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The KLDpT activation loop motif is critical for MARK kinase activity.

Sonntag T, Moresco JJ, Yates JR 3rd, Montminy M.

PLoS One. 2019 Dec 3;14(12):e0225727. doi: 10.1371/journal.pone.0225727. eCollection 2019.


The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer.

Rodón L, Svensson RU, Wiater E, Chun MGH, Tsai WW, Eichner LJ, Shaw RJ, Montminy M.

Sci Adv. 2019 Jul 24;5(7):eaaw6455. doi: 10.1126/sciadv.aaw6455. eCollection 2019 Jul.


A comparison between intravascular ultrasound and venography in identifying key parameters essential for iliac vein stenting.

Montminy ML, Thomasson JD, Tanaka GJ, Lamanilao LM, Crim W, Raju S.

J Vasc Surg Venous Lymphat Disord. 2019 Nov;7(6):801-807. doi: 10.1016/j.jvsv.2019.03.015. Epub 2019 Jun 10.


CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers.

Van de Velde S, Wiater E, Tran M, Hwang Y, Cole PA, Montminy M.

Mol Cell Biol. 2019 Aug 12;39(17). pii: e00200-19. doi: 10.1128/MCB.00200-19. Print 2019 Sep 1.


Venous Arterialization with Common Endovascular Devices.

Béland M, Méthot M, Bradette S, Montminy M, Lalonde C.

J Vasc Interv Radiol. 2019 Apr;30(4):570-571. doi: 10.1016/j.jvir.2018.11.022. No abstract available.


Adaptive Transcriptional Responses by CRTC Coactivators in Cancer.

Tasoulas J, Rodon L, Kaye FJ, Montminy M, Amelio AL.

Trends Cancer. 2019 Feb;5(2):111-127. doi: 10.1016/j.trecan.2018.12.002. Epub 2019 Jan 29. Review.


Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

Sonntag T, Ostojić J, Vaughan JM, Moresco JJ, Yoon YS, Yates JR 3rd, Montminy M.

iScience. 2019 Jan 25;11:134-145. doi: 10.1016/j.isci.2018.12.012. Epub 2018 Dec 19.


cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis.

Yoon YS, Tsai WW, Van de Velde S, Chen Z, Lee KF, Morgan DA, Rahmouni K, Matsumura S, Wiater E, Song Y, Montminy M.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5289-E5297. doi: 10.1073/pnas.1805257115. Epub 2018 May 21.


A systematic review of the efficacy and limitations of venous intervention in stasis ulceration.

Montminy ML, Jayaraj A, Raju S.

J Vasc Surg Venous Lymphat Disord. 2018 May;6(3):376-398.e1. doi: 10.1016/j.jvsv.2017.11.007. Epub 2018 Feb 13. Review.


β2-Agonists Enhance Asthma-Relevant Inflammatory Mediators in Human Airway Epithelial Cells.

Ritchie AI, Singanayagam A, Wiater E, Edwards MR, Montminy M, Johnston SL.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):128-132. doi: 10.1165/rcmb.2017-0315LE. No abstract available.


14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).

Sonntag T, Vaughan JM, Montminy M.

FEBS J. 2018 Feb;285(3):467-480. doi: 10.1111/febs.14351. Epub 2018 Jan 9.


CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.

Kim JH, Hedrick S, Tsai WW, Wiater E, Le Lay J, Kaestner KH, Leblanc M, Loar A, Montminy M.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11739-11744. doi: 10.1073/pnas.1712616114. Epub 2017 Oct 16.


Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members.

Sonntag T, Moresco JJ, Vaughan JM, Matsumura S, Yates JR 3rd, Montminy M.

PLoS One. 2017 Feb 24;12(2):e0173013. doi: 10.1371/journal.pone.0173013. eCollection 2017.


Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance.

Shen R, Wang B, Giribaldi MG, Ayres J, Thomas JB, Montminy M.

Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3307-14. doi: 10.1073/pnas.1606106113. Epub 2016 May 20.


Factors Influencing the Prescription of Cardiovascular Preventive Therapies in Patients with Peripheral Arterial Disease.

Montminy ML, Gauvin V, Turcotte S, Milot A, Douville Y, Bairati I.

PLoS One. 2016 Feb 5;11(2):e0148069. doi: 10.1371/journal.pone.0148069. eCollection 2016.


Role of the cAMP Pathway in Glucose and Lipid Metabolism.

Ravnskjaer K, Madiraju A, Montminy M.

Handb Exp Pharmacol. 2016;233:29-49. doi: 10.1007/164_2015_32. Review.


CREB pathway links PGE2 signaling with macrophage polarization.

Luan B, Yoon YS, Le Lay J, Kaestner KH, Hedrick S, Montminy M.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15642-7. doi: 10.1073/pnas.1519644112. Epub 2015 Dec 7.


Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2.

Hogan MF, Ravnskjaer K, Matsumura S, Huising MO, Hull RL, Kahn SE, Montminy M.

J Biol Chem. 2015 Oct 23;290(43):25997-6006. doi: 10.1074/jbc.M115.679266. Epub 2015 Sep 4.


The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation.

Hernandez JB, Chang C, LeBlanc M, Grimm D, Le Lay J, Kaestner KH, Zheng Y, Montminy M.

Nat Commun. 2015 Jun 2;6:7216. doi: 10.1038/ncomms8216.


ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis.

Tsai WW, Matsumura S, Liu W, Phillips NG, Sonntag T, Hao E, Lee S, Hai T, Montminy M.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2699-704. doi: 10.1073/pnas.1424641112. Epub 2015 Feb 17.


Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance.

Blanchet E, Van de Velde S, Matsumura S, Hao E, LeLay J, Kaestner K, Montminy M.

Cell Rep. 2015 Feb 24;10(7):1149-57. doi: 10.1016/j.celrep.2015.01.046. Epub 2015 Feb 19.


Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.

Paz JC, Park S, Phillips N, Matsumura S, Tsai WW, Kasper L, Brindle PK, Zhang G, Zhou MM, Wright PE, Montminy M.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17116-21. doi: 10.1073/pnas.1420389111. Epub 2014 Nov 17.


Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4.

Luan B, Goodarzi MO, Phillips NG, Guo X, Chen YD, Yao J, Allison M, Rotter JI, Shaw R, Montminy M.

Cell Metab. 2014 Jun 3;19(6):1058-65. doi: 10.1016/j.cmet.2014.03.024. Epub 2014 Apr 24.


Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.

Ravnskjaer K, Hogan MF, Lackey D, Tora L, Dent SY, Olefsky J, Montminy M.

J Clin Invest. 2013 Oct;123(10):4318-28. doi: 10.1172/JCI69035. Epub 2013 Sep 24.


PRMT5 modulates the metabolic response to fasting signals.

Tsai WW, Niessen S, Goebel N, Yates JR 3rd, Guccione E, Montminy M.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8870-5. doi: 10.1073/pnas.1304602110. Epub 2013 May 13.


Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2.

Yu J, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS.

J Biol Chem. 2013 Feb 8;288(6):3823-30. doi: 10.1074/jbc.M112.397885. Epub 2012 Dec 26.


Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2.

Luo Q, Viste K, Urday-Zaa JC, Senthil Kumar G, Tsai WW, Talai A, Mayo KE, Montminy M, Radhakrishnan I.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20865-70. doi: 10.1073/pnas.1219028109. Epub 2012 Dec 4.


Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

Wang Y, Li G, Goode J, Paz JC, Ouyang K, Screaton R, Fischer WH, Chen J, Tabas I, Montminy M.

Nature. 2012 Apr 8;485(7396):128-32. doi: 10.1038/nature10988.


Wylie Vale: neuroendocrine master.

Montminy M, Lee KF, Rivier JE, Rivier C, Reichlin S.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3604-5. doi: 10.1073/pnas.1201696109. Epub 2012 Feb 21. No abstract available.


mTOR links incretin signaling to HIF induction in pancreatic beta cells.

Van de Velde S, Hogan MF, Montminy M.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16876-82. doi: 10.1073/pnas.1114228108. Epub 2011 Sep 26.


CREB is activated by muscle injury and promotes muscle regeneration.

Stewart R, Flechner L, Montminy M, Berdeaux R.

PLoS One. 2011;6(9):e24714. doi: 10.1371/journal.pone.0024714. Epub 2011 Sep 13.


Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis.

Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, Shaw RJ.

Cell. 2011 May 13;145(4):607-21. doi: 10.1016/j.cell.2011.03.043.


A hormone-dependent module regulating energy balance.

Wang B, Moya N, Niessen S, Hoover H, Mihaylova MM, Shaw RJ, Yates JR 3rd, Fischer WH, Thomas JB, Montminy M.

Cell. 2011 May 13;145(4):596-606. doi: 10.1016/j.cell.2011.04.013.


CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.

Altarejos JY, Montminy M.

Nat Rev Mol Cell Biol. 2011 Mar;12(3):141-51. doi: 10.1038/nrm3072. Review.


Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.

Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A.

Nature. 2011 Feb 17;470(7334):404-8. doi: 10.1038/nature09706.


CRTC3 links catecholamine signalling to energy balance.

Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR; CHARGE Consortium; GIANT Consortium, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M.

Nature. 2010 Dec 16;468(7326):933-9. doi: 10.1038/nature09564.


Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis.

Yoon YS, Lee MW, Ryu D, Kim JH, Ma H, Seo WY, Kim YN, Kim SS, Lee CH, Hunter T, Choi CS, Montminy MR, Koo SH.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17704-9. doi: 10.1073/pnas.1012665107. Epub 2010 Sep 27.


Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis.

Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay SA.

Nat Med. 2010 Oct;16(10):1152-6. doi: 10.1038/nm.2214. Epub 2010 Sep 19.


The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.

Zmuda EJ, Qi L, Zhu MX, Mirmira RG, Montminy MR, Hai T.

Mol Endocrinol. 2010 Jul;24(7):1423-33. doi: 10.1210/me.2009-0463. Epub 2010 Jun 2.


Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity.

Wang Y, Inoue H, Ravnskjaer K, Viste K, Miller N, Liu Y, Hedrick S, Vera L, Montminy M.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3087-92. doi: 10.1073/pnas.0914897107. Epub 2010 Jan 26.


The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis.

Wang Y, Vera L, Fischer WH, Montminy M.

Nature. 2009 Jul 23;460(7254):534-7. doi: 10.1038/nature08111. Epub 2009 Jun 21.


Adipocyte CREB promotes insulin resistance in obesity.

Qi L, Saberi M, Zmuda E, Wang Y, Altarejos J, Zhang X, Dentin R, Hedrick S, Bandyopadhyay G, Hai T, Olefsky J, Montminy M.

Cell Metab. 2009 Mar;9(3):277-86. doi: 10.1016/j.cmet.2009.01.006.


TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.

Ryu D, Oh KJ, Jo HY, Hedrick S, Kim YN, Hwang YJ, Park TS, Han JS, Choi CS, Montminy M, Koo SH.

Cell Metab. 2009 Mar;9(3):240-51. doi: 10.1016/j.cmet.2009.01.007.


A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J 3rd, Olefsky J, Guarente L, Montminy M.

Nature. 2008 Nov 13;456(7219):269-73. doi: 10.1038/nature07349. Epub 2008 Oct 5.


The Creb1 coactivator Crtc1 is required for energy balance and fertility.

Altarejos JY, Goebel N, Conkright MD, Inoue H, Xie J, Arias CM, Sawchenko PE, Montminy M.

Nat Med. 2008 Oct;14(10):1112-7. doi: 10.1038/nm.1866. Epub 2008 Aug 31.


The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila.

Wang B, Goode J, Best J, Meltzer J, Schilman PE, Chen J, Garza D, Thomas JB, Montminy M.

Cell Metab. 2008 May;7(5):434-44. doi: 10.1016/j.cmet.2008.02.010.


Hepatic glucose sensing via the CREB coactivator CRTC2.

Dentin R, Hedrick S, Xie J, Yates J 3rd, Montminy M.

Science. 2008 Mar 7;319(5868):1402-5. doi: 10.1126/science.1151363.


Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2.

Dentin R, Liu Y, Koo SH, Hedrick S, Vargas T, Heredia J, Yates J 3rd, Montminy M.

Nature. 2007 Sep 20;449(7160):366-9. Epub 2007 Sep 5.


Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression.

Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR 3rd, Montminy M.

EMBO J. 2007 Jun 20;26(12):2880-9. Epub 2007 May 3.


SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes.

Berdeaux R, Goebel N, Banaszynski L, Takemori H, Wandless T, Shelton GD, Montminy M.

Nat Med. 2007 May;13(5):597-603. Epub 2007 Apr 29.


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