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Loss of myeloid-specific protein phosphatase 2A enhances lung injury and fibrosis and results in IL-10 dependent sensitization of epithelial cell apoptosis.

Sun L, Hult EM, Cornell TT, Kim KK, Shanley TP, Wilke CA, Agarwal M, Gurcynski SJ, Moore BB, Dahmer MK.

Am J Physiol Lung Cell Mol Physiol. 2019 Mar 6. doi: 10.1152/ajplung.00299.2018. [Epub ahead of print]


Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis.

O'Dwyer DN, Ashley SL, Gurczynski SJ, Xia M, Wilke C, Falkowski NR, Norman KC, Arnold KB, Huffnagle GB, Salisbury ML, Han MK, Flaherty KR, White ES, Martinez FJ, Erb-Downward JR, Murray S, Moore BB, Dickson RP.

Am J Respir Crit Care Med. 2019 Feb 21. doi: 10.1164/rccm.201809-1650OC. [Epub ahead of print]


First Onset Herpesviral Infection and Lung Injury in Allogeneic Hematopoietic Cell Transplantation.

Zhou X, O'Dwyer DN, Xia M, Miller HK, Chan PR, Trulik K, Chadwick MM, Hoffman TC, Bulte C, Sekerak K, Wilke CA, Patel SJ, Yokoyama WM, Murray S, Yanik GA, Moore BB.

Am J Respir Crit Care Med. 2019 Feb 11. doi: 10.1164/rccm.201809-1635OC. [Epub ahead of print]


Histone Methylation Directs Myeloid TLR4 Expression and Regulates Wound Healing following Cutaneous Tissue Injury.

Davis FM, Kimball A, denDekker A, Joshi AD, Boniakowski AE, Nysz D, Allen RM, Obi A, Singer K, Henke PK, Moore BB, Kunkel SL, Gallagher KA.

J Immunol. 2019 Mar 15;202(6):1777-1785. doi: 10.4049/jimmunol.1801258. Epub 2019 Feb 1.


Influenza-induced immune suppression to methicillin-resistant Staphylococcus aureus is mediated by TLR9.

Martínez-Colón GJ, Warheit-Niemi H, Gurczynski SJ, Taylor QM, Wilke CA, Podsiad AB, Crespo J, Bhan U, Moore BB.

PLoS Pathog. 2019 Jan 25;15(1):e1007560. doi: 10.1371/journal.ppat.1007560. eCollection 2019 Jan.


Attracting Attention: Discovery of IL-8/CXCL8 and the Birth of the Chemokine Field.

Moore BB, Kunkel SL.

J Immunol. 2019 Jan 1;202(1):3-4. doi: 10.4049/jimmunol.1801485. No abstract available.


CCR2 mediates increased susceptibility to post-H1N1 bacterial pneumonia by limiting dendritic cell induction of IL-17.

Gurczynski SJ, Nathani N, Warheit-Niemi HI, Hult EM, Podsiad A, Deng J, Zemans RL, Bhan U, Moore BB.

Mucosal Immunol. 2019 Mar;12(2):518-530. doi: 10.1038/s41385-018-0106-4. Epub 2018 Nov 29.


Natural Secretory Immunoglobulins Promote Enteric Viral Infections.

Turula H, Bragazzi Cunha J, Mainou BA, Ramakrishnan SK, Wilke CA, Gonzalez-Hernandez MB, Pry A, Fava J, Bassis CM, Edelman J, Shah YM, Corthesy B, Moore BB, Wobus CE.

J Virol. 2018 Sep 19. pii: JVI.00826-18. doi: 10.1128/JVI.00826-18. [Epub ahead of print]


A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq.

Green CD, Ma Q, Manske GL, Shami AN, Zheng X, Marini S, Moritz L, Sultan C, Gurczynski SJ, Moore BB, Tallquist MD, Li JZ, Hammoud SS.

Dev Cell. 2018 Sep 10;46(5):651-667.e10. doi: 10.1016/j.devcel.2018.07.025. Epub 2018 Aug 23.


Proteomics: Clinical and research applications in respiratory diseases.

Norman KC, Moore BB, Arnold KB, O'Dwyer DN.

Respirology. 2018 Nov;23(11):993-1003. doi: 10.1111/resp.13383. Epub 2018 Aug 13. Review.


Animal Models of Pulmonary Fibrosis.

O'Dwyer DN, Moore BB.

Methods Mol Biol. 2018;1809:363-378. doi: 10.1007/978-1-4939-8570-8_24.


Murine macrophage chemokine receptor CCR2 plays a crucial role in macrophage recruitment and regulated inflammation in wound healing.

Boniakowski AE, Kimball AS, Joshi A, Schaller M, Davis FM, denDekker A, Obi AT, Moore BB, Kunkel SL, Gallagher KA.

Eur J Immunol. 2018 Sep;48(9):1445-1455. doi: 10.1002/eji.201747400. Epub 2018 Jun 26.


Lung Dysbiosis, Inflammation, and Injury in Hematopoietic Cell Transplantation.

O'Dwyer DN, Zhou X, Wilke CA, Xia M, Falkowski NR, Norman KC, Arnold KB, Huffnagle GB, Murray S, Erb-Downward JR, Yanik GA, Moore BB, Dickson RP.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1312-1321. doi: 10.1164/rccm.201712-2456OC.


Phagocytosis by Fibrocytes as a Mechanism to Decrease Bacterial Burden and Increase Survival in Sepsis.

Collins D, Fry C, Moore BB, Nemzek JA.

Shock. 2019 Apr;51(4):464-471. doi: 10.1097/SHK.0000000000001161.


Pulmonary immunity and extracellular matrix interactions.

O'Dwyer DN, Gurczynski SJ, Moore BB.

Matrix Biol. 2018 Nov;73:122-134. doi: 10.1016/j.matbio.2018.04.003. Epub 2018 Apr 9. Review.


Location or origin? What is critical for macrophage propagation of lung fibrosis?

Zhou X, Moore BB.

Eur Respir J. 2018 Mar 1;51(3). pii: 1800103. doi: 10.1183/13993003.00103-2018. Print 2018 Mar. No abstract available.


Prostaglandin E2 as a Regulator of Immunity to Pathogens.

Martínez-Colón GJ, Moore BB.

Pharmacol Ther. 2018 May;185:135-146. doi: 10.1016/j.pharmthera.2017.12.008. Epub 2017 Dec 22. Review.


Lung Section Staining and Microscopy.

Zhou X, Moore BB.

Bio Protoc. 2017 May 20;7(10). pii: e2286. doi: 10.21769/BioProtoc.2286.


Transbronchial biopsy in the management of pulmonary complications of hematopoietic stem cell transplantation.

O'Dwyer DN, Duvall AS, Xia M, Hoffman TC, Bloye KS, Bulte CA, Zhou X, Murray S, Moore BB, Yanik GA.

Bone Marrow Transplant. 2018 Feb;53(2):193-198. doi: 10.1038/bmt.2017.238. Epub 2017 Oct 23.


Bone marrow transplant-induced alterations in Notch signaling promote pathologic Th17 responses to γ-herpesvirus infection.

Gurczynski SJ, Zhou X, Flaherty M, Wilke CA, Moore BB.

Mucosal Immunol. 2018 May;11(3):881-893. doi: 10.1038/mi.2017.85. Epub 2017 Oct 18.


Exploitation of Scavenger Receptor, Macrophage Receptor with Collagenous Structure, by Cryptococcus neoformans Promotes Alternative Activation of Pulmonary Lymph Node CD11b+ Conventional Dendritic Cells and Non-Protective Th2 Bias.

Xu J, Flaczyk A, Neal LM, Fa Z, Cheng D, Ivey M, Moore BB, Curtis JL, Osterholzer JJ, Olszewski MA.

Front Immunol. 2017 Sep 28;8:1231. doi: 10.3389/fimmu.2017.01231. eCollection 2017.


The role of periostin in lung fibrosis and airway remodeling.

O'Dwyer DN, Moore BB.

Cell Mol Life Sci. 2017 Dec;74(23):4305-4314. doi: 10.1007/s00018-017-2649-z. Epub 2017 Sep 16. Review.


IL-17 in the lung: the good, the bad, and the ugly.

Gurczynski SJ, Moore BB.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L6-L16. doi: 10.1152/ajplung.00344.2017. Epub 2017 Aug 31. Review.


IL-17A deficiency mitigates bleomycin-induced complement activation during lung fibrosis.

Cipolla E, Fisher AJ, Gu H, Mickler EA, Agarwal M, Wilke CA, Kim KK, Moore BB, Vittal R.

FASEB J. 2017 Dec;31(12):5543-5556. doi: 10.1096/fj.201700289R. Epub 2017 Aug 17.


Groundhog Day for Rodent Models of Acute Lung Injury: Clear Relevance or Renewed Debate?

Moore BB.

Am J Respir Cell Mol Biol. 2017 Aug;57(2):141-142. doi: 10.1165/rcmb.2017-0119ED. No abstract available.


Erratum: The peripheral blood proteome signature of idiopathic pulmonary fibrosis is distinct from normal and is associated with novel immunological processes.

O'Dwyer DN, Norman KC, Xia M, Huang Y, Gurczynski SJ, Ashley SL, White ES, Flaherty KR, Martinez FJ, Murray S, Noth I, Arnold KB, Moore BB.

Sci Rep. 2017 Jun 30;7:46860. doi: 10.1038/srep46860.


Adoptive Transfer of Lung Antigen Presenting Cells.

Zhou X, Moore BB.

Bio Protoc. 2017 Mar 20;7(6). pii: e2182.


Elevated prostaglandin E2 post-bone marrow transplant mediates interleukin-1β-related lung injury.

Martínez-Colón GJ, Taylor QM, Wilke CA, Podsiad AB, Moore BB.

Mucosal Immunol. 2018 Mar;11(2):319-332. doi: 10.1038/mi.2017.51. Epub 2017 Jun 7.


An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis.

Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES; ATS Assembly on Respiratory Cell and Molecular Biology.

Am J Respir Cell Mol Biol. 2017 May;56(5):667-679. doi: 10.1165/rcmb.2017-0096ST.


The peripheral blood proteome signature of idiopathic pulmonary fibrosis is distinct from normal and is associated with novel immunological processes.

O'Dwyer DN, Norman KC, Xia M, Huang Y, Gurczynski SJ, Ashley SL, White ES, Flaherty KR, Martinez FJ, Murray S, Noth I, Arnold KB, Moore BB.

Sci Rep. 2017 Apr 25;7:46560. doi: 10.1038/srep46560. Erratum in: Sci Rep. 2017 Jun 30;7:46860.


Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection.

Xu J, Flaczyk A, Neal LM, Fa Z, Eastman AJ, Malachowski AN, Cheng D, Moore BB, Curtis JL, Osterholzer JJ, Olszewski MA.

J Immunol. 2017 May 1;198(9):3548-3557. doi: 10.4049/jimmunol.1700057. Epub 2017 Mar 15.


IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and -negative bacterial pneumonia.

Kovach MA, Singer B, Martinez-Colon G, Newstead MW, Zeng X, Mancuso P, Moore TA, Kunkel SL, Peters-Golden M, Moore BB, Standiford TJ.

Mucosal Immunol. 2017 Sep;10(5):1320-1334. doi: 10.1038/mi.2016.130. Epub 2017 Feb 8.


Microbes Are Associated with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis.

Huang Y, Ma SF, Espindola MS, Vij R, Oldham JM, Huffnagle GB, Erb-Downward JR, Flaherty KR, Moore BB, White ES, Zhou T, Li J, Lussier YA, Han MK, Kaminski N, Garcia JGN, Hogaboam CM, Martinez FJ, Noth I; COMET-IPF Investigators.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):208-219. doi: 10.1164/rccm.201607-1525OC.


Six-SOMAmer Index Relating to Immune, Protease and Angiogenic Functions Predicts Progression in IPF.

Ashley SL, Xia M, Murray S, O'Dwyer DN, Grant E, White ES, Flaherty KR, Martinez FJ, Moore BB.

PLoS One. 2016 Aug 4;11(8):e0159878. doi: 10.1371/journal.pone.0159878. eCollection 2016.


Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis.

O'Dwyer DN, Ashley SL, Moore BB.

Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L590-601. doi: 10.1152/ajplung.00221.2016. Epub 2016 Jul 29. Review.


Loss of CCR2 signaling alters leukocyte recruitment and exacerbates γ-herpesvirus-induced pneumonitis and fibrosis following bone marrow transplantation.

Gurczynski SJ, Procario MC, O'Dwyer DN, Wilke CA, Moore BB.

Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L611-27. doi: 10.1152/ajplung.00193.2016. Epub 2016 Jul 22.


Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis.

Warsinske HC, Wheaton AK, Kim KK, Linderman JJ, Moore BB, Kirschner DE.

Front Pharmacol. 2016 Jun 23;7:183. doi: 10.3389/fphar.2016.00183. eCollection 2016.


Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis.

Ashley SL, Wilke CA, Kim KK, Moore BB.

Mucosal Immunol. 2017 Mar;10(2):341-351. doi: 10.1038/mi.2016.61. Epub 2016 Jul 20.


Resveratrol-Mediated Repression and Reversion of Prostatic Myofibroblast Phenoconversion.

Gharaee-Kermani M, Moore BB, Macoska JA.

PLoS One. 2016 Jul 1;11(7):e0158357. doi: 10.1371/journal.pone.0158357. eCollection 2016.


The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease.

O'Dwyer DN, Dickson RP, Moore BB.

J Immunol. 2016 Jun 15;196(12):4839-47. doi: 10.4049/jimmunol.1600279. Review.


Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation.

Speth JM, Bourdonnay E, Penke LR, Mancuso P, Moore BB, Weinberg JB, Peters-Golden M.

J Immunol. 2016 Jun 15;196(12):5112-20. doi: 10.4049/jimmunol.1502153. Epub 2016 May 13.


Plasma Surfactant Protein-D, Matrix Metalloproteinase-7, and Osteopontin Index Distinguishes Idiopathic Pulmonary Fibrosis from Other Idiopathic Interstitial Pneumonias.

White ES, Xia M, Murray S, Dyal R, Flaherty CM, Flaherty KR, Moore BB, Cheng L, Doyle TJ, Villalba J, Dellaripa PF, Rosas IO, Kurtis JD, Martinez FJ.

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1242-1251.


Roles of Periostin in Respiratory Disorders.

Izuhara K, Conway SJ, Moore BB, Matsumoto H, Holweg CT, Matthews JG, Arron JR.

Am J Respir Crit Care Med. 2016 May 1;193(9):949-56. doi: 10.1164/rccm.201510-2032PP. Review.


Viruses in Idiopathic Pulmonary Fibrosis. Etiology and Exacerbation.

Moore BB, Moore TA.

Ann Am Thorac Soc. 2015 Nov;12 Suppl 2:S186-92. doi: 10.1513/AnnalsATS.201502-088AW. Review.


MicroRNA-155 regulates host immune response to postviral bacterial pneumonia via IL-23/IL-17 pathway.

Podsiad A, Standiford TJ, Ballinger MN, Eakin R, Park P, Kunkel SL, Moore BB, Bhan U.

Am J Physiol Lung Cell Mol Physiol. 2016 Mar 1;310(5):L465-75. doi: 10.1152/ajplung.00224.2015. Epub 2015 Nov 20.


Inhibition of Neutrophil Extracellular Trap Formation after Stem Cell Transplant by Prostaglandin E2.

Domingo-Gonzalez R, Martínez-Colón GJ, Smith AJ, Smith CK, Ballinger MN, Xia M, Murray S, Kaplan MJ, Yanik GA, Moore BB.

Am J Respir Crit Care Med. 2016 Jan 15;193(2):186-97. doi: 10.1164/rccm.201501-0161OC.


Prostaglandin E2 Production and T Cell Function in Mouse Adenovirus Type 1 Infection following Allogeneic Bone Marrow Transplantation.

McCarthy MK, Procario MC, Wilke CA, Moore BB, Weinberg JB.

PLoS One. 2015 Sep 25;10(9):e0139235. doi: 10.1371/journal.pone.0139235. eCollection 2015.


Identifying Mechanisms of Homeostatic Signaling in Fibroblast Differentiation.

Warsinske HC, Ashley SL, Linderman JJ, Moore BB, Kirschner DE.

Bull Math Biol. 2015 Aug;77(8):1556-82. doi: 10.1007/s11538-015-0096-2. Epub 2015 Sep 18.


Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis.

Ashley SL, Sisson TH, Wheaton AK, Kim KK, Wilke CA, Ajayi IO, Subbotina N, Wang S, Duckett CS, Moore BB, Horowitz JC.

Am J Respir Cell Mol Biol. 2016 Apr;54(4):482-92. doi: 10.1165/rcmb.2015-0148OC.


Bone marrow transplantation alters lung antigen-presenting cells to promote TH17 response and the development of pneumonitis and fibrosis following gammaherpesvirus infection.

Zhou X, Loomis-King H, Gurczynski SJ, Wilke CA, Konopka KE, Ptaschinski C, Coomes SM, Iwakura Y, van Dyk LF, Lukacs NW, Moore BB.

Mucosal Immunol. 2016 May;9(3):610-20. doi: 10.1038/mi.2015.85. Epub 2015 Sep 16.

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