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Items: 1 to 50 of 120

1.

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux.

Perotin JM, Schofield JPR, Wilson SJ, Ward J, Brandsma J, Strazzeri F, Bansal A, Yang X, Rowe A, Corfield J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlén B, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Auffray C, De Meulder B, Lefaudeux D, Riley JH, Sousa AR, Dahlen SE, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Collins JE, Davies DE, Djukanović R; U-BIOPRED Study Group; U-BIOPRED:.

Eur Respir J. 2019 Jun 27;53(6). pii: 1900453. doi: 10.1183/13993003.00453-2019. Print 2019 Jun. No abstract available.

PMID:
31023846
2.

IL-17-high asthma with features of a psoriasis immunophenotype.

Östling J, van Geest M, Schofield JPR, Jevnikar Z, Wilson S, Ward J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Auffray C, Sousa AR, Guo Y, Adcock IM, Howarth P, Chung KF, Bigler J, Sterk PJ, Skipp PJ, Djukanović R, Vaarala O; U-BIOPRED Study Group.

J Allergy Clin Immunol. 2019 Apr 15. pii: S0091-6749(19)30484-1. doi: 10.1016/j.jaci.2019.03.027. [Epub ahead of print]

PMID:
30998987
3.

Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma.

Tariq K, Schofield JPR, Nicholas BL, Burg D, Brandsma J, Bansal AT, Wilson SJ, Lutter R, Fowler SJ, Bakke, Caruso M, Dahlen B, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Geiser T, Pandis I, Sousa AR, Adcock IM, Shaw DE, Auffray C, Howarth PH, Sterk PJ, Chung KF, Skipp PJ, Dimitrov B, Djukanović R; U-BIOPRED Study Group.

Respir Med. 2019 Apr;150:66-73. doi: 10.1016/j.rmed.2019.02.008. Epub 2019 Feb 11.

PMID:
30961953
4.

Stratification of asthma phenotypes by airway proteomic signatures.

Schofield JPR, Burg D, Nicholas B, Strazzeri F, Brandsma J, Staykova D, Folisi C, Bansal AT, Xian Y, Guo Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Riley J, Auffray C, De Meulder B, Lefaudeux D, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Djukanović R; U-BIOPRED Study Group.

J Allergy Clin Immunol. 2019 Jul;144(1):70-82. doi: 10.1016/j.jaci.2019.03.013. Epub 2019 Mar 28.

PMID:
30928653
5.

Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers.

Brandsma J, Goss VM, Yang X, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandström T, Shaw DE, Chung KF, Singer F, Fleming LJ, Sousa AR, Pandis I, Bansal AT, Sterk PJ, Djukanović R, Postle AD; U-BIOPRED Study Group.

Metabolomics. 2018 Sep 17;14(10):123. doi: 10.1007/s11306-018-1412-2.

6.

Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma.

Brinkman P, Wagener AH, Hekking PP, Bansal AT, Maitland-van der Zee AH, Wang Y, Weda H, Knobel HH, Vink TJ, Rattray NJ, D'Amico A, Pennazza G, Santonico M, Lefaudeux D, De Meulder B, Auffray C, Bakke PS, Caruso M, Chanez P, Chung KF, Corfield J, Dahlén SE, Djukanovic R, Geiser T, Horvath I, Krug N, Musial J, Sun K, Riley JH, Shaw DE, Sandström T, Sousa AR, Montuschi P, Fowler SJ, Sterk PJ; U-BIOPRED Study Group.

J Allergy Clin Immunol. 2019 May;143(5):1811-1820.e7. doi: 10.1016/j.jaci.2018.10.058. Epub 2018 Dec 6.

PMID:
30529449
7.

Treatable traits in the European U-BIOPRED adult asthma cohorts.

Simpson AJ, Hekking PP, Shaw DE, Fleming LJ, Roberts G, Riley JH, Bates S, Sousa AR, Bansal AT, Pandis I, Sun K, Bakke PS, Caruso M, Dahlén B, Dahlén SE, Horvath I, Krug N, Montuschi P, Sandstrom T, Singer F, Adcock IM, Wagers SS, Djukanovic R, Chung KF, Sterk PJ, Fowler SJ; U-BIOPRED Study Group.

Allergy. 2019 Feb;74(2):406-411. doi: 10.1111/all.13629. Epub 2018 Nov 12. No abstract available.

8.

Methodological considerations for large-scale breath analysis studies: lessons from the U-BIOPRED severe asthma project.

Ahmed WM, Brinkman P, Weda H, Knobel HH, Xu Y, Nijsen TM, Goodacre R, Rattray N, Vink TJ, Santonico M, Pennazza G, Montuschi P, Sterk PJ, Fowler SJ.

J Breath Res. 2018 Oct 30;13(1):016001. doi: 10.1088/1752-7163/aae557.

PMID:
30272570
9.

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort.

Emma R, Bansal AT, Kolmert J, Wheelock CE, Dahlen SE, Loza MJ, De Meulder B, Lefaudeux D, Auffray C, Dahlen B, Bakke PS, Chanez P, Fowler SJ, Horvath I, Montuschi P, Krug N, Sanak M, Sandstrom T, Shaw DE, Fleming LJ, Djukanovic R, Howarth PH, Singer F, Sousa AR, Sterk PJ, Corfield J, Pandis I, Chung KF, Adcock IM, Lutter R, Fabbella L, Caruso M; U-BIOPRED Study Group.

PLoS One. 2018 Sep 21;13(9):e0203874. doi: 10.1371/journal.pone.0203874. eCollection 2018.

10.

Metabolomic Analysis by Nuclear Magnetic Resonance Spectroscopy as a New Approach to Understanding Inflammation and Monitoring of Pharmacological Therapy in Children and Young Adults With Cystic Fibrosis.

Montuschi P, Lucidi V, Paris D, Montemitro E, Shohreh R, Mores N, Melck D, Santini G, Majo F, Motta A.

Front Pharmacol. 2018 Jun 18;9:595. doi: 10.3389/fphar.2018.00595. eCollection 2018.

11.

Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome.

Burg D, Schofield JPR, Brandsma J, Staykova D, Folisi C, Bansal A, Nicholas B, Xian Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Fleming L, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Hashimoto S, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Singer F, Sun K, Pandis I, Auffray C, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Djukanović R, Skipp PJ, The U-Biopred Study Group.

J Proteome Res. 2018 Jun 1;17(6):2072-2091. doi: 10.1021/acs.jproteome.8b00018. Epub 2018 May 23.

12.

Breathomics for Assessing the Effects of Treatment and Withdrawal With Inhaled Beclomethasone/Formoterol in Patients With COPD.

Montuschi P, Santini G, Mores N, Vignoli A, Macagno F, Shoreh R, Tenori L, Zini G, Fuso L, Mondino C, Di Natale C, D'Amico A, Luchinat C, Barnes PJ, Higenbottam T.

Front Pharmacol. 2018 Apr 17;9:258. doi: 10.3389/fphar.2018.00258. eCollection 2018.

13.

Comparison of two exhaled biomarkers in children with and without sleep disordered breathing.

Barreto M, Montuschi P, Evangelisti M, Bonafoni S, Cecili M, Shohreh R, Santini G, Villa MP.

Sleep Med. 2018 May;45:83-88. doi: 10.1016/j.sleep.2018.01.011. Epub 2018 Feb 10.

PMID:
29680435
14.

Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis.

Takahashi K, Pavlidis S, Ng Kee Kwong F, Hoda U, Rossios C, Sun K, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Dahlen SE, Krug N, Sandstrom T, Shaw DE, Lutter R, Bakke P, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; , on behalf of the U-BIOPRED study group.

Eur Respir J. 2018 May 3;51(5). pii: 1702173. doi: 10.1183/13993003.02173-2017. Print 2018 May.

PMID:
29650557
15.

The discovery and development of aclidinium bromide for the treatment of chronic obstructive pulmonary disease.

Malerba M, Radaeli A, Santini G, Morjaria J, Mores N, Mondino C, Macis G, Montuschi P.

Expert Opin Drug Discov. 2018 Jun;13(6):563-577. doi: 10.1080/17460441.2018.1455661. Epub 2018 Apr 4. Review.

PMID:
29616842
16.

Impulse oscillometry and nitrogen washout test in the assessment of small airway dysfunction in asthma: Correlation with quantitative computed tomography.

Fuso L, Macis G, Condoluci C, Sbarra M, Contu C, Conte EG, Angeletti G, Montuschi P.

J Asthma. 2019 Mar;56(3):323-331. doi: 10.1080/02770903.2018.1452032. Epub 2018 Apr 3.

PMID:
29611767
17.

Single-inhaler triple therapy utilizing the once-daily combination of fluticasone furoate, umeclidinium and vilanterol in the management of COPD: the current evidence base and future prospects.

Malerba M, Nardin M, Santini G, Mores N, Radaeli A, Montuschi P.

Ther Adv Respir Dis. 2018 Jan-Dec;12:1753466618760779. doi: 10.1177/1753466618760779. Review.

18.

The potential role of endothelial dysfunction and platelet activation in the development of thrombotic risk in COPD patients.

Malerba M, Nardin M, Radaeli A, Montuschi P, Carpagnano GE, Clini E.

Expert Rev Hematol. 2017 Sep;10(9):821-832. doi: 10.1080/17474086.2017.1353416. Epub 2017 Jul 12. Review.

PMID:
28693343
19.

A European Respiratory Society technical standard: exhaled biomarkers in lung disease.

Horváth I, Barnes PJ, Loukides S, Sterk PJ, Högman M, Olin AC, Amann A, Antus B, Baraldi E, Bikov A, Boots AW, Bos LD, Brinkman P, Bucca C, Carpagnano GE, Corradi M, Cristescu S, de Jongste JC, Dinh-Xuan AT, Dompeling E, Fens N, Fowler S, Hohlfeld JM, Holz O, Jöbsis Q, Van De Kant K, Knobel HH, Kostikas K, Lehtimäki L, Lundberg J, Montuschi P, Van Muylem A, Pennazza G, Reinhold P, Ricciardolo FLM, Rosias P, Santonico M, van der Schee MP, van Schooten FJ, Spanevello A, Tonia T, Vink TJ.

Eur Respir J. 2017 Apr 26;49(4). pii: 1600965. doi: 10.1183/13993003.00965-2016. Print 2017 Apr.

20.

Virtual Character Animation Based on Affordable Motion Capture and Reconfigurable Tangible Interfaces.

Lamberti F, Paravati G, Gatteschi V, Cannavo A, Montuschi P.

IEEE Trans Vis Comput Graph. 2018 May;24(5):1742-1755. doi: 10.1109/TVCG.2017.2690433. Epub 2017 Apr 3.

PMID:
28391197
21.

Investigational beta-2 adrenergic agonists for the treatment of chronic obstructive pulmonary disease.

Malerba M, Radaeli A, Montuschi P, Babu KS, Morjaria JB.

Expert Opin Investig Drugs. 2017 Mar;26(3):319-329. doi: 10.1080/13543784.2017.1287172. Epub 2017 Feb 6. Review.

PMID:
28117615
22.

Dupilumab for the treatment of asthma.

Santini G, Mores N, Malerba M, Mondino C, Anzivino R, Macis G, Montuschi P.

Expert Opin Investig Drugs. 2017 Mar;26(3):357-366. doi: 10.1080/13543784.2017.1282458. Epub 2017 Feb 7. Review.

PMID:
28085503
23.

Triple inhaled therapy for chronic obstructive pulmonary disease.

Montuschi P, Malerba M, Macis G, Mores N, Santini G.

Drug Discov Today. 2016 Nov;21(11):1820-1827. doi: 10.1016/j.drudis.2016.07.009. Epub 2016 Jul 21. Review.

PMID:
27452453
24.

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics.

Lefaudeux D, De Meulder B, Loza MJ, Peffer N, Rowe A, Baribaud F, Bansal AT, Lutter R, Sousa AR, Corfield J, Pandis I, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fleming LJ, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandstrom T, Shaw DE, Singer F, Sterk PJ, Roberts G, Adcock IM, Djukanovic R, Auffray C, Chung KF; U-BIOPRED Study Group.

J Allergy Clin Immunol. 2017 Jun;139(6):1797-1807. doi: 10.1016/j.jaci.2016.08.048. Epub 2016 Oct 20.

25.

Vilanterol trifenatate for the treatment of COPD.

Malerba M, Radaeli A, Montuschi P, Morjaria JB.

Expert Rev Respir Med. 2016 Jul;10(7):719-31. doi: 10.1080/17476348.2016.1184976. Epub 2016 May 25. Review.

PMID:
27143334
26.

Investigational prostaglandin D2 receptor antagonists for airway inflammation.

Santini G, Mores N, Malerba M, Mondino C, Macis G, Montuschi P.

Expert Opin Investig Drugs. 2016 Jun;25(6):639-52. doi: 10.1080/13543784.2016.1175434. Epub 2016 Apr 25. Review.

PMID:
27094922
27.

8-isoprostane in exhaled breath condensate after experimental exposure to wood smoke in humans.

Murgia N, Barregard L, Sallsten G, Almstrand AC, Montuschi P, Ciabattoni G, Olin AC.

J Biol Regul Homeost Agents. 2016 Jan-Mar;30(1):263-70.

PMID:
27049101
28.

Exhaled and non-exhaled non-invasive markers for assessment of respiratory inflammation in patients with stable COPD and healthy smokers.

Santini G, Mores N, Shohreh R, Valente S, Dabrowska M, Trové A, Zini G, Cattani P, Fuso L, Mautone A, Mondino C, Pagliari G, Sala A, Folco G, Aiello M, Pisi R, Chetta A, Losi M, Clini E, Ciabattoni G, Montuschi P.

J Breath Res. 2016 Jan 27;10(1):017102. doi: 10.1088/1752-7155/10/1/017102.

29.

Electronic Nose and Exhaled Breath NMR-based Metabolomics Applications in Airways Disease.

Santini G, Mores N, Penas A, Capuano R, Mondino C, Trové A, Macagno F, Zini G, Cattani P, Martinelli E, Motta A, Macis G, Ciabattoni G, Montuschi P.

Curr Top Med Chem. 2016;16(14):1610-30. Review.

PMID:
26693732
30.

Comparison of classification methods in breath analysis by electronic nose.

Leopold JH, Bos LD, Sterk PJ, Schultz MJ, Fens N, Horvath I, Bikov A, Montuschi P, Di Natale C, Yates DH, Abu-Hanna A.

J Breath Res. 2015 Dec 15;9(4):046002. doi: 10.1088/1752-7155/9/4/046002.

PMID:
26669708
31.

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.

Shaw DE, Sousa AR, Fowler SJ, Fleming LJ, Roberts G, Corfield J, Pandis I, Bansal AT, Bel EH, Auffray C, Compton CH, Bisgaard H, Bucchioni E, Caruso M, Chanez P, Dahlén B, Dahlen SE, Dyson K, Frey U, Geiser T, Gerhardsson de Verdier M, Gibeon D, Guo YK, Hashimoto S, Hedlin G, Jeyasingham E, Hekking PP, Higenbottam T, Horváth I, Knox AJ, Krug N, Erpenbeck VJ, Larsson LX, Lazarinis N, Matthews JG, Middelveld R, Montuschi P, Musial J, Myles D, Pahus L, Sandström T, Seibold W, Singer F, Strandberg K, Vestbo J, Vissing N, von Garnier C, Adcock IM, Wagers S, Rowe A, Howarth P, Wagener AH, Djukanovic R, Sterk PJ, Chung KF; U-BIOPRED Study Group.

Eur Respir J. 2015 Nov;46(5):1308-21. doi: 10.1183/13993003.00779-2015. Epub 2015 Sep 10. Erratum in: Eur Respir J. 2017 Jun 22;49(6):.

32.

The Combined Impact of Exhaled Nitric Oxide and Sputum Eosinophils Monitoring in Asthma Treatment: A Prospective Cohort Study.

Malerba M, Radaeli A, Olivini A, Ragnoli B, Ricciardolo F, Montuschi P.

Curr Pharm Des. 2015;21(32):4752-62.

PMID:
26166613
33.

Bronchodilating drugs for chronic obstructive pulmonary disease: current status and future trends.

Montuschi P, Ciabattoni G.

J Med Chem. 2015 May 28;58(10):4131-64. doi: 10.1021/jm5013227. Epub 2015 Feb 9.

PMID:
25587755
34.

Role of beta-blockers in patients with COPD: current perspective.

Malerba M, Montuschi P, Radaeli A, Pirisi M.

Drug Discov Today. 2015 Jan;20(1):129-35. doi: 10.1016/j.drudis.2014.09.005. Epub 2014 Sep 17. Review.

PMID:
25238736
35.

Pharmacological treatment of chronic obstructive pulmonary disease: from evidence-based medicine to phenotyping.

Montuschi P, Malerba M, Santini G, Miravitlles M.

Drug Discov Today. 2014 Dec;19(12):1928-35. doi: 10.1016/j.drudis.2014.08.004. Epub 2014 Aug 23. Review.

PMID:
25182512
36.

Nuclear magnetic resonance-based metabolomics discriminates primary ciliary dyskinesia from cystic fibrosis.

Montuschi P, Paris D, Montella S, Melck D, Mirra V, Santini G, Mores N, Montemitro E, Majo F, Lucidi V, Bush A, Motta A, Santamaria F.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):229-33. doi: 10.1164/rccm.201402-0249LE. No abstract available.

PMID:
25025356
37.

Transcriptional regulation of kinases downstream of the T cell receptor: another immunomodulatory mechanism of glucocorticoids.

Petrillo MG, Fettucciari K, Montuschi P, Ronchetti S, Cari L, Migliorati G, Mazzon E, Bereshchenko O, Bruscoli S, Nocentini G, Riccardi C.

BMC Pharmacol Toxicol. 2014 Jul 3;15:35. doi: 10.1186/2050-6511-15-35.

38.

Exhaled nitric oxide as a biomarker in COPD and related comorbidities.

Malerba M, Radaeli A, Olivini A, Damiani G, Ragnoli B, Montuschi P, Ricciardolo FL.

Biomed Res Int. 2014;2014:271918. doi: 10.1155/2014/271918. Epub 2014 Feb 27. Review.

39.

Liquid chromatography-mass spectrometry measurement of leukotrienes in asthma and other respiratory diseases.

Montuschi P, Santini G, Valente S, Mondino C, Macagno F, Cattani P, Zini G, Mores N.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:12-25. doi: 10.1016/j.jchromb.2014.02.059. Epub 2014 Mar 12. Review.

PMID:
24656639
40.

High sputum total adiponectin is associated with low odds for asthma.

Sood A, Seagrave J, Herbert G, Harkins M, Alam Y, Chiavaroli A, Shohreh R, Montuschi P, Campen M, Harmon M, Qualls C, Berwick M, Schuyler M.

J Asthma. 2014 Jun;51(5):459-66. doi: 10.3109/02770903.2014.882934. Epub 2014 Feb 11.

PMID:
24447284
41.

Exhaled breath condensate, nasal eosinophil cationic protein level and nasal cytology during immunotherapy for cypress allergy.

Ventura MT, Murgia N, Montuschi P, Gelardi M, Ciabattoni G, Buquicchio R, Resta O, Passalacqua G.

J Biol Regul Homeost Agents. 2013 Oct-Dec;27(4):1083-9.

PMID:
24382191
42.

Within-day and between-day repeatability of measurements with an electronic nose in patients with COPD.

Bofan M, Mores N, Baron M, Dabrowska M, Valente S, Schmid M, Trové A, Conforto S, Zini G, Cattani P, Fuso L, Mautone A, Mondino C, Pagliari G, D'Alessio T, Montuschi P.

J Breath Res. 2013 Mar;7(1):017103. doi: 10.1088/1752-7155/7/1/017103. Epub 2013 Feb 27.

PMID:
23445725
43.

Long-acting beta-agonists and their association with inhaled corticosteroids in COPD.

Fuso L, Mores N, Valente S, Malerba M, Montuschi P.

Curr Med Chem. 2013;20(12):1477-95. Review.

PMID:
23409722
44.

Application of 'omics technologies to biomarker discovery in inflammatory lung diseases.

Wheelock CE, Goss VM, Balgoma D, Nicholas B, Brandsma J, Skipp PJ, Snowden S, Burg D, D'Amico A, Horvath I, Chaiboonchoe A, Ahmed H, Ballereau S, Rossios C, Chung KF, Montuschi P, Fowler SJ, Adcock IM, Postle AD, Dahlén SE, Rowe A, Sterk PJ, Auffray C, Djukanovic R; U-BIOPRED Study Group.

Eur Respir J. 2013 Sep;42(3):802-25. doi: 10.1183/09031936.00078812. Epub 2013 Feb 8. Review.

45.

Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate.

de Laurentiis G, Paris D, Melck D, Montuschi P, Maniscalco M, Bianco A, Sofia M, Motta A.

J Proteome Res. 2013 Mar 1;12(3):1502-11. doi: 10.1021/pr301171p. Epub 2013 Feb 12.

PMID:
23360153
46.

The electronic nose in respiratory medicine.

Montuschi P, Mores N, Trové A, Mondino C, Barnes PJ.

Respiration. 2013;85(1):72-84. doi: 10.1159/000340044. Epub 2012 Sep 25. Review.

47.

Drugs for chronic obstructive pulmonary disease.

Montuschi P.

Curr Med Chem. 2013;20(12):1461-3. No abstract available.

PMID:
23016550
48.

Inhaled muscarinic acetylcholine receptor antagonists for treatment of COPD.

Montuschi P, Macagno F, Valente S, Fuso L.

Curr Med Chem. 2013;20(12):1464-76. Review.

PMID:
22963553
49.

Exhaled nitric oxide measurement in patients affected by nasal polyposis.

Galli J, Montuschi P, Passàli GC, Laruffa M, Parrilla C, Paludetti G.

Otolaryngol Head Neck Surg. 2012 Aug;147(2):351-6. doi: 10.1177/0194599812442322. Epub 2012 Apr 2.

PMID:
22470156
50.

Non-invasive biomarkers of lung inflammation in smoking subjects.

Malerba M, Montuschi P.

Curr Med Chem. 2012;19(2):187-96. Review.

PMID:
22320297

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