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Resistance profile of Neisseria gonorrhoeae in KwaZulu-Natal, South Africa questioning the effect of the currently advocated dual therapy.

Rambaran S, Naidoo K, Dookie N, Moodley P, Sturm AW.

Sex Transm Dis. 2018 Dec 5. doi: 10.1097/OLQ.0000000000000961. [Epub ahead of print]


Development of artificial neural network tools for predicting sugar yields from inorganic salt-based pretreatment of lignocellulosic biomass.

Moodley P, Rorke DCS, Gueguim Kana EB.

Bioresour Technol. 2019 Feb;273:682-686. doi: 10.1016/j.biortech.2018.11.034. Epub 2018 Nov 9.


Congenital rubella syndrome surveillance in South Africa using a sentinel site approach: a cross-sectional study.

Motaze NV, Manamela J, Smit S, Rabie H, Harper K, duPlessis N, Reubenson G, Coetzee M, Ballot D, Moore D, Nuttall J, Linley L, Tooke L, Kriel J, Hallbauer U, Sutton C, Moodley P, Hardie D, Mazanderani AH, Goosen F, Kyaw T, Leroux D, Hussain A, Singh R, Kelly C, Ducasse G, Muller M, Blaauw M, Hamese M, Leeuw T, Mekgoe O, Rakgole P, Dungwa N, Maphosa T, Sanyane K, Preiser W, Cohen C, Suchard M.

Clin Infect Dis. 2018 Sep 8. doi: 10.1093/cid/ciy758. [Epub ahead of print]


Extensively drug-resistant tuberculosis in South Africa: genomic evidence supporting transmission in communities.

Auld SC, Shah NS, Mathema B, Brown TS, Ismail N, Omar SV, Brust JCM, Nelson KN, Allana S, Campbell A, Mlisana K, Moodley P, Gandhi NR.

Eur Respir J. 2018 Oct 18;52(4). pii: 1800246. doi: 10.1183/13993003.00246-2018. Print 2018 Oct.


Spatial Patterns of Extensively Drug-Resistant Tuberculosis Transmission in KwaZulu-Natal, South Africa.

Nelson KN, Shah NS, Mathema B, Ismail N, Brust JCM, Brown TS, Auld SC, Omar SV, Morris N, Campbell A, Allana S, Moodley P, Mlisana K, Gandhi NR.

J Infect Dis. 2018 Nov 5;218(12):1964-1973. doi: 10.1093/infdis/jiy394.


The efficacy and safety of topical tranexamic acid: A systematic review and meta-analysis.

Montroy J, Hutton B, Moodley P, Fergusson NA, Cheng W, Tinmouth A, Lavallée LT, Fergusson DA, Breau RH.

Transfus Med Rev. 2018 Feb 19. pii: S0887-7963(17)30151-7. doi: 10.1016/j.tmrv.2018.02.003. [Epub ahead of print] Review.


An evaluation of infection control in private and public sector intensive care units in South Africa.

Mahomed S, Sturm AW, Knight S, Moodley P.

J Infect Prev. 2018 Mar;19(2):87-93. doi: 10.1177/1757177417733061. Epub 2017 Nov 2.


Improved Survival and Cure Rates With Concurrent Treatment for Multidrug-Resistant Tuberculosis-Human Immunodeficiency Virus Coinfection in South Africa.

Brust JCM, Shah NS, Mlisana K, Moodley P, Allana S, Campbell A, Johnson BA, Master I, Mthiyane T, Lachman S, Larkan LM, Ning Y, Malik A, Smith JP, Gandhi NR.

Clin Infect Dis. 2018 Apr 3;66(8):1246-1253. doi: 10.1093/cid/cix1125.


A comparison of private and public sector intensive care unit infrastructure in South Africa.

Mahomed S, Sturm AW, Moodley P.

S Afr Med J. 2017 Nov 27;107(12):1086-1090. doi: 10.7196/SAMJ.2017.v107i12.12631.


Challenges with Surveillance of Healthcare-Associated Infections in Intensive Care Units in South Africa.

Mahomed S, Mahomed O, Sturm AW, Knight S, Moodley P.

Crit Care Res Pract. 2017;2017:7296317. doi: 10.1155/2017/7296317. Epub 2017 Oct 12.


Spatial distribution of extensively drug-resistant tuberculosis (XDR TB) patients in KwaZulu-Natal, South Africa.

Kapwata T, Morris N, Campbell A, Mthiyane T, Mpangase P, Nelson KN, Allana S, Brust JCM, Moodley P, Mlisana K, Gandhi NR, Shah NS.

PLoS One. 2017 Oct 13;12(10):e0181797. doi: 10.1371/journal.pone.0181797. eCollection 2017.


Rates of virological suppression and drug resistance in adult HIV-1-positive patients attending primary healthcare facilities in KwaZulu-Natal, South Africa.

Hunt GM, Dokubo EK, Takuva S, de Oliveira T, Ledwaba J, Dube N, Moodley P, Sabatier J, Deyde V, Morris L, Raizes E.

J Antimicrob Chemother. 2017 Nov 1;72(11):3141-3148. doi: 10.1093/jac/dkx252. Erratum in: J Antimicrob Chemother. 2017 Nov 1;72(11):3222.


Protocol for a randomised controlled implementation trial of point-of-care viral load testing and task shifting: the Simplifying HIV TREAtment and Monitoring (STREAM) study.

Dorward J, Garrett N, Quame-Amaglo J, Samsunder N, Ngobese H, Ngomane N, Moodley P, Mlisana K, Schaafsma T, Donnell D, Barnabas R, Naidoo K, Abdool Karim S, Celum C, Drain PK.

BMJ Open. 2017 Sep 27;7(9):e017507. doi: 10.1136/bmjopen-2017-017507.


Rates of virological suppression and drug resistance in adult HIV-1-positive patients attending primary healthcare facilities in KwaZulu-Natal, South Africa.

Hunt GM, Kainne Dokubo E, Takuva S, de Oliveira T, Ledwaba J, Dube N, Moodley P, Sabatier J, Deyde V, Morris L, Raizes E.

J Antimicrob Chemother. 2017 Nov 1;72(11):3222. doi: 10.1093/jac/dkx340. No abstract available.


Cellular Architecture of Spinal Granulomas and the Immunological Response in Tuberculosis Patients Coinfected with HIV.

Bhattacharya D, Danaviah S, Muema DM, Akilimali NA, Moodley P, Ndung'u T, Das G.

Front Immunol. 2017 Sep 11;8:1120. doi: 10.3389/fimmu.2017.01120. eCollection 2017.


A19 Genetic markers for protease inhibitor drug resistance in regions outside of the protease gene.

Giandhari J, Gordon M, van Vuuren C, Moodley P, de Oliveira T.

Virus Evol. 2017 Mar 5;3(Suppl 1). pii: vew036.018. doi: 10.1093/ve/vew036.018. eCollection 2017 Mar. No abstract available.


Molecular Characterization of Corynebacterium diphtheriae Outbreak Isolates, South Africa, March-June 2015.

du Plessis M, Wolter N, Allam M, de Gouveia L, Moosa F, Ntshoe G, Blumberg L, Cohen C, Smith M, Mutevedzi P, Thomas J, Horne V, Moodley P, Archary M, Mahabeer Y, Mahomed S, Kuhn W, Mlisana K, McCarthy K, von Gottberg A.

Emerg Infect Dis. 2017 Aug;23(8):1308-1315. doi: 10.3201/eid2308.162039.


The REVAMP trial to evaluate HIV resistance testing in sub-Saharan Africa: a case study in clinical trial design in resource limited settings to optimize effectiveness and cost effectiveness estimates.

Siedner MJ, Bwana MB, Moosa MS, Paul M, Pillay S, McCluskey S, Aturinda I, Ard K, Muyindike W, Moodley P, Brijkumar J, Rautenberg T, George G, Johnson B, Gandhi RT, Sunpath H, Marconi VC.

HIV Clin Trials. 2017 Jul;18(4):149-155. doi: 10.1080/15284336.2017.1349028. Epub 2017 Jul 18. Review.


Polymorphisms in the vitamin D receptor gene are associated with reduced rate of sputum culture conversion in multidrug-resistant tuberculosis patients in South Africa.

Magee MJ, Sun YV, Brust JCM, Shah NS, Ning Y, Allana S, Campbell A, Hui Q, Mlisana K, Moodley P, Gandhi NR.

PLoS One. 2017 Jul 10;12(7):e0180916. doi: 10.1371/journal.pone.0180916. eCollection 2017.


An isolated outbreak of diphtheria in South Africa, 2015 - Erratum.

Mahomed S, Archary M, Mutevedzi P, Mahabeer Y, Govender P, Ntshoe G, Kuhn W, Thomas J, Olowolagba A, Blumberg L, McCarthy K, Mlisana K, Du Plessis M, Von Gottberg A, Moodley P.

Epidemiol Infect. 2018 Apr;146(5):664. doi: 10.1017/S0950268817001376. Epub 2017 Jul 3. No abstract available.


An isolated outbreak of diphtheria in South Africa, 2015.

Mahomed S, Archary M, Mutevedzi P, Mahabeer Y, Govender P, Ntshoe G, Kuhn W, Thomas J, Olowolagba A, Blumberg L, McCarthy K, Mlisana K, DU Plessis M, VON Gottberg A, Moodley P.

Epidemiol Infect. 2017 Jul;145(10):2100-2108. doi: 10.1017/S0950268817000851. Epub 2017 May 8. Erratum in: Epidemiol Infect. 2018 Apr;146(5):664.


Microwave-assisted inorganic salt pretreatment of sugarcane leaf waste: Effect on physiochemical structure and enzymatic saccharification.

Moodley P, Kana EBG.

Bioresour Technol. 2017 Jul;235:35-42. doi: 10.1016/j.biortech.2017.03.031. Epub 2017 Mar 8.


pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia.

Allana S, Shashkina E, Mathema B, Bablishvili N, Tukvadze N, Shah NS, Kempker RR, Blumberg HM, Moodley P, Mlisana K, Brust JC, Gandhi NR.

Emerg Infect Dis. 2017 Mar;23(3):491-495. doi: 10.3201/eid2303.161034.


Hepatic tuberculosis in human immunodeficiency virus co-infected adults: a case series of South African adults.

Gounder L, Moodley P, Drain PK, Hickey AJ, Moosa MS.

BMC Infect Dis. 2017 Feb 1;17(1):115. doi: 10.1186/s12879-017-2222-2.


Transmission of Extensively Drug-Resistant Tuberculosis in South Africa.

Shah NS, Auld SC, Brust JC, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, van der Meulen H, Omar SV, Brown TS, Narechania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR.

N Engl J Med. 2017 Jan 19;376(3):243-253. doi: 10.1056/NEJMoa1604544.


Genomic diversity in autopsy samples reveals within-host dissemination of HIV-associated Mycobacterium tuberculosis.

Lieberman TD, Wilson D, Misra R, Xiong LL, Moodley P, Cohen T, Kishony R.

Nat Med. 2016 Dec;22(12):1470-1474. doi: 10.1038/nm.4205. Epub 2016 Oct 31.


HIV-1 Drug Resistance by Ultra-Deep Sequencing Following Short Course Zidovudine, Single-Dose Nevirapine, and Single-Dose Tenofovir with Emtricitabine for Prevention of Mother-to-Child Transmission.

Samuel R, Julian MN, Paredes R, Parboosing R, Moodley P, Singh L, Naidoo A, Gordon M.

J Acquir Immune Defic Syndr. 2016 Dec 1;73(4):384-389.


Reply to Chen et al.

Cohen T, Chindelevitch L, Misra R, Kempner ME, Galea J, Moodley P, Wilson D.

J Infect Dis. 2016 Oct 15;214(8):1287-8. doi: 10.1093/infdis/jiw351. Epub 2016 Aug 4. No abstract available.


Strains of Mycobacterium tuberculosis differ in affinity for human osteoblasts and alveolar cells in vitro.

Sarkar S, Dlamini MG, Bhattacharya D, Ashiru OT, Sturm AW, Moodley P.

Springerplus. 2016 Feb 24;5:163. doi: 10.1186/s40064-016-1819-z. eCollection 2016.


The prevalence of hepatitis B virus infection in HIV-positive and HIV-negative infants: KwaZulu-Natal, South Africa.

Mdlalose N, Parboosing R, Moodley P.

Afr J Lab Med. 2016 Mar 31;5(1):283. doi: 10.4102/ajlm.v5i1.283. eCollection 2016.


Real-time polymerase chain reaction optimised for hepatitis C virus detection in dried blood spots from HIV-exposed infants, KwaZulu-Natal, South Africa.

Naidoo A, Parboosing R, Moodley P.

Afr J Lab Med. 2016 Mar 18;5(1):269. doi: 10.4102/ajlm.v5i1.269. eCollection 2016.


Dried blood spot specimen quality and validation of a new pre-analytical processing method for qualitative HIV-1 PCR, KwaZulu-Natal, South Africa.

Govender K, Parboosing R, Siyaca N, Moodley P.

Afr J Lab Med. 2016 Feb 25;5(1):349. doi: 10.4102/ajlm.v5i1.349. eCollection 2016.


ClassTR: Classifying Within-Host Heterogeneity Based on Tandem Repeats with Application to Mycobacterium tuberculosis Infections.

Chindelevitch L, Colijn C, Moodley P, Wilson D, Cohen T.

PLoS Comput Biol. 2016 Feb 1;12(2):e1004475. doi: 10.1371/journal.pcbi.1004475. eCollection 2016 Feb. Erratum in: PLoS Comput Biol. 2016 Feb;12(2):e1004806.


Within-Host Heterogeneity of Mycobacterium tuberculosis Infection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study.

Cohen T, Chindelevitch L, Misra R, Kempner ME, Galea J, Moodley P, Wilson D.

J Infect Dis. 2016 Jun 1;213(11):1796-9. doi: 10.1093/infdis/jiw014. Epub 2016 Jan 14.


A post-partum single-dose TDF/FTC tail does not prevent the selection of NNRTI resistance in women receiving pre-partum ZDV and intrapartum single-dose nevirapine to prevent mother-to- child HIV-1 transmission.

Samuel R, Paredes R, Parboosing R, Moodley P, Singh L, Naidoo A, Gordon M.

J Med Virol. 2015 Oct;87(10):1662-7. doi: 10.1002/jmv.24220. Epub 2015 May 4.


Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.

Arai M, Kamiya K, Pruksakorn P, Sumii Y, Kotoku N, Joubert JP, Moodley P, Han C, Shin D, Kobayashi M.

Bioorg Med Chem. 2015 Jul 1;23(13):3534-41. doi: 10.1016/j.bmc.2015.04.033. Epub 2015 Apr 17.


The pros, cons, and unknowns of search and destroy for carbapenem-resistant enterobacteriaceae.

Moodley P, Whitelaw A.

Curr Infect Dis Rep. 2015 Jun;17(6):483. doi: 10.1007/s11908-015-0483-8.


Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis.

Rahman MA, Sobia P, Dwivedi VP, Bhawsar A, Singh DK, Sharma P, Moodley P, Van Kaer L, Bishai WR, Das G.

J Biol Chem. 2015 Jun 5;290(23):14407-17. doi: 10.1074/jbc.M115.653600. Epub 2015 Apr 6.


Clinical evaluation of the OneStep Gonorrhea RapiCard InstaTest for detection of Neisseria gonorrhoeae in symptomatic patients from KwaZulu-Natal, South Africa.

Abbai NS, Moodley P, Reddy T, Zondi TG, Rambaran S, Naidoo K, Ramjee G.

J Clin Microbiol. 2015 Apr;53(4):1348-50. doi: 10.1128/JCM.03603-14. Epub 2015 Jan 21.


High prevalence and incidence of asymptomatic sexually transmitted infections during pregnancy and postdelivery in KwaZulu Natal, South Africa.

Moodley D, Moodley P, Sebitloane M, Soowamber D, McNaughton-Reyes HL, Groves AK, Maman S.

Sex Transm Dis. 2015 Jan;42(1):43-7. doi: 10.1097/OLQ.0000000000000219.


Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis.

Bhattacharya D, Dwivedi VP, Kumar S, Reddy MC, Van Kaer L, Moodley P, Das G.

J Biol Chem. 2014 Nov 28;289(48):33404-11. doi: 10.1074/jbc.M114.600452. Epub 2014 Oct 14.


Minority HIV-1 drug-resistant mutations and prevention of mother-to-child transmission: perspectives for resource-limited countries.

Samuel R, Paredes R, Parboosing R, Moodley P, Gordon M.

AIDS Rev. 2014 Oct-Dec;16(4):187-98. Review.


Cervical ectopy: associations with sexually transmitted infections and HIV. A cross-sectional study of high school students in rural South Africa.

Kleppa E, Holmen SD, Lillebø K, Kjetland EF, Gundersen SG, Taylor M, Moodley P, Onsrud M.

Sex Transm Infect. 2015 Mar;91(2):124-9. doi: 10.1136/sextrans-2014-051674. Epub 2014 Oct 3.


Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection.

Tousif S, Singh DK, Ahmad S, Moodley P, Bhattacharyya M, Van Kaer L, Das G.

J Biol Chem. 2014 Oct 31;289(44):30190-5. doi: 10.1074/jbc.C114.598946. Epub 2014 Sep 8.


Moxifloxacin resistance in the F15/LAM4/KZN extensively drug-resistant strain of Mycobacterium tuberculosis.

Dookie N, Sturm AW, Moodley P.

Infect Drug Resist. 2014 Aug 19;7:223-8. doi: 10.2147/IDR.S65417. eCollection 2014.


A peptide fragment from the human COX3 protein disrupts association of Mycobacterium tuberculosis virulence proteins ESAT-6 and CFP10, inhibits mycobacterial growth and mounts protective immune response.

Samuchiwal SK, Tousif S, Singh DK, Kumar A, Ghosh A, Bhalla K, Prakash P, Kumar S, Bhattacharyya M, Moodley P, Das G, Ranganathan A.

BMC Infect Dis. 2014 Jul 1;14:355. doi: 10.1186/1471-2334-14-355.


Factors Associated with Symptomatic Vulvovaginal Candidiasis: A Study among Women Attending a Primary Healthcare Clinic in Kwazulu-Natal, South Africa.

Apalata T, Longo-Mbenza B, Sturm A, Carr W, Moodley P.

Ann Med Health Sci Res. 2014 May;4(3):410-6. doi: 10.4103/2141-9248.133470.


Efficacy of enhanced HIV counseling for risk reduction during pregnancy and in the postpartum period: a randomized controlled trial.

Maman S, Moodley D, McNaughton-Reyes HL, Groves AK, Kagee A, Moodley P.

PLoS One. 2014 May 13;9(5):e97092. doi: 10.1371/journal.pone.0097092. eCollection 2014.

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