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Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer.

Yim SY, Shim JJ, Shin JH, Jeong YS, Kang SH, Kim SB, Eun YG, Lee DJ, Conner EA, Factor VM, Moore DD, Johnson RL, Thorgeirsson SS, Lee JS.

Mol Cancer Res. 2018 Aug 6. pii: molcanres.0313.2018. doi: 10.1158/1541-7786.MCR-18-0313. [Epub ahead of print]


TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic and pressure induced stress in mice.

Eblimit Z, Thevananther S, Karpen SJ, Taegtmeyer H, Moore DD, Adorini L, Penny DJ, Desai MS.

Cardiovasc Ther. 2018 Aug 2:e12462. doi: 10.1111/1755-5922.12462. [Epub ahead of print]


miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity.

Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, Moore DD, Deng T, McGuire SE, Hartig SM.

Diabetes. 2018 Jul 12. pii: db171378. doi: 10.2337/db17-1378. [Epub ahead of print]


Characterization of doxycycline-loaded calcium phosphate cement: implications for treatment of aneurysmal bone cysts.

Daley E, Kurdziel MD, Koueiter D, Moore DD.

J Mater Sci Mater Med. 2018 Jul 10;29(7):109. doi: 10.1007/s10856-018-6117-6.


Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis.

Kim KH, Choi JM, Li F, Arizpe A, Wooton-Kee CR, Anakk S, Jung SY, Finegold MJ, Moore DD.

Endocrinology. 2018 Jun 1;159(6):2435-2446. doi: 10.1210/en.2018-00110.


Effect of Bisphosphonate Pretreatment on Fresh Osteochondral Allografts: Analysis of In Vitro Graft Structure and In Vivo Osseous Incorporation.

Moore DD, Baker KC, Baker EA, Fleischer MM, Newton MD, Barreras N, Vaupel ZM, Fortin PT.

Orthopedics. 2018 May 1;41(3):e376-e382. doi: 10.3928/01477447-20180320-04. Epub 2018 Mar 26.


Seroprevalence of anti-polio antibodies in children from polio high risk area of Afghanistan: A cross sectional survey 2017.

Hussain I, Mach O, Hamid NA, Bhatti ZS, Moore DD, Oberste MS, Khan S, Khan H, Weldon WC, Sutter RW, Bhutta ZA, Soofi SB.

Vaccine. 2018 Apr 5;36(15):1921-1924. doi: 10.1016/j.vaccine.2018.02.055. Epub 2018 Mar 3.


Asprosin is a centrally acting orexigenic hormone.

Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Sutton VR, Moore DD, Butte NF, Krashes MJ, Xu Y, Chopra AR.

Nat Med. 2017 Dec;23(12):1444-1453. doi: 10.1038/nm.4432. Epub 2017 Nov 6.


Cost Analysis, Complications, and Discharge Disposition Associated With Simultaneous vs Staged Bilateral Total Knee Arthroplasty.

Sobh AH, Siljander MP, Mells AJ, Koueiter DM, Moore DD, Karadsheh MS.

J Arthroplasty. 2018 Feb;33(2):320-323. doi: 10.1016/j.arth.2017.09.004. Epub 2017 Sep 13.


Pediatric Chondrosarcoma of the Sternum Resected with Thorascopic Assistance.

Bawa HS, Moore DD, Pelayo JC, Cipriani N, Mak G, Haydon RC.

Open Orthop J. 2017 May 31;11:479-485. doi: 10.2174/1874325001711010479. eCollection 2017.


A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis.

Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Lu Y, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F.

Neoplasia. 2017 May;19(5):421-428. doi: 10.1016/j.neo.2017.03.003. Epub 2017 Apr 20.


Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice.

Kim KH, Choi S, Zhou Y, Kim EY, Lee JM, Saha PK, Anakk S, Moore DD.

Hepatology. 2017 Aug;66(2):498-509. doi: 10.1002/hep.29199. Epub 2017 Jun 26.


Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice.

Kumar R, Mota LC, Litoff EJ, Rooney JP, Boswell WT, Courter E, Henderson CM, Hernandez JP, Corton JC, Moore DD, Baldwin WS.

PLoS One. 2017 Mar 28;12(3):e0174355. doi: 10.1371/journal.pone.0174355. eCollection 2017.


Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance.

Preidis GA, Kim KH, Moore DD.

J Clin Invest. 2017 Apr 3;127(4):1193-1201. doi: 10.1172/JCI88893. Epub 2017 Mar 13. Review.


Regulation of Liver Energy Balance by the Nuclear Receptors Farnesoid X Receptor and Peroxisome Proliferator Activated Receptor α.

Kim KH, Moore DD.

Dig Dis. 2017;35(3):203-209. doi: 10.1159/000450912. Epub 2017 Mar 1. Review.


Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.

Kettner NM, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L.

Cancer Cell. 2016 Dec 12;30(6):909-924. doi: 10.1016/j.ccell.2016.10.007. Epub 2016 Nov 23.


Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart.

Desai MS, Mathur B, Eblimit Z, Vasquez H, Taegtmeyer H, Karpen SJ, Penny DJ, Moore DD, Anakk S.

Hepatology. 2017 Jan;65(1):189-201. doi: 10.1002/hep.28890. Epub 2016 Nov 29.


Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice.

Wu N, Kim KH, Zhou Y, Lee JM, Kettner NM, Mamrosh JL, Choi S, Fu L, Moore DD.

Mol Endocrinol. 2016 Sep;30(9):988-95. doi: 10.1210/me.2015-1295. Epub 2016 Jul 18.


Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells.

Kim KH, Lee JM, Zhou Y, Harpavat S, Moore DD.

Mol Endocrinol. 2016 Aug;30(8):905-16. doi: 10.1210/me.2016-1029. Epub 2016 Jun 29.


Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight.

Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA.

Diabetes. 2016 Sep;65(9):2732-41. doi: 10.2337/db16-0309. Epub 2016 May 23.


Asprosin, a Fasting-Induced Glucogenic Protein Hormone.

Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha PK, Del Solar M, Zhu B, York B, Sarkar P, Rendon DA, Gaber MW, LeMaire SA, Coselli JS, Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR.

Cell. 2016 Apr 21;165(3):566-79. doi: 10.1016/j.cell.2016.02.063. Epub 2016 Apr 14.


A novel chemically modified curcumin reduces inflammation-mediated connective tissue breakdown in a rat model of diabetes: periodontal and systemic effects.

Elburki MS, Moore DD, Terezakis NG, Zhang Y, Lee HM, Johnson F, Golub LM.

J Periodontal Res. 2017 Apr;52(2):186-200. doi: 10.1111/jre.12381. Epub 2016 Apr 1.


Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.

Gomez-Ospina N, Potter CJ, Xiao R, Manickam K, Kim MS, Kim KH, Shneider BL, Picarsic JL, Jacobson TA, Zhang J, He W, Liu P, Knisely AS, Finegold MJ, Muzny DM, Boerwinkle E, Lupski JR, Plon SE, Gibbs RA, Eng CM, Yang Y, Washington GC, Porteus MH, Berquist WE, Kambham N, Singh RJ, Xia F, Enns GM, Moore DD.

Nat Commun. 2016 Feb 18;7:10713. doi: 10.1038/ncomms10713.


Life After Bariatric Surgery: Perceptions of Male Patients and Their Intimate Relationships.

Moore DD, Cooper CE.

J Marital Fam Ther. 2016 Jul;42(3):495-508. doi: 10.1111/jmft.12155. Epub 2016 Jan 25.


Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1.

Ahn HY, Kim HH, Kim YA, Kim M, Ohn JH, Chung SS, Lee YK, Park DJ, Park KS, Moore DD, Park YJ.

Endocrinol Metab (Seoul). 2015 Dec;30(4):584-92. doi: 10.3803/EnM.2015.30.4.584. Epub 2015 Oct 20.


Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism.

Wagner M, Choi S, Panzitt K, Mamrosh JL, Lee JM, Zaufel A, Xiao R, Wooton-Kee R, Ståhlman M, Newgard CB, Borén J, Moore DD.

Hepatology. 2016 Jan;63(1):95-106. doi: 10.1002/hep.28124. Epub 2015 Oct 10.


Elevated copper impairs hepatic nuclear receptor function in Wilson's disease.

Wooton-Kee CR, Jain AK, Wagner M, Grusak MA, Finegold MJ, Lutsenko S, Moore DD.

J Clin Invest. 2015 Sep;125(9):3449-60. doi: 10.1172/JCI78991. Epub 2015 Aug 4.


Neutralization of Enterovirus D68 isolated from the 2014 US outbreak by commercial intravenous immune globulin products.

Zhang Y, Moore DD, Nix WA, Oberste MS, Weldon WC.

J Clin Virol. 2015 Aug;69:172-5. doi: 10.1016/j.jcv.2015.06.086. Epub 2015 Jun 19.


Correction: Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution.

Mamrosh JL, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, DeMayo FJ, Moore DD.

Elife. 2015 Jul 24;4:e10084. doi: 10.7554/eLife.10084. No abstract available.


Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation.

Yuk JM, Kim TS, Kim SY, Lee HM, Han J, Dufour CR, Kim JK, Jin HS, Yang CS, Park KS, Lee CH, Kim JM, Kweon GR, Choi HS, Vanacker JM, Moore DD, Giguère V, Jo EK.

Immunity. 2015 Jul 21;43(1):80-91. doi: 10.1016/j.immuni.2015.07.003.


Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes.

Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE.

Mol Endocrinol. 2015 Sep;29(9):1320-33. doi: 10.1210/me.2015-1084. Epub 2015 Jul 20.


Circadian Dysfunction Induces Leptin Resistance in Mice.

Kettner NM, Mayo SA, Hua J, Lee C, Moore DD, Fu L.

Cell Metab. 2015 Sep 1;22(3):448-59. doi: 10.1016/j.cmet.2015.06.005. Epub 2015 Jul 9.


Using Google Reverse Image Search to Decipher Biological Images.

Mamrosh JL, Moore DD.

Curr Protoc Mol Biol. 2015 Jul 1;111:19.13.1-4. doi: 10.1002/0471142727.mb1913s111.


Imaging Diagnosis of Solitary Tumors of the Phalanges and Metacarpals of the Hand.

Ahmed O, Moore DD, Stacy GS.

AJR Am J Roentgenol. 2015 Jul;205(1):106-15. doi: 10.2214/AJR.14.13340. Review.


MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids.

Fu X, Dong B, Tian Y, Lefebvre P, Meng Z, Wang X, Pattou F, Han W, Wang X, Lou F, Jove R, Staels B, Moore DD, Huang W.

J Clin Invest. 2015 Jun;125(6):2497-509. doi: 10.1172/JCI75438. Epub 2015 May 11.


The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice.

Tseng HT, Park YJ, Lee YK, Moore DD.

J Biomed Sci. 2015 May 8;22:30. doi: 10.1186/s12929-015-0133-3.


Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis.

Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, Finegold MJ, Moore DD.

Nat Commun. 2015 Feb 9;6:5944. doi: 10.1038/ncomms6944.


Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.

Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC.

Science. 2015 Jan 2;347(6217):83-6. doi: 10.1126/science.1258857.


Nutrient-sensing nuclear receptors coordinate autophagy.

Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD.

Nature. 2014 Dec 4;516(7529):112-5. doi: 10.1038/nature13961. Epub 2014 Nov 12.


Osteoma of long bone: an expanding spectrum of imaging findings.

Hansford BG, Pytel P, Moore DD, Stacy GS.

Skeletal Radiol. 2015 May;44(5):755-61. doi: 10.1007/s00256-014-2046-8. Epub 2014 Nov 9.


Endocrine Society 2014 Laureate Awards.

Gustafsson JA, Katzenellenbogen B, Jameson JL, Roth J, Melmed S, McDonnell D, Wartofsky L, Crowley WF Jr, Griz LH, Becker C, Moore DD, Drucker D, Singh N, O'Malley B.

Horm Cancer. 2014 Oct;5(5):339-55. doi: 10.1007/s12672-014-0193-y. No abstract available.


Ewing's sarcoma of bone.

Moore DD, Haydon RC.

Cancer Treat Res. 2014;162:93-115. doi: 10.1007/978-3-319-07323-1_5. Review.



Moore DD, Luu HH.

Cancer Treat Res. 2014;162:65-92. doi: 10.1007/978-3-319-07323-1_4. Review.


Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution.

Mamrosh JL, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, Demayo FJ, Moore DD.

Elife. 2014 Apr 15;3:e01694. doi: 10.7554/eLife.01694. Erratum in: Elife. 2015;4:e10084.


Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.

Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS.

Gastroenterology. 2014 Apr;146(4):1048-59. doi: 10.1053/j.gastro.2013.12.027. Epub 2013 Dec 21.


Cardiomyopathy reverses with recovery of liver injury, cholestasis and cholanemia in mouse model of biliary fibrosis.

Desai MS, Eblimit Z, Thevananther S, Kosters A, Moore DD, Penny DJ, Karpen SJ.

Liver Int. 2015 Apr;35(4):1464-77. doi: 10.1111/liv.12438. Epub 2014 Jan 12.


Bile acids activate YAP to promote liver carcinogenesis.

Anakk S, Bhosale M, Schmidt VA, Johnson RL, Finegold MJ, Moore DD.

Cell Rep. 2013 Nov 27;5(4):1060-9. doi: 10.1016/j.celrep.2013.10.030. Epub 2013 Nov 21.


Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters.

Shah P, Guo T, Moore DD, Ghose R.

Drug Metab Dispos. 2014 Jan;42(1):172-81. doi: 10.1124/dmd.113.053850. Epub 2013 Nov 5.


Physiology: A metabolic minuet.

Moore DD.

Nature. 2013 Oct 24;502(7472):454-5. doi: 10.1038/502454a. No abstract available.


Shoulder surgeons' perceptions of interscalene nerve blocks and a review of complications rates in the literature.

Moore DD, Maerz T, Anderson K.

Phys Sportsmed. 2013 Sep;41(3):77-84. doi: 10.3810/psm.2013.09.2026.


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