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NR1H4-related Progressive Familial Intrahepatic Cholestasis 5: Further Evidence for Rapidly Progressive Liver Failure.

Himes RW, Mojarrad M, Eslahi A, Finegold MJ, Maroofian R, Moore DD.

J Pediatr Gastroenterol Nutr. 2020 Feb 24. doi: 10.1097/MPG.0000000000002670. [Epub ahead of print]


FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis.

Panzitt K, Jungwirth E, Krones E, Lee JM, Pollheimer M, Thallinger GG, Kolb-Lenz D, Xiao R, Thorell A, Trauner M, Fickert P, Marschall HU, Moore DD, Wagner M.

J Hepatol. 2020 Jan 28. pii: S0168-8278(20)30031-3. doi: 10.1016/j.jhep.2020.01.014. [Epub ahead of print]


Metabolic dysregulation in the Atp7b -/- Wilson's disease mouse model.

Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM.

Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2076-2083. doi: 10.1073/pnas.1914267117. Epub 2020 Jan 10.


Periprosthetic fractures about total knee arthroplasty.

Lombardo DJ, Siljander MP, Sobh A, Moore DD, Karadsheh MS.

Musculoskelet Surg. 2019 Oct 23. doi: 10.1007/s12306-019-00628-9. [Epub ahead of print] Review.


Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice.

Dong B, Zhou Y, Wang W, Scott J, Kim K, Sun Z, Guo Q, Lu Y, Gonzales NM, Wu H, Hartig SM, York RB, Yang F, Moore DD.

Hepatology. 2019 Sep 11. doi: 10.1002/hep.30937. [Epub ahead of print]


Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.

Mays SG, Flynn AR, Cornelison JL, Okafor CD, Wang H, Wang G, Huang X, Donaldson HN, Millings EJ, Polavarapu R, Moore DD, Calvert JW, Jui NT, Ortlund EA.

J Med Chem. 2019 Dec 26;62(24):11022-11034. doi: 10.1021/acs.jmedchem.9b00753. Epub 2019 Sep 6.


Vitamin D Receptor Activation in Liver Macrophages Protects Against Hepatic Endoplasmic Reticulum Stress in Mice.

Zhou Y, Dong B, Kim KH, Choi S, Sun Z, Wu N, Wu Y, Scott J, Moore DD.

Hepatology. 2019 Aug 5. doi: 10.1002/hep.30887. [Epub ahead of print]


Methyl-Sensing Nuclear Receptor Liver Receptor Homolog-1 Regulates Mitochondrial Function in Mouse Hepatocytes.

Choi S, Dong B, Lin CJ, Heo MJ, Kim KH, Sun Z, Wagner M, Putluri N, Suh JM, Wang MC, Moore DD.

Hepatology. 2020 Mar;71(3):1055-1069. doi: 10.1002/hep.30884. Epub 2019 Dec 23.


Does Taper Design Affect Taper Fretting Corrosion in Ceramic-on-Polyethylene Total Hip Arthroplasty? A Retrieval Analysis.

Siljander MP, Gehrke CK, Wheeler SD, Sobh AH, Moore DD, Flierl MA, Baker EA.

J Arthroplasty. 2019 Jul;34(7S):S366-S372.e2. doi: 10.1016/j.arth.2019.02.058. Epub 2019 Mar 6.


Fretting and Corrosion Damage of Retrieved Dual-Mobility Total Hip Arthroplasty Systems.

Lombardo DJ, Siljander MP, Gehrke CK, Moore DD, Karadsheh MS, Baker EA.

J Arthroplasty. 2019 Jun;34(6):1273-1278. doi: 10.1016/j.arth.2019.02.008. Epub 2019 Feb 14.


MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling.

Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, Yang F.

J Clin Invest. 2019 Mar 1;129(3):1015-1029. doi: 10.1172/JCI97712. Epub 2019 Jan 28.


Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis.

Kim KH, Choi JM, Li F, Dong B, Wooton-Kee CR, Arizpe A, Anakk S, Jung SY, Hartig SM, Moore DD.

Hepatol Commun. 2018 Dec 4;3(1):147-159. doi: 10.1002/hep4.1274. eCollection 2019 Jan.


Intramuscular hemangioma after total hip arthroplasty: an iatrogenic etiology.

Sobh AH, Brown L, Moore DD.

Arthroplast Today. 2017 Dec 21;4(4):417-420. doi: 10.1016/j.artd.2017.11.010. eCollection 2018 Dec.


LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.

Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA.

Nat Commun. 2018 Oct 10;9(1):4055. doi: 10.1038/s41467-018-06137-w.


Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing.

Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD.

Gastroenterology. 2018 Dec;155(6):1967-1970.e6. doi: 10.1053/j.gastro.2018.08.037. Epub 2018 Aug 28.


Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer.

Yim SY, Shim JJ, Shin JH, Jeong YS, Kang SH, Kim SB, Eun YG, Lee DJ, Conner EA, Factor VM, Moore DD, Johnson RL, Thorgeirsson SS, Lee JS.

Mol Cancer Res. 2018 Nov;16(11):1713-1723. doi: 10.1158/1541-7786.MCR-18-0313. Epub 2018 Aug 6.


TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic, and pressure-induced stress in mice.

Eblimit Z, Thevananther S, Karpen SJ, Taegtmeyer H, Moore DD, Adorini L, Penny DJ, Desai MS.

Cardiovasc Ther. 2018 Oct;36(5):e12462. doi: 10.1111/1755-5922.12462. Epub 2018 Aug 22.


miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity.

Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, Moore DD, Deng T, McGuire SE, Hartig SM.

Diabetes. 2018 Dec;67(12):2541-2553. doi: 10.2337/db17-1378. Epub 2018 Jul 12.


Characterization of doxycycline-loaded calcium phosphate cement: implications for treatment of aneurysmal bone cysts.

Daley E, Kurdziel MD, Koueiter D, Moore DD.

J Mater Sci Mater Med. 2018 Jul 10;29(7):109. doi: 10.1007/s10856-018-6117-6.


Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis.

Kim KH, Choi JM, Li F, Arizpe A, Wooton-Kee CR, Anakk S, Jung SY, Finegold MJ, Moore DD.

Endocrinology. 2018 Jun 1;159(6):2435-2446. doi: 10.1210/en.2018-00110.


Effect of Bisphosphonate Pretreatment on Fresh Osteochondral Allografts: Analysis of In Vitro Graft Structure and In Vivo Osseous Incorporation.

Moore DD, Baker KC, Baker EA, Fleischer MM, Newton MD, Barreras N, Vaupel ZM, Fortin PT.

Orthopedics. 2018 May 1;41(3):e376-e382. doi: 10.3928/01477447-20180320-04. Epub 2018 Mar 26.


Seroprevalence of anti-polio antibodies in children from polio high risk area of Afghanistan: A cross sectional survey 2017.

Hussain I, Mach O, Hamid NA, Bhatti ZS, Moore DD, Oberste MS, Khan S, Khan H, Weldon WC, Sutter RW, Bhutta ZA, Soofi SB.

Vaccine. 2018 Apr 5;36(15):1921-1924. doi: 10.1016/j.vaccine.2018.02.055. Epub 2018 Mar 3.


Asprosin is a centrally acting orexigenic hormone.

Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Sutton VR, Moore DD, Butte NF, Krashes MJ, Xu Y, Chopra AR.

Nat Med. 2017 Dec;23(12):1444-1453. doi: 10.1038/nm.4432. Epub 2017 Nov 6.


Cost Analysis, Complications, and Discharge Disposition Associated With Simultaneous vs Staged Bilateral Total Knee Arthroplasty.

Sobh AH, Siljander MP, Mells AJ, Koueiter DM, Moore DD, Karadsheh MS.

J Arthroplasty. 2018 Feb;33(2):320-323. doi: 10.1016/j.arth.2017.09.004. Epub 2017 Sep 13.


Pediatric Chondrosarcoma of the Sternum Resected with Thorascopic Assistance.

Bawa HS, Moore DD, Pelayo JC, Cipriani N, Mak G, Haydon RC.

Open Orthop J. 2017 May 31;11:479-485. doi: 10.2174/1874325001711010479. eCollection 2017.


A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis.

Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Lu Y, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F.

Neoplasia. 2017 May;19(5):421-428. doi: 10.1016/j.neo.2017.03.003. Epub 2017 Apr 20.


Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice.

Kim KH, Choi S, Zhou Y, Kim EY, Lee JM, Saha PK, Anakk S, Moore DD.

Hepatology. 2017 Aug;66(2):498-509. doi: 10.1002/hep.29199. Epub 2017 Jun 26.


Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice.

Kumar R, Mota LC, Litoff EJ, Rooney JP, Boswell WT, Courter E, Henderson CM, Hernandez JP, Corton JC, Moore DD, Baldwin WS.

PLoS One. 2017 Mar 28;12(3):e0174355. doi: 10.1371/journal.pone.0174355. eCollection 2017.


Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance.

Preidis GA, Kim KH, Moore DD.

J Clin Invest. 2017 Apr 3;127(4):1193-1201. doi: 10.1172/JCI88893. Epub 2017 Mar 13. Review.


Regulation of Liver Energy Balance by the Nuclear Receptors Farnesoid X Receptor and Peroxisome Proliferator Activated Receptor α.

Kim KH, Moore DD.

Dig Dis. 2017;35(3):203-209. doi: 10.1159/000450912. Epub 2017 Mar 1. Review.


Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.

Kettner NM, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L.

Cancer Cell. 2016 Dec 12;30(6):909-924. doi: 10.1016/j.ccell.2016.10.007. Epub 2016 Nov 23.


Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart.

Desai MS, Mathur B, Eblimit Z, Vasquez H, Taegtmeyer H, Karpen SJ, Penny DJ, Moore DD, Anakk S.

Hepatology. 2017 Jan;65(1):189-201. doi: 10.1002/hep.28890. Epub 2016 Nov 29.


Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice.

Wu N, Kim KH, Zhou Y, Lee JM, Kettner NM, Mamrosh JL, Choi S, Fu L, Moore DD.

Mol Endocrinol. 2016 Sep;30(9):988-95. doi: 10.1210/me.2015-1295. Epub 2016 Jul 18.


Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells.

Kim KH, Lee JM, Zhou Y, Harpavat S, Moore DD.

Mol Endocrinol. 2016 Aug;30(8):905-16. doi: 10.1210/me.2016-1029. Epub 2016 Jun 29.


Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight.

Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA.

Diabetes. 2016 Sep;65(9):2732-41. doi: 10.2337/db16-0309. Epub 2016 May 23.


Asprosin, a Fasting-Induced Glucogenic Protein Hormone.

Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha PK, Del Solar M, Zhu B, York B, Sarkar P, Rendon DA, Gaber MW, LeMaire SA, Coselli JS, Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR.

Cell. 2016 Apr 21;165(3):566-79. doi: 10.1016/j.cell.2016.02.063. Epub 2016 Apr 14.


A novel chemically modified curcumin reduces inflammation-mediated connective tissue breakdown in a rat model of diabetes: periodontal and systemic effects.

Elburki MS, Moore DD, Terezakis NG, Zhang Y, Lee HM, Johnson F, Golub LM.

J Periodontal Res. 2017 Apr;52(2):186-200. doi: 10.1111/jre.12381. Epub 2016 Apr 1.


Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.

Gomez-Ospina N, Potter CJ, Xiao R, Manickam K, Kim MS, Kim KH, Shneider BL, Picarsic JL, Jacobson TA, Zhang J, He W, Liu P, Knisely AS, Finegold MJ, Muzny DM, Boerwinkle E, Lupski JR, Plon SE, Gibbs RA, Eng CM, Yang Y, Washington GC, Porteus MH, Berquist WE, Kambham N, Singh RJ, Xia F, Enns GM, Moore DD.

Nat Commun. 2016 Feb 18;7:10713. doi: 10.1038/ncomms10713.


Life After Bariatric Surgery: Perceptions of Male Patients and Their Intimate Relationships.

Moore DD, Cooper CE.

J Marital Fam Ther. 2016 Jul;42(3):495-508. doi: 10.1111/jmft.12155. Epub 2016 Jan 25.


Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1.

Ahn HY, Kim HH, Kim YA, Kim M, Ohn JH, Chung SS, Lee YK, Park DJ, Park KS, Moore DD, Park YJ.

Endocrinol Metab (Seoul). 2015 Dec;30(4):584-92. doi: 10.3803/EnM.2015.30.4.584. Epub 2015 Oct 20.


Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism.

Wagner M, Choi S, Panzitt K, Mamrosh JL, Lee JM, Zaufel A, Xiao R, Wooton-Kee R, Ståhlman M, Newgard CB, Borén J, Moore DD.

Hepatology. 2016 Jan;63(1):95-106. doi: 10.1002/hep.28124. Epub 2015 Oct 10.


Elevated copper impairs hepatic nuclear receptor function in Wilson's disease.

Wooton-Kee CR, Jain AK, Wagner M, Grusak MA, Finegold MJ, Lutsenko S, Moore DD.

J Clin Invest. 2015 Sep;125(9):3449-60. doi: 10.1172/JCI78991. Epub 2015 Aug 4.


Neutralization of Enterovirus D68 isolated from the 2014 US outbreak by commercial intravenous immune globulin products.

Zhang Y, Moore DD, Nix WA, Oberste MS, Weldon WC.

J Clin Virol. 2015 Aug;69:172-5. doi: 10.1016/j.jcv.2015.06.086. Epub 2015 Jun 19.


Correction: Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution.

Mamrosh JL, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, DeMayo FJ, Moore DD.

Elife. 2015 Jul 24;4:e10084. doi: 10.7554/eLife.10084. No abstract available.


Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation.

Yuk JM, Kim TS, Kim SY, Lee HM, Han J, Dufour CR, Kim JK, Jin HS, Yang CS, Park KS, Lee CH, Kim JM, Kweon GR, Choi HS, Vanacker JM, Moore DD, Giguère V, Jo EK.

Immunity. 2015 Jul 21;43(1):80-91. doi: 10.1016/j.immuni.2015.07.003.


Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes.

Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE.

Mol Endocrinol. 2015 Sep;29(9):1320-33. doi: 10.1210/me.2015-1084. Epub 2015 Jul 20.


Circadian Dysfunction Induces Leptin Resistance in Mice.

Kettner NM, Mayo SA, Hua J, Lee C, Moore DD, Fu L.

Cell Metab. 2015 Sep 1;22(3):448-59. doi: 10.1016/j.cmet.2015.06.005. Epub 2015 Jul 9.


Using Google Reverse Image Search to Decipher Biological Images.

Mamrosh JL, Moore DD.

Curr Protoc Mol Biol. 2015 Jul 1;111:19.13.1-19.13.4. doi: 10.1002/0471142727.mb1913s111.


Imaging Diagnosis of Solitary Tumors of the Phalanges and Metacarpals of the Hand.

Ahmed O, Moore DD, Stacy GS.

AJR Am J Roentgenol. 2015 Jul;205(1):106-15. doi: 10.2214/AJR.14.13340. Review.


MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids.

Fu X, Dong B, Tian Y, Lefebvre P, Meng Z, Wang X, Pattou F, Han W, Wang X, Lou F, Jove R, Staels B, Moore DD, Huang W.

J Clin Invest. 2015 Jun;125(6):2497-509. doi: 10.1172/JCI75438. Epub 2015 May 11.

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