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Items: 1 to 50 of 232

1.

ALG9 Mutation Carriers Develop Kidney and Liver Cysts.

Besse W, Chang AR, Luo JZ, Triffo WJ, Moore BS, Gulati A, Hartzel DN, Mane S; Regeneron Genetics Center, Torres VE, Somlo S, Mirshahi T.

J Am Soc Nephrol. 2019 Aug 8. pii: ASN.2019030298. doi: 10.1681/ASN.2019030298. [Epub ahead of print]

PMID:
31395617
2.

Genetic platforms for heterologous expression of microbial natural products.

Zhang JJ, Tang X, Moore BS.

Nat Prod Rep. 2019 Jun 14. doi: 10.1039/c9np00025a. [Epub ahead of print] Review.

PMID:
31197291
3.

Direct cloning and heterologous expression of natural product biosynthetic gene clusters by transformation-associated recombination.

Zhang JJ, Yamanaka K, Tang X, Moore BS.

Methods Enzymol. 2019;621:87-110. doi: 10.1016/bs.mie.2019.02.026. Epub 2019 Mar 21.

PMID:
31128791
4.

Bacterial Tetrabromopyrrole Debrominase Shares a Reductive Dehalogenation Strategy with Human Thyroid Deiodinase.

Chekan JR, Lee GY, El Gamal A, Purdy TN, Houk KN, Moore BS.

Biochemistry. 2019 May 22. doi: 10.1021/acs.biochem.9b00318. [Epub ahead of print]

PMID:
31117392
5.

Comparative Genomics of Cyanobacterial Symbionts Reveals Distinct, Specialized Metabolism in Tropical Dysideidae Sponges.

Schorn MA, Jordan PA, Podell S, Blanton JM, Agarwal V, Biggs JS, Allen EE, Moore BS.

MBio. 2019 May 14;10(3). pii: e00821-19. doi: 10.1128/mBio.00821-19.

6.

Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis.

Moore BS.

Synlett. 2018 Mar;29(4):401-409. doi: 10.1055/s-0036-1590919. Epub 2017 Sep 27.

7.

Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid.

Chekan JR, McKinnie SMK, Moore ML, Poplawski SG, Michael TP, Moore BS.

Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8454-8457. doi: 10.1002/anie.201902910. Epub 2019 May 10.

PMID:
30995339
8.

Biosynthesis of l-4-Chlorokynurenine, an Antidepressant Prodrug and a Non-Proteinogenic Amino Acid Found in Lipopeptide Antibiotics.

Luhavaya H, Sigrist R, Chekan JR, McKinnie SMK, Moore BS.

Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8394-8399. doi: 10.1002/anie.201901571. Epub 2019 May 13.

PMID:
30963655
9.

Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives.

Rothe ML, Li J, Garibay E, Moore BS, McKinnie SMK.

Org Biomol Chem. 2019 Mar 27;17(13):3416-3423. doi: 10.1039/c8ob03109f.

PMID:
30869693
10.

Refactoring the Cryptic Streptophenazine Biosynthetic Gene Cluster Unites Phenazine, Polyketide, and Nonribosomal Peptide Biochemistry.

Bauman KD, Li J, Murata K, Mantovani SM, Dahesh S, Nizet V, Luhavaya H, Moore BS.

Cell Chem Biol. 2019 May 16;26(5):724-736.e7. doi: 10.1016/j.chembiol.2019.02.004. Epub 2019 Mar 7.

PMID:
30853419
11.

Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas.

Busch J, Agarwal V, Schorn M, Machado H, Moore BS, Rouse GW, Gram L, Jensen PR.

Environ Microbiol. 2019 May;21(5):1575-1585. doi: 10.1111/1462-2920.14532. Epub 2019 Feb 22.

PMID:
30652406
12.

Insights into Thiotemplated Pyrrole Biosynthesis Gained from the Crystal Structure of Flavin-Dependent Oxidase in Complex with Carrier Protein.

Thapa HR, Robbins JM, Moore BS, Agarwal V.

Biochemistry. 2019 Feb 19;58(7):918-929. doi: 10.1021/acs.biochem.8b01177. Epub 2019 Jan 23.

13.

Total Enzyme Syntheses of Napyradiomycins A1 and B1.

McKinnie SMK, Miles ZD, Jordan PA, Awakawa T, Pepper HP, Murray LAM, George JH, Moore BS.

J Am Chem Soc. 2018 Dec 26;140(51):17840-17845. doi: 10.1021/jacs.8b10134. Epub 2018 Dec 14.

14.

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2019 Jan 1;36(1):248-249. doi: 10.1039/c8np90041h. Epub 2018 Nov 23.

15.

The chemical cue tetrabromopyrrole induces rapid cellular stress and mortality in phytoplankton.

Whalen KE, Kirby C, Nicholson RM, O'Reilly M, Moore BS, Harvey EL.

Sci Rep. 2018 Oct 19;8(1):15498. doi: 10.1038/s41598-018-33945-3.

16.

Pangenomic comparison of globally distributed Poribacteria associated with sponge hosts and marine particles.

Podell S, Blanton JM, Neu A, Agarwal V, Biggs JS, Moore BS, Allen EE.

ISME J. 2019 Feb;13(2):468-481. doi: 10.1038/s41396-018-0292-9. Epub 2018 Oct 5.

PMID:
30291328
17.

Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom.

Brunson JK, McKinnie SMK, Chekan JR, McCrow JP, Miles ZD, Bertrand EM, Bielinski VA, Luhavaya H, Oborník M, Smith GJ, Hutchins DA, Allen AE, Moore BS.

Science. 2018 Sep 28;361(6409):1356-1358. doi: 10.1126/science.aau0382.

18.

Structural Elucidation of Trace Components Combining GC/MS, GC/IR, DFT-Calculation and Synthesis-Salinilactones, Unprecedented Bicyclic Lactones from Salinispora Bacteria.

Schlawis C, Kern S, Kudo Y, Grunenberg J, Moore BS, Schulz S.

Angew Chem Int Ed Engl. 2018 Nov 5;57(45):14921-14925. doi: 10.1002/anie.201807923. Epub 2018 Oct 15.

19.

Enzymatic Cascade Reactions in Biosynthesis.

Walsh CT, Moore BS.

Angew Chem Int Ed Engl. 2019 May 20;58(21):6846-6879. doi: 10.1002/anie.201807844. Epub 2019 Feb 20. Review.

PMID:
30156048
20.

Engineering Salinispora tropica for heterologous expression of natural product biosynthetic gene clusters.

Zhang JJ, Moore BS, Tang X.

Appl Microbiol Biotechnol. 2018 Oct;102(19):8437-8446. doi: 10.1007/s00253-018-9283-z. Epub 2018 Aug 13.

PMID:
30105571
21.

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2019 Jan 1;36(1):35-107. doi: 10.1039/c7np00064b. Epub 2018 Jul 13. Review. Erratum in: Nat Prod Rep. 2018 Nov 23;:.

22.

Genetic variants help define the role of the MC4R C-terminus in signaling and cell surface stability.

Moore BS, Mirshahi T.

Sci Rep. 2018 Jul 10;8(1):10397. doi: 10.1038/s41598-018-28758-3.

23.

Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products.

Murray LAM, McKinnie SMK, Pepper HP, Erni R, Miles ZD, Cruickshank MC, López-Pérez B, Moore BS, George JH.

Angew Chem Int Ed Engl. 2018 Aug 20;57(34):11009-11014. doi: 10.1002/anie.201804351. Epub 2018 Jul 23.

24.

Correction to Organohalogens Naturally Biosynthesized in Marine Environments and Produced As Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.

Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN.

Environ Sci Technol. 2018 Jul 3;52(13):7594. doi: 10.1021/acs.est.8b03174. Epub 2018 Jun 19. No abstract available.

PMID:
29916692
25.

Preface.

Moore BS.

Methods Enzymol. 2018;605:xv-xvi. doi: 10.1016/S0076-6879(18)30229-5. No abstract available.

PMID:
29909840
26.

Preparation and Characterization of Tetrabromopyrrole Debrominase From Marine Proteobacteria.

Chekan JR, Moore BS.

Methods Enzymol. 2018;605:253-265. doi: 10.1016/bs.mie.2018.01.031. Epub 2018 Mar 16.

27.

Preface.

Moore BS.

Methods Enzymol. 2018;604:xv-xvi. doi: 10.1016/S0076-6879(18)30193-9. No abstract available.

PMID:
29779668
28.

Characterization and Biochemical Assays of Streptomyces Vanadium-Dependent Chloroperoxidases.

McKinnie SMK, Miles ZD, Moore BS.

Methods Enzymol. 2018;604:405-424. doi: 10.1016/bs.mie.2018.02.016. Epub 2018 Apr 2.

29.

Enzymatic control of dioxygen binding and functionalization of the flavin cofactor.

Saleem-Batcha R, Stull F, Sanders JN, Moore BS, Palfey BA, Houk KN, Teufel R.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):4909-4914. doi: 10.1073/pnas.1801189115. Epub 2018 Apr 23. Erratum in: Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15309.

30.

Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.

Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN.

Environ Sci Technol. 2018 May 1;52(9):5469-5478. doi: 10.1021/acs.est.8b00512. Epub 2018 Apr 20. Erratum in: Environ Sci Technol. 2018 Jul 3;52(13):7594.

31.

Natural Product Reports 35 years on.

Moore BS.

Nat Prod Rep. 2018 Jan 1;35(1):6-7. doi: 10.1039/c8np90001a. Epub 2018 Jan 25. No abstract available.

PMID:
29367974
32.

Biosynthesis of the Antibiotic Bicyclomycin in Soil and Pathogenic Bacteria.

Chekan JR, Moore BS.

Biochemistry. 2018 Feb 13;57(6):897-898. doi: 10.1021/acs.biochem.7b01204. Epub 2018 Jan 9. No abstract available.

PMID:
29313351
33.

Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality.

Amos GCA, Awakawa T, Tuttle RN, Letzel AC, Kim MC, Kudo Y, Fenical W, Moore BS, Jensen PR.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11121-E11130. doi: 10.1073/pnas.1714381115. Epub 2017 Dec 11.

34.

Spiking Suppression Precedes Cued Attentional Enhancement of Neural Responses in Primary Visual Cortex.

Cox MA, Dougherty K, Adams GK, Reavis EA, Westerberg JA, Moore BS, Leopold DA, Maier A.

Cereb Cortex. 2019 Jan 1;29(1):77-90. doi: 10.1093/cercor/bhx305.

PMID:
29186348
35.

Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster.

Reynolds KA, Luhavaya H, Li J, Dahesh S, Nizet V, Yamanaka K, Moore BS.

J Antibiot (Tokyo). 2018 Feb;71(2):333-338. doi: 10.1038/ja.2017.146. Epub 2017 Nov 29.

36.

A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis.

Miles ZD, Diethelm S, Pepper HP, Huang DM, George JH, Moore BS.

Nat Chem. 2017 Dec;9(12):1235-1242. doi: 10.1038/nchem.2829. Epub 2017 Jul 31.

37.

Broad-Host-Range Expression Reveals Native and Host Regulatory Elements That Influence Heterologous Antibiotic Production in Gram-Negative Bacteria.

Zhang JJ, Tang X, Zhang M, Nguyen D, Moore BS.

MBio. 2017 Sep 5;8(5). pii: e01291-17. doi: 10.1128/mBio.01291-17.

38.

Enzymatic C-H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity.

Li J, Tang X, Awakawa T, Moore BS.

Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12234-12239. doi: 10.1002/anie.201705239. Epub 2017 Sep 1.

39.

Health Literacy: Cancer Prevention Strategies for Early Adults.

Simmons RA, Cosgrove SC, Romney MC, Plumb JD, Brawer RO, Gonzalez ET, Fleisher LG, Moore BS.

Am J Prev Med. 2017 Sep;53(3S1):S73-S77. doi: 10.1016/j.amepre.2017.03.016.

40.

Function-related replacement of bacterial siderophore pathways.

Bruns H, Crüsemann M, Letzel AC, Alanjary M, McInerney JO, Jensen PR, Schulz S, Moore BS, Ziemert N.

ISME J. 2018 Feb;12(2):320-329. doi: 10.1038/ismej.2017.137. Epub 2017 Aug 15.

41.

Genomic insights into specialized metabolism in the marine actinomycete Salinispora.

Letzel AC, Li J, Amos GCA, Millán-Aguiñaga N, Ginigini J, Abdelmohsen UR, Gaudêncio SP, Ziemert N, Moore BS, Jensen PR.

Environ Microbiol. 2017 Sep;19(9):3660-3673. doi: 10.1111/1462-2920.13867. Epub 2017 Aug 14.

42.

Editorial: Are natural products the solution to antimicrobial resistance?

Moore BS, Carter GT, Brönstrup M.

Nat Prod Rep. 2017 Jul 1;34(7):685-686. doi: 10.1039/c7np90026k. Epub 2017 Jul 3. No abstract available.

PMID:
28671218
43.

Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation.

Tang X, Li J, Moore BS.

Chembiochem. 2017 Jun 19;18(12):1072-1076. doi: 10.1002/cbic.201700090. Epub 2017 May 11.

44.

Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols.

Crüsemann M, O'Neill EC, Larson CB, Melnik AV, Floros DJ, da Silva RR, Jensen PR, Dorrestein PC, Moore BS.

J Nat Prod. 2017 Mar 24;80(3):588-597. doi: 10.1021/acs.jnatprod.6b00722. Epub 2016 Nov 11.

45.

PCR-Independent Method of Transformation-Associated Recombination Reveals the Cosmomycin Biosynthetic Gene Cluster in an Ocean Streptomycete.

Larson CB, Crüsemann M, Moore BS.

J Nat Prod. 2017 Apr 28;80(4):1200-1204. doi: 10.1021/acs.jnatprod.6b01121. Epub 2017 Mar 23.

46.

Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges.

Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden JW, Allen EE, Moore BS.

Nat Chem Biol. 2017 May;13(5):537-543. doi: 10.1038/nchembio.2330. Epub 2017 Mar 20.

47.

Erratum: Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides.

Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL Jr, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, De Mot R, Moore BS, Medema MH, Dorrestein PC.

Nat Microbiol. 2017 Jan 23;2:17010. doi: 10.1038/nmicrobiol.2017.10. No abstract available.

PMID:
28112718
48.

Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.

Agarwal V, Miles ZD, Winter JM, Eustáquio AS, El Gamal AA, Moore BS.

Chem Rev. 2017 Apr 26;117(8):5619-5674. doi: 10.1021/acs.chemrev.6b00571. Epub 2017 Jan 20. Review.

49.

Effects of Actinomycete Secondary Metabolites on Sediment Microbial Communities.

Patin NV, Schorn M, Aguinaldo K, Lincecum T, Moore BS, Jensen PR.

Appl Environ Microbiol. 2017 Feb 1;83(4). pii: e02676-16. doi: 10.1128/AEM.02676-16. Print 2017 Feb 15.

50.

Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters.

Schorn MA, Alanjary MM, Aguinaldo K, Korobeynikov A, Podell S, Patin N, Lincecum T, Jensen PR, Ziemert N, Moore BS.

Microbiology. 2016 Dec;162(12):2075-2086. doi: 10.1099/mic.0.000386. Epub 2016 Oct 27.

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