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Behavioral Analysis of SNAP-25 and Synaptobrevin-2 Haploinsufficiency in Mice.

Monteggia LM, Lin PY, Adachi M, Kavalali ET.

Neuroscience. 2018 Aug 23. pii: S0306-4522(18)30559-1. doi: 10.1016/j.neuroscience.2018.08.014. [Epub ahead of print]


Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses.

Lin PY, Kavalali ET, Monteggia LM.

Cell Rep. 2018 Aug 7;24(6):1550-1561. doi: 10.1016/j.celrep.2018.07.020.


Meeting Report: Can We Make Animal Models of Human Mental Illness?

Monteggia LM, Heimer H, Nestler EJ.

Biol Psychiatry. 2018 Oct 1;84(7):542-545. doi: 10.1016/j.biopsych.2018.02.010. Epub 2018 Feb 22.


MeCP2 as an Activator of Gene Expression.

Horvath PM, Monteggia LM.

Trends Neurosci. 2018 Feb;41(2):72-74. doi: 10.1016/j.tins.2017.11.005. Review.


Correction: D-cycloserine improves synaptic transmission in an animal mode of Rett syndrome.

Na ES, De Jesús-Cortés H, Martinez-Rivera A, Kabir ZD, Wang J, Ramesh V, Onder Y, Rajadhyaksha AM, Monteggia LM, Pieper AA.

PLoS One. 2018 Jan 25;13(1):e0192057. doi: 10.1371/journal.pone.0192057. eCollection 2018.


Inactivation of NMDA Receptors in the Ventral Tegmental Area during Cocaine Self-Administration Prevents GluA1 Upregulation but with Paradoxical Increases in Cocaine-Seeking Behavior.

Guzman D, Carreira MB, Friedman AK, Adachi M, Neve RL, Monteggia LM, Han MH, Cowan CW, Self DW.

J Neurosci. 2018 Jan 17;38(3):575-585. doi: 10.1523/JNEUROSCI.2828-16.2017. Epub 2017 Dec 1.


The Ketamine Metabolite 2R,6R-Hydroxynorketamine Blocks NMDA Receptors and Impacts Downstream Signaling Linked to Antidepressant Effects.

Kavalali ET, Monteggia LM.

Neuropsychopharmacology. 2018 Jan;43(1):221-222. doi: 10.1038/npp.2017.210. No abstract available.


Engineering MeCP2 to spy on its targets.

Horvath PM, Monteggia LM.

Nat Med. 2017 Oct 6;23(10):1120-1122. doi: 10.1038/nm.4425. No abstract available.


D-cycloserine improves synaptic transmission in an animal model of Rett syndrome.

Na ES, De Jesús-Cortés H, Martinez-Rivera A, Kabir ZD, Wang J, Ramesh V, Onder Y, Rajadhyaksha AM, Monteggia LM, Pieper AA.

PLoS One. 2017 Aug 16;12(8):e0183026. doi: 10.1371/journal.pone.0183026. eCollection 2017. Erratum in: PLoS One. 2018 Jan 25;13(1):e0192057.


Effects of a ketamine metabolite on synaptic NMDAR function.

Suzuki K, Nosyreva E, Hunt KW, Kavalali ET, Monteggia LM.

Nature. 2017 Jun 21;546(7659):E1-E3. doi: 10.1038/nature22084. No abstract available.


Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling.

Gideons ES, Lin PY, Mahgoub M, Kavalali ET, Monteggia LM.

Elife. 2017 Jun 16;6. pii: e25480. doi: 10.7554/eLife.25480.


Loss of Doc2-Dependent Spontaneous Neurotransmission Augments Glutamatergic Synaptic Strength.

Ramirez DMO, Crawford DC, Chanaday NL, Trauterman B, Monteggia LM, Kavalali ET.

J Neurosci. 2017 Jun 28;37(26):6224-6230. doi: 10.1523/JNEUROSCI.0418-17.2017. Epub 2017 May 24.


Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy.

Crawford DC, Ramirez DM, Trauterman B, Monteggia LM, Kavalali ET.

Nat Commun. 2017 Feb 10;8:14436. doi: 10.1038/ncomms14436.


CRISPR/Cas9 system-mediated impairment of synaptobrevin/VAMP function in postmitotic hippocampal neurons.

Horvath PM, Kavalali ET, Monteggia LM.

J Neurosci Methods. 2017 Feb 15;278:57-64. doi: 10.1016/j.jneumeth.2016.12.015. Epub 2016 Dec 23.


MeCP2 and histone deacetylases 1 and 2 in dorsal striatum collectively suppress repetitive behaviors.

Mahgoub M, Adachi M, Suzuki K, Liu X, Kavalali ET, Chahrour MH, Monteggia LM.

Nat Neurosci. 2016 Nov;19(11):1506-1512. doi: 10.1038/nn.4395. Epub 2016 Sep 26.


TrkB Signaling in Dorsal Raphe Nucleus is Essential for Antidepressant Efficacy and Normal Aggression Behavior.

Adachi M, Autry AE, Mahgoub M, Suzuki K, Monteggia LM.

Neuropsychopharmacology. 2017 Mar;42(4):886-894. doi: 10.1038/npp.2016.201. Epub 2016 Sep 16.


Impact of DNMT1 and DNMT3a forebrain knockout on depressive- and anxiety like behavior in mice.

Morris MJ, Na ES, Autry AE, Monteggia LM.

Neurobiol Learn Mem. 2016 Nov;135:139-145. doi: 10.1016/j.nlm.2016.08.012. Epub 2016 Aug 18.


Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK.

Biol Psychiatry. 2016 Jul 15;80(2):84-86. doi: 10.1016/j.biopsych.2016.05.004. No abstract available.


Postnatal Loss of Mef2c Results in Dissociation of Effects on Synapse Number and Learning and Memory.

Adachi M, Lin PY, Pranav H, Monteggia LM.

Biol Psychiatry. 2016 Jul 15;80(2):140-148. doi: 10.1016/j.biopsych.2015.09.018. Epub 2015 Oct 8.


Toward Better Animal Models for Molecular Psychiatry.

Monteggia LM.

Biol Psychiatry. 2016 Jan 1;79(1):2-3. doi: 10.1016/j.biopsych.2015.10.019. No abstract available.


BDNF - a key transducer of antidepressant effects.

Björkholm C, Monteggia LM.

Neuropharmacology. 2016 Mar;102:72-9. doi: 10.1016/j.neuropharm.2015.10.034. Epub 2015 Nov 11. Review.


Antidepressant actions of ketamine: from molecular mechanisms to clinical practice.

Monteggia LM, Zarate C Jr.

Curr Opin Neurobiol. 2015 Feb;30:139-43. doi: 10.1016/j.conb.2014.12.004. Epub 2015 Jan 3. Review.


Age dependence of the rapid antidepressant and synaptic effects of acute NMDA receptor blockade.

Nosyreva E, Autry AE, Kavalali ET, Monteggia LM.

Front Mol Neurosci. 2014 Dec 1;7:94. doi: 10.3389/fnmol.2014.00094. eCollection 2014.


How does ketamine elicit a rapid antidepressant response?

Kavalali ET, Monteggia LM.

Curr Opin Pharmacol. 2015 Feb;20:35-9. doi: 10.1016/j.coph.2014.11.005. Epub 2014 Nov 25. Review.


Depression: the best way forward.

Monteggia LM, Malenka RC, Deisseroth K.

Nature. 2014 Nov 13;515(7526):200-1. doi: 10.1038/515200a. No abstract available.


Role of DNA methylation and the DNA methyltransferases in learning and memory.

Morris MJ, Monteggia LM.

Dialogues Clin Neurosci. 2014 Sep;16(3):359-71. Review.


A role for histone deacetylases in the cellular and behavioral mechanisms underlying learning and memory.

Mahgoub M, Monteggia LM.

Learn Mem. 2014 Sep 16;21(10):564-8. doi: 10.1101/lm.036012.114. Print 2014 Oct. Review.


Selective role for DNMT3a in learning and memory.

Morris MJ, Adachi M, Na ES, Monteggia LM.

Neurobiol Learn Mem. 2014 Nov;115:30-7. doi: 10.1016/j.nlm.2014.06.005. Epub 2014 Jun 14.


Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses.

Gideons ES, Kavalali ET, Monteggia LM.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8649-54. doi: 10.1073/pnas.1323920111. Epub 2014 May 27.


GABAA receptor antagonism ameliorates behavioral and synaptic impairments associated with MeCP2 overexpression.

Na ES, Morris MJ, Nelson ED, Monteggia LM.

Neuropsychopharmacology. 2014 Jul;39(8):1946-54. doi: 10.1038/npp.2014.43. Epub 2014 Feb 19.


Decoding transcriptional repressor complexes in the adult central nervous system.

Adachi M, Monteggia LM.

Neuropharmacology. 2014 May;80:45-52. doi: 10.1016/j.neuropharm.2013.12.024. Epub 2014 Jan 10. Review.


Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission.

Bal M, Leitz J, Reese AL, Ramirez DM, Durakoglugil M, Herz J, Monteggia LM, Kavalali ET.

Neuron. 2013 Nov 20;80(4):934-46. doi: 10.1016/j.neuron.2013.08.024. Epub 2013 Nov 7.


mTOR complexes in neurodevelopmental and neuropsychiatric disorders.

Costa-Mattioli M, Monteggia LM.

Nat Neurosci. 2013 Nov;16(11):1537-43. doi: 10.1038/nn.3546. Epub 2013 Oct 28. Review.


Scopolamine and ketamine: evidence of convergence?

Monteggia LM, Kavalali ET.

Biol Psychiatry. 2013 Nov 15;74(10):712-3. doi: 10.1016/j.biopsych.2013.08.011. No abstract available.


Epigenetics and psychiatry.

Mahgoub M, Monteggia LM.

Neurotherapeutics. 2013 Oct;10(4):734-41. doi: 10.1007/s13311-013-0213-6. Review.


Adenosine A1 and dopamine d1 receptor regulation of AMPA receptor phosphorylation and cocaine-seeking behavior.

Hobson BD, O'Neill CE, Levis SC, Monteggia LM, Neve RL, Self DW, Bachtell RK.

Neuropsychopharmacology. 2013 Sep;38(10):1974-83. doi: 10.1038/npp.2013.96. Epub 2013 Apr 18.


Acute suppression of spontaneous neurotransmission drives synaptic potentiation.

Nosyreva E, Szabla K, Autry AE, Ryazanov AG, Monteggia LM, Kavalali ET.

J Neurosci. 2013 Apr 17;33(16):6990-7002. doi: 10.1523/JNEUROSCI.4998-12.2013.


Loss of histone deacetylase 2 improves working memory and accelerates extinction learning.

Morris MJ, Mahgoub M, Na ES, Pranav H, Monteggia LM.

J Neurosci. 2013 Apr 10;33(15):6401-11. doi: 10.1523/JNEUROSCI.1001-12.2013.


Synaptic mechanisms underlying rapid antidepressant action of ketamine.

Kavalali ET, Monteggia LM.

Am J Psychiatry. 2012 Nov;169(11):1150-6. Review.


Unique functional roles for class I and class II histone deacetylases in central nervous system development and function.

Morris MJ, Monteggia LM.

Int J Dev Neurosci. 2013 Oct;31(6):370-81. doi: 10.1016/j.ijdevneu.2013.02.005. Epub 2013 Mar 4. Review.


Circadian rhythms: Depression brought to light.

Monteggia LM, Kavalali ET.

Nature. 2012 Nov 22;491(7425):537-8. doi: 10.1038/nature11752. Epub 2012 Nov 14. No abstract available.


The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine.

Monteggia LM, Gideons E, Kavalali ET.

Biol Psychiatry. 2013 Jun 15;73(12):1199-203. doi: 10.1016/j.biopsych.2012.09.006. Epub 2012 Oct 11. Review.


An essential role for histone deacetylase 4 in synaptic plasticity and memory formation.

Kim MS, Akhtar MW, Adachi M, Mahgoub M, Bassel-Duby R, Kavalali ET, Olson EN, Monteggia LM.

J Neurosci. 2012 Aug 8;32(32):10879-86. doi: 10.1523/JNEUROSCI.2089-12.2012.


The impact of MeCP2 loss- or gain-of-function on synaptic plasticity.

Na ES, Nelson ED, Kavalali ET, Monteggia LM.

Neuropsychopharmacology. 2013 Jan;38(1):212-9. doi: 10.1038/npp.2012.116. Epub 2012 Jul 11. Review.


Sensitivity of hippocampal 5-HT1A receptors to mild stress in BDNF-deficient mice.

Burke TF, Advani T, Adachi M, Monteggia LM, Hensler JG.

Int J Neuropsychopharmacol. 2013 Apr;16(3):631-45. doi: 10.1017/S1461145712000466. Epub 2012 May 10.


In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival.

Akhtar MW, Kim MS, Adachi M, Morris MJ, Qi X, Richardson JA, Bassel-Duby R, Olson EN, Kavalali ET, Monteggia LM.

PLoS One. 2012;7(4):e34863. doi: 10.1371/journal.pone.0034863. Epub 2012 Apr 9.


Brain-derived neurotrophic factor and neuropsychiatric disorders.

Autry AE, Monteggia LM.

Pharmacol Rev. 2012 Apr;64(2):238-58. doi: 10.1124/pr.111.005108. Epub 2012 Mar 8. Review.


Induction of the plasticity-associated immediate early gene Arc by stress and hallucinogens: role of brain-derived neurotrophic factor.

Benekareddy M, Nair AR, Dias BG, Suri D, Autry AE, Monteggia LM, Vaidya VA.

Int J Neuropsychopharmacol. 2013 Mar;16(2):405-15. doi: 10.1017/S1461145712000168. Epub 2012 Mar 12.


A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission.

Na ES, Nelson ED, Adachi M, Autry AE, Mahgoub MA, Kavalali ET, Monteggia LM.

J Neurosci. 2012 Feb 29;32(9):3109-17. doi: 10.1523/JNEUROSCI.6000-11.2012.


NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.

Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF, Kavalali ET, Monteggia LM.

Nature. 2011 Jun 15;475(7354):91-5. doi: 10.1038/nature10130.

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