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ER stress and Rho kinase activation underlie the vasculopathy of CADASIL.

Neves KB, Harvey AP, Moreton F, Montezano AC, Rios FJ, Alves-Lopes R, Nguyen Dinh Cat A, Rocchiccioli P, Delles C, Joutel A, Muir K, Touyz RM.

JCI Insight. 2019 Oct 24. pii: 131344. doi: 10.1172/jci.insight.131344. [Epub ahead of print]


Selective ETA versus dual ETA/B receptor blockade for the prevention of sunitinib-induced hypertension and albuminuria in WKY rats.

Mirabito Colafella KM, Neves KB, Montezano AC, Garrelds IM, van Veghel R, de Vries R, Uijl E, Baelde HJ, van den Meiracker AH, Touyz RM, Danser AHJ, Versmissen J.

Cardiovasc Res. 2019 Oct 8. pii: cvz260. doi: 10.1093/cvr/cvz260. [Epub ahead of print]


Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis.

Rios FJ, Zou ZG, Harvey AP, Harvey KY, Nosalski R, Anyfanti P, Camargo LL, Lacchini S, Ryazanov AG, Ryazanova L, McGrath S, Guzik TJ, Goodyear CS, Montezano AC, Touyz RM.

Cardiovasc Res. 2019 Jun 28. pii: cvz164. doi: 10.1093/cvr/cvz164. [Epub ahead of print]


TRPM7, Magnesium, and Signaling.

Zou ZG, Rios FJ, Montezano AC, Touyz RM.

Int J Mol Sci. 2019 Apr 16;20(8). pii: E1877. doi: 10.3390/ijms20081877. Review.


NOX5: Molecular biology and pathophysiology.

Touyz RM, Anagnostopoulou A, Rios F, Montezano AC, Camargo LL.

Exp Physiol. 2019 May;104(5):605-616. doi: 10.1113/EP086204. Epub 2019 Mar 18.


Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury.

Neves KB, Rios FJ, Jones R, Evans TRJ, Montezano AC, Touyz RM.

Cardiovasc Res. 2019 Apr 15;115(5):978-988. doi: 10.1093/cvr/cvz021.


Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress.

Bruder-Nascimento T, Callera GE, Montezano AC, Belin de Chantemele EJ, Tostes RC, Touyz RM.

Life Sci. 2019 Mar 15;221:29-34. doi: 10.1016/j.lfs.2019.01.043. Epub 2019 Feb 2.


Vascular Biology of Superoxide-Generating NADPH Oxidase 5-Implications in Hypertension and Cardiovascular Disease.

Touyz RM, Anagnostopoulou A, Camargo LL, Rios FJ, Montezano AC.

Antioxid Redox Signal. 2019 Mar 1;30(7):1027-1040. doi: 10.1089/ars.2018.7583. Epub 2018 Nov 15.


Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive and Akt-dependent pathways.

Neves KB, Nguyen Dinh Cat A, Alves-Lopes R, Harvey KY, Costa RMD, Lobato NS, Montezano AC, Oliveira AM, Touyz RM, Tostes RC.

Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1851-H1860. doi: 10.1152/ajpheart.00285.2018. Epub 2018 Sep 14.


Systemic microvascular dysfunction in microvascular and vasospastic angina.

Ford TJ, Rocchiccioli P, Good R, McEntegart M, Eteiba H, Watkins S, Shaukat A, Lindsay M, Robertson K, Hood S, Yii E, Sidik N, Harvey A, Montezano AC, Beattie E, Haddow L, Oldroyd KG, Touyz RM, Berry C.

Eur Heart J. 2018 Dec 7;39(46):4086-4097. doi: 10.1093/eurheartj/ehy529.


Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice.

Neves KB, Montezano AC, Alves-Lopes R, Bruder-Nascimento T, Costa RM, Costa RS, Touyz RM, Tostes RC.

Int J Mol Sci. 2018 Aug 19;19(8). pii: E2454. doi: 10.3390/ijms19082454.


NADPH Oxidase 5 Is a Pro-Contractile Nox Isoform and a Point of Cross-Talk for Calcium and Redox Signaling-Implications in Vascular Function.

Montezano AC, De Lucca Camargo L, Persson P, Rios FJ, Harvey AP, Anagnostopoulou A, Palacios R, Gandara ACP, Alves-Lopes R, Neves KB, Dulak-Lis M, Holterman CE, de Oliveira PL, Graham D, Kennedy C, Touyz RM.

J Am Heart Assoc. 2018 Jun 15;7(12). pii: e009388. doi: 10.1161/JAHA.118.009388.


Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in Hypertension.

Camargo LL, Harvey AP, Rios FJ, Tsiropoulou S, Da Silva RNO, Cao Z, Graham D, McMaster C, Burchmore RJ, Hartley RC, Bulleid N, Montezano AC, Touyz RM.

Hypertension. 2018 Jul;72(1):235-246. doi: 10.1161/HYPERTENSIONAHA.118.10824. Epub 2018 May 29.


VEGFR (Vascular Endothelial Growth Factor Receptor) Inhibition Induces Cardiovascular Damage via Redox-Sensitive Processes.

Neves KB, Rios FJ, van der Mey L, Alves-Lopes R, Cameron AC, Volpe M, Montezano AC, Savoia C, Touyz RM.

Hypertension. 2018 Apr;71(4):638-647. doi: 10.1161/HYPERTENSIONAHA.117.10490. Epub 2018 Feb 26.


Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling.

Nguyen Dinh Cat A, Callera GE, Friederich-Persson M, Sanchez A, Dulak-Lis MG, Tsiropoulou S, Montezano AC, He Y, Briones AM, Jaisser F, Touyz RM.

Sci Rep. 2018 Feb 13;8(1):2952. doi: 10.1038/s41598-018-21087-5.


Vascular smooth muscle contraction in hypertension.

Touyz RM, Alves-Lopes R, Rios FJ, Camargo LL, Anagnostopoulou A, Arner A, Montezano AC.

Cardiovasc Res. 2018 Mar 15;114(4):529-539. doi: 10.1093/cvr/cvy023. Review.


Temporal changes in cardiac oxidative stress, inflammation and remodeling induced by exercise in hypertension: Role for local angiotensin II reduction.

Silva SD Jr, Jara ZP, Peres R, Lima LS, Scavone C, Montezano AC, Touyz RM, Casarini DE, Michelini LC.

PLoS One. 2017 Dec 12;12(12):e0189535. doi: 10.1371/journal.pone.0189535. eCollection 2017.


Angiotensin-(1-7) and Vascular Function: The Clinical Context.

Touyz RM, Montezano AC.

Hypertension. 2018 Jan;71(1):68-69. doi: 10.1161/HYPERTENSIONAHA.117.10406. Epub 2017 Dec 4. No abstract available. Erratum in: Hypertension. 2018 Mar;71(3):e9.


Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications.

Lucas-Herald AK, Alves-Lopes R, Montezano AC, Ahmed SF, Touyz RM.

Clin Sci (Lond). 2017 Jul 1;131(13):1405-1418. doi: 10.1042/CS20170090. Review.


Redox Stress Defines the Small Artery Vasculopathy of Hypertension: How Do We Bridge the Bench-to-Bedside Gap?

Touyz RM, Montezano AC, Rios F, Widlansky ME, Liang M.

Circ Res. 2017 May 26;120(11):1721-1723. doi: 10.1161/CIRCRESAHA.117.310672. Review. No abstract available.


Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: The aldosterone-mineralocorticoid receptor-Nox1 axis.

Harvey AP, Montezano AC, Hood KY, Lopes RA, Rios F, Ceravolo G, Graham D, Touyz RM.

Life Sci. 2017 Jun 15;179:110-119. doi: 10.1016/j.lfs.2017.05.002. Epub 2017 May 3.


Serotonin Signaling Through the 5-HT1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension.

Hood KY, Mair KM, Harvey AP, Montezano AC, Touyz RM, MacLean MR.

Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):1361-1370. doi: 10.1161/ATVBAHA.116.308929. Epub 2017 May 4.


Isolation and Culture of Vascular Smooth Muscle Cells from Small and Large Vessels.

Montezano AC, Lopes RA, Neves KB, Rios F, Touyz RM.

Methods Mol Biol. 2017;1527:349-354. doi: 10.1007/978-1-4939-6625-7_27.


Isolation and Culture of Endothelial Cells from Large Vessels.

Montezano AC, Neves KB, Lopes RA, Rios F.

Methods Mol Biol. 2017;1527:345-348. doi: 10.1007/978-1-4939-6625-7_26.


Isolation and Differentiation of Human Macrophages.

Rios FJ, Touyz RM, Montezano AC.

Methods Mol Biol. 2017;1527:311-320. doi: 10.1007/978-1-4939-6625-7_24.


Isolation and Differentiation of Murine Macrophages.

Rios FJ, Touyz RM, Montezano AC.

Methods Mol Biol. 2017;1527:297-309. doi: 10.1007/978-1-4939-6625-7_23.


Brown Adipose Tissue Regulates Small Artery Function Through NADPH Oxidase 4-Derived Hydrogen Peroxide and Redox-Sensitive Protein Kinase G-1α.

Friederich-Persson M, Nguyen Dinh Cat A, Persson P, Montezano AC, Touyz RM.

Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):455-465. doi: 10.1161/ATVBAHA.116.308659. Epub 2016 Dec 22.


Anti-atherosclerotic effect of the angiotensin 1-7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis.

Skiba DS, Nosalski R, Mikolajczyk TP, Siedlinski M, Rios FJ, Montezano AC, Jawien J, Olszanecki R, Korbut R, Czesnikiewicz-Guzik M, Touyz RM, Guzik TJ.

Br J Pharmacol. 2017 Nov;174(22):4055-4069. doi: 10.1111/bph.13685. Epub 2017 Feb 1.


Differential renal effects of candesartan at high and ultra-high doses in diabetic mice-potential role of the ACE2/AT2R/Mas axis.

Callera GE, Antunes TT, Correa JW, Moorman D, Gutsol A, He Y, Cat AN, Briones AM, Montezano AC, Burns KD, Touyz RM.

Biosci Rep. 2016 Oct 27;36(5). pii: e00398. Print 2016 Oct.


Novel Biosensors Reveal a Shift in the Redox Paradigm From Oxidative to Reductive Stress in Heart Disease.

Touyz RM, Anagnostopoulou A, De Lucca Camargo L, Montezano AC.

Circ Res. 2016 Oct 14;119(9):969-971. No abstract available.


Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3.

Bruder-Nascimento T, Callera G, Montezano AC, Antunes TT, He Y, Cat AN, Ferreira NS, Barreto PA, Olivon VC, Tostes RC, Touyz RM.

PLoS One. 2016 Sep 20;11(9):e0162731. doi: 10.1371/journal.pone.0162731. eCollection 2016.


c-Src Inhibition Improves Cardiovascular Function but not Remodeling or Fibrosis in Angiotensin II-Induced Hypertension.

Callera GE, Antunes TT, He Y, Montezano AC, Yogi A, Savoia C, Touyz RM.

Hypertension. 2016 Nov;68(5):1179-1190. Epub 2016 Sep 12.


Internal Pudental Artery Dysfunction in Diabetes Mellitus Is Mediated by NOX1-Derived ROS-, Nrf2-, and Rho Kinase-Dependent Mechanisms.

Alves-Lopes R, Neves KB, Montezano AC, Harvey A, Carneiro FS, Touyz RM, Tostes RC.

Hypertension. 2016 Oct;68(4):1056-64. doi: 10.1161/HYPERTENSIONAHA.116.07518. Epub 2016 Aug 15.


Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension.

Hood KY, Montezano AC, Harvey AP, Nilsen M, MacLean MR, Touyz RM.

Hypertension. 2016 Sep;68(3):796-808. doi: 10.1161/HYPERTENSIONAHA.116.07668. Epub 2016 Jul 11.


Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase.

Nguyen Dinh Cat A, Antunes TT, Callera GE, Sanchez A, Tsiropoulou S, Dulak-Lis MG, Anagnostopoulou A, He Y, Montezano AC, Jaisser F, Touyz RM.

Diabetes. 2016 Aug;65(8):2392-403. doi: 10.2337/db15-1627. Epub 2016 Apr 19.


Vascular Fibrosis in Aging and Hypertension: Molecular Mechanisms and Clinical Implications.

Harvey A, Montezano AC, Lopes RA, Rios F, Touyz RM.

Can J Cardiol. 2016 May;32(5):659-68. doi: 10.1016/j.cjca.2016.02.070. Epub 2016 Mar 3. Review.


Off-Target Vascular Effects of Cholesteryl Ester Transfer Protein Inhibitors Involve Redox-Sensitive and Signal Transducer and Activator of Transcription 3-Dependent Pathways.

Rios FJ, Lopes RA, Neves KB, Camargo LL, Montezano AC, Touyz RM.

J Pharmacol Exp Ther. 2016 May;357(2):415-22. doi: 10.1124/jpet.115.230748. Epub 2016 Mar 3.


Progenitor Cells, Bone Marrow-Derived Fibrocytes and Endothelial-to-Mesenchymal Transition: New Players in Vascular Fibrosis.

Rios FJ, Harvey A, Lopes RA, Montezano AC, Touyz RM.

Hypertension. 2016 Feb;67(2):272-4. doi: 10.1161/HYPERTENSIONAHA.115.06220. Epub 2015 Dec 22. No abstract available.


Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension.

Lopes RA, Neves KB, Tostes RC, Montezano AC, Touyz RM.

Hypertension. 2015 Dec;66(6):1240-50. doi: 10.1161/HYPERTENSIONAHA.115.06163. Epub 2015 Oct 26.


PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases.

Kolisek M, Montezano AC, Sponder G, Anagnostopoulou A, Vormann J, Touyz RM, Aschenbach JR.

Clin Sci (Lond). 2015 Dec;129(12):1143-50. doi: 10.1042/CS20150355. Epub 2015 Sep 28.


Redox signaling, Nox5 and vascular remodeling in hypertension.

Montezano AC, Tsiropoulou S, Dulak-Lis M, Harvey A, Camargo Lde L, Touyz RM.

Curr Opin Nephrol Hypertens. 2015 Sep;24(5):425-33. doi: 10.1097/MNH.0000000000000153. Review.


Chemerin Regulates Crosstalk Between Adipocytes and Vascular Cells Through Nox.

Neves KB, Nguyen Dinh Cat A, Lopes RA, Rios FJ, Anagnostopoulou A, Lobato NS, de Oliveira AM, Tostes RC, Montezano AC, Touyz RM.

Hypertension. 2015 Sep;66(3):657-66. doi: 10.1161/HYPERTENSIONAHA.115.05616. Epub 2015 Jul 6.


Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus.

Silva MA, Cau SB, Lopes RA, Manzato CP, Neves KB, Bruder-Nascimento T, Mestriner FL, Montezano AC, Nguyen Dinh Cat A, Touyz RM, Tostes RC.

Clin Sci (Lond). 2015 Oct;129(7):533-45. doi: 10.1042/CS20140758. Epub 2015 May 13.


Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies.

Montezano AC, Dulak-Lis M, Tsiropoulou S, Harvey A, Briones AM, Touyz RM.

Can J Cardiol. 2015 May;31(5):631-41. doi: 10.1016/j.cjca.2015.02.008. Epub 2015 Feb 14. Review.


Vascular biology of ageing-Implications in hypertension.

Harvey A, Montezano AC, Touyz RM.

J Mol Cell Cardiol. 2015 Jun;83:112-21. doi: 10.1016/j.yjmcc.2015.04.011. Epub 2015 Apr 17. Review.


Across the globe in 4 months: two International Society of Hypertension new investigator symposia in 2014.

Veerabhadrappa P, Burger D, Brouwers S, Christofidou P, Bikai RE, Hannah-Shmouni F, Kruger R, Marques FZ, Rehman Mian MO, Montezano AC, Romero CA, Peña-Silva RA, Wainford RD, Charchar FJ, Schutte AE, Tomaszewski M.

J Hypertens. 2015 Apr;33(4):891-3. doi: 10.1097/HJH.0000000000000525. No abstract available.


Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes.

Rios FJ, Neves KB, Nguyen Dinh Cat A, Even S, Palacios R, Montezano AC, Touyz RM.

J Pharmacol Exp Ther. 2015 Apr;353(1):27-34. doi: 10.1124/jpet.114.221002. Epub 2015 Jan 23.


Reply to Letter by McIntyre et al.

Touyz RM, Montezano AC, Rios FJ, Savoia C.

Can J Cardiol. 2014 Dec;30(12):1733.e3. doi: 10.1016/j.cjca.2014.10.004. Epub 2014 Oct 7. No abstract available.


An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies.

Ceravolo GS, Montezano AC, Jordão MT, Akamine EH, Costa TJ, Takano AP, Fernandes DC, Barreto-Chaves ML, Laurindo FR, Tostes RC, Fortes ZB, Chopard RP, Touyz RM, Carvalho MH.

PLoS One. 2014 Nov 4;9(11):e111117. doi: 10.1371/journal.pone.0111117. eCollection 2014.

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