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Items: 1 to 50 of 181

1.

Lipids hide or step aside for CD1-autoreactive T cell receptors.

Cotton RN, Shahine A, Rossjohn J, Moody DB.

Curr Opin Immunol. 2018 Jun;52:93-99. doi: 10.1016/j.coi.2018.04.013. Epub 2018 May 5. Review.

PMID:
29738961
2.

Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy.

Lee-Sarwar K, Kelly RS, Lasky-Su J, Moody DB, Mola AR, Cheng TY, Comstock LE, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Bunyavanich S, Savage JH, Weiss ST, Brennan PJ, Litonjua AA.

J Allergy Clin Immunol. 2018 Jul;142(1):335-338.e9. doi: 10.1016/j.jaci.2018.04.016. Epub 2018 May 2. No abstract available.

PMID:
29729303
3.

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.

Wun KS, Reijneveld JF, Cheng TY, Ladell K, Uldrich AP, Le Nours J, Miners KL, McLaren JE, Grant EJ, Haigh OL, Watkins TS, Suliman S, Iwany S, Jimenez J, Calderon R, Tamara KL, Leon SR, Murray MB, Mayfield JA, Altman JD, Purcell AW, Miles JJ, Godfrey DI, Gras S, Price DA, Van Rhijn I, Moody DB, Rossjohn J.

Nat Immunol. 2018 Apr;19(4):397-406. doi: 10.1038/s41590-018-0065-7. Epub 2018 Mar 12.

PMID:
29531339
4.

Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface.

Carette X, Platig J, Young DC, Helmel M, Young AT, Wang Z, Potluri LP, Moody CS, Zeng J, Prisic S, Paulson JN, Muntel J, Madduri AVR, Velarde J, Mayfield JA, Locher C, Wang T, Quackenbush J, Rhee KY, Moody DB, Steen H, Husson RN.

MBio. 2018 Mar 6;9(2). pii: e02333-17. doi: 10.1128/mBio.02333-17.

5.

CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis.

James CA, Yu KKQ, Gilleron M, Prandi J, Yedulla VR, Moleda ZZ, Diamanti E, Khan M, Aggarwal VK, Reijneveld JF, Reinink P, Lenz S, Emerson RO, Scriba TJ, Souter MNT, Godfrey DI, Pellicci DG, Moody DB, Minnaard AJ, Seshadri C, Van Rhijn I.

Cell Chem Biol. 2018 Apr 19;25(4):392-402.e14. doi: 10.1016/j.chembiol.2018.01.006. Epub 2018 Feb 1.

PMID:
29398561
6.

How T cells grasp mycobacterial lipid antigens.

Moody DB.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13312-13314. doi: 10.1073/pnas.1719260115. Epub 2017 Dec 7. No abstract available.

7.

CD1: From Molecules to Diseases.

Moody DB, Suliman S.

F1000Res. 2017 Oct 30;6:1909. doi: 10.12688/f1000research.12178.1. eCollection 2017. Review.

8.

An Antibacterial β-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis.

Lehmann J, Cheng TY, Aggarwal A, Park AS, Zeiler E, Raju RM, Akopian T, Kandror O, Sacchettini JC, Moody DB, Rubin EJ, Sieber SA.

Angew Chem Int Ed Engl. 2018 Jan 2;57(1):348-353. doi: 10.1002/anie.201709365. Epub 2017 Dec 5.

PMID:
29067779
9.

A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.

Shahine A, Van Rhijn I, Cheng TY, Iwany S, Gras S, Moody DB, Rossjohn J.

Sci Immunol. 2017 Oct 20;2(16). pii: eaao1384. doi: 10.1126/sciimmunol.aao1384.

PMID:
29054999
10.

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.

Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L.

Cell. 2017 Aug 24;170(5):973-985.e10. doi: 10.1016/j.cell.2017.07.030.

11.

Four pathways of CD1 antigen presentation to T cells.

Moody DB, Cotton RN.

Curr Opin Immunol. 2017 Jun;46:127-133. doi: 10.1016/j.coi.2017.07.013. Epub 2017 Jul 28. Review.

12.

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface.

Brennan PJ, Cheng TY, Pellicci DG, Watts GFM, Veerapen N, Young DC, Rossjohn J, Besra GS, Godfrey DI, Brenner MB, Moody DB.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8348-8353. doi: 10.1073/pnas.1705882114. Epub 2017 Jul 17.

13.

CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails.

Van Rhijn I, Iwany SK, Fodran P, Cheng TY, Gapin L, Minnaard AJ, Moody DB.

Eur J Immunol. 2017 Sep;47(9):1525-1534. doi: 10.1002/eji.201747062. Epub 2017 Jul 31.

14.

CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice.

Bagchi S, He Y, Zhang H, Cao L, Van Rhijn I, Moody DB, Gudjonsson JE, Wang CR.

J Clin Invest. 2017 Jun 1;127(6):2339-2352. doi: 10.1172/JCI92217. Epub 2017 May 2.

15.

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.

Cheng JM, Liu L, Pellicci DG, Reddiex SJ, Cotton RN, Cheng TY, Young DC, Van Rhijn I, Moody DB, Rossjohn J, Fairlie DP, Godfrey DI, Williams SJ.

Chemistry. 2017 Jan 31;23(7):1694-1701. doi: 10.1002/chem.201605287. Epub 2017 Jan 18.

PMID:
27925318
16.

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid.

Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J.

Nat Commun. 2016 Oct 27;7:13257. doi: 10.1038/ncomms13257.

17.

Donor-unrestricted T cells in the human CD1 system.

Huang S, Moody DB.

Immunogenetics. 2016 Aug;68(8):577-96. doi: 10.1007/s00251-016-0942-x. Epub 2016 Aug 9. Review.

18.

Stereoselective Synthesis of 1-Tuberculosinyl Adenosine; a Virulence Factor of Mycobacterium tuberculosis.

Buter J, Heijnen D, Wan IC, Bickelhaupt FM, Young DC, Otten E, Moody DB, Minnaard AJ.

J Org Chem. 2016 Aug 5;81(15):6686-96. doi: 10.1021/acs.joc.6b01332. Epub 2016 Jul 26.

PMID:
27398789
19.

Cell-Envelope Remodeling as a Determinant of Phenotypic Antibacterial Tolerance in Mycobacterium tuberculosis.

Larrouy-Maumus G, Marino LB, Madduri AV, Ragan TJ, Hunt DM, Bassano L, Gutierrez MG, Moody DB, Pavan FR, de Carvalho LP.

ACS Infect Dis. 2016 May 13;2(5):352-360. Epub 2016 Mar 28.

20.

Rifampin Resistance Mutations Are Associated with Broad Chemical Remodeling of Mycobacterium tuberculosis.

Lahiri N, Shah RR, Layre E, Young D, Ford C, Murray MB, Fortune SM, Moody DB.

J Biol Chem. 2016 Jul 1;291(27):14248-56. doi: 10.1074/jbc.M116.716704. Epub 2016 May 10.

21.

Spatially distinct and metabolically active membrane domain in mycobacteria.

Hayashi JM, Luo CY, Mayfield JA, Hsu T, Fukuda T, Walfield AL, Giffen SR, Leszyk JD, Baer CE, Bennion OT, Madduri A, Shaffer SA, Aldridge BB, Sassetti CM, Sandler SJ, Kinoshita T, Moody DB, Morita YS.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5400-5. doi: 10.1073/pnas.1525165113. Epub 2016 Apr 25.

22.

Corrigendum: The burgeoning family of unconventional T cells.

Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB.

Nat Immunol. 2016 Apr;17(4):469. doi: 10.1038/ni0416-469a. No abstract available.

PMID:
27002846
23.

Monstrous Mycobacterial Lipids.

Seeliger J, Moody DB.

Cell Chem Biol. 2016 Feb 18;23(2):207-209. doi: 10.1016/j.chembiol.2016.02.004.

24.

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase.

Jarrett R, Salio M, Lloyd-Lavery A, Subramaniam S, Bourgeois E, Archer C, Cheung KL, Hardman C, Chandler D, Salimi M, Gutowska-Owsiak D, de la Serna JB, Fallon PG, Jolin H, Mckenzie A, Dziembowski A, Podobas EI, Bal W, Johnson D, Moody DB, Cerundolo V, Ogg G.

Sci Transl Med. 2016 Feb 10;8(325):325ra18. doi: 10.1126/scitranslmed.aad6833.

25.

Corrigendum: The burgeoning family of unconventional T cells.

Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB.

Nat Immunol. 2016 Feb;17(2):214. doi: 10.1038/ni0216-214a. No abstract available.

PMID:
26784266
26.

Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.

Roy S, Ly D, Castro CD, Li NS, Hawk AJ, Altman JD, Meredith SC, Piccirilli JA, Moody DB, Adams EJ.

J Immunol. 2016 Feb 15;196(4):1933-42. doi: 10.4049/jimmunol.1502202. Epub 2016 Jan 11.

27.

Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis.

Martinot AJ, Farrow M, Bai L, Layre E, Cheng TY, Tsai JH, Iqbal J, Annand JW, Sullivan ZA, Hussain MM, Sacchettini J, Moody DB, Seeliger JC, Rubin EJ.

PLoS Pathog. 2016 Jan 11;12(1):e1005351. doi: 10.1371/journal.ppat.1005351. eCollection 2016 Jan.

28.

Human autoreactive T cells recognize CD1b and phospholipids.

Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):380-5. doi: 10.1073/pnas.1520947112. Epub 2015 Nov 30.

29.

Elevated and cross-responsive CD1a-reactive T cells in bee and wasp venom allergic individuals.

Subramaniam S, Aslam A, Misbah SA, Salio M, Cerundolo V, Moody DB, Ogg G.

Eur J Immunol. 2016 Jan;46(1):242-52. doi: 10.1002/eji.201545869. Epub 2015 Nov 17.

30.

The burgeoning family of unconventional T cells.

Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB.

Nat Immunol. 2015 Nov;16(11):1114-23. doi: 10.1038/ni.3298. Review. Erratum in: Nat Immunol. 2016 Apr;17(4):469. Nat Immunol. 2016 Feb;17(2):214.

PMID:
26482978
31.

T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents.

Seshadri C, Lin L, Scriba TJ, Peterson G, Freidrich D, Frahm N, DeRosa SC, Moody DB, Prandi J, Gilleron M, Mahomed H, Jiang W, Finak G, Hanekom WA, Gottardo R, McElrath MJ, Hawn TR.

J Immunol. 2015 Nov 15;195(10):4595-603. doi: 10.4049/jimmunol.1501285. Epub 2015 Oct 14.

32.

Lipid and small-molecule display by CD1 and MR1.

Van Rhijn I, Godfrey DI, Rossjohn J, Moody DB.

Nat Rev Immunol. 2015 Oct;15(10):643-54. doi: 10.1038/nri3889. Epub 2015 Sep 21. Review.

PMID:
26388332
33.

HIV Disrupts Human T Cells That Target Mycobacterial Glycolipids.

Kasprowicz VO, Cheng TY, Ndung'u T, Sunpath H, Moody DB, Kasmar AG.

J Infect Dis. 2016 Feb 15;213(4):628-33. doi: 10.1093/infdis/jiv455. Epub 2015 Sep 15.

34.

Donor Unrestricted T Cells: A Shared Human T Cell Response.

Van Rhijn I, Moody DB.

J Immunol. 2015 Sep 1;195(5):1927-32. doi: 10.4049/jimmunol.1500943. Review.

35.

Biomarkers for Tuberculosis Based on Secreted, Species-Specific, Bacterial Small Molecules.

Pan SJ, Tapley A, Adamson J, Little T, Urbanowski M, Cohen K, Pym A, Almeida D, Dorasamy A, Layre E, Young DC, Singh R, Patel VB, Wallengren K, Ndung'u T, Wilson D, Moody DB, Bishai W.

J Infect Dis. 2015 Dec 1;212(11):1827-34. doi: 10.1093/infdis/jiv312. Epub 2015 May 26.

36.

In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection.

Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB, Moody DB.

Chem Biol. 2015 Apr 23;22(4):516-526. doi: 10.1016/j.chembiol.2015.03.015.

37.

Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis.

Madigan CA, Martinot AJ, Wei JR, Madduri A, Cheng TY, Young DC, Layre E, Murry JP, Rubin EJ, Moody DB.

PLoS Pathog. 2015 Mar 27;11(3):e1004792. doi: 10.1371/journal.ppat.1004792. eCollection 2015 Mar.

38.

CD1 Antigen Presentation and Autoreactivity in the Pregnant Human Uterus.

Guerin L, Wu V, Houser B, Tilburgs T, de Jong A, Moody DB, Strominger JL.

Am J Reprod Immunol. 2015 Aug;74(2):126-35. doi: 10.1111/aji.12375. Epub 2015 Mar 4.

39.

CD1 and mycobacterial lipids activate human T cells.

Van Rhijn I, Moody DB.

Immunol Rev. 2015 Mar;264(1):138-53. doi: 10.1111/imr.12253. Review.

40.

αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands.

Birkinshaw RW, Pellicci DG, Cheng TY, Keller AN, Sandoval-Romero M, Gras S, de Jong A, Uldrich AP, Moody DB, Godfrey DI, Rossjohn J.

Nat Immunol. 2015 Mar;16(3):258-66. doi: 10.1038/ni.3098. Epub 2015 Feb 2.

PMID:
25642819
41.

Bee venom processes human skin lipids for presentation by CD1a.

Bourgeois EA, Subramaniam S, Cheng TY, De Jong A, Layre E, Ly D, Salimi M, Legaspi A, Modlin RL, Salio M, Cerundolo V, Moody DB, Ogg G.

J Exp Med. 2015 Feb 9;212(2):149-63. doi: 10.1084/jem.20141505. Epub 2015 Jan 12.

42.

Discovery of invariant T cells by next-generation sequencing of the human TCR α-chain repertoire.

van Schaik B, Klarenbeek P, Doorenspleet M, van Kampen A, Moody DB, de Vries N, Van Rhijn I.

J Immunol. 2014 Nov 15;193(10):5338-44. doi: 10.4049/jimmunol.1401380. Epub 2014 Oct 22.

43.

Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells.

Roy S, Ly D, Li NS, Altman JD, Piccirilli JA, Moody DB, Adams EJ.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4648-57. doi: 10.1073/pnas.1408549111. Epub 2014 Oct 8.

44.

Human T cells use CD1 and MR1 to recognize lipids and small molecules.

Layre E, de Jong A, Moody DB.

Curr Opin Chem Biol. 2014 Dec;23:31-8. doi: 10.1016/j.cbpa.2014.09.007. Epub 2014 Sep 29. Review.

PMID:
25271021
45.

Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.

Kawasaki N, Rillahan CD, Cheng TY, Van Rhijn I, Macauley MS, Moody DB, Paulson JC.

J Immunol. 2014 Aug 15;193(4):1560-6. doi: 10.4049/jimmunol.1303278. Epub 2014 Jul 7.

46.

TCR bias and affinity define two compartments of the CD1b-glycolipid-specific T Cell repertoire.

Van Rhijn I, Gherardin NA, Kasmar A, de Jager W, Pellicci DG, Kostenko L, Tan LL, Bhati M, Gras S, Godfrey DI, Rossjohn J, Moody DB.

J Immunol. 2014 May 1;192(9):4054-60. doi: 10.4049/jimmunol.1400158. Epub 2014 Mar 28.

47.

The CD1 size problem: lipid antigens, ligands, and scaffolds.

Ly D, Moody DB.

Cell Mol Life Sci. 2014 Aug;71(16):3069-79. Review.

48.

Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c.

Layre E, Lee HJ, Young DC, Martinot AJ, Buter J, Minnaard AJ, Annand JW, Fortune SM, Snider BB, Matsunaga I, Rubin EJ, Alber T, Moody DB.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):2978-83. doi: 10.1073/pnas.1315883111. Epub 2014 Feb 10.

49.

Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling.

Jones CM, Wells RM, Madduri AV, Renfrow MB, Ratledge C, Moody DB, Niederweis M.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1945-50. doi: 10.1073/pnas.1311402111. Epub 2014 Jan 13.

50.

CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens.

de Jong A, Cheng TY, Huang S, Gras S, Birkinshaw RW, Kasmar AG, Van Rhijn I, Peña-Cruz V, Ruan DT, Altman JD, Rossjohn J, Moody DB.

Nat Immunol. 2014 Feb;15(2):177-85. doi: 10.1038/ni.2790. Epub 2013 Dec 22.

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