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Items: 1 to 50 of 191

1.

A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.

Reinink P, Shahine A, Gras S, Cheng TY, Farquhar R, Lopez K, Suliman SA, Reijneveld JF, Le Nours J, Tan LL, León SR, Jimenez J, Calderon R, Lecca L, Murray MB, Rossjohn J, Moody DB, Van Rhijn I.

J Immunol. 2019 Nov 6. pii: ji1900872. doi: 10.4049/jimmunol.1900872. [Epub ahead of print]

PMID:
31694911
2.

Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians.

Luo Y, Suliman S, Asgari S, Amariuta T, Baglaenko Y, Martínez-Bonet M, Ishigaki K, Gutierrez-Arcelus M, Calderon R, Lecca L, León SR, Jimenez J, Yataco R, Contreras C, Galea JT, Becerra M, Nejentsev S, Nigrovic PA, Moody DB, Murray MB, Raychaudhuri S.

Nat Commun. 2019 Aug 21;10(1):3765. doi: 10.1038/s41467-019-11664-1.

3.

Mycobacterium tuberculosis releases an antacid that remodels phagosomes.

Buter J, Cheng TY, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN, Layre E, Ramnarine AK, Mayfield JA, Young DC, Jezek Martinot A, Siddiqi N, Wakabayashi S, Botella H, Calderon R, Murray M, Ehrt S, Snider BB, Reed MB, Oldfield E, Tan S, Rubin EJ, Behr MA, van der Wel NN, Minnaard AJ, Moody DB.

Nat Chem Biol. 2019 Sep;15(9):889-899. doi: 10.1038/s41589-019-0336-0. Epub 2019 Aug 19.

PMID:
31427817
4.

The late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol.

Park SY, Yang JS, Li Z, Deng P, Zhu X, Young D, Ericsson M, Andringa RLH, Minnaard AJ, Zhu C, Sun F, Moody DB, Morris AJ, Fan J, Hsu VW.

Nat Commun. 2019 Jul 30;10(1):3409. doi: 10.1038/s41467-019-11324-4.

5.

Total Synthesis of an Immunogenic Trehalose Phospholipid from Salmonella Typhi and Elucidation of Its sn-Regiochemistry by Mass Spectrometry.

Mishra VK, Buter J, Blevins MS, Witte MD, Van Rhijn I, Moody DB, Brodbelt JS, Minnaard AJ.

Org Lett. 2019 Jul 5;21(13):5126-5131. doi: 10.1021/acs.orglett.9b01725. Epub 2019 Jun 20.

6.

Harnessing donor unrestricted T-cells for new vaccines against tuberculosis.

Joosten SA, Ottenhoff THM, Lewinsohn DM, Hoft DF, Moody DB, Seshadri C; Collaboration for Tuberculosis Vaccine Discovery - Donor-Unrestricted T-cells Working Group, Bill and Melinda Gates Foundation.

Vaccine. 2019 May 21;37(23):3022-3030. doi: 10.1016/j.vaccine.2019.04.050. Epub 2019 Apr 27. Review.

7.

CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells.

Reinink P, Souter MNT, Cheng TY, van Gorkom T, Lenz S, Kubler-Kielb J, Strle K, Kremer K, Thijsen SFT, Steere AC, Godfrey DI, Pellicci DG, Moody DB, Van Rhijn I.

Eur J Immunol. 2019 May;49(5):737-746. doi: 10.1002/eji.201847949. Epub 2019 Mar 20.

8.

Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria.

Reinink P, Buter J, Mishra VK, Ishikawa E, Cheng TY, Willemsen PTJ, Porwollik S, Brennan PJ, Heinz E, Mayfield JA, Dougan G, van Els CA, Cerundolo V, Napolitani G, Yamasaki S, Minnaard AJ, McClelland M, Moody DB, Van Rhijn I.

J Exp Med. 2019 Apr 1;216(4):757-771. doi: 10.1084/jem.20181812. Epub 2019 Feb 25.

9.

Demethylmenaquinone Methyl Transferase Is a Membrane Domain-Associated Protein Essential for Menaquinone Homeostasis in Mycobacterium smegmatis.

Puffal J, Mayfield JA, Moody DB, Morita YS.

Front Microbiol. 2018 Dec 18;9:3145. doi: 10.3389/fmicb.2018.03145. eCollection 2018.

10.

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.

Shahine A, Reinink P, Reijneveld JF, Gras S, Holzheimer M, Cheng TY, Minnaard AJ, Altman JD, Lenz S, Prandi J, Kubler-Kielb J, Moody DB, Rossjohn J, Van Rhijn I.

Nat Commun. 2019 Jan 4;10(1):56. doi: 10.1038/s41467-018-07898-0.

11.

Lipids hide or step aside for CD1-autoreactive T cell receptors.

Cotton RN, Shahine A, Rossjohn J, Moody DB.

Curr Opin Immunol. 2018 Jun;52:93-99. doi: 10.1016/j.coi.2018.04.013. Epub 2018 May 5. Review.

12.

Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy.

Lee-Sarwar K, Kelly RS, Lasky-Su J, Moody DB, Mola AR, Cheng TY, Comstock LE, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Bunyavanich S, Savage JH, Weiss ST, Brennan PJ, Litonjua AA.

J Allergy Clin Immunol. 2018 Jul;142(1):335-338.e9. doi: 10.1016/j.jaci.2018.04.016. Epub 2018 May 2. No abstract available.

13.

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.

Wun KS, Reijneveld JF, Cheng TY, Ladell K, Uldrich AP, Le Nours J, Miners KL, McLaren JE, Grant EJ, Haigh OL, Watkins TS, Suliman S, Iwany S, Jimenez J, Calderon R, Tamara KL, Leon SR, Murray MB, Mayfield JA, Altman JD, Purcell AW, Miles JJ, Godfrey DI, Gras S, Price DA, Van Rhijn I, Moody DB, Rossjohn J.

Nat Immunol. 2018 Apr;19(4):397-406. doi: 10.1038/s41590-018-0065-7. Epub 2018 Mar 12.

14.

Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface.

Carette X, Platig J, Young DC, Helmel M, Young AT, Wang Z, Potluri LP, Moody CS, Zeng J, Prisic S, Paulson JN, Muntel J, Madduri AVR, Velarde J, Mayfield JA, Locher C, Wang T, Quackenbush J, Rhee KY, Moody DB, Steen H, Husson RN.

MBio. 2018 Mar 6;9(2). pii: e02333-17. doi: 10.1128/mBio.02333-17.

15.

CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis.

James CA, Yu KKQ, Gilleron M, Prandi J, Yedulla VR, Moleda ZZ, Diamanti E, Khan M, Aggarwal VK, Reijneveld JF, Reinink P, Lenz S, Emerson RO, Scriba TJ, Souter MNT, Godfrey DI, Pellicci DG, Moody DB, Minnaard AJ, Seshadri C, Van Rhijn I.

Cell Chem Biol. 2018 Apr 19;25(4):392-402.e14. doi: 10.1016/j.chembiol.2018.01.006. Epub 2018 Feb 1.

16.

How T cells grasp mycobacterial lipid antigens.

Moody DB.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13312-13314. doi: 10.1073/pnas.1719260115. Epub 2017 Dec 7. No abstract available.

17.

CD1: From Molecules to Diseases.

Moody DB, Suliman S.

F1000Res. 2017 Oct 30;6:1909. doi: 10.12688/f1000research.12178.1. eCollection 2017. Review.

18.

An Antibacterial β-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis.

Lehmann J, Cheng TY, Aggarwal A, Park AS, Zeiler E, Raju RM, Akopian T, Kandror O, Sacchettini JC, Moody DB, Rubin EJ, Sieber SA.

Angew Chem Int Ed Engl. 2018 Jan 2;57(1):348-353. doi: 10.1002/anie.201709365. Epub 2017 Dec 5.

19.

A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.

Shahine A, Van Rhijn I, Cheng TY, Iwany S, Gras S, Moody DB, Rossjohn J.

Sci Immunol. 2017 Oct 20;2(16). pii: eaao1384. doi: 10.1126/sciimmunol.aao1384.

20.

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.

Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L.

Cell. 2017 Aug 24;170(5):973-985.e10. doi: 10.1016/j.cell.2017.07.030.

21.

Four pathways of CD1 antigen presentation to T cells.

Moody DB, Cotton RN.

Curr Opin Immunol. 2017 Jun;46:127-133. doi: 10.1016/j.coi.2017.07.013. Epub 2017 Jul 28. Review.

22.

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface.

Brennan PJ, Cheng TY, Pellicci DG, Watts GFM, Veerapen N, Young DC, Rossjohn J, Besra GS, Godfrey DI, Brenner MB, Moody DB.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8348-8353. doi: 10.1073/pnas.1705882114. Epub 2017 Jul 17.

23.

CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails.

Van Rhijn I, Iwany SK, Fodran P, Cheng TY, Gapin L, Minnaard AJ, Moody DB.

Eur J Immunol. 2017 Sep;47(9):1525-1534. doi: 10.1002/eji.201747062. Epub 2017 Jul 31.

24.

CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice.

Bagchi S, He Y, Zhang H, Cao L, Van Rhijn I, Moody DB, Gudjonsson JE, Wang CR.

J Clin Invest. 2017 Jun 1;127(6):2339-2352. doi: 10.1172/JCI92217. Epub 2017 May 2.

25.

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.

Cheng JM, Liu L, Pellicci DG, Reddiex SJ, Cotton RN, Cheng TY, Young DC, Van Rhijn I, Moody DB, Rossjohn J, Fairlie DP, Godfrey DI, Williams SJ.

Chemistry. 2017 Jan 31;23(7):1694-1701. doi: 10.1002/chem.201605287. Epub 2017 Jan 18.

26.

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid.

Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J.

Nat Commun. 2016 Oct 27;7:13257. doi: 10.1038/ncomms13257.

27.

Donor-unrestricted T cells in the human CD1 system.

Huang S, Moody DB.

Immunogenetics. 2016 Aug;68(8):577-96. doi: 10.1007/s00251-016-0942-x. Epub 2016 Aug 9. Review.

28.

Stereoselective Synthesis of 1-Tuberculosinyl Adenosine; a Virulence Factor of Mycobacterium tuberculosis.

Buter J, Heijnen D, Wan IC, Bickelhaupt FM, Young DC, Otten E, Moody DB, Minnaard AJ.

J Org Chem. 2016 Aug 5;81(15):6686-96. doi: 10.1021/acs.joc.6b01332. Epub 2016 Jul 26.

29.

Cell-Envelope Remodeling as a Determinant of Phenotypic Antibacterial Tolerance in Mycobacterium tuberculosis.

Larrouy-Maumus G, Marino LB, Madduri AV, Ragan TJ, Hunt DM, Bassano L, Gutierrez MG, Moody DB, Pavan FR, de Carvalho LP.

ACS Infect Dis. 2016 May 13;2(5):352-360. Epub 2016 Mar 28.

30.

Rifampin Resistance Mutations Are Associated with Broad Chemical Remodeling of Mycobacterium tuberculosis.

Lahiri N, Shah RR, Layre E, Young D, Ford C, Murray MB, Fortune SM, Moody DB.

J Biol Chem. 2016 Jul 1;291(27):14248-56. doi: 10.1074/jbc.M116.716704. Epub 2016 May 10.

31.

Spatially distinct and metabolically active membrane domain in mycobacteria.

Hayashi JM, Luo CY, Mayfield JA, Hsu T, Fukuda T, Walfield AL, Giffen SR, Leszyk JD, Baer CE, Bennion OT, Madduri A, Shaffer SA, Aldridge BB, Sassetti CM, Sandler SJ, Kinoshita T, Moody DB, Morita YS.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5400-5. doi: 10.1073/pnas.1525165113. Epub 2016 Apr 25.

32.

Corrigendum: The burgeoning family of unconventional T cells.

Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB.

Nat Immunol. 2016 Apr;17(4):469. doi: 10.1038/ni0416-469a. No abstract available.

PMID:
27002846
33.

Monstrous Mycobacterial Lipids.

Seeliger J, Moody DB.

Cell Chem Biol. 2016 Feb 18;23(2):207-209. doi: 10.1016/j.chembiol.2016.02.004.

34.

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase.

Jarrett R, Salio M, Lloyd-Lavery A, Subramaniam S, Bourgeois E, Archer C, Cheung KL, Hardman C, Chandler D, Salimi M, Gutowska-Owsiak D, de la Serna JB, Fallon PG, Jolin H, Mckenzie A, Dziembowski A, Podobas EI, Bal W, Johnson D, Moody DB, Cerundolo V, Ogg G.

Sci Transl Med. 2016 Feb 10;8(325):325ra18. doi: 10.1126/scitranslmed.aad6833.

35.

Corrigendum: The burgeoning family of unconventional T cells.

Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB.

Nat Immunol. 2016 Feb;17(2):214. doi: 10.1038/ni0216-214a. No abstract available.

PMID:
26784266
36.

Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.

Roy S, Ly D, Castro CD, Li NS, Hawk AJ, Altman JD, Meredith SC, Piccirilli JA, Moody DB, Adams EJ.

J Immunol. 2016 Feb 15;196(4):1933-42. doi: 10.4049/jimmunol.1502202. Epub 2016 Jan 11.

37.

Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis.

Martinot AJ, Farrow M, Bai L, Layre E, Cheng TY, Tsai JH, Iqbal J, Annand JW, Sullivan ZA, Hussain MM, Sacchettini J, Moody DB, Seeliger JC, Rubin EJ.

PLoS Pathog. 2016 Jan 11;12(1):e1005351. doi: 10.1371/journal.ppat.1005351. eCollection 2016 Jan.

38.

Human autoreactive T cells recognize CD1b and phospholipids.

Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):380-5. doi: 10.1073/pnas.1520947112. Epub 2015 Nov 30.

39.

Elevated and cross-responsive CD1a-reactive T cells in bee and wasp venom allergic individuals.

Subramaniam S, Aslam A, Misbah SA, Salio M, Cerundolo V, Moody DB, Ogg G.

Eur J Immunol. 2016 Jan;46(1):242-52. doi: 10.1002/eji.201545869. Epub 2015 Nov 17.

40.

The burgeoning family of unconventional T cells.

Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB.

Nat Immunol. 2015 Nov;16(11):1114-23. doi: 10.1038/ni.3298. Review. Erratum in: Nat Immunol. 2016 Feb;17(2):214. Nat Immunol. 2016 Apr;17(4):469.

PMID:
26482978
41.

T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents.

Seshadri C, Lin L, Scriba TJ, Peterson G, Freidrich D, Frahm N, DeRosa SC, Moody DB, Prandi J, Gilleron M, Mahomed H, Jiang W, Finak G, Hanekom WA, Gottardo R, McElrath MJ, Hawn TR.

J Immunol. 2015 Nov 15;195(10):4595-603. doi: 10.4049/jimmunol.1501285. Epub 2015 Oct 14.

42.

Lipid and small-molecule display by CD1 and MR1.

Van Rhijn I, Godfrey DI, Rossjohn J, Moody DB.

Nat Rev Immunol. 2015 Oct;15(10):643-54. doi: 10.1038/nri3889. Epub 2015 Sep 21. Review.

PMID:
26388332
43.

HIV Disrupts Human T Cells That Target Mycobacterial Glycolipids.

Kasprowicz VO, Cheng TY, Ndung'u T, Sunpath H, Moody DB, Kasmar AG.

J Infect Dis. 2016 Feb 15;213(4):628-33. doi: 10.1093/infdis/jiv455. Epub 2015 Sep 15.

44.

Donor Unrestricted T Cells: A Shared Human T Cell Response.

Van Rhijn I, Moody DB.

J Immunol. 2015 Sep 1;195(5):1927-32. doi: 10.4049/jimmunol.1500943. Review.

45.

Biomarkers for Tuberculosis Based on Secreted, Species-Specific, Bacterial Small Molecules.

Pan SJ, Tapley A, Adamson J, Little T, Urbanowski M, Cohen K, Pym A, Almeida D, Dorasamy A, Layre E, Young DC, Singh R, Patel VB, Wallengren K, Ndung'u T, Wilson D, Moody DB, Bishai W.

J Infect Dis. 2015 Dec 1;212(11):1827-34. doi: 10.1093/infdis/jiv312. Epub 2015 May 26.

46.

In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection.

Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB, Moody DB.

Chem Biol. 2015 Apr 23;22(4):516-526. doi: 10.1016/j.chembiol.2015.03.015.

47.

Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis.

Madigan CA, Martinot AJ, Wei JR, Madduri A, Cheng TY, Young DC, Layre E, Murry JP, Rubin EJ, Moody DB.

PLoS Pathog. 2015 Mar 27;11(3):e1004792. doi: 10.1371/journal.ppat.1004792. eCollection 2015 Mar.

48.

CD1 Antigen Presentation and Autoreactivity in the Pregnant Human Uterus.

Guerin L, Wu V, Houser B, Tilburgs T, de Jong A, Moody DB, Strominger JL.

Am J Reprod Immunol. 2015 Aug;74(2):126-35. doi: 10.1111/aji.12375. Epub 2015 Mar 4.

49.

CD1 and mycobacterial lipids activate human T cells.

Van Rhijn I, Moody DB.

Immunol Rev. 2015 Mar;264(1):138-53. doi: 10.1111/imr.12253. Review.

50.

αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands.

Birkinshaw RW, Pellicci DG, Cheng TY, Keller AN, Sandoval-Romero M, Gras S, de Jong A, Uldrich AP, Moody DB, Godfrey DI, Rossjohn J.

Nat Immunol. 2015 Mar;16(3):258-66. doi: 10.1038/ni.3098. Epub 2015 Feb 2.

PMID:
25642819

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