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Peripheral inflammatory biomarkers in Alzheimer's disease: a brief review.

Park JC, Han SH, Mook-Jung I.

BMB Rep. 2020 Jan;53(1):10-19.


Acetylation changes tau interactome to degrade tau in Alzheimer's disease animal and organoid models.

Choi H, Kim HJ, Yang J, Chae S, Lee W, Chung S, Kim J, Choi H, Song H, Lee CK, Jun JH, Lee YJ, Lee K, Kim S, Sim HR, Choi YI, Ryu KH, Park JC, Lee D, Han SH, Hwang D, Kyung J, Mook-Jung I.

Aging Cell. 2020 Jan;19(1):e13081. doi: 10.1111/acel.13081. Epub 2019 Nov 25.


Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer's disease.

Kim DK, Han D, Park J, Choi H, Park JC, Cha MY, Woo J, Byun MS, Lee DY, Kim Y, Mook-Jung I.

Exp Mol Med. 2019 Nov 15;51(11):1-17. doi: 10.1038/s12276-019-0326-z.


Mimicry of Central-Peripheral Immunity in Alzheimer's Disease and Discovery of Neurodegenerative Roles in Neutrophil.

Park J, Baik SH, Mook-Jung I, Irimia D, Cho H.

Front Immunol. 2019 Sep 25;10:2231. doi: 10.3389/fimmu.2019.02231. eCollection 2019.


Prognostic plasma protein panel for Aβ deposition in the brain in Alzheimer's disease.

Park JC, Han SH, Lee H, Jeong H, Byun MS, Bae J, Kim H, Lee DY, Yi D, Shin SA, Kim YK, Hwang D, Lee SW, Mook-Jung I.

Prog Neurobiol. 2019 Dec;183:101690. doi: 10.1016/j.pneurobio.2019.101690. Epub 2019 Oct 9.


Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model.

Kim MS, Kim Y, Choi H, Kim W, Park S, Lee D, Kim DK, Kim HJ, Choi H, Hyun DW, Lee JY, Choi EY, Lee DS, Bae JW, Mook-Jung I.

Gut. 2020 Feb;69(2):283-294. doi: 10.1136/gutjnl-2018-317431. Epub 2019 Aug 30.


Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation.

Park JS, Lee J, Jung ES, Kim MH, Kim IB, Son H, Kim S, Kim S, Park YM, Mook-Jung I, Yu SJ, Lee JH.

Nat Commun. 2019 Jul 12;10(1):3090. doi: 10.1038/s41467-019-11000-7.


Hearing loss as a risk factor for cognitive impairment and loss of synapses in the hippocampus.

Chang M, Kim HJ, Mook-Jung I, Oh SH.

Behav Brain Res. 2019 Oct 17;372:112069. doi: 10.1016/j.bbr.2019.112069. Epub 2019 Jul 2.


A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease.

Baik SH, Kang S, Lee W, Choi H, Chung S, Kim JI, Mook-Jung I.

Cell Metab. 2019 Sep 3;30(3):493-507.e6. doi: 10.1016/j.cmet.2019.06.005. Epub 2019 Jun 27.


Autophagy-Mediated Secretory Pathway is Responsible for Both Normal and Pathological Tau in Neurons.

Kang S, Son SM, Baik SH, Yang J, Mook-Jung I.

J Alzheimers Dis. 2019;70(3):667-680. doi: 10.3233/JAD-190180.


Harnessing Intramolecular Rotation To Enhance Two-photon Imaging of Aβ Plaques through Minimizing Background Fluorescence.

Shin J, Verwilst P, Choi H, Kang S, Han J, Kim NH, Choi JG, Oh MS, Hwang JS, Kim D, Mook-Jung I, Kim JS.

Angew Chem Int Ed Engl. 2019 Apr 16;58(17):5648-5652. doi: 10.1002/anie.201900549. Epub 2019 Mar 20.


Plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimer's disease.

Park JC, Han SH, Yi D, Byun MS, Lee JH, Jang S, Ko K, Jeon SY, Lee YS, Kim YK, Lee DY, Mook-Jung I.

Brain. 2019 Mar 1;142(3):771-786. doi: 10.1093/brain/awy347. Erratum in: Brain. 2019 May 1;142(5):e19.


Amyloid β-induced elevation of O-GlcNAcylated c-Fos promotes neuronal cell death.

Choi H, Kim C, Song H, Cha MY, Cho HJ, Son SM, Kim HJ, Mook-Jung I.

Aging Cell. 2019 Feb;18(1):e12872. doi: 10.1111/acel.12872. Epub 2018 Dec 4.


Nurr1 (NR4A2) regulates Alzheimer's disease-related pathogenesis and cognitive function in the 5XFAD mouse model.

Moon M, Jung ES, Jeon SG, Cha MY, Jang Y, Kim W, Lopes C, Mook-Jung I, Kim KS.

Aging Cell. 2019 Feb;18(1):e12866. doi: 10.1111/acel.12866. Epub 2018 Dec 4.


Blood acetylcholinesterase level is a potential biomarker for the early detection of cerebral amyloid deposition in cognitively normal individuals.

Han SH, Park JC, Byun MS, Yi D, Lee JH, Lee DY, Mook-Jung I; KBASE Research Group.

Neurobiol Aging. 2019 Jan;73:21-29. doi: 10.1016/j.neurobiolaging.2018.09.001. Epub 2018 Sep 8.


Specific autophagy and ESCRT components participate in the unconventional secretion of CFTR.

Noh SH, Gee HY, Kim Y, Piao H, Kim J, Kang CM, Lee G, Mook-Jung I, Lee Y, Cho JW, Lee MG.

Autophagy. 2018;14(10):1761-1778. doi: 10.1080/15548627.2018.1489479. Epub 2018 Jul 31.


O-GlcNAcylation regulates endoplasmic reticulum exit sites through Sec31A modification in conventional secretory pathway.

Cho HJ, Mook-Jung I.

FASEB J. 2018 Sep;32(9):4641-4657. doi: 10.1096/fj.201701523R. Epub 2018 Apr 17.


Intrahippocampal injection of a lentiviral vector expressing neurogranin enhances cognitive function in 5XFAD mice.

Jeon SG, Kang M, Kim YS, Kim DH, Nam DW, Song EJ, Mook-Jung I, Moon M.

Exp Mol Med. 2018 Mar 23;50(3):e461. doi: 10.1038/emm.2017.302.


Thrombospondin-1 protects against Aβ-induced mitochondrial fragmentation and dysfunction in hippocampal cells.

Kang S, Byun J, Son SM, Mook-Jung I.

Cell Death Discov. 2018 Feb 20;4:31. doi: 10.1038/s41420-017-0023-4. eCollection 2018 Dec.


Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer's Disease.

Jeon SG, Kim YJ, Kim KA, Mook-Jung I, Moon M.

Mol Neurobiol. 2018 Oct;55(10):7886-7899. doi: 10.1007/s12035-018-0918-y. Epub 2018 Feb 27.


Molecular and functional signatures in a novel Alzheimer's disease mouse model assessed by quantitative proteomics.

Kim DK, Park J, Han D, Yang J, Kim A, Woo J, Kim Y, Mook-Jung I.

Mol Neurodegener. 2018 Jan 16;13(1):2. doi: 10.1186/s13024-017-0234-4.


Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway.

Cha-Molstad H, Lee SH, Kim JG, Sung KW, Hwang J, Shim SM, Ganipisetti S, McGuire T, Mook-Jung I, Ciechanover A, Xie XQ, Kim BY, Kwon YT.

Autophagy. 2018;14(2):359-361. doi: 10.1080/15548627.2017.1415190. Epub 2018 Jan 29.


Mitochondrial abnormalities related to the dysfunction of circulating endothelial colony-forming cells in moyamoya disease.

Choi JW, Son SM, Mook-Jung I, Moon YJ, Lee JY, Wang KC, Kang HS, Phi JH, Choi SA, Chong S, Byun J, Kim SK.

J Neurosurg. 2018 Nov 1;129(5):1151-1159. doi: 10.3171/2017.5.JNS17147.


Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease: Methodology and Baseline Sample Characteristics.

Byun MS, Yi D, Lee JH, Choe YM, Sohn BK, Lee JY, Choi HJ, Baek H, Kim YK, Lee YS, Sohn CH, Mook-Jung I, Choi M, Lee YJ, Lee DW, Ryu SH, Kim SG, Kim JW, Woo JI, Lee DY; KBASE Research Group.

Psychiatry Investig. 2017 Nov;14(6):851-863. doi: 10.4306/pi.2017.14.6.851. Epub 2017 Nov 7.


Low Serum Phosphorus Correlates with Cerebral Aβ Deposition in Cognitively Impaired Subjects: Results from the KBASE Study.

Park JC, Han SH, Byun MS, Yi D, Lee JH, Park K, Lee DY, Mook-Jung I.

Front Aging Neurosci. 2017 Nov 6;9:362. doi: 10.3389/fnagi.2017.00362. eCollection 2017.


SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease.

Lee J, Kim Y, Liu T, Hwang YJ, Hyeon SJ, Im H, Lee K, Alvarez VE, McKee AC, Um SJ, Hur M, Mook-Jung I, Kowall NW, Ryu H.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12679. Epub 2017 Nov 11.


TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia.

Kim SM, Mun BR, Lee SJ, Joh Y, Lee HY, Ji KY, Choi HR, Lee EH, Kim EM, Jang JH, Song HW, Mook-Jung I, Choi WS, Kang HS.

Sci Rep. 2017 Sep 11;7(1):11118. doi: 10.1038/s41598-017-11634-x.


p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.

Cha-Molstad H, Yu JE, Feng Z, Lee SH, Kim JG, Yang P, Han B, Sung KW, Yoo YD, Hwang J, McGuire T, Shim SM, Song HD, Ganipisetti S, Wang N, Jang JM, Lee MJ, Kim SJ, Lee KH, Hong JT, Ciechanover A, Mook-Jung I, Kim KP, Xie XQ, Kwon YT, Kim BY.

Nat Commun. 2017 Jul 24;8(1):102. doi: 10.1038/s41467-017-00085-7.


Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition.

Park JC, Han SH, Cho HJ, Byun MS, Yi D, Choe YM, Kang S, Jung ES, Won SJ, Kim EH, Kim YK, Lee DY, Mook-Jung I.

Alzheimers Res Ther. 2017 Mar 22;9(1):20. doi: 10.1186/s13195-017-0248-8.


Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport.

Choi H, Kim HJ, Kim J, Kim S, Yang J, Lee W, Park Y, Hyeon SJ, Lee DS, Ryu H, Chung J, Mook-Jung I.

Mol Neurodegener. 2017 Feb 28;12(1):23. doi: 10.1186/s13024-017-0164-1.


Retraction of "β-Amyloid and α-Synuclein Cooperate To Block SNARE-Dependent Vesicle Fusion".

Choi BK, Kim JY, Cha MY, Mook-Jung I, Shin YK, Lee NK.

Biochemistry. 2017 Feb 21;56(7):1026. doi: 10.1021/acs.biochem.7b00054. Epub 2017 Feb 10. No abstract available.


Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer's Disease.

Cha MY, Kwon YW, Ahn HS, Jeong H, Lee YY, Moon M, Baik SH, Kim DK, Song H, Yi EC, Hwang D, Kim HS, Mook-Jung I.

Stem Cells Transl Med. 2017 Jan;6(1):293-305. doi: 10.5966/sctm.2016-0081. Epub 2016 Aug 15.


HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation.

Kim JY, Woo SY, Hong YB, Choi H, Kim J, Choi H, Mook-Jung I, Ha N, Kyung J, Koo SK, Jung SC, Choi BO.

Stem Cells Int. 2016;2016:9475981. doi: 10.1155/2016/9475981. Epub 2016 Dec 26.


PRAK mediates Aβ-RAGE driven autophagy pathway.

Kim Y, Mook-Jung I.

Oncotarget. 2017 Jan 24;8(4):5648-5649. doi: 10.18632/oncotarget.14544. No abstract available.


Close Correlation of Monoamine Oxidase Activity with Progress of Alzheimer's Disease in Mice, Observed by in Vivo Two-Photon Imaging.

Kim D, Baik SH, Kang S, Cho SW, Bae J, Cha MY, Sailor MJ, Mook-Jung I, Ahn KH.

ACS Cent Sci. 2016 Dec 28;2(12):967-975. doi: 10.1021/acscentsci.6b00309. Epub 2016 Dec 7.


Cytosolic Extract of Human Adipose Stem Cells Reverses the Amyloid Beta-Induced Mitochondrial Apoptosis via P53/Foxo3a Pathway.

Liu T, Lee M, Ban JJ, Im W, Mook-Jung I, Kim M.

PLoS One. 2017 Jan 3;12(1):e0168859. doi: 10.1371/journal.pone.0168859. eCollection 2017.


Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease.

Kim T, Yang HY, Park BG, Jung SY, Park JH, Park KD, Min SJ, Tae J, Yang H, Cho S, Cho SJ, Song H, Mook-Jung I, Lee J, Pae AN.

Eur J Med Chem. 2017 Jan 5;125:1172-1192. doi: 10.1016/j.ejmech.2016.11.017. Epub 2016 Nov 9.


Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model.

Baik SH, Kang S, Son SM, Mook-Jung I.

Glia. 2016 Dec;64(12):2274-2290. doi: 10.1002/glia.23074. Epub 2016 Sep 23.


Annexin A1 restores Aβ1-42 -induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway.

Park JC, Baik SH, Han SH, Cho HJ, Choi H, Kim HJ, Choi H, Lee W, Kim DK, Mook-Jung I.

Aging Cell. 2017 Feb;16(1):149-161. doi: 10.1111/acel.12530. Epub 2016 Sep 16.


PiB-PET Imaging-Based Serum Proteome Profiles Predict Mild Cognitive Impairment and Alzheimer's Disease.

Kang S, Jeong H, Baek JH, Lee SJ, Han SH, Cho HJ, Kim H, Hong HS, Kim YH, Yi EC, Seo SW, Na DL, Hwang D, Mook-Jung I.

J Alzheimers Dis. 2016 Jul 6;53(4):1563-76. doi: 10.3233/JAD-160025.


A quadrupolar two-photon fluorescent probe for in vivo imaging of amyloid-β plaques.

Heo CH, Sarkar AR, Baik SH, Jung TS, Kim JJ, Kang H, Mook-Jung I, Kim HM.

Chem Sci. 2016 Jul 1;7(7):4600-4606. doi: 10.1039/c6sc00355a. Epub 2016 Apr 7.


p53-dependent SIRT6 expression protects Aβ42-induced DNA damage.

Jung ES, Choi H, Song H, Hwang YJ, Kim A, Ryu H, Mook-Jung I.

Sci Rep. 2016 May 9;6:25628. doi: 10.1038/srep25628.


DMC (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone) improves glucose tolerance as a potent AMPK activator.

Choi JW, Kim M, Song H, Lee CS, Oh WK, Mook-Jung I, Chung SS, Park KS.

Metabolism. 2016 Apr;65(4):533-42. doi: 10.1016/j.metabol.2015.12.010. Epub 2015 Dec 29.


Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation.

Son SM, Shin HJ, Byun J, Kook SY, Moon M, Chang YJ, Mook-Jung I.

J Alzheimers Dis. 2016;51(4):1197-208. doi: 10.3233/JAD-151200.


Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.

Son SM, Cha MY, Choi H, Kang S, Choi H, Lee MS, Park SA, Mook-Jung I.

Autophagy. 2016 May 3;12(5):784-800. doi: 10.1080/15548627.2016.1159375. Epub 2016 Mar 10.


Inhibition of Cholesterol Biosynthesis Reduces γ-Secretase Activity and Amyloid-β Generation.

Kim Y, Kim C, Jang HY, Mook-Jung I.

J Alzheimers Dis. 2016;51(4):1057-68. doi: 10.3233/JAD-150982.


Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer's Disease.

Kwon HJ, Cha MY, Kim D, Kim DK, Soh M, Shin K, Hyeon T, Mook-Jung I.

ACS Nano. 2016 Feb 23;10(2):2860-70. doi: 10.1021/acsnano.5b08045. Epub 2016 Feb 10.


The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer's disease pathogenesis.

Kim Y, Kim C, Son SM, Song H, Hong HS, Han SH, Mook-Jung I.

Mol Neurodegener. 2016 Jan 12;11:4. doi: 10.1186/s13024-016-0068-5.


Amyloid β-interacting partners in Alzheimer's disease: From accomplices to possible therapeutic targets.

Han SH, Park JC, Mook-Jung I.

Prog Neurobiol. 2016 Feb;137:17-38. doi: 10.1016/j.pneurobio.2015.12.004. Epub 2015 Dec 23. Review.


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