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Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation.

Salgado-Polo F, van Veen M, van den Broek B, Jalink K, Leyton-Puig D, Perrakis A, Moolenaar WH, Matas-Rico E.

J Cell Sci. 2020 Feb 10;133(3). pii: jcs235044. doi: 10.1242/jcs.235044.


Editorial overview: Signaling dynamics moving to the nanoscale.

Moolenaar WH, Balla T.

Curr Opin Cell Biol. 2019 Apr;57:iii-vi. doi: 10.1016/ No abstract available.


Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.

Lin S, Haque A, Raeman R, Guo L, He P, Denning TL, El-Rayes B, Moolenaar WH, Yun CC.

FASEB J. 2019 Mar;33(3):3623-3635. doi: 10.1096/fj.201801415RR. Epub 2018 Nov 27.


Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation.

Argenzio E, Klarenbeek J, Kedziora KM, Nahidiazar L, Isogai T, Perrakis A, Jalink K, Moolenaar WH, Innocenti M.

J Biol Chem. 2018 Dec 14;293(50):19161-19176. doi: 10.1074/jbc.RA118.002779. Epub 2018 Oct 31.


Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish.

van Veen M, Mans LA, Matas-Rico E, van Pelt J, Perrakis A, Moolenaar WH, Haramis AG.

Int J Biochem Cell Biol. 2018 Jan;94:71-78. doi: 10.1016/j.biocel.2017.11.015. Epub 2017 Dec 22.


Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells.

van Veen M, Matas-Rico E, van de Wetering K, Leyton-Puig D, Kedziora KM, De Lorenzi V, Stijf-Bultsma Y, van den Broek B, Jalink K, Sidenius N, Perrakis A, Moolenaar WH.

Elife. 2017 Aug 29;6. pii: e23649. doi: 10.7554/eLife.23649.


GDE2/GDPD5 in neuroblastoma.

Matas-Rico E, van Veen M, Moolenaar WH.

Oncotarget. 2017 Jan 24;8(4):5672-5673. doi: 10.18632/oncotarget.14233. No abstract available.


Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

Matas-Rico E, van Veen M, Leyton-Puig D, van den Berg J, Koster J, Kedziora KM, Molenaar B, Weerts MJA, de Rink I, Medema RH, Giepmans BNG, Perrakis A, Jalink K, Versteeg R, Moolenaar WH.

Cancer Cell. 2016 Dec 12;30(6):986. doi: 10.1016/j.ccell.2016.11.008. No abstract available.


Neuronal differentiation through GPI-anchor cleavage.

Matas-Rico E, van Veen M, Moolenaar WH.

Cell Cycle. 2017 Mar 4;16(5):388-389. doi: 10.1080/15384101.2016.1259894. Epub 2016 Nov 18. No abstract available.


Emerging biological roles of Cl- intracellular channel proteins.

Argenzio E, Moolenaar WH.

J Cell Sci. 2016 Nov 15;129(22):4165-4174. Review.


Discovery of potent inhibitors of the lysophospholipase autotaxin.

Shah P, Cheasty A, Foxton C, Raynham T, Farooq M, Gutierrez IF, Lejeune A, Pritchard M, Turnbull A, Pang L, Owen P, Boyd S, Stowell A, Jordan A, Hamilton NM, Hitchin JR, Stockley M, MacDonald E, Quesada MJ, Trivier E, Skeete J, Ovaa H, Moolenaar WH, Ryder H.

Bioorg Med Chem Lett. 2016 Nov 15;26(22):5403-5410. doi: 10.1016/j.bmcl.2016.10.036. Epub 2016 Oct 14.


Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.

Matas-Rico E, van Veen M, Leyton-Puig D, van den Berg J, Koster J, Kedziora KM, Molenaar B, Weerts MJ, de Rink I, Medema RH, Giepmans BN, Perrakis A, Jalink K, Versteeg R, Moolenaar WH.

Cancer Cell. 2016 Oct 10;30(4):548-562. doi: 10.1016/j.ccell.2016.08.016. Epub 2016 Sep 29. Erratum in: Cancer Cell. 2016 Dec 12;30(6):986.


Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.

Keune WJ, Hausmann J, Bolier R, Tolenaars D, Kremer A, Heidebrecht T, Joosten RP, Sunkara M, Morris AJ, Matas-Rico E, Moolenaar WH, Oude Elferink RP, Perrakis A.

Nat Commun. 2016 Apr 14;7:11248. doi: 10.1038/ncomms11248.


ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation.

Nishioka T, Arima N, Kano K, Hama K, Itai E, Yukiura H, Kise R, Inoue A, Kim SH, Solnica-Krezel L, Moolenaar WH, Chun J, Aoki J.

Sci Rep. 2016 Mar 23;6:23433. doi: 10.1038/srep23433.


Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases.

Kedziora KM, Leyton-Puig D, Argenzio E, Boumeester AJ, van Butselaar B, Yin T, Wu YI, van Leeuwen FN, Innocenti M, Jalink K, Moolenaar WH.

J Biol Chem. 2016 Feb 26;291(9):4323-33. doi: 10.1074/jbc.M115.695940. Epub 2016 Jan 6.


Introduction to the ECR special issue on lysophospholipids in biology.

Moolenaar WH.

Exp Cell Res. 2015 May 1;333(2):165. doi: 10.1016/j.yexcr.2015.02.021. Epub 2015 Mar 5. No abstract available.


CLIC4 regulates cell adhesion and β1 integrin trafficking.

Argenzio E, Margadant C, Leyton-Puig D, Janssen H, Jalink K, Sonnenberg A, Moolenaar WH.

J Cell Sci. 2014 Dec 15;127(Pt 24):5189-203. doi: 10.1242/jcs.150623. Epub 2014 Oct 24.


Combining anti-tumor alkyl-phospholipid analogs and radiotherapy: rationale and clinical outlook.

Verheij M, Moolenaar WH, Blitterswijk WJ.

Anticancer Agents Med Chem. 2014 May;14(4):618-28. Review.


Autotaxin: structure-function and signaling.

Perrakis A, Moolenaar WH.

J Lipid Res. 2014 Jun;55(6):1010-8. doi: 10.1194/jlr.R046391. Epub 2014 Feb 18. Review.


Role of phosphatidylinositol 5-phosphate 4-kinase α in zebrafish development.

Elouarrat D, van der Velden YU, Jones DR, Moolenaar WH, Divecha N, Haramis AP.

Int J Biochem Cell Biol. 2013 Jul;45(7):1293-301. doi: 10.1016/j.biocel.2013.03.009. Epub 2013 Mar 26.


The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans.

Houben AJ, van Wijk XM, van Meeteren LA, van Zeijl L, van de Westerlo EM, Hausmann J, Fish A, Perrakis A, van Kuppevelt TH, Moolenaar WH.

J Biol Chem. 2013 Jan 4;288(1):510-9. doi: 10.1074/jbc.M112.358416. Epub 2012 Nov 13.


Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right asymmetry in zebrafish.

Lai SL, Yao WL, Tsao KC, Houben AJ, Albers HM, Ovaa H, Moolenaar WH, Lee SJ.

Development. 2012 Dec 1;139(23):4439-48. doi: 10.1242/dev.081745. Epub 2012 Oct 24.


Structure-function relationships of autotaxin, a secreted lysophospholipase D.

Hausmann J, Perrakis A, Moolenaar WH.

Adv Biol Regul. 2013 Jan;53(1):112-7. doi: 10.1016/j.jbior.2012.09.010. Epub 2012 Sep 28. Review.


Structure of NPP1, an ectonucleotide pyrophosphatase/phosphodiesterase involved in tissue calcification.

Jansen S, Perrakis A, Ulens C, Winkler C, Andries M, Joosten RP, Van Acker M, Luyten FP, Moolenaar WH, Bollen M.

Structure. 2012 Nov 7;20(11):1948-59. doi: 10.1016/j.str.2012.09.001. Epub 2012 Oct 4.


Autotaxin in embryonic development.

Moolenaar WH, Houben AJ, Lee SJ, van Meeteren LA.

Biochim Biophys Acta. 2013 Jan;1831(1):13-9. doi: 10.1016/j.bbalip.2012.09.013. Epub 2012 Sep 28. Review.


SnapShot: Bioactive lysophospholipids.

Moolenaar WH, Hla T.

Cell. 2012 Jan 20;148(1-2):378-378.e2. doi: 10.1016/j.cell.2012.01.013. No abstract available.


LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.

Jongsma M, Matas-Rico E, Rzadkowski A, Jalink K, Moolenaar WH.

PLoS One. 2011;6(12):e29260. doi: 10.1371/journal.pone.0029260. Epub 2011 Dec 14.


Autotaxin and LPA receptor signaling in cancer.

Houben AJ, Moolenaar WH.

Cancer Metastasis Rev. 2011 Dec;30(3-4):557-65. doi: 10.1007/s10555-011-9319-7. Review.


Insights into autotaxin: how to produce and present a lipid mediator.

Moolenaar WH, Perrakis A.

Nat Rev Mol Cell Biol. 2011 Sep 14;12(10):674-9. doi: 10.1038/nrm3188. Review.


Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid.

Dusaulcy R, Rancoule C, Grès S, Wanecq E, Colom A, Guigné C, van Meeteren LA, Moolenaar WH, Valet P, Saulnier-Blache JS.

J Lipid Res. 2011 Jun;52(6):1247-55. doi: 10.1194/jlr.M014985. Epub 2011 Mar 18.


Structural basis of substrate discrimination and integrin binding by autotaxin.

Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ, Moolenaar WH, Perrakis A.

Nat Struct Mol Biol. 2011 Feb;18(2):198-204. doi: 10.1038/nsmb.1980. Epub 2011 Jan 16.


International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature.

Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH.

Pharmacol Rev. 2010 Dec;62(4):579-87. doi: 10.1124/pr.110.003111. Review.


Development of an activity-based probe for autotaxin.

Cavalli S, Houben AJ, Albers HM, van Tilburg EW, de Ru A, Aoki J, van Veelen P, Moolenaar WH, Ovaa H.

Chembiochem. 2010 Nov 2;11(16):2311-7. doi: 10.1002/cbic.201000349.


Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein.

Hausmann J, Christodoulou E, Kasiem M, De Marco V, van Meeteren LA, Moolenaar WH, Axford D, Owen RL, Evans G, Perrakis A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt 9):1130-5. doi: 10.1107/S1744309110032938. Epub 2010 Aug 31.


Lysophosphatidic acid is a potential mediator of cholestatic pruritus.

Kremer AE, Martens JJ, Kulik W, Ruëff F, Kuiper EM, van Buuren HR, van Erpecum KJ, Kondrackiene J, Prieto J, Rust C, Geenes VL, Williamson C, Moolenaar WH, Beuers U, Oude Elferink RP.

Gastroenterology. 2010 Sep;139(3):1008-18, 1018.e1. doi: 10.1053/j.gastro.2010.05.009. Epub 2010 Jun 19.


Discovery and optimization of boronic acid based inhibitors of autotaxin.

Albers HM, van Meeteren LA, Egan DA, van Tilburg EW, Moolenaar WH, Ovaa H.

J Med Chem. 2010 Jul 8;53(13):4958-67. doi: 10.1021/jm1005012.


Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.

Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, Schuurman K, van Tellingen O, Morris AJ, Smyth SS, Moolenaar WH, Ovaa H.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7257-62. doi: 10.1073/pnas.1001529107. Epub 2010 Apr 1.


G protein-coupled receptors: the inside story.

Jalink K, Moolenaar WH.

Bioessays. 2010 Jan;32(1):13-6. doi: 10.1002/bies.200900153. Review.


Spatiotemporal regulation of chloride intracellular channel protein CLIC4 by RhoA.

Ponsioen B, van Zeijl L, Langeslag M, Berryman M, Littler D, Jalink K, Moolenaar WH.

Mol Biol Cell. 2009 Nov;20(22):4664-72. doi: 10.1091/mbc.E09-06-0529. Epub 2009 Sep 23.


Mammary tumorigenesis through LPA receptor signaling.

Jonkers J, Moolenaar WH.

Cancer Cell. 2009 Jun 2;15(6):457-9. doi: 10.1016/j.ccr.2009.05.003.


Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.

Pamuklar Z, Federico L, Liu S, Umezu-Goto M, Dong A, Panchatcharam M, Fulkerson Z, Berdyshev E, Natarajan V, Fang X, van Meeteren LA, Moolenaar WH, Mills GB, Morris AJ, Smyth SS.

J Biol Chem. 2009 Mar 13;284(11):7385-94. doi: 10.1074/jbc.M807820200. Epub 2009 Jan 12. Erratum in: J Biol Chem. 2009 Jul 31;284(31):21100. Fulerson, Zachary [corrected to Fulkerson, Zachary].


In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.

Taghavi P, Verhoeven E, Jacobs JJ, Lambooij JP, Stortelers C, Tanger E, Moolenaar WH, van Lohuizen M.

Oncogene. 2008 Nov 20;27(54):6806-16. doi: 10.1038/onc.2008.294. Epub 2008 Sep 1.


Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling.

Kortlever RM, Brummelkamp TR, van Meeteren LA, Moolenaar WH, Bernards R.

Mol Cancer Res. 2008 Sep;6(9):1452-60. doi: 10.1158/1541-7786.MCR-08-0066. Epub 2008 Aug 22.


Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling.

Stortelers C, Kerkhoven R, Moolenaar WH.

BMC Genomics. 2008 Aug 14;9:387. doi: 10.1186/1471-2164-9-387.


Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.

van Meeteren LA, Brinkmann V, Saulnier-Blache JS, Lynch KR, Moolenaar WH.

Cancer Lett. 2008 Aug 8;266(2):203-8. doi: 10.1016/j.canlet.2008.02.052. Epub 2008 Apr 18.


Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate.

van Zeijl L, Ponsioen B, Giepmans BN, Ariaens A, Postma FR, Várnai P, Balla T, Divecha N, Jalink K, Moolenaar WH.

J Cell Biol. 2007 Jun 4;177(5):881-91. Epub 2007 May 29.


Regulation and biological activities of the autotaxin-LPA axis.

van Meeteren LA, Moolenaar WH.

Prog Lipid Res. 2007 Mar;46(2):145-60. Epub 2007 Mar 16. Review.


Upregulation of cytokine expression in fibroblasts exposed to loxosceles sphingomyelinase D: what is the trigger?

van Meeteren LA, Stortelers C, Moolenaar WH.

J Invest Dermatol. 2007 May;127(5):1266-7; author reply 1267-8. Epub 2007 Mar 8. No abstract available.


Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma.

Savaskan NE, Rocha L, Kotter MR, Baer A, Lubec G, van Meeteren LA, Kishi Y, Aoki J, Moolenaar WH, Nitsch R, Bräuer AU.

Cell Mol Life Sci. 2007 Jan;64(2):230-43.


Direct measurement of cyclic AMP diffusion and signaling through connexin43 gap junctional channels.

Ponsioen B, van Zeijl L, Moolenaar WH, Jalink K.

Exp Cell Res. 2007 Jan 15;313(2):415-23. Epub 2006 Nov 6.


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