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Items: 1 to 50 of 183

1.

Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity.

Tatsukawa T, Raveau M, Ogiwara I, Hattori S, Miyamoto H, Mazaki E, Itohara S, Miyakawa T, Montal M, Yamakawa K.

Mol Autism. 2019 Mar 28;10:15. doi: 10.1186/s13229-019-0265-5. eCollection 2019.

2.

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa K.

Commun Biol. 2018;1. pii: 96. doi: 10.1038/s42003-018-0099-2. Epub 2018 Jul 19.

3.

Altered hippocampal replay is associated with memory impairment in mice heterozygous for the Scn2a gene.

Middleton SJ, Kneller EM, Chen S, Ogiwara I, Montal M, Yamakawa K, McHugh TJ.

Nat Neurosci. 2018 Jul;21(7):996-1003. doi: 10.1038/s41593-018-0163-8. Epub 2018 Jun 4.

PMID:
29867081
4.

Tetanus neurotoxin: conformational plasticity as an adaptive strategy.

Montal M.

EMBO Rep. 2017 Aug;18(8):1268-1270. doi: 10.15252/embr.201744500. Epub 2017 Jul 12. No abstract available.

5.

LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.

Syeda R, Qiu Z, Dubin AE, Murthy SE, Florendo MN, Mason DE, Mathur J, Cahalan SM, Peters EC, Montal M, Patapoutian A.

Cell. 2016 Jan 28;164(3):499-511. doi: 10.1016/j.cell.2015.12.031.

6.

The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine.

Syeda R, Santos JS, Montal M.

J Biol Chem. 2016 Feb 5;291(6):2931-7. doi: 10.1074/jbc.M115.683185. Epub 2015 Dec 1.

7.

Chemical activation of the mechanotransduction channel Piezo1.

Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A.

Elife. 2015 May 22;4. doi: 10.7554/eLife.07369.

8.

Redox regulation of botulinum neurotoxin toxicity: therapeutic implications.

Montal M.

Trends Mol Med. 2014 Nov;20(11):602-3. doi: 10.1016/j.molmed.2014.09.005. Epub 2014 Sep 18.

9.

Lipid bilayer modules as determinants of K+ channel gating.

Syeda R, Santos JS, Montal M.

J Biol Chem. 2014 Feb 14;289(7):4233-43. doi: 10.1074/jbc.M113.530055. Epub 2013 Dec 20.

10.

Stabilization of the conductive conformation of a voltage-gated K+ (Kv) channel: the lid mechanism.

Santos JS, Syeda R, Montal M.

J Biol Chem. 2013 Jun 7;288(23):16619-28. doi: 10.1074/jbc.M113.468728. Epub 2013 Apr 22.

11.

Molecular dissection of botulinum neurotoxin reveals interdomain chaperone function.

Fischer A, Montal M.

Toxicon. 2013 Dec 1;75:101-7. doi: 10.1016/j.toxicon.2013.01.007. Epub 2013 Feb 5. Review.

12.

Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes.

Santos JS, Asmar-Rovira GA, Han GW, Liu W, Syeda R, Cherezov V, Baker KA, Stevens RC, Montal M.

J Biol Chem. 2012 Dec 14;287(51):43063-70. doi: 10.1074/jbc.M112.415091. Epub 2012 Oct 24. Erratum in: J Biol Chem. 2013 Feb 1;288(5):3476.

13.

Tetrameric assembly of KvLm K+ channels with defined numbers of voltage sensors.

Syeda R, Santos JS, Montal M, Bayley H.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16917-22. doi: 10.1073/pnas.1205592109. Epub 2012 Sep 27.

14.

Piezo proteins are pore-forming subunits of mechanically activated channels.

Coste B, Xiao B, Santos JS, Syeda R, Grandl J, Spencer KS, Kim SE, Schmidt M, Mathur J, Dubin AE, Montal M, Patapoutian A.

Nature. 2012 Feb 19;483(7388):176-81. doi: 10.1038/nature10812.

15.

Beltless translocation domain of botulinum neurotoxin A embodies a minimum ion-conductive channel.

Fischer A, Sambashivan S, Brunger AT, Montal M.

J Biol Chem. 2012 Jan 13;287(3):1657-61. doi: 10.1074/jbc.C111.319400. Epub 2011 Dec 12.

16.

Botulinum neurotoxin: a marvel of protein design.

Montal M.

Annu Rev Biochem. 2010;79:591-617. doi: 10.1146/annurev.biochem.051908.125345. Review.

PMID:
20233039
17.

De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies.

Ogiwara I, Ito K, Sawaishi Y, Osaka H, Mazaki E, Inoue I, Montal M, Hashikawa T, Shike T, Fujiwara T, Inoue Y, Kaneda M, Yamakawa K.

Neurology. 2009 Sep 29;73(13):1046-53. doi: 10.1212/WNL.0b013e3181b9cebc.

18.

Vpu matchmakers as a therapeutic strategy for HIV infection.

Montal M.

PLoS Pathog. 2009 May;5(5):e1000246. doi: 10.1371/journal.ppat.1000246. Epub 2009 May 29. No abstract available.

19.

Bimodal modulation of the botulinum neurotoxin protein-conducting channel.

Fischer A, Nakai Y, Eubanks LM, Clancy CM, Tepp WH, Pellett S, Dickerson TJ, Johnson EA, Janda KD, Montal M.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1330-5. doi: 10.1073/pnas.0812839106. Epub 2009 Jan 21.

20.

Translocation of botulinum neurotoxin light chain protease by the heavy chain protein-conducting channel.

Montal M.

Toxicon. 2009 Oct;54(5):565-9. doi: 10.1016/j.toxicon.2008.11.018. Epub 2008 Dec 14. Review.

21.

Botulinum neurotoxin devoid of receptor binding domain translocates active protease.

Fischer A, Mushrush DJ, Lacy DB, Montal M.

PLoS Pathog. 2008 Dec;4(12):e1000245. doi: 10.1371/journal.ppat.1000245. Epub 2008 Dec 19.

22.
23.

Molecular architecture of botulinum neurotoxin E revealed by single particle electron microscopy.

Fischer A, Garcia-Rodriguez C, Geren I, Lou J, Marks JD, Nakagawa T, Montal M.

J Biol Chem. 2008 Feb 15;283(7):3997-4003. Epub 2007 Nov 20.

24.

Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain.

Brunger AT, Breidenbach MA, Jin R, Fischer A, Santos JS, Montal M.

PLoS Pathog. 2007 Sep 7;3(9):1191-4. No abstract available.

25.
26.

Single molecule detection of intermediates during botulinum neurotoxin translocation across membranes.

Fischer A, Montal M.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10447-52. Epub 2007 Jun 11.

27.

Molecular template for a voltage sensor in a novel K+ channel. II. Conservation of a eukaryotic sensor fold in a prokaryotic K+ channel.

Lundby A, Santos JS, Zazueta C, Montal M.

J Gen Physiol. 2006 Sep;128(3):293-300. Epub 2006 Aug 14.

29.

Characterization of Clostridial botulinum neurotoxin channels in neuroblastoma cells.

Fisher A, Montal M.

Neurotox Res. 2006 Apr;9(2-3):93-100.

PMID:
16785104
30.

A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline.

Kamiya K, Kaneda M, Sugawara T, Mazaki E, Okamura N, Montal M, Makita N, Tanaka M, Fukushima K, Fujiwara T, Inoue Y, Yamakawa K.

J Neurosci. 2004 Mar 17;24(11):2690-8.

31.

Functional characterization and NMR spectroscopy on full-length Vpu from HIV-1 prepared by total chemical synthesis.

Kochendoerfer GG, Jones DH, Lee S, Oblatt-Montal M, Opella SJ, Montal M.

J Am Chem Soc. 2004 Mar 3;126(8):2439-46.

PMID:
14982452
32.
33.

Three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) from HIV-1.

Park SH, Mrse AA, Nevzorov AA, Mesleh MF, Oblatt-Montal M, Montal M, Opella SJ.

J Mol Biol. 2003 Oct 17;333(2):409-24.

PMID:
14529626
34.

Structure-function correlates of Vpu, a membrane protein of HIV-1.

Montal M.

FEBS Lett. 2003 Sep 18;552(1):47-53. Review.

35.

Probing conformational changes of gramicidin ion channels by single-molecule patch-clamp fluorescence microscopy.

Harms GS, Orr G, Montal M, Thrall BD, Colson SD, Lu HP.

Biophys J. 2003 Sep;85(3):1826-38.

36.

Nav1.1 channels with mutations of severe myoclonic epilepsy in infancy display attenuated currents.

Sugawara T, Tsurubuchi Y, Fujiwara T, Mazaki-Miyazaki E, Nagata K, Montal M, Inoue Y, Yamakawa K.

Epilepsy Res. 2003 May;54(2-3):201-7.

PMID:
12837571
37.

Translocation of botulinum neurotoxin light chain protease through the heavy chain channel.

Koriazova LK, Montal M.

Nat Struct Biol. 2003 Jan;10(1):13-8.

PMID:
12459720
38.

The structure of the M2 channel-lining segment from the nicotinic acetylcholine receptor.

Montal M, Opella SJ.

Biochim Biophys Acta. 2002 Oct 11;1565(2):287-93. Review.

39.

Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Na(v)1.6).

Kearney JA, Buchner DA, De Haan G, Adamska M, Levin SI, Furay AR, Albin RL, Jones JM, Montal M, Stevens MJ, Sprunger LK, Meisler MH.

Hum Mol Genet. 2002 Oct 15;11(22):2765-75.

PMID:
12374766
41.

Expression, purification, and activities of full-length and truncated versions of the integral membrane protein Vpu from HIV-1.

Ma C, Marassi FM, Jones DH, Straus SK, Bour S, Strebel K, Schubert U, Oblatt-Montal M, Montal M, Opella SJ.

Protein Sci. 2002 Mar;11(3):546-57.

42.

A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction.

Sugawara T, Tsurubuchi Y, Agarwala KL, Ito M, Fukuma G, Mazaki-Miyazaki E, Nagafuji H, Noda M, Imoto K, Wada K, Mitsudome A, Kaneko S, Montal M, Nagata K, Hirose S, Yamakawa K.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6384-9. Erratum in: Proc Natl Acad Sci U S A 2001 Aug 28;98(18):10515.

43.

Structural compatibility between the putative voltage sensor of voltage-gated K+ channels and the prokaryotic KcsA channel.

Caprini M, Ferroni S, Planells-Cases R, Rueda J, Rapisarda C, Ferrer-Montiel A, Montal M.

J Biol Chem. 2001 Jun 15;276(24):21070-6. Epub 2001 Mar 26.

44.

An N-methyl-D-aspartate receptor channel blocker with neuroprotective activity.

Tai KK, Blondelle SE, Ostresh JM, Houghten RA, Montal M.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3519-24.

45.

Modular assembly of voltage-gated channel proteins: a sequence analysis and phylogenetic study.

Nelson RD, Kuan G, Saier MH Jr, Montal M.

J Mol Microbiol Biotechnol. 1999 Nov;1(2):281-7. Review.

PMID:
10943557
46.

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

Planells-Cases R, Caprini M, Zhang J, Rockenstein EM, Rivera RR, Murre C, Masliah E, Montal M.

Biophys J. 2000 Jun;78(6):2878-91.

47.

Structural and functional modularity of voltage-gated potassium channels.

Patten CD, Caprini M, Planells-Cases R, Montal M.

FEBS Lett. 1999 Dec 17;463(3):375-81.

48.

Peptides that mimic the carboxy-terminal domain of SNAP-25 block acetylcholine release at an Aplysia synapse.

Apland JP, Biser JA, Adler M, Ferrer-Montiel AV, Montal M, Canaves JM, Filbert MG.

J Appl Toxicol. 1999 Dec;19 Suppl 1:S23-6. Erratum in: J Appl Toxicol 2000 Nov-Dec;20(6):499.

PMID:
10594895
49.

Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1.

Marassi FM, Ma C, Gratkowski H, Straus SK, Strebel K, Oblatt-Montal M, Montal M, Opella SJ.

Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14336-41.

50.

Activation of store-operated Ca2+ current in Xenopus oocytes requires SNAP-25 but not a diffusible messenger.

Yao Y, Ferrer-Montiel AV, Montal M, Tsien RY.

Cell. 1999 Aug 20;98(4):475-85.

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