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Items: 1 to 50 of 97

1.

Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests.

Meccariello A, Salvemini M, Primo P, Hall B, Koskinioti P, Dalíková M, Gravina A, Gucciardino MA, Forlenza F, Gregoriou ME, Ippolito D, Monti SM, Petrella V, Perrotta MM, Schmeing S, Ruggiero A, Scolari F, Giordano E, Tsoumani KT, Marec F, Windbichler N, Arunkumar KP, Bourtzis K, Mathiopoulos KD, Ragoussis J, Vitagliano L, Tu Z, Papathanos PA, Robinson MD, Saccone G.

Science. 2019 Sep 27;365(6460):1457-1460. doi: 10.1126/science.aax1318. Epub 2019 Aug 29.

PMID:
31467189
2.

Exploration of the residues modulating the catalytic features of human carbonic anhydrase XIII by a site-specific mutagenesis approach.

De Simone G, Di Fiore A, Truppo E, Langella E, Vullo D, Supuran CT, Monti SM.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1506-1510. doi: 10.1080/14756366.2019.1653290.

3.

Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity.

Langella E, Alterio V, D'Ambrosio K, Cadoni R, Winum JY, Supuran CT, Monti SM, De Simone G, Di Fiore A.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1498-1505. doi: 10.1080/14756366.2019.1653291.

4.

Identification of non-specific Lipid Transfer Protein gene family members in Solanum lycopersicum and insights into the features of Sola l 3 protein.

D'Agostino N, Buonanno M, Ayoub J, Barone A, Monti SM, Rigano MM.

Sci Rep. 2019 Feb 7;9(1):1607. doi: 10.1038/s41598-018-38301-z.

5.

Role of Antioxidants in the Protection from Aging-Related Diseases.

Monti DM, Rigano MM, Monti SM, Peixoto HS.

Oxid Med Cell Longev. 2019 Jan 8;2019:7450693. doi: 10.1155/2019/7450693. eCollection 2019. No abstract available.

6.

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.

Buemi MR, Di Fiore A, De Luca L, Angeli A, Mancuso F, Ferro S, Monti SM, Buonanno M, Russo E, De Sarro G, De Simone G, Supuran CT, Gitto R.

Eur J Med Chem. 2019 Feb 1;163:443-452. doi: 10.1016/j.ejmech.2018.11.073. Epub 2018 Dec 1.

PMID:
30530195
7.

Protective Role of Carbonic Anhydrases III and VII in Cellular Defense Mechanisms upon Redox Unbalance.

Di Fiore A, Monti DM, Scaloni A, De Simone G, Monti SM.

Oxid Med Cell Longev. 2018 Aug 5;2018:2018306. doi: 10.1155/2018/2018306. eCollection 2018. Review.

8.

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding.

De Simone G, Angeli A, Bozdag M, Supuran CT, Winum JY, Monti SM, Alterio V.

Chem Commun (Camb). 2018 Sep 11;54(73):10312-10315. doi: 10.1039/c8cc05755a.

PMID:
30140816
9.

Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal.

Mishra CB, Kumari S, Angeli A, Bua S, Buonanno M, Monti SM, Tiwari M, Supuran CT.

Eur J Med Chem. 2018 Aug 5;156:430-443. doi: 10.1016/j.ejmech.2018.07.019. Epub 2018 Jul 9.

PMID:
30015076
10.

The zinc - but not cadmium - containing ζ-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids.

Angeli A, Buonanno M, Donald WA, Monti SM, Supuran CT.

Bioorg Chem. 2018 Oct;80:261-265. doi: 10.1016/j.bioorg.2018.05.027. Epub 2018 May 26.

PMID:
29966872
11.

The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior.

Buonanno M, Di Fiore A, Langella E, D'Ambrosio K, Supuran CT, Monti SM, De Simone G.

Int J Mol Sci. 2018 May 24;19(6). pii: E1571. doi: 10.3390/ijms19061571.

12.

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.

Supuran CT, Alterio V, Di Fiore A, D' Ambrosio K, Carta F, Monti SM, De Simone G.

Med Res Rev. 2018 Sep;38(6):1799-1836. doi: 10.1002/med.21497. Epub 2018 Apr 10. Review.

PMID:
29635752
13.

Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX.

Langella E, Buonanno M, Vullo D, Dathan N, Leone M, Supuran CT, De Simone G, Monti SM.

Cell Mol Life Sci. 2018 Sep;75(17):3283-3296. doi: 10.1007/s00018-018-2798-8. Epub 2018 Mar 21.

PMID:
29564477
14.

Inhibition studies of Brucella suis β-carbonic anhydrases with a series of 4-substituted pyridine-3-sulphonamides.

Monti SM, Meccariello A, Ceruso M, Szafrański K, Sławiński J, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):255-259. doi: 10.1080/14756366.2017.1413097.

PMID:
29271264
15.

Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor.

Alterio V, Esposito D, Monti SM, Supuran CT, De Simone G.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):151-157. doi: 10.1080/14756366.2017.1405263.

PMID:
29199489
16.

Prosystemin, a prohormone that modulates plant defense barriers, is an intrinsically disordered protein.

Buonanno M, Coppola M, Di Lelio I, Molisso D, Leone M, Pennacchio F, Langella E, Rao R, Monti SM.

Protein Sci. 2018 Mar;27(3):620-632. doi: 10.1002/pro.3348. Epub 2017 Dec 5.

17.

Highly efficient DNA-free gene disruption in the agricultural pest Ceratitis capitata by CRISPR-Cas9 ribonucleoprotein complexes.

Meccariello A, Monti SM, Romanelli A, Colonna R, Primo P, Inghilterra MG, Del Corsano G, Ramaglia A, Iazzetti G, Chiarore A, Patti F, Heinze SD, Salvemini M, Lindsay H, Chiavacci E, Burger A, Robinson MD, Mosimann C, Bopp D, Saccone G.

Sci Rep. 2017 Aug 30;7(1):10061. doi: 10.1038/s41598-017-10347-5.

18.

Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations.

De Simone G, Langella E, Esposito D, Supuran CT, Monti SM, Winum JY, Alterio V.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):1002-1011. doi: 10.1080/14756366.2017.1349764.

19.

Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides.

Bruno E, Buemi MR, Di Fiore A, De Luca L, Ferro S, Angeli A, Cirilli R, Sadutto D, Alterio V, Monti SM, Supuran CT, De Simone G, Gitto R.

J Med Chem. 2017 May 25;60(10):4316-4326. doi: 10.1021/acs.jmedchem.7b00264. Epub 2017 May 9.

PMID:
28453941
20.

Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements.

Buonanno M, Langella E, Zambrano N, Succoio M, Sasso E, Alterio V, Di Fiore A, Sandomenico A, Supuran CT, Scaloni A, Monti SM, De Simone G.

ACS Chem Biol. 2017 Jun 16;12(6):1460-1465. doi: 10.1021/acschembio.7b00055. Epub 2017 Apr 19.

PMID:
28388044
21.

Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment.

Mishra CB, Kumari S, Angeli A, Monti SM, Buonanno M, Tiwari M, Supuran CT.

J Med Chem. 2017 Mar 23;60(6):2456-2469. doi: 10.1021/acs.jmedchem.6b01804. Epub 2017 Mar 14.

PMID:
28253618
22.

Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties.

Altug C, Güneş H, Nocentini A, Monti SM, Buonanno M, Supuran CT.

Bioorg Med Chem. 2017 Feb 15;25(4):1456-1464. doi: 10.1016/j.bmc.2017.01.008. Epub 2017 Jan 11.

PMID:
28111158
23.

Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors.

Angapelly S, Ramya PV, Angeli A, Monti SM, Buonanno M, Alvala M, Supuran CT, Arifuddin M.

Bioorg Med Chem. 2017 Jan 15;25(2):539-544. doi: 10.1016/j.bmc.2016.11.027. Epub 2016 Nov 19.

PMID:
27919611
24.

Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage.

Monti DM, De Simone G, Langella E, Supuran CT, Di Fiore A, Monti SM.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):5-12. doi: 10.1080/14756366.2016.1225046. Epub 2016 Oct 21. Review.

25.

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition.

Alterio V, Cadoni R, Esposito D, Vullo D, Fiore AD, Monti SM, Caporale A, Ruvo M, Sechi M, Dumy P, Supuran CT, De Simone G, Winum JY.

Chem Commun (Camb). 2016 Sep 29;52(80):11983-11986.

PMID:
27722534
26.

Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars.

Mollica A, Locatelli M, Macedonio G, Carradori S, Sobolev AP, De Salvador RF, Monti SM, Buonanno M, Zengin G, Angeli A, Supuran CT.

J Enzyme Inhib Med Chem. 2016;31(sup4):1-6. Epub 2016 Aug 10.

PMID:
27541737
27.

Editorial (Thematic Issue: Bacterial Metallo-Enzymes as Drug Targets).

Monti SM, D'Ambrosio K, De Simone G.

Curr Top Med Chem. 2016;16(21):2329. No abstract available.

PMID:
27464882
28.

Evolution of protein bound Maillard reaction end-products and free Amadori compounds in low lactose milk in presence of fructosamine oxidase I.

Troise AD, Buonanno M, Fiore A, Monti SM, Fogliano V.

Food Chem. 2016 Dec 1;212:722-9. doi: 10.1016/j.foodchem.2016.06.037. Epub 2016 Jun 15.

PMID:
27374589
29.

Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors.

Vullo D, Supuran CT, Scozzafava A, De Simone G, Monti SM, Alterio V, Carta F.

Bioorg Med Chem. 2016 Aug 15;24(16):3643-8. doi: 10.1016/j.bmc.2016.06.005. Epub 2016 Jun 4.

PMID:
27316543
30.

Design, synthesis and biological evaluation of N-(5-methyl-isoxazol-3-yl/1,3,4-thiadiazol-2-yl)-4-(3-substitutedphenylureido) benzenesulfonamides as human carbonic anhydrase isoenzymes I, II, VII and XII inhibitors.

Mishra CB, Kumari S, Angeli A, Monti SM, Buonanno M, Prakash A, Tiwari M, Supuran CT.

J Enzyme Inhib Med Chem. 2016;31(sup2):174-179. Epub 2016 Jun 17.

PMID:
27314170
31.

Impact of a Videoconference Educational Intervention on Physical Restraint and Antipsychotic Use in Nursing Homes: Results From the ECHO-AGE Pilot Study.

Gordon SE, Dufour AB, Monti SM, Mattison ML, Catic AG, Thomas CP, Lipsitz LA.

J Am Med Dir Assoc. 2016 Jun 1;17(6):553-6. doi: 10.1016/j.jamda.2016.03.002. Epub 2016 May 6.

32.

L-Histidinol Dehydrogenase as a New Target for Old Diseases.

Monti SM, De Simone G, D'Ambrosio K.

Curr Top Med Chem. 2016;16(21):2369-78. Review.

PMID:
27072690
33.

Protein conformational perturbations in hereditary amyloidosis: Differential impact of single point mutations in ApoAI amyloidogenic variants.

Del Giudice R, Arciello A, Itri F, Merlino A, Monti M, Buonanno M, Penco A, Canetti D, Petruk G, Monti SM, Relini A, Pucci P, Piccoli R, Monti DM.

Biochim Biophys Acta. 2016 Feb;1860(2):434-44. doi: 10.1016/j.bbagen.2015.10.019. Epub 2015 Oct 26.

PMID:
26515634
34.

A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases.

Langella E, D'Ambrosio K, D'Ascenzio M, Carradori S, Monti SM, Supuran CT, De Simone G.

Chemistry. 2016 Jan 4;22(1):97-100. doi: 10.1002/chem.201503748. Epub 2015 Nov 30.

PMID:
26507456
35.

Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.

La Regina G, Coluccia A, Famiglini V, Pelliccia S, Monti L, Vullo D, Nuti E, Alterio V, De Simone G, Monti SM, Pan P, Parkkila S, Supuran CT, Rossello A, Silvestri R.

J Med Chem. 2015 Nov 12;58(21):8564-72. doi: 10.1021/acs.jmedchem.5b01144. Epub 2015 Nov 4.

PMID:
26497049
36.

Thermostable Carbonic Anhydrases in Biotechnological Applications.

Di Fiore A, Alterio V, Monti SM, De Simone G, D'Ambrosio K.

Int J Mol Sci. 2015 Jul 8;16(7):15456-80. doi: 10.3390/ijms160715456. Review.

37.

Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties.

Ceruso M, Carta F, Osman SM, Alothman Z, Monti SM, Supuran CT.

Bioorg Med Chem. 2015 Aug 1;23(15):4181-7. doi: 10.1016/j.bmc.2015.06.050. Epub 2015 Jun 26.

PMID:
26145821
38.

Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors.

Di Fiore A, Vergara A, Caterino M, Alterio V, Monti SM, Ombouma J, Dumy P, Vullo D, Supuran CT, Winum JY, De Simone G.

Chem Commun (Camb). 2015 Jul 21;51(57):11519-22. doi: 10.1039/c5cc03711e.

PMID:
26094945
39.

Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense.

De Simone G, Monti SM, Alterio V, Buonanno M, De Luca V, Rossi M, Carginale V, Supuran CT, Capasso C, Di Fiore A.

Bioorg Med Chem Lett. 2015 May 1;25(9):2002-6. doi: 10.1016/j.bmcl.2015.02.068. Epub 2015 Mar 6.

PMID:
25817590
40.

Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii.

Alterio V, Langella E, De Simone G, Monti SM.

Mar Drugs. 2015 Mar 25;13(4):1688-97. doi: 10.3390/md13041688. Review.

41.

X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor.

Alterio V, Tanc M, Ivanova J, Zalubovskis R, Vozny I, Monti SM, Di Fiore A, De Simone G, Supuran CT.

Org Biomol Chem. 2015 Apr 7;13(13):4064-9. doi: 10.1039/c4ob02648a.

PMID:
25733161
42.

A virulence factor encoded by a polydnavirus confers tolerance to transgenic tobacco plants against lepidopteran larvae, by impairing nutrient absorption.

Di Lelio I, Caccia S, Coppola M, Buonanno M, Di Prisco G, Varricchio P, Franzetti E, Corrado G, Monti SM, Rao R, Casartelli M, Pennacchio F.

PLoS One. 2014 Dec 1;9(12):e113988. doi: 10.1371/journal.pone.0113988. eCollection 2014.

43.

Out of the active site binding pocket for carbonic anhydrase inhibitors.

D'Ambrosio K, Carradori S, Monti SM, Buonanno M, Secci D, Vullo D, Supuran CT, De Simone G.

Chem Commun (Camb). 2015;51(2):302-5. doi: 10.1039/c4cc07320g.

PMID:
25407638
44.

Simultaneous quantification of amino acids and Amadori products in foods through ion-pairing liquid chromatography-high-resolution mass spectrometry.

Troise AD, Fiore A, Roviello G, Monti SM, Fogliano V.

Amino Acids. 2015 Jan;47(1):111-24. doi: 10.1007/s00726-014-1845-5. Epub 2014 Oct 17.

PMID:
25323735
45.

ECHO-AGE: an innovative model of geriatric care for long-term care residents with dementia and behavioral issues.

Catic AG, Mattison ML, Bakaev I, Morgan M, Monti SM, Lipsitz L.

J Am Med Dir Assoc. 2014 Dec;15(12):938-42. doi: 10.1016/j.jamda.2014.08.014. Epub 2014 Oct 11.

PMID:
25306294
46.

Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors.

De Simone G, Pizika G, Monti SM, Di Fiore A, Ivanova J, Vozny I, Trapencieris P, Zalubovskis R, Supuran CT, Alterio V.

Biomed Res Int. 2014;2014:523210. doi: 10.1155/2014/523210. Epub 2014 Sep 2.

47.

The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors.

Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G.

Biopolymers. 2014 Jul;101(7):769-78. doi: 10.1002/bip.22456.

PMID:
24374484
48.

Thermal-stable carbonic anhydrases: a structural overview.

Alterio V, Monti SM, De Simone G.

Subcell Biochem. 2014;75:387-404. doi: 10.1007/978-94-007-7359-2_19. Review.

PMID:
24146389
49.

Structural basis for the rational design of new anti-Brucella agents: the crystal structure of the C366S mutant of L-histidinol dehydrogenase from Brucella suis.

D'ambrosio K, Lopez M, Dathan NA, Ouahrani-Bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G.

Biochimie. 2014 Feb;97:114-20. doi: 10.1016/j.biochi.2013.09.028. Epub 2013 Oct 17.

PMID:
24140957
50.

Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates.

Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY.

J Med Chem. 2013 Nov 14;56(21):8512-20. doi: 10.1021/jm4009532. Epub 2013 Oct 31.

PMID:
24128000

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