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Items: 1 to 50 of 283

1.

Metabolism as an early predictor of DPSCs aging.

Macrin D, Alghadeer A, Zhao YT, Miklas JW, Hussein AM, Detraux D, Robitaille AM, Madan A, Moon RT, Wang Y, Devi A, Mathieu J, Ruohola-Baker H.

Sci Rep. 2019 Feb 18;9(1):2195. doi: 10.1038/s41598-018-37489-4.

2.

Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency.

Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, Levy S, Robitaille AM, Ferreccio A, Bottorff T, McAlister A, Somasundaram L, Artoni F, Battle S, Hawkins RD, Moon RT, Ware CB, Paddison PJ, Ruohola-Baker H.

Nat Commun. 2019 Feb 7;10(1):632. doi: 10.1038/s41467-018-08020-0.

3.

ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells.

Hofsteen P, Robitaille AM, Strash N, Palpant N, Moon RT, Pabon L, Murry CE.

iScience. 2018 Apr 27;2:88-100. doi: 10.1016/j.isci.2018.03.010.

4.

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping.

Czerniecki SM, Cruz NM, Harder JL, Menon R, Annis J, Otto EA, Gulieva RE, Islas LV, Kim YK, Tran LM, Martins TJ, Pippin JW, Fu H, Kretzler M, Shankland SJ, Himmelfarb J, Moon RT, Paragas N, Freedman BS.

Cell Stem Cell. 2018 Jun 1;22(6):929-940.e4. doi: 10.1016/j.stem.2018.04.022. Epub 2018 May 17.

5.

First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor.

Moody JD, Levy S, Mathieu J, Xing Y, Kim W, Dong C, Tempel W, Robitaille AM, Dang LT, Ferreccio A, Detraux D, Sidhu S, Zhu L, Carter L, Xu C, Valensisi C, Wang Y, Hawkins RD, Min J, Moon RT, Orkin SH, Baker D, Ruohola-Baker H.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10125-10130. doi: 10.1073/pnas.1706907114. Epub 2017 Sep 1.

6.

Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish.

Rabinowitz JS, Robitaille AM, Wang Y, Ray CA, Thummel R, Gu H, Djukovic D, Raftery D, Berndt JD, Moon RT.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E717-E726. doi: 10.1073/pnas.1620755114. Epub 2017 Jan 17.

7.

WNT/β-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner.

Brown K, Yang P, Salvador D, Kulikauskas R, Ruohola-Baker H, Robitaille AM, Chien AJ, Moon RT, Sherwood V.

Oncogene. 2017 Jun 1;36(22):3119-3136. doi: 10.1038/onc.2016.450. Epub 2017 Jan 16.

8.

Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells.

Xu Z, Robitaille AM, Berndt JD, Davidson KC, Fischer KA, Mathieu J, Potter JC, Ruohola-Baker H, Moon RT.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6382-E6390. Epub 2016 Oct 3.

9.

Wnt/β-catenin signaling promotes regeneration after adult zebrafish spinal cord injury.

Strand NS, Hoi KK, Phan TMT, Ray CA, Berndt JD, Moon RT.

Biochem Biophys Res Commun. 2016 Sep 2;477(4):952-956. doi: 10.1016/j.bbrc.2016.07.006. Epub 2016 Jul 4.

10.

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.

Madan B, Walker MP, Young R, Quick L, Orgel KA, Ryan M, Gupta P, Henrich IC, Ferrer M, Marine S, Roberts BS, Arthur WT, Berndt JD, Oliveira AM, Moon RT, Virshup DM, Chou MM, Major MB.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2945-54. doi: 10.1073/pnas.1605691113. Epub 2016 May 9.

11.

Beyond canonical: The Wnt and β-catenin story.

Moon RT, Gough NR.

Sci Signal. 2016 Apr 5;9(422):eg5. doi: 10.1126/scisignal.aaf6192.

PMID:
27048563
12.

Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling.

Hofsteen P, Robitaille AM, Chapman DP, Moon RT, Murry CE.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1002-7. doi: 10.1073/pnas.1523930113. Epub 2016 Jan 11.

13.

The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice.

Forero A, Tisoncik-Go J, Watanabe T, Zhong G, Hatta M, Tchitchek N, Selinger C, Chang J, Barker K, Morrison J, Berndt JD, Moon RT, Josset L, Kawaoka Y, Katze MG.

J Virol. 2015 Dec 9;90(5):2240-53. doi: 10.1128/JVI.02974-15.

14.

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.

Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, Fischer KA, Devi A, Detraux D, Gu H, Battle SL, Showalter M, Valensisi C, Bielas JH, Ericson NG, Margaretha L, Robitaille AM, Margineantu D, Fiehn O, Hockenbery D, Blau CA, Raftery D, Margolin AA, Hawkins RD, Moon RT, Ware CB, Ruohola-Baker H.

Nat Cell Biol. 2015 Dec;17(12):1523-35. doi: 10.1038/ncb3264. Epub 2015 Nov 16.

15.

Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells.

Ugarte GD, Vargas MF, Medina MA, León P, Necuñir D, Elorza AA, Gutiérrez SE, Moon RT, Loyola A, De Ferrari GV.

Blood. 2015 Oct 8;126(15):1785-9. doi: 10.1182/blood-2015-04-638494. Epub 2015 Sep 2.

PMID:
26333776
16.

A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17.

Clarke RL, Robitaille AM, Moon RT, Keller G.

Stem Cell Reports. 2015 Aug 11;5(2):291-304. doi: 10.1016/j.stemcr.2015.07.008.

17.

Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes.

Palpant NJ, Pabon L, Roberts M, Hadland B, Jones D, Jones C, Moon RT, Ruzzo WL, Bernstein I, Zheng Y, Murry CE.

Development. 2015 Sep 15;142(18):3198-209. doi: 10.1242/dev.117010. Epub 2015 Jul 7.

18.

Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.

Hadland BK, Varnum-Finney B, Poulos MG, Moon RT, Butler JM, Rafii S, Bernstein ID.

J Clin Invest. 2015 May;125(5):2032-45. doi: 10.1172/JCI80137. Epub 2015 Apr 13.

19.

Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.

Kim TY, Siesser PF, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss MJ, Moon RT, Der CJ, Major MB.

Mol Cell Biol. 2015 Jan;35(1):167-81. doi: 10.1128/MCB.00857-14. Epub 2014 Oct 20.

20.

Macrophages modulate adult zebrafish tail fin regeneration.

Petrie TA, Strand NS, Yang CT, Rabinowitz JS, Moon RT.

Development. 2014 Jul;141(13):2581-91. doi: 10.1242/dev.098459. Erratum in: Development. 2015 Jan 15;142(2):406. Tsung-Yang, Chao [corrected to Yang, Chao-Tsung].

21.

WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors.

Anastas JN, Kulikauskas RM, Tamir T, Rizos H, Long GV, von Euw EM, Yang PT, Chen HW, Haydu L, Toroni RA, Lucero OM, Chien AJ, Moon RT.

J Clin Invest. 2014 Jul;124(7):2877-90. doi: 10.1172/JCI70156. Epub 2014 May 27.

22.

Botulinum toxin induces muscle paralysis and inhibits bone regeneration in zebrafish.

Recidoro AM, Roof AC, Schmitt M, Worton LE, Petrie T, Strand N, Ausk BJ, Srinivasan S, Moon RT, Gardiner EM, Kaminsky W, Bain SD, Allan CH, Gross TS, Kwon RY.

J Bone Miner Res. 2014 Nov;29(11):2346-56. doi: 10.1002/jbmr.2274.

23.

Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt/β-catenin signaling.

Chien AJ, Haydu LE, Biechele TL, Kulikauskas RM, Rizos H, Kefford RF, Scolyer RA, Moon RT, Long GV.

PLoS One. 2014 Apr 14;9(4):e94748. doi: 10.1371/journal.pone.0094748. eCollection 2014.

24.

Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency.

Mathieu J, Zhou W, Xing Y, Sperber H, Ferreccio A, Agoston Z, Kuppusamy KT, Moon RT, Ruohola-Baker H.

Cell Stem Cell. 2014 May 1;14(5):592-605. doi: 10.1016/j.stem.2014.02.012. Epub 2014 Mar 20.

25.

Simvastatin promotes adult hippocampal neurogenesis by enhancing Wnt/β-catenin signaling.

Robin NC, Agoston Z, Biechele TL, James RG, Berndt JD, Moon RT.

Stem Cell Reports. 2013 Dec 26;2(1):9-17. doi: 10.1016/j.stemcr.2013.11.002. eCollection 2014 Jan 14.

26.

FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells.

Conrad W, Major MB, Cleary MA, Ferrer M, Roberts B, Marine S, Chung N, Arthur WT, Moon RT, Berndt JD, Chien AJ.

Version 2. F1000Res. 2013 May 31 [revised 2013 Jan 1];2:134. doi: 10.12688/f1000research.2-134.v2. eCollection 2013.

27.

Porous implants modulate healing and induce shifts in local macrophage polarization in the foreign body reaction.

Sussman EM, Halpin MC, Muster J, Moon RT, Ratner BD.

Ann Biomed Eng. 2014 Jul;42(7):1508-16. doi: 10.1007/s10439-013-0933-0. Epub 2013 Nov 19.

PMID:
24248559
28.

Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells.

James RG, Bosch KA, Kulikauskas RM, Yang PT, Robin NC, Toroni RA, Biechele TL, Berndt JD, von Haller PD, Eng JK, Wolf-Yadlin A, Chien AJ, Moon RT.

J Biol Chem. 2013 Nov 29;288(48):34658-70. doi: 10.1074/jbc.M113.500314. Epub 2013 Oct 10.

29.

A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation.

Martin PM, Yang X, Robin N, Lam E, Rabinowitz JS, Erdman CA, Quinn J, Weiss LA, Hamilton SP, Kwok PY, Moon RT, Cheyette BN.

Transl Psychiatry. 2013 Sep 3;3:e301. doi: 10.1038/tp.2013.75.

30.

Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.

Palpant NJ, Pabon L, Rabinowitz JS, Hadland BK, Stoick-Cooper CL, Paige SL, Bernstein ID, Moon RT, Murry CE.

Development. 2013 Sep;140(18):3799-808. doi: 10.1242/dev.094789. Epub 2013 Aug 7.

31.

Activation of Wnt/β-catenin signaling increases apoptosis in melanoma cells treated with trail.

Zimmerman ZF, Kulikauskas RM, Bomsztyk K, Moon RT, Chien AJ.

PLoS One. 2013 Jul 15;8(7):e69593. doi: 10.1371/journal.pone.0069593. Print 2013.

32.

Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells.

Block GJ, Narayanan D, Amell AM, Petek LM, Davidson KC, Bird TD, Tawil R, Moon RT, Miller DG.

Hum Mol Genet. 2013 Dec 1;22(23):4661-72. doi: 10.1093/hmg/ddt314. Epub 2013 Jul 2.

33.

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

Dai X, James RG, Habib T, Singh S, Jackson S, Khim S, Moon RT, Liggitt D, Wolf-Yadlin A, Buckner JH, Rawlings DJ.

J Clin Invest. 2013 May;123(5):2024-36. doi: 10.1172/JCI66963. Epub 2013 Apr 24.

34.

Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS).

Korvatska O, Strand NS, Berndt JD, Strovas T, Chen DH, Leverenz JB, Kiianitsa K, Mata IF, Karakoc E, Greenup JL, Bonkowski E, Chuang J, Moon RT, Eichler EE, Nickerson DA, Zabetian CP, Kraemer BC, Bird TD, Raskind WH.

Hum Mol Genet. 2013 Aug 15;22(16):3259-68. doi: 10.1093/hmg/ddt180. Epub 2013 Apr 16.

35.

Cell biology. Making a point with Wnt signals.

Berndt JD, Moon RT.

Science. 2013 Mar 22;339(6126):1388-9. doi: 10.1126/science.1236641. No abstract available.

PMID:
23520097
36.

WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma.

Arensman MD, Kovochich AN, Kulikauskas RM, Lay AR, Yang PT, Li X, Donahue T, Major MB, Moon RT, Chien AJ, Dawson DW.

Oncogene. 2014 Feb 13;33(7):899-908. doi: 10.1038/onc.2013.23. Epub 2013 Feb 18.

37.

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.

Ren S, Johnson BG, Kida Y, Ip C, Davidson KC, Lin SL, Kobayashi A, Lang RA, Hadjantonakis AK, Moon RT, Duffield JS.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1440-5. doi: 10.1073/pnas.1211179110. Epub 2013 Jan 9. Erratum in: Proc Natl Acad Sci U S A. 2016 Nov 14;:.

38.

Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling.

Zhang B, Li M, McDonald T, Holyoake TL, Moon RT, Campana D, Shultz L, Bhatia R.

Blood. 2013 Mar 7;121(10):1824-38. doi: 10.1182/blood-2012-02-412890. Epub 2013 Jan 8.

39.

WNT signalling pathways as therapeutic targets in cancer.

Anastas JN, Moon RT.

Nat Rev Cancer. 2013 Jan;13(1):11-26. doi: 10.1038/nrc3419. Review.

PMID:
23258168
40.

Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells.

Cimetta E, Sirabella D, Yeager K, Davidson K, Simon J, Moon RT, Vunjak-Novakovic G.

Lab Chip. 2013 Feb 7;13(3):355-64. doi: 10.1039/c2lc40836h.

41.

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.

James RG, Davidson KC, Bosch KA, Biechele TL, Robin NC, Taylor RJ, Major MB, Camp ND, Fowler K, Martins TJ, Moon RT.

PLoS One. 2012;7(12):e50457. doi: 10.1371/journal.pone.0050457. Epub 2012 Dec 5.

42.

A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer's disease.

Alarcón MA, Medina MA, Hu Q, Avila ME, Bustos BI, Pérez-Palma E, Peralta A, Salazar P, Ugarte GD, Reyes AE, Martin GM, Opazo C, Moon RT, De Ferrari GV.

Neurobiol Aging. 2013 Jun;34(6):1709.e9-18. doi: 10.1016/j.neurobiolaging.2012.11.004. Epub 2012 Dec 6.

PMID:
23218566
43.

WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis.

Yang PT, Anastas JN, Toroni RA, Shinohara MM, Goodson JM, Bosserhoff AK, Chien AJ, Moon RT.

EMBO Mol Med. 2012 Dec;4(12):1294-307. doi: 10.1002/emmm.201201486. Epub 2012 Nov 6.

44.

Targeting Wnt pathways in disease.

Zimmerman ZF, Moon RT, Chien AJ.

Cold Spring Harb Perspect Biol. 2012 Nov 1;4(11). pii: a008086. doi: 10.1101/cshperspect.a008086. Review.

45.

A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development.

Paige SL, Thomas S, Stoick-Cooper CL, Wang H, Maves L, Sandstrom R, Pabon L, Reinecke H, Pratt G, Keller G, Moon RT, Stamatoyannopoulos J, Murry CE.

Cell. 2012 Sep 28;151(1):221-32. doi: 10.1016/j.cell.2012.08.027. Epub 2012 Sep 11.

46.

Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation.

Conrad WH, Swift RD, Biechele TL, Kulikauskas RM, Moon RT, Chien AJ.

Cell Cycle. 2012 Oct 15;11(20):3724-30. doi: 10.4161/cc.21645. Epub 2012 Aug 16.

47.

Wnt5a and Wnt11 are essential for second heart field progenitor development.

Cohen ED, Miller MF, Wang Z, Moon RT, Morrisey EE.

Development. 2012 Jun;139(11):1931-40. doi: 10.1242/dev.069377.

48.

Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4.

Davidson KC, Adams AM, Goodson JM, McDonald CE, Potter JC, Berndt JD, Biechele TL, Taylor RJ, Moon RT.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4485-90. doi: 10.1073/pnas.1118777109. Epub 2012 Mar 5.

49.

Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver.

Shin D, Weidinger G, Moon RT, Stainier DY.

Mech Dev. 2012 Jan-Feb;128(11-12):525-35. doi: 10.1016/j.mod.2012.01.005. Epub 2012 Jan 31.

50.

Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment.

Morrone S, Cheng Z, Moon RT, Cong F, Xu W.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1500-5. doi: 10.1073/pnas.1116618109. Epub 2012 Jan 17.

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