, Moore JP, Ward AB, Sattentau QJ.

PLoS Pathog. 2018 May 10;14(5):e1006986. doi: 10.1371/journal.ppat.1006986. eCollection 2018 May.


Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro.

Ozorowski G, Cupo A, Golabek M, LoPiccolo M, Ketas TA, Cavallary M, Cottrell CA, Klasse PJ, Ward AB, Moore JP.

J Virol. 2018 Jun 13;92(13). pii: e00381-18. doi: 10.1128/JVI.00381-18. Print 2018 Jul 1.


Ventricular arrhythmia burden after transcatheter versus surgical pulmonary valve replacement.

Wadia SK, Lluri G, Aboulhosn JA, Shivkumar K, Reemtsen BL, Laks H, Biniwale RM, Levi DS, Salem M, Moore JP.

Heart. 2018 Nov;104(21):1791-1796. doi: 10.1136/heartjnl-2017-312769. Epub 2018 Apr 10.


The effect of aerobic walking and lower body resistance exercise on serum COMP and hyaluronan, in both males and females.

Roberts HM, Moore JP, Thom JM.

Eur J Appl Physiol. 2018 Jun;118(6):1095-1105. doi: 10.1007/s00421-018-3837-8. Epub 2018 Mar 13.


Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.

Klasse PJ, Ketas TJ, Cottrell CA, Ozorowski G, Debnath G, Camara D, Francomano E, Pugach P, Ringe RP, LaBranche CC, van Gils MJ, Bricault CA, Barouch DH, Crotty S, Silvestri G, Kasturi S, Pulendran B, Wilson IA, Montefiori DC, Sanders RW, Ward AB, Moore JP.

PLoS Pathog. 2018 Feb 23;14(2):e1006913. doi: 10.1371/journal.ppat.1006913. eCollection 2018 Feb.


Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages.

Behrens AJ, Kumar A, Medina-Ramirez M, Cupo A, Marshall K, Cruz Portillo VM, Harvey DJ, Ozorowski G, Zitzmann N, Wilson IA, Ward AB, Struwe WB, Moore JP, Sanders RW, Crispin M.

J Proteome Res. 2018 Mar 2;17(3):987-999. doi: 10.1021/acs.jproteome.7b00639. Epub 2018 Feb 8.


Leydig cell insufficiency in hypospermatogenesis: a paracrine effect of activin-inhibin signaling?

Winters SJ, Moore JP Jr, Clark BJ.

Andrology. 2018 Mar;6(2):262-271. doi: 10.1111/andr.12459. Epub 2018 Feb 6. Review.


Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination.

Torrents de la Peña A, de Taeye SW, Sliepen K, LaBranche CC, Burger JA, Schermer EE, Montefiori DC, Moore JP, Klasse PJ, Sanders RW.

J Virol. 2018 Mar 28;92(8). pii: e01957-17. doi: 10.1128/JVI.01957-17. Print 2018 Apr 15.


Chemoreflex mediated arrhythmia during apnea at 5,050 m in low- but not high-altitude natives.

Busch SA, Davies H, van Diepen S, Simpson LL, Sobierajski F, Riske L, Stembridge M, Ainslie PN, Willie CK, Hoiland R, Moore JP, Steinback CD.

J Appl Physiol (1985). 2018 Apr 1;124(4):930-937. doi: 10.1152/japplphysiol.00774.2017. Epub 2017 Dec 21.


Predictors of electrocardiographic screening failure for the subcutaneous implantable cardioverter-defibrillator in children: A prospective multicenter study.

Campbell M, Moore JP, Sreeram N, von Alvensleben JC, Shah A, Batra A, Law I, Sanatani S, Thomas V, Nik-Ahd F, Williams S, Nosavan N, Maldonado J, Hart A, Nguyen T, Balaji S.

Heart Rhythm. 2018 May;15(5):703-707. doi: 10.1016/j.hrthm.2018.01.004. Epub 2018 Jan 5.


Transvenous pacemaker implantation after the bidirectional Glenn operation for patients with complex congenital disease.

Harake DE, Shannon KM, Aboulhosn JA, Moore JP.

J Cardiovasc Electrophysiol. 2018 Mar;29(3):497-503. doi: 10.1111/jce.13404. Epub 2018 Jan 5.


Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.

de Taeye SW, de la Peña AT, Vecchione A, Scutigliani E, Sliepen K, Burger JA, van der Woude P, Schorcht A, Schermer EE, van Gils MJ, LaBranche CC, Montefiori DC, Wilson IA, Moore JP, Ward AB, Sanders RW.

J Biol Chem. 2018 Feb 2;293(5):1688-1701. doi: 10.1074/jbc.RA117.000709. Epub 2017 Dec 8.


cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate.

Dey AK, Cupo A, Ozorowski G, Sharma VK, Behrens AJ, Go EP, Ketas TJ, Yasmeen A, Klasse PJ, Sayeed E, Desaire H, Crispin M, Wilson IA, Sanders RW, Hassell T, Ward AB, Moore JP.

Biotechnol Bioeng. 2018 Apr;115(4):885-899. doi: 10.1002/bit.26498. Epub 2017 Dec 11.


Exercise training and weight loss, not always a happy marriage: single blind exercise trials in females with diverse BMI.

Jackson M, Fatahi F, Alabduljader K, Jelleyman C, Moore JP, Kubis HP.

Appl Physiol Nutr Metab. 2018 Apr;43(4):363-370. doi: 10.1139/apnm-2017-0577. Epub 2017 Nov 2.


The diagnosis and management of long QT syndrome based on fetal echocardiography.

Blais BA, Satou G, Sklansky MS, Madnawat H, Moore JP.

HeartRhythm Case Rep. 2017 Jul 18;3(9):407-410. doi: 10.1016/j.hrcr.2017.04.007. eCollection 2017 Sep. No abstract available.


High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers.

Sullivan JT, Sulli C, Nilo A, Yasmeen A, Ozorowski G, Sanders RW, Ward AB, Klasse PJ, Moore JP, Doranz BJ.

J Virol. 2017 Oct 27;91(22). pii: e00862-17. doi: 10.1128/JVI.00862-17. Print 2017 Nov 15.


UBC-Nepal Expedition: acute alterations in sympathetic nervous activity do not influence brachial artery endothelial function at sea level and high altitude.

Tymko MM, Tremblay JC, Steinback CD, Moore JP, Hansen AB, Patrician A, Howe CA, Hoiland RL, Green DJ, Ainslie PN.

J Appl Physiol (1985). 2017 Nov 1;123(5):1386-1396. doi: 10.1152/japplphysiol.00583.2017. Epub 2017 Aug 31.


Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

Medina-Ramírez M, Garces F, Escolano A, Skog P, de Taeye SW, Del Moral-Sanchez I, McGuire AT, Yasmeen A, Behrens AJ, Ozorowski G, van den Kerkhof TLGM, Freund NT, Dosenovic P, Hua Y, Gitlin AD, Cupo A, van der Woude P, Golabek M, Sliepen K, Blane T, Kootstra N, van Breemen MJ, Pritchard LK, Stanfield RL, Crispin M, Ward AB, Stamatatos L, Klasse PJ, Moore JP, Nemazee D, Nussenzweig MC, Wilson IA, Sanders RW.

J Exp Med. 2017 Sep 4;214(9):2573-2590. doi: 10.1084/jem.20161160. Epub 2017 Aug 28.


Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.

Torrents de la Peña A, Julien JP, de Taeye SW, Garces F, Guttman M, Ozorowski G, Pritchard LK, Behrens AJ, Go EP, Burger JA, Schermer EE, Sliepen K, Ketas TJ, Pugach P, Yasmeen A, Cottrell CA, Torres JL, Vavourakis CD, van Gils MJ, LaBranche C, Montefiori DC, Desaire H, Crispin M, Klasse PJ, Lee KK, Moore JP, Ward AB, Wilson IA, Sanders RW.

Cell Rep. 2017 Aug 22;20(8):1805-1817. doi: 10.1016/j.celrep.2017.07.077.


HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers.

Capucci S, Wee EG, Schiffner T, LaBranche CC, Borthwick N, Cupo A, Dodd J, Dean H, Sattentau Q, Montefiori D, Klasse PJ, Sanders RW, Moore JP, Hanke T.

PLoS One. 2017 Aug 9;12(8):e0181886. doi: 10.1371/journal.pone.0181886. eCollection 2017.


Subvalvular catheter ablation of the cavotricuspid isthmus in a patient with Ebstein's anomaly and tricuspid valve replacement.

Gallotti RG, Shannon KM, Moore JP.

HeartRhythm Case Rep. 2017 May 30;3(7):336-339. doi: 10.1016/j.hrcr.2017.04.008. eCollection 2017 Jul. No abstract available.


Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike.

Ozorowski G, Pallesen J, de Val N, Lyumkis D, Cottrell CA, Torres JL, Copps J, Stanfield RL, Cupo A, Pugach P, Moore JP, Wilson IA, Ward AB.

Nature. 2017 Jul 20;547(7663):360-363. doi: 10.1038/nature23010. Epub 2017 Jul 12.


Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers.

Ringe RP, Ozorowski G, Rantalainen K, Struwe WB, Matthews K, Torres JL, Yasmeen A, Cottrell CA, Ketas TJ, LaBranche CC, Montefiori DC, Cupo A, Crispin M, Wilson IA, Ward AB, Sanders RW, Klasse PJ, Moore JP.

J Virol. 2017 Jul 12;91(15). pii: e00677-17. doi: 10.1128/JVI.00677-17. Print 2017 Aug 1.


Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial.

Kannankeril PJ, Moore JP, Cerrone M, Priori SG, Kertesz NJ, Ro PS, Batra AS, Kaufman ES, Fairbrother DL, Saarel EV, Etheridge SP, Kanter RJ, Carboni MP, Dzurik MV, Fountain D, Chen H, Ely EW, Roden DM, Knollmann BC.

JAMA Cardiol. 2017 Jul 1;2(7):759-766. doi: 10.1001/jamacardio.2017.1320.


Combining hydrothermal pretreatment with enzymes de-pectinates and exposes the innermost xyloglucan-rich hemicellulose layers of wine grape pomace.

Zietsman AJJ, Moore JP, Fangel JU, Willats WGT, Vivier MA.

Food Chem. 2017 Oct 1;232:340-350. doi: 10.1016/j.foodchem.2017.04.015. Epub 2017 Apr 6.


Introduction to the Congenital Heart Defects: Anatomy of the Conduction System.

Moore JP, Aboulhosn JA.

Card Electrophysiol Clin. 2017 Jun;9(2):167-175. doi: 10.1016/j.ccep.2017.02.001. Epub 2017 Mar 14. Review.


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